ライフサイエンスコーパス: acidification

1 na)- remained highly resilient to increasing acidification.

2 similar browning values to those obtained by acidification.

3 ich greatly amplified the negative effect of acidification.

4 f PtdIns4P is required for proper phagosomal acidification.

5 ss transcription factor OmpR is required for acidification.

6 s both bacterial uptake by DCs and endosomal acidification.

7 s in granitic alpine regions recovering from acidification.

8 uminal H(+) secretion and possibly lysosomal acidification.

9 obal change stressors, one of which is ocean acidification.

10 it altered pH homeostasis with extracellular acidification.

11 rane-anchored V0-sector, regulates lysosomal acidification.

12 a key driver of ecosystem change under ocean acidification.

13 ter, photochemical oxidants, and terrestrial acidification.

14 of pH in the range achievable by rhizosphere acidification.

15 r to each other in response to extracellular acidification.

16 d bypharmacological inhibition of phagosomal acidification.

17 e-dependent V-ATPase reassembly and vacuolar acidification.

18 ened ROS production and attenuated lysosomal acidification.

19 scue of autophagic flux upon acute lysosomal acidification.

20 obal warming potential, ozone depletion, and acidification.

21 result of increasing temperatures and ocean acidification.

22 ver, how redox reactions would contribute to acidification.

23 er receptors by responding to synaptic cleft acidification.

24 nt of TCIRG1, as well as to promote lysosome acidification.

25 rotonophore activity that leads to cytoplasm acidification.

26 bal environmental change, particularly ocean acidification.

27 ases on cell surfaces further contributes to acidification.

28 se is the main regulator of intra-organellar acidification.

29 sulting from global climate change and ocean acidification.

30 hydrolase maturation, and impaired lysosomal acidification.

31 also partially corrected IFN-gamma-mediated acidification.

32 This untimely egress depends on host cell acidification.

33 cerevisiae, including impairment of vacuole acidification.

34 sp. settled later and were more tolerant to acidification.

35 systems in a similar way to ocean warming or acidification.

36 to initiating self-assembly through solution acidification.

37 starter have been crucial for a satisfactory acidification.

38 embly trigger, which changes the kinetics of acidification.

39 ation sensitivities to temperature and ocean acidification.

40 ore expression homeostasis response to ocean acidification.

41 experiment, while effects of low-temperature acidification (28 degrees C/888 ppm-v) were not apparent

42 eria, viruses, mangroves, turtles, and ocean acidification; (3) physical and chemical stressors such

43 32 degrees C/424 ppm-v) and high-temperature acidification (32 degrees C/940 ppm-v) on calcification

44 nd here we show that in brainstem astrocytes acidification activates Na(+)/HCO3(-) cotransport, which

45 Lysosome acidification also occurs during Xenopus oocyte maturati

46 ys: they are activated by both intracellular acidification and alkalinization and are regulated by th

47 ory circuitry that controls petunia vacuolar acidification and Arabidopsis hair development.

48 tion of T3S function, allowing for phagosome acidification and bacterial killing.

49 The heteromer was inhibited by extracellular acidification and by spadin similarly to TREK-1, and its

50 r signaling abolishes both the extracellular acidification and cellular expansion.

51 imate change--increasing temperatures, ocean acidification and changes in stratification over decadal

52 pressing TMEM106B exhibit impaired lysosomal acidification and degradative function, as well as incre

53 Auxin application triggers rapid cell wall acidification and elongation of aerial organs of plants,

54 ance by differential regulation of lysosomal acidification and enzymatic activity.

55 imatization or adaptation of corals to ocean acidification and even less about the molecular mechanis

56 This auxin-stimulated acidification and growth require TIR1/AFB-Aux/IAA nuclea

57 and dense-core vesicles, and control vesicle acidification and hence synaptic function, likely throug

58 ad to a poor acid buffering capacity, severe acidification and increased carbonate mineral dissolutio

59 -type proton (H(+)) ATPase (V-ATPase) impair acidification and intracellular trafficking of membrane-

60 iscover an intriguing link between phagosome acidification and lipid signposts on their outer membran

61 flux in cardiomyocytes by impairing lysosome acidification and lysosomal function.

