ライフサイエンスコーパス: acidic pH

1 iological conditions (high salts, serum, and acidic pH).

2 the PLA2R NC3 fragment and was increased in acidic pH.

3 itial stages of glucagon fibril formation at acidic pH.

4 p promoted better growth at alkaline than at acidic pH.

5 shold required to inhibit the RIM pathway at acidic pH.

6 modified with rhodamine-lactam responsive to acidic pH.

7 nitrosative reactions are not influenced by acidic pH.

8 rotein synthesis when cells were cultured at acidic pH.

9 /A is induced by interacting with NTNHA-A at acidic pH.

10 eled with (111)In by 20 min of heating at an acidic pH.

11 d by substantial FeS dissolution at slightly acidic pH.

12 en conformations coexist as discrete ones at acidic pH.

13 II secretion system (T3SS) is upregulated by acidic pH.

14 its open and locally closed conformations at acidic pH.

15 Greater lipid oxidation occurred under an acidic pH.

16 onment of tryptophan was less hydrophilic at acidic pH.

17 RP3 receptor abolished IL-1beta secretion at acidic pH.

18 sole aerobic succinate transporter active at acidic pH.

19 embranes highlighting the requirement for an acidic pH.

20 most polyphenols, since they are unstable at acidic pH.

21 h higher at near neutral or basic pH than at acidic pH.

22 ion via the reversible dissociation of V1 at acidic pH.

23 ive-stain electron microscopy at neutral and acidic pH.

24 rganic species are able to reduce Fe(III) at acidic pH.

25 ducts protons into the virion under external acidic pH.

26 phosphatidylserine (PC/PS) under neutral and acidic pH.

27 n-grown Sindbis virus responds to moderately acidic pH.

28 disassembled HPV16 pseudovirions at slightly acidic pH.

29 ine and ceramide and has optimum activity at acidic pH.

30 can often be populated by exposure to mildly acidic pH.

31 wave and differential pulse voltammograms at acidic pH.

32 to inhibition by active Galpha(q) protein or acidic pH.

33 is most stable under reducing conditions and acidic pH.

34 ammaENaC that are required for regulation by acidic pH.

35 an bind to ox-LDL without the requirement of acidic pH.

36 l under iron-restricted growth conditions at acidic pH.

37 ld-type CRP, E42Q CRP remained pentameric at acidic pH.

38 I) inserted as a transmembrane (TM) helix at acidic pH.

39 emains bound to wild-type OLF at neutral and acidic pH.

40 e with endosomal membranes upon encountering acidic pH.

41 0453 increased efflux of fluorophore only at acidic pH.

42 ith the dependence of IgG-FcRn binding in an acidic pH.

43 n improved the microstructure of the gels at acidic pH.

44 boxilic acids (C4-diC) transporter active at acidic pH.

45 with bound antibodies and in the presence of acidic pH.

46 retion, and redox metabolism, in response to acidic pH.

47 the composition of the phases at neutral and acidic pH.

48 sing by furin-like proteases and exposure to acidic pH.

49 s of poly(rA) were first proposed to form at acidic pH.

50 he latter PhoQ-activating signals but not to acidic pH.

51 mer of hairpins seen in gp26 crystallized at acidic pH.

52 spholipids such as phosphatidylserine and an acidic pH.

53 ered and finely regulated at either basic or acidic pHs.

54 port in the environment at neutral to mildly acidic pHs.

55 lysosomal subcellular compartments and their acidic pHs.

56 more predominant nucleophiles at neutral and acidic pHs.

57 Cuniculiplasmataceae, recently isolated from acidic (pH 1-1.5) sites in Spain and UK that are 16S rRN

58 sets from a high-temperature (80 degrees C) acidic (pH 2) hot spring located in Yellowstone National

59 aining the Maurliden mine (Sweden) is highly acidic (pH 2.3) and rich in zinc ( approximately 460 mg

60 S) wetland sediments under varying redox and acidic (pH = 2.6-5.8) conditions using U L3-edge X-ray a

61 es within high-temperature (65-75 degrees C) acidic (pH = 2.7-3.8) Fe(III)-oxide microbial mats, and

62 tensive sulfide mineralization and generated acidic (pH 3.2-4.5), iron-rich drainage waters (up to 1.

63 in the presence of the organic exudate under acidic (pH 4) and alkaline (pH 8) conditions.

