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1 esent in an acidic compartment rich in Ca2+ (acidocalcisome).
2 and possessing a high calcium content (i.e., acidocalcisomes).
3 polyP hydrolysis and Ca(2+) release from the acidocalcisome.
4 reduced levels of polyphosphate and altered acidocalcisomes.
5 a short chain polyP kinase that localizes to acidocalcisomes.
6 in acidic, calcium-rich organelles known as acidocalcisomes.
7 vacuolar proton pyrophosphatase, a marker of acidocalcisomes.
8 -localization with antibodies against VP1 to acidocalcisomes.
9 ls of inorganic polyphosphate (polyP) within acidocalcisomes.
10 n, and high density, are similar to those of acidocalcisomes.
11 imalarial chloroquine to deplete Ca(2+) from acidocalcisomes.
12 xoplasma gondii tachyzoites is stored within acidocalcisomes.
13 phore membranes, is predominantly located in acidocalcisomes.
14 pyrophosphatase (V-H(+)-PPase), a marker of acidocalcisomes.
15 umefaciens possess properties similar to the acidocalcisomes.
16 ane, endoplasmic reticulum, mitochondria and acidocalcisomes.
17 polyphosphatase activities characteristic of acidocalcisomes.
18 calcium, and magnesium, as found before for acidocalcisomes.
19 ata, a link between these organelles and the acidocalcisomes.
20 proteins (VSPs), which are localized to its acidocalcisomes.
21 ologically and by X-ray microanalysis as the acidocalcisomes.
22 )-ATPase activity was detectable in isolated acidocalcisomes.
23 disappearance of the electron density of the acidocalcisomes.
25 of the spt2- promastigotes involving 'empty' acidocalcisomes (ACs), which may point to the origin of
27 TgVP1), a membrane proton pump, localizes to acidocalcisomes and a novel lysosome-like compartment te
30 that AP-3 is essential for the biogenesis of acidocalcisomes and for growth and virulence of T. bruce
31 from permeabilized trypanosomes or isolated acidocalcisomes and photolytic release of IP(3) in intac
32 flagellar pocket, that was distinct from the acidocalcisomes and that was identified by immunogold el
33 r, these results strongly support a role for acidocalcisomes and the contractile vacuole complex in o
34 ng together, the presence of an aquaporin in acidocalcisomes and the contractile vacuole complex of T
35 pathway to the synthesis of polyphosphate in acidocalcisomes, and may lead to better understanding of
36 an platelet dense granules strongly resemble acidocalcisomes, and we recently showed that they contai
37 nic phosphate (Pi) from the cytosol into the acidocalcisome- and lysosome-related vacuoles of yeast,
44 The combined results provide evidence that acidocalcisomes are organelles different from lysosomes
46 on acting as an intracellular proton pump in acidocalcisomes but in PPi synthesis in the chromatophor
47 ase) activity was detectable in the isolated acidocalcisome, but ionophore experiments indicated that
50 f purified T. brucei, T. cruzi, and L. major acidocalcisomes, calcium and phosphorus storage organell
51 nules of D. discoideum are homologous to the acidocalcisomes described in protozoan parasites and are
54 the ars76 phenotypes, suggesting that normal acidocalcisome formation in cells deprived of S requires
55 of virulence was associated with a defect in acidocalcisome formation, as this unique organelle was g
56 les generally indicated no enrichment in the acidocalcisome fraction; glycosomes were concentrated 5-
57 ol density gradients for purification of the acidocalcisome from Trypanosoma cruzi epimastigotes.
58 rference (RNAi) resulted in disappearance of acidocalcisomes from both procyclic and bloodstream form
59 Our data also indicate that a deficiency in acidocalcisome function impacts trafficking of periplasm
61 respond to what were described previously as acidocalcisomes, i.e. acidic compartments rich in Ca2+.
62 dation processes suggest a major role of the acidocalcisome in reshaping the cell during acclimation
63 de further evidence for the unique nature of acidocalcisomes in comparison with other, previously des
64 scribe organelles with properties similar to acidocalcisomes in the green alga Chlamydomonas reinhard
65 e we present evidence that the biogenesis of acidocalcisomes in Trypanosoma brucei is linked to the e
69 hat a Ca(2+) signaling pathway that involves acidocalcisomes is required for growth and establishment
70 density gradient method previously used for acidocalcisome isolation from Trypanosoma cruzi epimasti
73 In this work we demonstrate that swelling of acidocalcisomes mediated by an aquaporin and microtubule
74 ic polyphosphate is an abundant component of acidocalcisomes of bacteria and unicellular eukaryotes.
76 PPase was located in the plasma membrane and acidocalcisomes of the three different forms of the para
77 ports on the localization of this channel to acidocalcisomes of Trypanosoma brucei and suggest that c
78 tional IP(3)R as a Ca(2+) release channel in acidocalcisomes of trypanosomes and suggest that a Ca(2+
79 analysis to be particularly associated with acidocalcisomes, organelles shown previously to contain
80 we present evidence that Trypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate
82 od for the isolation and characterization of acidocalcisomes, showing that they are distinct from oth
83 crotubule- and cyclic AMP-mediated fusion of acidocalcisomes to the contractile vacuole complex with
86 lectron microscopy), are similar to those of acidocalcisomes (volutin granules, polyP bodies) of bact
89 l electron-dense granules of some parasites (acidocalcisomes) whereby H+-coupled Ca2+ transport is in
90 y located in an acidic compartment named the acidocalcisome, which among other pumps and exchangers p
91 ith the vacuolar H(+)-pyrophosphatase to the acidocalcisomes while TbPMC2 localized to the plasma mem
92 cuoles of C. reinhardtii are very similar to acidocalcisomes with regard to their chemical compositio
93 vacuolar proton pyrophosphatase, a marker of acidocalcisomes, with the Golgi marker Golgi reassembly
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