62 sizes, food prices, greenhouse gas emission, acidification and marine eutrophication estimates were a

63 ating PM H(+)-ATPases to facilitate apoplast acidification and mechanical wall loosening.

64 Acidification and NHE1 overexpression both reduce cell-c

65 ase AP1 and V0 subunits, impairing lysosomal acidification and normalizing lysosomal protein levels i

66 and T78 played important roles in hydrolytic-acidification and oil-organics degradation.

67 m simultaneous measurements of extracellular acidification and oxygen consumption.

68 Acidification and pollution are two major threats to agr

69 obial community responses to co-existed soil acidification and pollution remain less explored.

70 sion by both loosening the cell wall through acidification and promoting solute uptake.

71 Pulses are stimulated by local acidification and propagate - in analogy to sound - at v

72 ancreatitis, we observed substantive luminal acidification and provide evidence that ANO1/TMEM16A act

73 2 in DCs, which in turn inhibited phagosomal acidification and reduced the degradation of tumor mitoc

74 bone resorption by stimulating extracellular acidification and regulating cell survival.

75 ted that the Ham test is highly dependent on acidification and requires a serum factor destroyed by h

76 Indeed, T3S prevented phagosome acidification and resisted killing inside these compartm

77 ATP production rates from raw extracellular acidification and respiration data.

78 tential of these genes may be related to the acidification and severe plant disease of degraded soils

79 ional in CF airway epithelium leading to ASL acidification and that these processes may contribute to

80 Endolysosomal acidification and the endosomal transporter protein UNC9

81 st that endogenous auxin controls apoplastic acidification and the onset of cellular elongation in ro

82 tes cell elongation by stimulating cell wall acidification and thus expansin action.

83 aper explores the contributions of endosomal acidification and various proteases to coronavirus infec

84 ndage and the carapace under long-term ocean acidification and warming conditions.

85 how coral calcification may respond to ocean acidification and warming depends on our understanding o

86 Therefore, while next-century ocean acidification and warming will reduce the rate at which

87 ted multiple climate change stressors (ocean acidification and warming) on Antarctic fishes.

88 pods are among the first responders to ocean acidification and warming, but have not yet been widely

89 mining which species will benefit from ocean acidification and why.

90 Sequential offline acidifications and filtrations afforded ciprofloxacin an

91 such as NO synthase, the respiratory burst, acidification, and autophagy, how human macrophages cont

92 ey are implicated in cell volume regulation, acidification, and cell cycle.

93 ge, the combined influence of ocean warming, acidification, and deoxygenation, poses a serious threat

94 allenges: overfishing, climate change, ocean acidification, and pollution.

95 alinization of astrocytes, and extracellular acidification, and thereby reduce susceptibility to epil

96 ase), the key proton pump for endo-lysosomal acidification, and two previously uncharacterised V-ATPa

97 Climate change and ocean acidification are altering marine ecosystems and, from a

98 f POC forcing under climate change and ocean acidification are then applied to investigate how benthi

99 ophosphate-induced enteroid intracellular pH acidification as part of duodenal HCO3(-) secretion appe

100 adults were significantly more vulnerable to acidification as well as the additional stressors.

101 removed increased phosphorus solubilized by acidification at the end of second cycle, however, it al

102 Inhibition of phagosomal acidification blocks TLR9 accumulation on phagosomes con

103 min-mediated membrane scission and endosomal acidification but is distinct from clathrin-dependent or

104 ective in endosomal trafficking or organelle acidification but not those defective in autophagy displ

105 metabolic acidosis (MAc), AE3 speeds initial acidification, but limits the extent of pHi decrease in

106 ing-were negatively impacted by next-century acidification, but not by next-century warming.

