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1 pathway where the pH changes from neutral to acidic.
2 nt to reduction, is unreactive toward weakly acidic 4-NO2-phenol, and stronger acids cleave the metal
5 proper selection of quenching solvent (e.g., acidic acetonitrile:methanol:water) can mitigate such pr
6 he yeast Tra1 subunit is the major target of acidic activators such as Gal4, VP16, or Gcn4 but little
7 little adsorption onto sediment minerals in acidic, alkaline or high ionic-strength aqueous media th
8 O] hydrogen bonding interactions between the acidic alpha-H protons in CBPQT(4+) and the oxygen atoms
9 -GlcNAcylation sites, several motifs with an acidic amino acid around the sites were identified, whic
10 alysis of the pKa values of ion-coordinating acidic amino acid residues suggested that the face-speci
12 M for the neutral amino acids and 500 nM for acidic amino acids and were used to analyze samples coll
15 Ps was tested with variations of solution at acidic and basic conditions and different levels of sali
17 of Au(I) and Pt(0) complexes to act as Lewis acidic and basic fragments, respectively, while employin
20 ed ca. 10 times higher mass activity in both acidic and basic solution toward the methanol oxidation
23 t of large particles and become increasingly acidic and proteolytic, ultimately fusing with lysosomes
24 xtracellular matrix protein secreted protein acidic and rich in cysteine (SPARC) is up-regulated and
26 Field NO emission pulses were lowest in the acidic and SOM-rich soils (4-72 ng NO-N m(-2) s(-1) ), b
28 dicate the formation of microdomains between acidic and SR calcium stores, supporting emerging interp
29 However, these catalysts are only weakly acidic and therefore require highly reactive electrophil
31 molecular compounds obtained by evaporating acidic aqueous Th-nitrate solutions in the presence of A
32 s demonstrated the utility of using appended acidic/basic groups to catalyze prototropic exchange for
33 ibutions to postprandial responses caused by acidic beverages.As primary outcome, the incremental are
35 showed that exposure of esophageal cells to acidic bile salts induces phosphorylation of the p47(pho
37 ic cyclization reaction using a highly Lewis acidic borane with concomitant C-H or C-C bond formation
38 o achieve acceleration of CO2 dissolution in acidic brine containing high salinity content, the catal
39 pore space completely, with the result that acidic brine continues to diffuse through the carbonated
41 High deuterium incorporation (up to 49%) in acidic C-H bonds of ketone and alkyne substrates (pKa fr
42 00 family genes encode low molecular weight, acidic-Ca(2+) binding proteins implicating in a wide spe
43 h aryl (alkyl) hydrazines in the presence of acidic catalysts leads to formation of the corresponding
44 dic cerium (IV) and rhodamine B (Ce-RB), and acidic cerium (IV) and rhodamine 6G (Ce-R6G) enhanced by
45 ganate enhanced by formaldehyde (KMnO4-COH), acidic cerium (IV) and rhodamine B (Ce-RB), and acidic c
48 ut cells, intracellular CCVs still form, but acidic cluster proteins are depleted, although several o
52 nization (nESI) is often utilized to analyze acidic compounds, from small molecules to proteins, with
53 droxyphenyl substituents were synthesized by acidic condensation according to a slightly modified pro
57 racellular calcium increases; however, under acidic conditions E623 is partially protonated and works
58 The growth of T. gondii aldolase crystals in acidic conditions enabled trapping of the ternary comple
59 BODIPYs were treated with pyrrole under mild acidic conditions followed by column chromatographic pur
60 riazolo[3,2-c][1,2,4]triazole derivatives in acidic conditions has been achieved by acting on the ele
62 C7) forms long linear quadruplex wires under acidic conditions in the presence of Na(+) that consist
63 e challenges associated with the creation of acidic conditions in the subsurface, the potential for g
64 n water at neutral pH and release them under acidic conditions is evaluated with Gadolinium- 2,2',2''
66 y alpha-thioesterification requires strongly acidic conditions or complex chemical manipulations, whi
67 s, which underwent further degradation under acidic conditions produced after persulfate decomposed.
