ライフサイエンスコーパス: acidic amino acid

1 denotes arginine or lysine and X denotes non-acidic amino acids).

2 ominantly heptameric pore with a basic or an acidic amino acid.

3 mutagenesis approach that targets conserved acidic amino acids.

4 r k(cat)/K(m) when substrates contain nearby acidic amino acids.

5 ovel NLS identified in this study is rich in acidic amino acids.

6 ested that the active site contains reactive acidic amino acids.

7 y N terminal to the acidic box, a stretch of acidic amino acids.

8 E. coli sequence by inspection of conserved acidic amino acids.

9 intra- and intermolecular repulsions between acidic amino acids.

10 re it is coordinated by both MHC and peptide acidic amino acids.

11 divalent metal actually interacts with these acidic amino acids.

12 c surface with a pK value similar to that of acidic amino acids.

13 halophilic archaeal proteins are enriched in acidic amino acids.

14 may be due to strong binding of water by the acidic amino acids.

15 whether their activity is enhanced by nearby acidic amino acids.

16 a novel high-affinity system for neutral and acidic amino acids.

17 latory phosphorylation sites were changed to acidic amino acids.

18 ectus strains contained large proportions of acidic amino acids (13 to 27%) and that >34% of the amin

19 Consistent with the presence of nine acidic amino acids (16%) in M. smegmatis CAMLP, there is

20 tes the matrix protein is relatively high in acidic amino acids, a feature consistent with its solubi

21 cytosolic domain of gB contains a cluster of acidic amino acids, a motif that plays a pivotal role in

22 monstrated that the deletion of a cluster of acidic amino acids (aa 44 to 59) prevented wild-type tra

23 Mutation of either of two conserved acidic amino acids abrogated the catalytic activity of t

24 ficiency studies reveal that two clusters of acidic amino acids (ACs) within the PC6B-cd contain diff

25 However, other neutral and acidic amino acids act as strong competitors for proline

26 The two acidic amino acids adjacent to the middle cysteinyl resi

27 The position of glycine, proline, and acidic amino acids allows the glycosylation machinery to

28 iptional activation is unlikely to depend on acidic amino acids alone.

29 replacing the lysines that flank VQDLL with acidic amino acids also reduced inhibitory activity, sug

30 C-terminal acidic amino acids, although present in many proteoglyca

31 th appreciable activities for cleavage after acidic amino acids and a broadened activity for cleavage

32 showed that the vicilin had high contents of acidic amino acids and a low lysine/arginine ratio.

33 ch as a BRCA1 C-terminal domain, clusters of acidic amino acids and consensus motifs for post-transla

34 DLL motif, which has a unique arrangement of acidic amino acids and hydrophobic leucines, functions a

35 M for the neutral amino acids and 500 nM for acidic amino acids and were used to analyze samples coll

36 eplaced with alanine, glycine, valine, or an acidic amino acid, and the activities of the mutated pro

37 His-2 zinc fingers, an N-terminal stretch of acidic amino acids, and a C-terminal leucine zipper-like

38 pecific sequence motif, in which one or more acidic amino acids are found at the carboxy end interact

39 The residues homologous to these acidic amino acids are highly conserved in the cNOR fami

40 beta-Branched and acidic amino acids are poor substrates.

41 In BR, acidic amino acids are stationary anions whose proton af

42 -GlcNAcylation sites, several motifs with an acidic amino acid around the sites were identified, whic

43 cetyltransferases in that it does not use an acidic amino acid as a catalytic base.

44 e exposed to the cytoplasm, we identify four acidic amino acids as putative calcium-binding residues.

45 e) can be controlled simply by adding chiral acidic amino acids (Asp and Glu).

46 flavodoxin mutants were studied in which 10 acidic amino acids--Asp62, Asp63, Glu66, Asp69, Asp70, A

47 smaller Pf% was due to protonation of three acidic amino acids (Asp646, Glu648, and Glu651) that are

48 tional activity; mutation of the sites to an acidic amino acid, aspartic acid, stimulates constitutiv

49 cleavage sites are frequently observed when acidic amino acids, aspartic and glutamic acids, are pre

50 critical determinant for this effect was an acidic amino acid at position 13 in the CCR5 N terminus,

51 rm a hydrogen bond with the side chain of an acidic amino acid at position 27.

52 and full phosphorylation at P2 required the acidic amino acids at A1 or their neutral counterparts.