64 and Fe(III) was investigated here under both acidic (pH 4) and alkaline (pH 8) conditions.

65 ermoproteus populations were found in mildly-acidic (pH 5-6) sulfur sediments, and Pyrobaculum popula

66 as greater in weakly basic (pH 9) and weakly acidic (pH 5.5) pH.

67 ts the majority of 5mC to 5fC under slightly acidic (pH 5.8) and neutral conditions.

68 ized defects in synthetic lipid membranes at acidic pH 5 and low peptide concentration.

69 ion of alphaS and betaS at pH 7.3 and mildly acidic pH 5.8, and we demonstrate that pH serves as an o

70 of over 2000 m, the pool is characterized by acidic pH (5.3), high temperature (68 degrees C), salini

71 to iron-limited media, oxidative stress, and acidic pH (5.5) for 0.5 to 2 h had no effect on abcA exp

72 end corresponded to a transition from mildly acidic (pH 6-7) and oxic conditions to mildly alkaline (

73 osystem is anoxic and consists of a slightly acidic (pH 6.2) sodium chloride-dominated brine.

74 an IC50 value that is 10-fold more potent at acidic pH 6.9 associated with ischemic tissue compared t

75 At weakly acidic pH (6.5), bisulfite and nitrite exhibited much st

76 ighter association of LDL with LDLR-R410S at acidic pH, a reduced LDL delivery to late endosomes/lyso

77 and triggers membrane fusion in response to acidic pH--a strategy common to many viral fusogens.

78 nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially loca

79 A mildly acidic pH activates the master virulence regulatory syst

80 At acidic pH, all three Mfps adhered strongly to the CH3-te

81 An acidic pH also attenuated LL-37 killing of Pseudomonas a

82 Cathepsins are most stable at acidic pH, although growing evidence indicates that they

83 nds to H7N9 HA with subnanomolar affinity at acidic pH and 10-fold lower affinity at neutral pH.

84 hannels were resistant to inhibition by both acidic pH and active Galpha(q) protein.

85 Gleevec phenotypes require an intracellular acidic pH and are independent of tyrosine kinase inhibit

86 's cytoplasmic domain hindered activation by acidic pH and attenuated virulence in mice, but did not

87 The goal of this study was to examine how acidic pH and available carbon sources interact to regul

88 athogen, Salmonella Typhimurium, responds to acidic pH and CAMP through the PhoPQ two-component regul

89 abolic studies demonstrate that signals from acidic pH and carbon source are integrated to remodel pa

90 erum and plasma, and their responsiveness to acidic pH and cis-diols (such as mannitol, a safe FDA ap

91 nic interactions at the HA1-HA2 interface at acidic pH and deformation of the HA1 membrane-distal dom

92 Recombinant OsHAD1 is active at acidic pH and dephosphorylates a broad range of organic

93 to CAMP, but is inhibited for activation by acidic pH and divalent cation limitation.

94 imurium is virulent in mice, indicating that acidic pH and divalent cation sensing by PhoQ are dispen

95 ncluding under diverse conditions such as at acidic pH and elevated temperature, or in the presence o

96 bon sources, Mtb fully arrests its growth at acidic pH and establishes a state of non-replicating per

97 se of lycopene in simulated gastric fluid at acidic pH and faster release in simulated intestinal flu

98 proteolytic activity of an enzyme at highly acidic pH and for determining the kinetics of protein-DN

99 ory system is required to slow Mtb growth at acidic pH and functions to maintain redox homeostasis.

100 fluorimetric assay, which demonstrated that acidic pH and high osmotic pressure suppress genome rele

101 These reactions are further enhanced at acidic pH and higher concentrations of Cr(VI).

102 3-bound fibrinogen/fibrin and plasminogen at acidic pH and increased plasmin-mediated fibrinolysis.

103 itrificans cells, confirming its activity at acidic pH and inhibition by pepstatin.

104 lycopeptides at HDX quench conditions, i.e., acidic pH and low temperature.

105 ine pair at this location destabilizes HA at acidic pH and mediates fusion at a higher pH, while a gl

106 The large granules had an acidic pH and normal activity of lysosomal enzymes and w

107 GAGs induce fast sCT fibrillation at acidic pH and only bind monomeric sCT at acidic pH, indu

108 ions tested, has a better solubility at mild acidic pH and preserves a significant thermal stability

109 LRP1 with high affinity at both neutral and acidic pH and proved to be a potent inhibitor of LRP1 fu

110 In addition to survival at acidic pH and resistance to polymyxin, PhoP was required

111 s its accumulation at the plasma membrane at acidic pH and thereby inhibits RIM signaling.