68 of methoxy- or phenylthio-diazepinones under acidic conditions resulted in the corresponding 3-functi
69 AA) when chlorine is present, although those acidic conditions that favor N-Cl-DCAM degradation are g
70 lies upon decatungstate photocatalysis under acidic conditions using either H2 O2 or O2 as the termin
72 at condensing pyrrole with an aldehyde under acidic conditions yields the "precursor" porphyrinogen m
74 ited to UV spectrophotometric analysis under acidic conditions, and the aqueous association constants
75 oluble and injectable formulations in mildly acidic conditions, form insoluble depots at neutral pH,
93 lycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related
95 fferences may be explained by the lack of an acidic, disordered C-terminal tail in human mtSSB protei
97 16 and Phenylalanine1037 with the N-terminal acidic domain of the telomere shelterin protein TRF1 and
98 itory domain has been mapped to the carboxyl acidic domain of TSPX, truncation of which renders TSPX
99 of 540 mV at 10 mA cm(-2) is attained in an acidic electrolyte and stable for over 30 h, which is th
100 hanced activities toward oxygen reduction in acidic electrolyte, the rational design of sacrificial m
101 g galvanostatic deposition of copper from an acidic electrolyte, we find that the growth front initia
102 ble PEC reaction in either strongly basic or acidic electrolytes without degradation of the semicondu
103 ms are operable on metallic Cu electrodes in acidic electrolytes: (i) electrocatalytic hydrogenation
104 ton diffusion-limited conditions in slightly acidic electrolytes: a model system to study the relativ
105 but that once cleaved, the drug escapes the acidic endo-lysosomal compartment into the cytosol and t
106 acks the autophagic vacuoles to mature in an acidic environment and release progeny virions in a memb
107 rives from FcRn binding to IgG in the weakly acidic environment contained within endosomes of hematop
108 rmance in neutral and alkaline media than in acidic environment may be problematic for practical appl
110 culture: (i) invasive cells that produce an acidic environment via upregulated aerobic glycolysis; a
111 ted species may be able to combat this harsh acidic environment which contains reactive oxygen specie
113 volutionary and physiological adaptations to acidic environments are still poorly understood, with on
114 By protonation of the four histidines in acidic environments, the overall charge and hydrophobic
116 emains a challenge, mainly due to the strong acidic/enzymatic environment of the gastric mucosa.
119 re appeared stable over time, whereas weakly acidic exposure decreased significantly in patients with
122 selective removal was accomplished using an acidic extraction solution (ES) containing acetonitrile
123 sulfate plays a key role in producing highly acidic fine aerosols capable of dissolving primary trans
126 complexes was synthesized by utilizing Lewis acidic group 13 metalloligands, M[N((o-C6H4)NCH2P(i)Pr2)
128 ing pathway, which initiates secretion of an acidic hydrolase mixture to decompose the victim and acq
136 and Gag, depends strongly on the presence of acidic lipids and is enhanced by cholesterol (Chol).
137 tatics between basic amino acid residues and acidic lipids such as phosphoinositides that play a prim
138 rminal region containing linear motifs (CKII-acidic, LXCXE, E2F(TD) -like and LXCXE-mimic) predicted
140 that distinct lung epithelial cells secrete acidic mammalian chitinase (AMCase), which is required f
141 irs in the latter are able to scavenge Lewis acidic MCl2; cagelike adducts of the in,in isomer, trans
142 eved respectable ORR activity in challenging acidic media (0.5 M H2SO4), showing a half-wave potentia
145 zing MoS2 at negative potentials (vs RHE) in acidic media or immersing MoS2 into certain acid solutio
146 yl compounds with hydroperoxides and H2O2 in acidic media, as such reactions involve alpha-cationic i
147 s for the oxygen reduction reaction (ORR) in acidic media, which is crucial for large-scale deploymen
151 ies approaching that of benchmark Pt/C in an acidic medium have been obtained on the catalyst dominat
152 with nitrite, a common food additive, in the acidic medium of stomach to form N- and C-nitroso compou
155 ociated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes
156 are now investigating complexes with a Lewis acidic moiety in the immediate vicinity of the transitio
162 ich are oxidation resistant and stable under acidic, neutral, and basic conditions, are more suitable
163 buted to the synergy between the small Lewis acidic NiO clusters and the redox-active CZ support, whi
164 of calcium on iron redox transformations in acidic nonirradiated and irradiated Suwannee River Fulvi
167 owth of probiotics in the presence of total, acidic or neutral polysaccharides and oligosaccharides w
170 ostatic interactions of K16, weakens H4 tail-acidic patch binding, and significantly increases H4 tai
171 ginine anchor' on CENP-C for the nucleosomal acidic patch disrupts the CENP-A nucleosome structural t
172 th the histone octamer, engaging the H2A-H2B acidic patch in a manner similar to other acidic patch-b
173 /SNF family remodellers, suggesting that the acidic patch may be generally required for chromatin rem
175 ounds that selectively target the nucleosome acidic patch, generating intra-nucleosomal H2A-H2B cross
177 2B acidic patch in a manner similar to other acidic patch-binding proteins such as herpesvirus latenc
180 nce (MF-CL) methods (based on reactions with acidic permanganate enhanced by formaldehyde (KMnO4-COH)
182 ion of alphaS and betaS at pH 7.3 and mildly acidic pH 5.8, and we demonstrate that pH serves as an o
183 nds to H7N9 HA with subnanomolar affinity at acidic pH and 10-fold lower affinity at neutral pH.