53 Q386E impaired the ability of ASCT1 to bind acidic amino acids at pH 5.5; however, this was reversed

54 he SMT active center is composed of a set of acidic amino acids at positions 125, 152, 195, and 276,

55 Mutation of the acidic amino acids at positions 298-300 (site A1) and/or

56 e are caused by differences in the number of acidic amino acids at the C terminus, so each protein is

57 the favorable binding motif characterized by acidic amino acids at the P9 position.

58 The present study investigated the role of acidic amino acids between P1 and P2 in regulating recep

59 This domain contains a cluster of 7 acidic amino acids between residues 475 and 483.

60 ompted functional evaluation of 11 invariant acidic amino acids by site-directed mutagenesis.

61 These results demonstrate that an acidic amino acid can supply the negative charge in the

62 rary to conventional views, neutral and even acidic amino acids can play crucial roles in NLSs.

63 so less active than phosphorylated wt, i.e., acidic amino acids cannot substitute for phospho-Ser-627

64 for the full activation of arrestin and that acidic amino acids (carboxyl and sulfonic) do not mimic

65 We also showed that the two acidic amino acid clusters are essential for this intera

66 that neutralizing or reversing the charge of acidic amino acid clusters stalled translocation in the

67 -terminal region of the heavy chain contains acidic amino acid clusters that are important for cofact

68 in the KRYK (VI) or KYEK (VII) sequences to acidic amino acids create mutants that bind F-actin with

69 a subunit by mutating three highly conserved acidic amino acids, D211V, E212L, and E226L, resulted in

70 C-terminal tail of PKAc within a cluster of acidic amino acids (DDYEEEE), which is a characteristic

71 uch as nucleoside phosphates or oligomers of acidic amino acids disaggregate actin bundles into singl

72 de of the anion conductance activated by the acidic amino acids does not correlate with rates of tran

73 o constructed a mutant in which a cluster of acidic amino acids (EDDDDAE) in the sensor domain is rep

74 The acidic amino acid enantiomers were resolved with gamma-c

75 binding site, only conversion of Val68 to an acidic amino acid facilitates ternary complex assembly w

76 Thus, substitution of an acidic amino acid for a nonpolar amino acid (i.e. Asp ve

77 hift to pAP* was mimicked by substituting an acidic amino acid for either Thr231 or Ser235, but the s

78 These results suggest that CPO cleaves acidic amino acids from dietary proteins and peptides, t

79 removal of covalently associated, inhibitory acidic amino acids from proximity with the Crp4 componen

80 er a neutral amino acid Ala (T229A) or by an acidic amino acid Glu (T229E).

81 moving the fixed negative charge of a single acidic amino acid (Glu(51)) in the lateral entrance to t

82 groups prompted evaluation of four invariant acidic amino acids (Glu-19, Glu-193, Asp-204, and Glu-29

83 tive site comprises the side-chains of three acidic amino acids (Glu20, Asp55 and Glu65) together wit

84 mains included a high proportion of strongly acidic amino acids (glutamate and aspartate), and these

85 urine, a gamma-aminobutyric acid (GABA)-like acidic amino acid, has previously been shown to be promi

86 Because acidic amino acids have a critical role in catalyzing DN

87 ase Sa) (pI=3.5) and a variant in which five acidic amino acids have been changed to lysine (5K) (pI=

88 tagenesis study of this protein, whereby all acidic amino acids have been individually replaced by ot

89 ast to other enzymes in this class, in which acidic amino acids have been shown to be essential for g

90 F from sugars accelerated in the presence of acidic amino acids (i.e. glutamic and aspartic acids).

91 We altered each conserved acidic amino acid in RAG1 and RAG2 by site-directed muta

92 An acidic amino acid in the -1 position increases the rate

93 nting the formation of a salt bridge with an acidic amino acid in the peptide.

94 ion as alphaA-wt, whereas the mutant with an acidic amino acid in this position, R116D, showed drasti

95 ized by a cytosolic YXXL downstream of three acidic amino acids in a sequence known as a hemITAM (hem

96 Critical vicinal acidic amino acids in ARH3, identified by mutagenesis (A

97 es required for toxin binding, extracellular acidic amino acids in domains I and IV of the type IIa N

98 sis and to also test whether other conserved acidic amino acids in Drosophila Rhodopsin 1 (Rh1) may s

99 The acidic amino acids in gum arabic were shown to play an i

100 No conserved acidic amino acids in RAG2 were critical for catalysis;

101 , MPZ-1 also interacts with other GPCRs with acidic amino acids in the -3 position of their PDZ bindi

102 A buried cluster of acidic amino acids in the binding groove predicted to be

103 Moreover, acidic amino acids in the C-terminus appear to negativel

104 In IE(k), two alpha chain acidic amino acids in the core of this network were muta

105 are detected along with several neutral and acidic amino acids in the Murchison sample.