112 The reaction is fast at acidic pH and tolerates alcohols, carboxylic acids, and

113 tter by noncovalent interactions at slightly acidic pH and, thus, potentially pollute natural water b

114 peptide charge (number of basic residues at acidic pH) and size.

115 y high concentrations of lactate, a slightly acidic pH, and specific short-chain fatty acid profiles,

116 Mg(2+) limitation, acidic pH, and the presence of cationic antimicrobial pe

117 Pilus gene expression was activated by acidic pH, and this effect was independent of CsrRS and

118 ith the addition of both chitosan, targeting acidic pH, and urokinase plasminogen activator (UPA), ta

119 ix native plant species to grow in extremely acidic (pH approximately 2.5) metalliferous (As, Pb, Zn:

120 w crystallization at ambient conditions from acidic (pH approximately 3) aqueous solutions.

121 To deliver the anti-lncRNA to the acidic (pH approximately 6) tumor microenvironment, PNAs

122 ate that the catalase activity is reduced at acidic pH, as compared with the activity at pH 7.4.

123 P-selectin/PSGL-1 binding is strengthened at acidic pH, as evidenced by the formation of a new hydrog

124 e binding strength and frequency increase at acidic pH, as indicated by the greater cell-rolling flux

125 The main determinant of acidic pH at the Golgi is the vacuolar-type H(+)-translo

126 While the acidic pH at the luminal side inhibited P2X4 activity, i

127 e; these enzymes are activated by the highly acidic pH (between 4.5 and 5.0) in the organelles' inter

128 Under acidic pH, boric acid self-assembled on the surface of d

129 pH, while the pr region interacts with E at acidic pH but is released at neutral pH.

130 enerated a channel that was not activated by acidic pH, but inhibition by alkaline pH was intact.

131 eous chi1 and chi2 torsional fluctuations at acidic pH, but only restricted chi1 fluctuations at high

132 sible timescale by conducting experiments at acidic pH, by the slow dilution of the protein in the in

133 mportant polymodal cellular sensor for heat, acidic pH, capsaicin, and other noxious stimuli.

134 At acidic pH, cathepsin D specifically cleaved caspase-8 bu

135 Acidic pH caused a dilation of PAs which was inhibited b

136 Changing to a slightly acidic pH caused no detectable change of structure for t

137 Acidic pH causes a catabolic and degenerate phenotype in

138 Our findings show that acidic pH causes an HSPG-mediated uptake and an enhancem

139 bservations extend previous indications that acidic pH causes the M1 layer to dissociate, leaving the

140 ndergo a structural change when subjected to acidic pH comparable to that seen in endosomal compartme

141 Further, it appears that acidic pHs comparable to those seen in late endosomes in

142 the released iron(II) ions from IO NPs under acidic-pH condition.

143 We show that acidic pH conditions caused by LAB and low temperatures

144 ermodynamic driving forces under neutral and acidic pH conditions for various fusion steps.

145 At acidic pH conditions, MtbESAT-6 underwent a significant

146 Under acidic pH conditions, the mature virus forms transient f

147 like aggregates are formed in solution under acidic pH conditions.

148 th NPC1 lumenal domain 2 is only detected at acidic pH, conditions that are optimal for cholesterol b

149 Despite the narrow acidic pH curve, the enzyme is active along a temperatur

150 howed its transport of riboflavin to have an acidic pH dependence, saturability (apparent Km = 1.4 +/

151 higher Vmax and Km values as well as higher acidic pH-dependent activity than NtRbcS-M, an isoform e

152 y at these positions is crucial for obligate acidic pH-dependent activity.