107 rease from a mean of 57% (in 2010) to 61% by acidification, but would decrease to 48% by incineration

108 IP binds to lipid membranes, and responds to acidification by undergoing a coupled folding/membrane i

109 tivity of calcification to local CO2-induced acidification caused by natural respiration in an unpert

110 CM obtained by direct acidification (CMA) had lower microbial counts and highe

111 yers of Mytilus edulis shells cultured under acidification conditions (1000 muatm pCO2) compared to p

112 ge had significantly higher % Mg under ocean acidification conditions, while oxidative stress levels

113 ch as anemones, which may thrive under ocean acidification conditions.

114 that go beyond 2100 projections in an ocean acidification context; 2) the relatively benign environm

115 Defective lysosomal acidification contributes to virtually all lysosomal sto

116 ase B1 subunit p.E161K SNP exhibit a urinary acidification deficit with an increased prevalence of ca

117 production, anthropogenic CO2 -driven ocean acidification, deoxygenation and ocean circulation.

118 Ocean warming, acidification, deoxygenation and reduced productivity ar

119 621-101 cells reduced extracellular pH with acidification dependent on 621-101 mechanistic target of

120 Acidification did not affect cytoplasmic pH, suggesting

121 location experiments demonstrated that ocean acidification did not drive increases in gastropod abund

122 es such as hypoxia, nutrient deprivation and acidification disturb protein folding in the endoplasmic

123 Furthermore, we show that cytoplasm acidification dramatically affects the dynamics and recr

124 Overall, transient and persistent acidification-driven changes in the biofouling community

125 ntrast to the prevailing view that lysosomal acidification drives Ca(2+) into the lysosome, inhibitin

126 For instance, acidification due to carbohydrate fermentation or inflam

127 ted solvent sites often leads to groundwater acidification due to electron donor fermentation and enh

128 ation and apoptosis in response to cytosolic acidification during cellular stress.

129 low us to present a structural model for how acidification during endocytic uptake of the virus trigg

130 ns of transgenerational acclimation to ocean acidification during experiments.

131 he presence of AE3 also speeds intracellular acidification during the early phase of metabolic acidos

132 Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide

133 30-day interval-indicating delayed onset of acidification effects at lower temperatures.

134 CO2 is relieved mid-succession, whether past acidification effects persist, are reversed by alleviati

135 e coldwater fish appears to be shifting from acidification effects to thermal impacts associated with

136 tage marine bivalves are vulnerable to ocean acidification, effects over successive generations are p

137 muscle phosphocreatine breakdown and muscle acidification, eliminated the glycolytic-associated cont

138 Following acidification, endocytosed CGs are recycled through earl

139 h well-defined species interactions to ocean acidification (enrichment of CO2 ) in isolation and in c

140 osystem services attributable to the reduced acidification expected from more stringent air pollution

141 ipneustes ventricosus) submitted to a 5 week acidification experiment (pHT of 8.1, 7.7, and 7.4).

142 ence of glucose, the glycosome exhibits mild acidification from pH 7.4 +/- 0.2 to 6.8 +/- 0.2.

143 Extracellular acidification from pHe7.4 to 6.4 decreases cell migratio

144 Here, we show that intracellular acidification generates excitatory responses in sour tas

145 Moreover, the results show that upon acidification, GlcCer solubility in the lo phase is incr

146 nd acid-base regulation in response to ocean acidification have been predicted to decrease the energy

147 rticle-bound aluminum from primary sludge by acidification (HCl or H2SO4), followed by separation usi

148 s that reflected both short- and longer-term acidification history.

149 The predictions for acidification, human health, and the eco-indicator 99 mo

150 lar H(+)-ATPases (V-ATPases) drive organelle acidification in all eukaryotes, and membrane-bound a-su

151 Inhibiting phagocytosis and endosomal acidification in BMDCs or moDCs impaired the release of

152 This leads to ASL acidification in CFHBE, which could only be mimicked in

153 biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open oce

154 potential contribution of redox reactions to acidification in coastal waters is unclear.