106 tro binding assays, we identified a group of acidic amino acids in the N-terminal leucine zipper dime

107 prin beta subunit has a clear preference for acidic amino acids in the P1 and P1' sites of substrates

108 structural changes caused by substitution of acidic amino acids in the Q(B) binding pocket of the bac

109 Substitution of the acidic amino acids in the TFP by neutral amino acids and

110 factor (FGF) receptors contain a cluster of acidic amino acids in their extracellular domains that i

111 Two adjacent acidic amino acids in this region (Asp-546 and Glu-547)

112 Deletion of the N-terminal acidic amino acids in uroguanylin demonstrated that thes

113 r HLA-DQ8, the P1 residue, which was also an acidic amino acid, influenced binding positively.

114 he wild-type lysine with either a neutral or acidic amino acid inhibited E5-induced receptor activati

115 Introduction of these acidic amino acids into the HA of CA/09 also improved va

116 a critical function in import of neutral and acidic amino acids into the tapetum cells for synthesis

117 phorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein kinas

118 Of note, the acidic amino acids L- and D-glutamate and aspartate were

119 Two clusters of acidic amino acids, L(958)DDV and D(986)NDD in the wild-

120 region at the COOH-end, and regions rich in acidic amino acids, leads to the hypothesis that the Pra

121 Here, we report that acidic amino acids lining the sRNA binding channel betwe

122 Nine acidic amino acids located within the S5-Pore-helix segm

123 Protein is a major constituent of bone, but acidic amino acids may promote bone resorption.

124 ikely form ionic interactions with conserved acidic amino acids on E7 since a stable pRB/E7 interacti

125 Arg substitution of three unique acidic amino acids on the surface of FN1 eliminated poly

126 lectivity of ASCT1 to allow the transport of acidic amino acids, particularly l-aspartate.

127 , -3, and -2) or a pair of distal N-terminal acidic amino acids (positions -6 and -5).

128 ow a differential effect of mutations to two acidic amino acids potentially involved in cation bindin

129 In the kidney it is involved in renal acidic amino-acid re-absorption and amino-acid metabolis

130 ts of the study suggested the presence of an acidic amino acid residue at the S(1)'-subsite of calpai

131 sults are consistent with the presence of an acidic amino acid residue at the S(1)'-subsite of calpai

132 Substitution of acidic amino acid residue E27, D35, or E54 caused severe

133 The acidic amino acid residue was found to be Glu261 via mol

134 tion with earlier studies which implicate an acidic amino acid residue, suggest that a crucial intera

135 ted that segments of ICP0R that were rich in acidic amino acid residues (amino acids 9 to 76 and 233

136 ffective method for profiling and localizing acidic amino acid residues (D/E), amide-containing resid

137 ve identified two homologous creatine kinase acidic amino acid residues (Glu232 and Asp326), and thes

138 ne residues are embedded within a cluster of acidic amino acid residues and account for nearly 90% of

139 n the protonated dimethylamino group and the acidic amino acid residues Asp(50), Glu(85), and Glu(94)

140 , at most contributing equivalently with the acidic amino acid residues clustered around the flavin t

141 Targeted mutation of selected acidic amino acid residues demonstrated that the binding

142 ectoenzyme that catalyzes the hydrolysis of acidic amino acid residues from the amino termini of reg

143 The role of acidic amino acid residues in cation recognition and sel

144 SH3 domain-binding surface and a cluster of acidic amino acid residues in Nef, both of which are als

145 by basic amino acids in the positive mode or acidic amino acid residues in the negative mode.

146 )(2+), we individually mutated each of these acidic amino acid residues in topoisomerase IIalpha to e

147 of these studies, we conclude that the four acidic amino acid residues interact with metal ions in t

148 ctions through the neutralization of certain acidic amino acid residues leading to faster overall obs

149 Mutations of any of the 3 acidic amino acid residues located at the active site ca

150 cting programs, TopPred II and MEMSAT, eight acidic amino acid residues located near or within transm

151 alysis of the pKa values of ion-coordinating acidic amino acid residues suggested that the face-speci

152 alpha-LA contains a large number of acidic amino acid residues that may influence the proper

153 y neutralized by the substitution of the six acidic amino acid residues with their amide equivalents.