184 erum and plasma, and their responsiveness to acidic pH and cis-diols (such as mannitol, a safe FDA ap
185 se of lycopene in simulated gastric fluid at acidic pH and faster release in simulated intestinal flu
187 ular pH homeostasis and were not observed if acidic pH in intracellular compartments was neutralized.
189 gered by pathogenic microenvironments (e.g., acidic pH or low oxygen levels) for localized and contro
191 idis at basic pH values (pH = 9) compared to acidic pH values (pH = 6) due to a smaller size and posi
193 with 2-mercaptoethanesulfonic acid at mildly acidic pH yielded alpha-thioesters that were directly us
195 ighter association of LDL with LDLR-R410S at acidic pH, a reduced LDL delivery to late endosomes/lyso
196 ate that the catalase activity is reduced at acidic pH, as compared with the activity at pH 7.4.
197 mib release was accelerated significantly by acidic pH, facilitating drug availability in the acidic
198 , traditionally assumed to be stable only at acidic pH, have been found to form under near-physiologi
199 FcRn with high affinity at both neutral and acidic pH, prevents the simultaneous binding of IgG, and
200 nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially loca
201 higher Vmax and Km values as well as higher acidic pH-dependent activity than NtRbcS-M, an isoform e
207 end corresponded to a transition from mildly acidic (pH 6-7) and oxic conditions to mildly alkaline (
211 tor IpgB1 from Shigella flexneri may bind to acidic phospholipids and regulate actin filament dynamic
213 we find that, although proton sensing in the acidic pocket is not required for channel function, it d
214 f galactose, glucose and mannose whereas the acidic polysaccharides contain fucose, xylose and 4-O-me
217 interactions between basic, glycosylated and acidic proline-rich proteins (bPRPS, gPRPs, aPRPs) and P
218 ncrease in the glial marker glial fibrillary acidic protein (GFAP) and in Slit2 at the glial wedge an
219 al growth factor (VEGF) and glial fibrillary acidic protein (GFAP) expressions were detected by immun
220 cific intermediate filament glial fibrillary acidic protein (GFAP) lead to the rare and fatal disorde
221 BACKGROUND & AIMS: When the glial fibrillary acidic protein (GFAP) promoter is used to express cellul
222 lial cell injury biomarker, glial fibrillary acidic protein (GFAP)-breakdown product (GBDPs) in injur
223 system (CNS) disorder with glial fibrillary acidic protein (GFAP)-IgG as biomarker was recently char
224 E and Toll-like receptor 4, glial fibrillary acidic protein and neuronal nitric-oxide synthase, and A
225 increase astrocyte-produced glial fibrillary acidic protein in the hippocampus, which was impaired in
226 der regulation of the mouse glial fibrillary acidic protein promoter to knock out the transcription f
227 or molecule 1), astrocytes (glial fibrillary acidic protein), and neuronal nuclei were performed.