155 by L lactis G121 was dependent on endosomal acidification in dendritic cells (DCs).

156 with forskolin caused enteroid intracellular acidification in HCO3(-)-free buffer.

157 ting v-ATPase function dysregulate lysosomal acidification in other LSDs and common neurodegenerative

158 osomal-delivered MPO also disrupts lysosomal acidification in RPE cells, which coincides with nuclear

159 lish a causative role for impaired lysosomal acidification in the deregulation of autophagy and beta-

160 e most vulnerable marine ecosystems to ocean acidification, in part because the very architecture of

161 differ in their ability to control cellular acidification, in the manner of inverse agonists.

162 Transient acidification increased the retrieval-induced lability o

163 Here we show that ocean acidification increases energetic demands on gastropods

164 typically have a lower sensitivity to ocean acidification induced changes.

165 Acidification-induced [Ca(2+)]i responses were also dram

166 cellular domains, and it proposes a model of acidification-induced conformational changes occurring i

167 Acidification-induced reductions in calcification are pr

168 We found that intracellular acidification induces conformational modifications in pr

169 How ocean acidification influences coccolithophore calcification i

170 eral experimental factors, including gastric acidification, intestinal transit time, presence of gast

171 Ocean acidification is a global challenge that faces marine or

172 Whether impaired lysosomal acidification is causally inhibiting autophagic flux and

173 the responses of macroalgal species to ocean acidification is complex, but we demonstrate that the re

174 In particular, ocean acidification is predicted to have a detrimental effect

175 Ocean acidification is predicted to have detrimental effects o

176 in their rhizosphere via plant-induced local acidification, leading to dissolution of carbonates and

177 dth enhances the response to small-amplitude acidifications likely to occur at the cleft and may prov

178 ns of carbon dioxide (CO2) are causing ocean acidification, lowering seawater aragonite (CaCO3) satur

179 industrial conditions, indicating that ocean acidification may already be impairing coral reef growth

180 Defective acidification may be caused by impaired recruitment of R

181 lity over time, but eutrophication and ocean acidification may be perturbing the water chemistry beyo

182 nteractions, and inhibitors of extracellular acidification may be potential therapies for LAM.

183 Ocean acidification may have far-reaching consequences for mar

184 forming oxygen consumption and extracellular acidification measurements of several hundreds to 1,000

185 as not observed by both co-precipitation and acidification methods.

186 r and digitoxin together cause intracellular acidification, mitochondrial calcium dysregulation and A

187 The working principle of the developed acidification module relies on the cation-exchange proce

188 By using the acidification module, the limit of detection of nitrite-

189 Cell death events including acidification, nuclear envelope permeabilization, and DN

190 ses of marine phytoplankton to ongoing ocean acidification (OA) are appearing rapidly in the literatu

191 e considered particularly sensitive to ocean acidification (OA) as their skeleton is made of high-mag

192 Ocean acidification (OA) due to elevated CO2 is hypothesised t

193 Ocean acidification (OA) increasingly threatens marine systems

194 Ocean acidification (OA) is driving rapid changes to the marin

195 Ocean acidification (OA) is expected to indirectly impact biot

196 The near-term progression of ocean acidification (OA) is projected to bring about sharp cha

197 To date, studies of ocean acidification (OA) on coral reefs have focused on organi

198 The effects of ocean acidification (OA) on the early recruitment of pteropods

199 Increasing seawater pCO2 leads to ocean acidification (OA) with a reduction in oceanic carbonate

200 r major global change drivers, such as ocean acidification (OA), will shape species distributions in

201 ng during the past century, leading to ocean acidification (OA).

202 arbonate ion concentrations: so called ocean acidification (OA).

203 one of the species most susceptible to ocean acidification (OA).

204 ojected climate change exacerbating seasonal acidification, OA of coastal habitats could represent a

205 duce ocean pH during the 21st century (ocean acidification, OA).