153 ld be attributed to enhanced activity of two acidic pH-dependent, ceramide-generating enzymes, beta-g

154 IFNgamma release blocked by acidic pH did not occur at the level of steady-state mRN

155 ther pentameric form of CRP, which exists at acidic pH, displays binding activity for oxidized LDL (o

156 e sought to examine the mechanistic basis of acidic pH-driven hENT3 nucleoside transport with site-di

157 e to cross cellular membranes, dissociate at acidic pH due to the iminobiotin linker and preserve the

158 e (SCX) strategy, operating at two different acidic pHs, enabling both separation and enrichment of d

159 Neutral (as opposed to acidic) pH enhanced GBS binding to vaginal epithelial ce

160 vely release its DOX payload triggered by an acidic pH environment (pH~5) and/or applying an 808nm NI

161 microparticles during a 10-hour period in an acidic pH environment and the complete degradation of on

162 An acidic pH environment blocked T-cell activation and limi

163 Furthermore, BCM could be disassembled in an acidic pH environment or by administrating mannitol, fac

164 n of membrane permeable properties in mildly acidic pH environments, such as the surface of tumor cel

165 hysiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they

166 overall icosahedral structure at this mildly acidic pH, except in the membrane-binding region, where

167 At acidic pH, excess protein unbinds from RNA/CP complexes

168 e variants with increased FcRn affinities at acidic pH exhibited extended serum half-lives relative t

169 construct is highly pH-sensitive in a mildly acidic pH, exhibiting high binding and internalization a

170 mib release was accelerated significantly by acidic pH, facilitating drug availability in the acidic

171 channels show rapid activation upon jumps to acidic pH followed by a time-dependent loss of conductan

172 the association of APOL1 with the bilayer at acidic pH, followed by the opening of APOL1-induced cati

173 ral pH, it becomes permeable to Na(+) at the acidic pH found in endosomes.

174 f simple secondary amines release are 0.5 at acidic pH from 3.9 to 6.6 dropping to 0.1 at neutral pH

175 sponse to chemical markers of disease (i.e., acidic pH, H2O2) is presented.

176 , traditionally assumed to be stable only at acidic pH, have been found to form under near-physiologi

177 -gradient (facilitated at alkaline pH(e) and acidic pH(i)).

178 cellent stability toward neutral to slightly acidic pH in 10 mM sodium phosphate buffer, mitigating t

179 ifts the pH dependence of activation to more acidic pH in ASIC1a and ASIC1b, whereas in ASIC3 this sh

180 ular pH homeostasis and were not observed if acidic pH in intracellular compartments was neutralized.

181 oP-dependent genes were minimally induced by acidic pH in the non-pathogenic species Salmonella bongo

182 the aggregation process of human insulin at acidic pH in the presence of sulfate ions using a combin

183 t-Golgi compartments and is dependent on the acidic pH in the secretory pathway.

184 elongated domains that associate in pairs at acidic pH in the stem region of VWF dimeric bouquets.

185 Bacterial exposure to acidic pH in vitro increased agr expression.

186 Interestingly, HTNV Gn crystallized at acidic pH, in a compact tetrameric configuration distinc

187 We previously found that acidic pH increases the activity of human ENaC, which re

188 uring acid-induced stress, and we found that acidic pH increases the open probability of SspA.

189 Even at very acidic pH indium was retained to >98% by nanofiltration,

190 ortantly, inhibition of ASIC-3 prevented the acidic pH induced proinflammatory and pain-related pheno

191 is hidden at physiological pH, is exposed by acidic pH-induced structural changes in pentameric CRP.

192 Influenza virus entry is mediated by the acidic-pH-induced activation of hemagglutinin (HA) prote

193 at acidic pH and only bind monomeric sCT at acidic pH, inducing sCT helicity.

194 sed the increased viscosity, suggesting that acidic pH influences mucin electrostatic interactions.

195 sthetic-activated and Galpha(q) protein- and acidic pH-inhibited potassium conductance important in n

196 Acidic pH initiates a series of E1 conformational change

197 The acidic pH inside these vesicles triggers a major structu

198 Because acidic pH is a common feature of hypoxia, as well as tum

199 Furthermore, because acidic pH is known to stabilize hypoxia-inducible factor

200 cumneutral pH (Keq = 10(-38.65)) compared to acidic pH (Keq = 10(-44.81)).

201 Drug binding at acidic pH largely suppresses this exchange, reverting th

202 e that long-term exposure of cancer cells to acidic pH leads to a metabolic reprogramming toward glut

203 Unlike RFC, PCFT is active at acidic pH levels characterizing the tumor microenvironme

204 ding does not exhibit significant changes at acidic pH levels, as shown both experimentally and compu

205 alent cations and induced in environments of acidic pH, limited divalent cations, and cationic antimi

206 ates in, rendering the lumenal flow strongly acidic (pH </= 2) that suppresses eluite weak acid disso

207 t 50% of the world's arable land is strongly acidic (pH </= 5).