229 ding adapter molecule 1 and glial fibrillary acidic protein, and behavioral deficits associated with
230 cells expressing vimentin, glial fibrillary acidic protein, and nestin, we show that the distributio
231 sing immunofluorescence for glial fibrillary acidic protein, microglia-specific proteins Iba1 and CD6
232 ostnatal ablation of LPL in glial fibrillary acidic protein-expressing astrocytes induced exaggerated
233 ocytochemistry, Timm stain, glial fibrillary acidic protein-immunocytochemistry, glutamic acid decarb
234 nt role of Lewis basic sites proximal to the acidic proton in facilitating protonation of the nitride
236 tly after one year, but the number of weakly acidic reflux episodes decreased significantly in the la
237 histone exchange activity of SWR, whereas an acidic region at the N-terminus is required for optimal
238 ce of Ng13-49 by showing that the N-terminal acidic region of Ng peptide pries open the beta-sheet st
240 e corresponding nitro precursor, followed by acidic removal of the 2-methoxyethoxymethyl protecting g
241 n of the Tyr(11) residue of NT[8-13] with an acidic residue (Glu(179)) located in the ECL2 of hNTS2 o
244 otif (NDSM) carries an additional stretch of acidic residues downstream of the consensus Psi-K-x-E/D
246 rimetry and NMR spectroscopy, we report that acidic residues in the BAZ2B PHD domain are essential fo
247 tutions in betaS, we localized the switch to acidic residues in the N-terminal and non-amyloid compon
248 thermore, protonation-mimicking mutations of acidic residues in the palm induce a dramatic accelerati
252 nes bound to CA II via an interaction of the acidic ring nitrogen with the CA II active site zinc, as
254 casein kinase 2 (CK2) phosphorylation of two acidic sequences within the MRE11 C terminus containing
256 mation, and electrostatic repulsions between acidic side chains, which collectively drive a sharp pH-
257 eficient heavy chalcogen atoms contain Lewis acidic sigma-holes which are able to form attractive sup
259 ed by resonating over a larger area, a Lewis acidic site emerges on nitrogen that can interact favour
260 results in the methyl esterification of all acidic sites and the conversion of amines to quaternary
261 that both the concentration and strength of acidic sites are highest for the catalyst with the large
262 aracterization of the catalytic activity and acidic sites as a function of PTA loading demonstrates t
263 a pincer-based Fe(II) complex provides Lewis acidic sites capable of binding 1 or 2 equiv of N2H4.
264 lysis of GVL by framework Zn-OH and Bronsted acidic sites to butene and then to aromatic compounds ha
265 a play an important role in nitrification in acidic soils, but their evolutionary and physiological a
266 pulates two OER mechanisms, one operating in acidic solution and another operating in alkaline soluti
268 erials that are completely soluble in mildly acidic solutions but precipitate upon injection into a p
270 obtained in neat acetonitrile with data from acidic solutions suggests that the inverted driving-forc
272 rced degradation study showed an increase in acidic species and a decrease in basic species when samp
273 DP action proposes that calcium release from acidic stores subsequently acts to enhance calcium relea
274 Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling
275 trols the binding of histones at its largest acidic stretch (A2) via direct competition with both the
277 he mechanism of metals dissolution by highly acidic sulfate aerosol and the effect on particle oxidat
278 ssolution of aluminum-containing minerals in acidic sulfate solutions, such as those that could resul
279 center via a direct interaction with a Lewis acidic support can be a powerful strategy for promoting
281 (5-HT) in response to the presence of sour (acidic) tastants and this released 5-HT activates 5-HT3
282 ompetitive binding experiments show that the acidic tip of the E. coli Hfq CTD transiently binds the
283 ding domain with the 9 amino acid C-terminal acidic tip that is involved in SSB binding to other prot
288 ed by a pentamer-forming domain and multiple acidic tracts that mediate histone binding and chaperone
290 lladium dichloride complex featuring a Lewis acidic trichlorostiborane moiety positioned within the l
292 rface charge reversal from -7.4 to 8.2 mV at acidic tumor tissue, for enhanced tumor penetration and
293 f experimental Air and Soil warming in moist acidic tundra, we show that Soil warming had a much stro
297 e through the cell membrane and further into acidic vesicles present in eukaryotic cells such as prot
298 through trapping in alpha4beta2R-containing acidic vesicles that is selective and nicotine-regulated
300 II) concentration is to be expected, even in acidic waters, since time scales of light-mediated Fe(II
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