206 We show that auxin-induced acidification occurs by local activation of H(+)-ATPases

207 muatm) is driving climate change and causing acidification of both marine and freshwater environments

208 In contrast, weak acidification of eczematous skin in conventionally house

209 ITM expression promoted virus uptake and the acidification of endosomal compartments, resulting in an

210 cAMP enhanced the acidification of endosomes for Fe(II) release to the LIP

211 , electrolyte movement across epithelia, and acidification of intracellular organelles.

212 in demonstrating industrial emissions caused acidification of lakes and associated ecosystem-wide imp

213 In addition, fusion or subsequent acidification of liposomes can be monitored by incorpora

214 Perforin-2 may derive from it regulating the acidification of Listeria-containing vacuoles, thereby d

215 se 6-phosphate receptor, and facilitated the acidification of lysosomes and degradation of CTSDmat.

216 The acidification of lysosomes was facilitated in cells tran

217 l function and biogenesis by controlling the acidification of lysosomes.

218 ion, P limitation enhanced the formation and acidification of membrane vesicles in the cytoplasm.

219 The resulting in-line acidification of natural waters with millimolar sodium c

220 1 transgene in nephrocytes also impaired the acidification of organelles.

221 Neuronal activity can result in transient acidification of presynaptic terminals, and such shifts

222 T: Neuronal activity can result in transient acidification of presynaptic terminals, and such shifts

223 Preventing intracellular acidification of Salmonella renders it avirulent, sugges

224 Acidification of seawater caused by anthropogenic carbon

225 ion of sulfite to volatile sulfur dioxide by acidification of the analyzed solution.

226 thogens, the assembly of the matrix, and the acidification of the biofilm microenvironment, promoting

227 caused by an influx of protons and a marked acidification of the cytoplasm, which leads to widesprea

228 hondrial membrane potential but dependent on acidification of the cytosol by FCCP.

229 Furthermore, C5a induced acidification of the extracellular micromilieu.

230 currence of tumor pHe changes that report on acidification of the interstitial fluid caused by an acc

231 ns of atmospheric carbon dioxide are causing acidification of the oceans.

232 ptic ASICs can be activated by the transient acidification of the synaptic cleft accompanying neurotr

233 during synaptic transmission, suggesting an acidification of the synaptic cleft due to the corelease

234 aptic current by responding to the transient acidification of the synaptic cleft that accompanies neu

235 by hypoxia is a metabolic shift resulting in acidification of the tumor microenvironment.

236 an integral membrane protein involved in the acidification of the viral interior, a step necessary fo

237 ts, despite the differences in the degree of acidification of their endosomes.

238 Acidification of US milk produced gels with increased fi

239 ation of the acidification process, and also acidification of vesicles destined for exocytosis.

240 ication of pH probes has been to monitor the acidification of vesicles during endocytosis, an essenti

241 escent pH probes are useful tools to monitor acidification of vesicles during endocytosis, but the si

242 diated intracellular alkalization (or lesser acidification) of AQP4-expressing oocytes, these data su

243 nts, we tested the indirect effects of ocean acidification on a calcifying herbivore (gastropod) with

244 We conclude that the effect of ocean acidification on algae (primary producers) can have a st

245 Here, we describe the effects of ocean acidification on an upwelling system that already experi

246 Yet, the indirect effects of ocean acidification on calcifying organisms, which may counter

247 We demonstrate that the effect of ocean acidification on grazer biomass (Phyllaplysia taylori an

248 Italy, was used to test the effects of ocean acidification on the bacterial community of two anemone

249 ssess the transgenerational effects of ocean acidification on two species of North Atlantic bivalve s

250 hesis, we found that inhibition of endosomal acidification only modestly decreased entry, and overexp

251 heroid formation are strongly impaired under acidification or NHE1 overexpression.