208 th an acidification pretreatment and at more acidic pH, MBM biochar causes precipitation of a ZnPO4 p

209 Performing the reaction at an acidic pH not only encourages aniline to desorb but also

210 protein secondary structure at an extremely acidic pH of 1.2.

211 Preexposure of isolated virions to mildly acidic pH of 5 to 6 partially inactivates HSV infectivit

212 we found that the trans-Golgi network had an acidic pH of 6.1, while the prevacuole and late prevacuo

213 physiological pH but reversible at the mild acidic pH of endosomes or lysosomes.

214 r shows heterogeneity that we ascribe to the acidic pH of the crystals.

215 PfA-M1 is both stable and active at the acidic pH of the food vacuole lumen.

216 molecular properties of this protein at the acidic pH of the lysosome.

217 the acclimation of this oncobacterium to the acidic pH of the stomach.

218 y, we investigated the influence of slightly acidic pH on the binding dynamics of selectins (P-, L-,

219 ake and secrete proteases predominantly with acidic pH optima.

220 An acidic pH optimum (~4.6) and colocalization with LAMP1 v

221 The acidic pH optimum for PCFT is relevant to intestinal abs

222 activity with p-nitrophenyl fucoside with an acidic pH optimum of 4.6.

223 3A is a functional phosphodiesterase with an acidic pH optimum.

224 (PCFT) is a proton-folate symporter with an acidic pH optimum.

225 In this context, acidic pH or alkaline pH with the presence of UO2(2+)- a

226 gered by pathogenic microenvironments (e.g., acidic pH or low oxygen levels) for localized and contro

227 cking OprD were more resistant to killing by acidic pH or normal human serum and had increased cytoto

228 ) , but not when PhoQ is activated by mildly acidic pH or the antimicrobial peptide C18G.

229 ly sensitive to pH: their induction required acidic pH (pH 5.3), but their magnitude could be increas

230 es in water, at either neutral or moderately acidic pH (phosphate buffer, pH 5) depending on the cata

231 FcRn with high affinity at both neutral and acidic pH, prevents the simultaneous binding of IgG, and

232 Although acidic pH promotes amyloid fibril formation by this and

233 survive within macrophages, possibly because acidic pH promotes expression of Salmonella virulence pr

234 Fe(III)-oxide phases was investigated in the acidic pH range (pH 2.5-6).

235 This unique sensitivity in the mildly acidic pH range can be applied to targeting the activati

236 An acidic pH reduced the biosolids charge while simultaneou

237 Importantly, an acidic pH reduced the synergistic effects of combination

238 These results indicate that an acidic pH reduces the activity of individual ASL antimic

239 concentration were observed, whereas the OER acidic pH regime exhibited a quasi-infinite Tafel slope

240 y both enzymes was stimulated severalfold at acidic pH, relative to normal physiologic pH.

241 Acidic pH represents a novel danger signal alerting the

242 Here we report that Mtb growth at acidic pH requires host-associated carbon sources that f

243 Acidic pH resulted in an increase in ASIC-3 expression.

244 re of P22 tail needle (gp26) crystallized at acidic pH reveals a slender fiber containing an N-termin

245 While the mechanisms underlying acidic pH sensation have been extensively characterized,

246 natants collected in sorption experiments at acidic pH showed that the approximately 5700 compounds i

247 Following endocytosis into host cells, acidic pH signals the prechannel to form the channel sta

248 aim here was to address the hypothesis that acidic pH, similar to that found in degenerate IVDs, lea

249 tion, prrAB transcription was induced, while acidic pH stress and carbon starvation did not significa

250 th Fe(3+) and Cu(2+) and retains activity at acidic pH, suggesting it may also function within intrac

251 1alpha and IL-1beta at pH 7.4 and pH 6.2, an acidic pH that can be reached under inflammatory or isch

252 anges produced in the PhoQ PD on exposure to acidic pH that indicate structural flexibility is induce

253 el Fc variants with high affinity binding at acidic pH that vary in pH 7.4 affinities and assessed ph

254 hus, apart from helping in ligand release at acidic pH, the C-terminus in ApolPBP1 also plays an impo