154 omain of Akt and a "pseudoligand" containing acidic amino acid residues, between cyan and yellow muta

155 ion 659-663, which contains five consecutive acidic amino acid residues, by site-directed mutagenesis

156 The alanine mutants of the three acidic amino acid residues, D61, E63, and D65, all have

157 nopropyl)carbodiimide (EDAC), which modifies acidic amino acid residues, resulted in a time- and conc

158 pha-lactalbumin, which displays a cluster of acidic amino acid residues, showed enhanced adsorption a

159 ns with a significantly higher proportion of acidic amino acid residues.

160 enzyme catalytic reactions involving His and acidic amino acid residues.

161 nce for sequons containing and/or flanked by acidic amino acid residues.

162 topoisomerases through a series of conserved acidic amino acid residues.

163 k output genes (the PAR [rich in proline and acidic amino acid residues] transcription factors dbp, h

164 mutagenesis of VH1-46 Abs demonstrates that acidic amino-acid residues introduced by somatic mutatio

165 ine zipper proteins containing a proline and acidic amino acid-rich (PAR) domain.

166 a factor (HLF), a member of the proline- and acidic amino acid-rich (PAR) subfamily of bZIP transcrip

167 namely the period genes and the proline- and acidic amino acid-rich basic leucine zipper (PAR-bZip) c

168 A targeting sequence (AYRV) and a second, acidic amino acid-rich region of the gpI cytosolic domai

169 but unmapped gene NEFA (DNA binding/EF hand/acidic amino-acid-rich).

170 In addition, their attraction to acidic amino acid side chains and formation of a hydroge

171 uclear localization signal, and a stretch of acidic amino acids similar to the activation domains of

172 a PB1 sequence that contains three essential acidic amino acids, similar to the active sites of other

173 In contrast, acidic amino acid substitution mutants interacted with T

174 tidine (basic amino acid) for aspartic acid (acidic amino acid) substitution in the encoded protein d

175 ivo activity of a form of ANTP that contains acidic amino acid substitutions at its CKII target sites

176 Combining three acidic amino acid substitutions in these sites in the HG

177 onsistent with phosphorylation of S338-S339, acidic amino acid substitutions of these residues partia

178 At positions 35 and 37, acidic amino acid substitutions reduced activity to less

179 ivation domain and alteration of most single acidic amino acids, suggesting that a previously postula

180 al catalytic core domain includes a triad of acidic amino acids that bind Mn2+ or Mg2+, the metal cof

181 e(44) in mouse pro-Crp4-(20-92) removes nine acidic amino acids that collectively block the membrane-

182 nal tails, specifically by the last 8 highly acidic amino acids that comprise the binding site for it

183 It contains three acidic amino acids that coordinate two divalent metal io

184 which is homologous to the highly conserved acidic amino acids that link protonation to activation o

185 codes a protein rich in glycine, serine, and acidic amino acids that shows no significant similarity

186 sess a stretch of 10-15 residues enriched in acidic amino acids, the acidic domain (AD), in the flexi

187 closely with hydroxyapatite, positioning the acidic amino acids to aid in controlling crystal growth.

188 Acidic amino acid transport by the EAATs is coupled to t

189 ilies possess a protein domain containing an acidic amino acid triad (DDE or DDD) that catalyzes the

190 a consensus motif for a calcium-coordinated acidic amino acid triad cluster as originally identified

191 d by the Y subunit, that cleaves bonds after acidic amino acids was designated as peptidylglutamyl-pe

192 When acidic amino acids were inserted in CP-RB19 and CP-31D t

193 is of the sequence identity of SS, conserved acidic amino acids were mutagenized to identify the spec

194 ved surface residues, including a cluster of acidic amino acids, were found to be located on a single

195 The nuclease domain contains conserved acidic amino acids, which in Escherichia coli RNase III

196 ctivating cleavages after branched chain and acidic amino acids while inhibiting cleavage of peptidyl

197 Conserved acidic amino acids, whose primary role appears to be che

198 Replacing the acidic amino acids within GPIHBP1 residues 38-48 with al

199 This repression required the presence of acidic amino acids within the AF2 domain.

200 line at position 3 or 4, and (iii) a lack of acidic amino acids within the first 12 residues.

201 A di-leucine sequence and a cluster of acidic amino acids within this region are essential elem

202 nine may be substituted for the aromatic and acidic amino acids without destroying transcriptional ac