252 scallops are unlikely to acclimate to ocean acidification over short time scales and that as coastal

253 In LAM cell-fibroblast co-cultures, acidification paralleled cathepsin K activity, and both

254 g of endocytosed material, regulation of the acidification process, and also acidification of vesicle

255 Two acidification profiles were imposed, in order to mimic t

256 find that the presence of AE3 increases the acidification rate constant during pHi recovery from int

257 ere was a 1.7-fold increase in extracellular acidification rate, a 1.4-fold increase in lactate produ

258 The oxygen consumption and extracellular acidification rate, a measure of glycolysis, are both gr

259 umption rate and increased the extracellular acidification rate, indicating preference for aerobic gl

260 power, oxygen consumption, and extracellular acidification rates.

261 y revealed an intimate link between vacuolar acidification, redox physiology, and virulence in M. tub

262 n macroalgal and epiphyte biomass with ocean acidification, regardless of nutrient concentration.

263 ity of calcifying ecosystems to future ocean acidification remains unknown.

264 The positive effect of acidification reported by Hutchins and co-workers is lik

265 withstanding a beneficial effect of high CO2 Acidification resulted in low cytosolic pH and reduced N

266 h a physical nonequilibrium model of vesicle acidification, revealed that pumping is stochastically i

267 A. equina will be winners under future ocean acidification scenarios.

268 to five prominent impacts of climate change: acidification, sea-level rise, intensification of storms

269 Acidification started once PCr depletion reached 60-75%.

270 nd native ASICs from sensory neurons to 1 ms acidification stimuli, switching from pH 8.0 to 5.0, as

271 Here, we show that extracellular acidification strongly potentiated glycine-gated current

272 n alter a large number of minerals via local acidification, targeted excretion of ligands, submicron-

273 ndicative of a more substantial influence of acidification than PAH pollution on bacteria driven ecol

274 skeleton formation less susceptible to ocean acidification than previously assumed.

275 activity, which is in stark contrast to the acidification that occurs in neighboring neurons.

276 eport on a novel approach for in-line sample acidification that results in a significant improvement

277 eory postulates that auxin triggers apoplast acidification, thereby activating cell wall-loosening en

278 alyses indicate that increased use of slurry acidification, thermal drying, incineration and pyrolysi

279 tion in Arabidopsis thaliana However, forced acidification through artificial proton pump activation

280 However, forced acidification through artificial proton pump activation

281 Loss of lysosomal acidification through inhibition of the vacuolar H(+)-ad

282 lactis, LlPC is required for efficient milk acidification through its essential role in aspartate bi

283 on, identifying a critical role of phagosome acidification to facilitate microbial digestion.

284 cades, determining the contribution of ocean acidification to these changes is difficult, if not impo

285 HID-1 KO cells also exhibit defects in TGN acidification together with mislocalization of the Golgi

286 e energy demand, global warming (IPCC 2007), acidification (TRACI), human health (Impact2000+), ecosy

287 d ZnT2 deletion impaired vesicle biogenesis, acidification, trafficking, and secretion.

288 Using HPTS, we demonstrate that cell wall acidification triggers cellular expansion, which is corr

289 sition but may improve as lakes recover from acidification under low emissions scenarios combined wit

290 s >10 000 muatm) long before the term 'ocean acidification' was coined, with limited detrimental effe

291 nvestigate the effect of this SNP on urinary acidification, we conducted a genotype-phenotype analysi

292 es of in hospite Symbiodinium in response to acidification were greater and less consistent among ree

293 n) and US treatment (at 20 degrees C) before acidification when compared with either heating or US al

294 For instance, TREK1 is inhibited by external acidification, whereas TREK2 is activated.

295 psi) component of the pmf, rather than lumen acidification, which in vivo increased PSII charge recom

296 duced by PKAc1 inactivation or environmental acidification, while a cGMP-phosphodiesterase inhibitor

297 h corals build their skeletons, next-century acidification will also modify the morphology and, poten

298 Recovery from acidification will not eliminate the threat of climate c

299 During infectious entry, acidification within the endosome triggers uncoating of

300 Our findings highlight the role of tumor acidification within the hypoxic niche in the regulation