255 hemical reduction of CO, finding that (1) at acidic pH, the C1 pathway proceeds through COH to CHOH t

256 omains packed in a firm assembly, whereas at acidic pH, the three IgG-binding domains form an elongat

257 FcRn and Y8 mAb bind their partners only at acidic pH, the Y8 mAb is proposed to carry out its antiv

258 Once forming a complex at acidic pH, they each adopt a stable conformation that is

259 In contrast, at acidic pH, this proton release group remains protonated

260 channel is closed at neutral pH and opens at acidic pH to allow the rapid access of urea to cytoplasm

261 herosclerosis because wild-type CRP requires acidic pH to bind to deposited, conformationally altered

262 ural integrity and occurred optimally at the acidic pH typical of urine from omnivorous humans.

263 gh these proteins could bind ligands even at acidic pH unlike wild-type ApolPBP1, they had ~4-fold re

264 The reduction was favorable at acidic pH (up to pH 5) and followed the pseudo-first-ord

265 While slightly acidic pH values (pH 6.2 and 5.2) enhanced the binding o

266 idis at basic pH values (pH = 9) compared to acidic pH values (pH = 6) due to a smaller size and posi

267 periphery shifts this self-assembly to more acidic pH values and also induces a spherical micellar m

268 Lysosomal catabolism is catalyzed at acidic pH values by cationic sphingolipid activator prot

269 This channel is activated at slightly acidic pH values in the endosome when the His(37) residu

270 that CrCAH3 was most active at the slightly acidic pH values prevalent in the thylakoid lumen under

271 ly relevant to drug delivery, occurs at more acidic pH values than previously considered.

272 gates have higher activities at the slightly acidic pH values that separate normal and cancerous tiss

273 ydrolysis half-lives of the polymers at mild acidic pH values was achieved, from a few minutes to a f

274 At acidic pH values, binding of heparin to FS288 and the FS

275 Na(+) dependence was observed at neutral and acidic pH values, indicating the exclusive use of Na(+)

276 Thus, at mildly acidic pH values, such as those, for example, that are p

277 At acidic pH values, the fluorophores were almost completel

278 lux through hTRPA1 occurred at physiological acidic pH values, were concentration-dependent, and were

279 In addition, acidic pH was found to inhibit the activity of the mitoc

280 The solubility of NaCas at acidic pH was improved, becoming pH-independent after 24

281 A hydrophobic effect at acidic pH was shown by the relatively high positive entr

282 neutral pH (but not membrane association at acidic pH) was prevented by the interaction of APOL1 wit

283 Female NOD mice that were maintained on acidic pH water (AW) developed insulitis and hyperglycem

284 using peptides that respond at increasingly acidic pH, we demonstrate that the route of entry for th

285 Under acidic pH, weakening of the interdomain interactions exp

286 Dilations induced by acidic pH were unaltered by inhibitors of K(ATP) channel

287 cate limited stability of trans-5-OH-TBOH at acidic pH where it undergoes concurrent, carbocation-med

288 The iM structure is formed at slightly acidic pH, where hemiprotonation of cytosine results in

289 acids (Ala, Cys) reduced ENaC stimulation by acidic pH, whereas reintroduction of a negative charge (

290 t neutral pH and a more ordered structure at acidic pH), which could be related to its acid stress re

291 revealed cis-12-OH-TBOH to be more stable at acidic pH, which is the only condition where its reversi

292 f the paclitaxel payload within six hours in acidic pH, which was accompanied by switching of fluores

293 ligand at physiological pH and release it at acidic pH while undergoing a conformational change.

294 acts with E at neutral pH but is released at acidic pH, while the pr region interacts with E at acidi

295 of a hydroxyl group enhanced the binding at acidic pH, whilst this substitution reduced the strength

296 nteraction at focal adhesions is enhanced at acidic pH, with a concomitant decrease in Tyr-397 phosph

297 tion and elongation are strongly enhanced at acidic pH, with a maximum close to the pI of actin.

298 t oxidants of Fe(II) in aqueous solutions at acidic pH, with rate constants substantially larger than

299 lus fumigatus and Cryptococcus neoformans at acidic pH, yet remained nontoxic.

300 with 2-mercaptoethanesulfonic acid at mildly acidic pH yielded alpha-thioesters that were directly us