ライフサイエンスコーパス: acinar cell

1 erentiated phenotype of the adult pancreatic acinar cell.

2 elicited simultaneously in the neighbouring acinar cells.

3 2R protein was expressed in mouse pancreatic acinar cells.

4 flammatory cells, compared to UEA-I purified acinar cells.

5 lithocholic acid 3-sulfate primarily affects acinar cells.

6 ed the regenerative potential of pre-labeled acinar cells.

7 trypsin activation were analyzed in isolated acinar cells.

8 SI rapidly accumulates in lumen formed by LG acinar cells.

9 a (PanIN), arise via reprogramming of mature acinar cells.

10 than 2-fold larger in PG and SMG than in SLG acinar cells.

11 16A or TMEM16B as well as from mouse parotid acinar cells.

12 imary basolateral Cl(-) uptake mechanisms in acinar cells.

13 a regeneration of digestive enzyme-producing acinar cells.

14 secretion from primary rabbit lacrimal gland acinar cells.

15 old number of Neurogenin 3 (Ngn3)-expressing acinar cells.

16 a conditional knockout of Atg5, in salivary acinar cells.

17 L, for different downstream responses of the acinar cells.

18 model that involves apoptosis of the central acinar cells.

19 lumen formation via apoptosis of the central acinar cells.

20 a(2+)]i) overload and necrosis of pancreatic acinar cells.

21 and for the formation and differentiation of acinar cells.

22 c duct and subsequent exposure to pancreatic acinar cells.

23 ducing lipolytic flux between adipocytes and acinar cells.

24 ated and Notch1 is deleted simultaneously in acinar cells.

25 KIAA1967 in the nuclei of normal pancreatic acinar cells.

26 associated with perturbed differentiation of acinar cells.

27 because they were not observed in CypD(-/-) acinar cells.

28 n the regulation of exocytosis in pancreatic acinar cells.

29 he neutrophil attractant CXCL1 in pancreatic acinar cells.

30 okine-pretreated (inflammation model) monkey acinar cells.

31 ccelerates disorders of the ER in pancreatic acinar cells.

32 CCK cellular actions directly affected human acinar cells.

33 xygen species generation in mouse pancreatic acinar cells.

34 r acinar cells are terminally differentiated acinar cells.

35 pathological Ca(2+) signals and necrosis in acinar cells.

36 cholate-induced necrosis in mouse pancreatic acinar cells.

37 ive intestinal peptide and secretin on intra-acinar cell adenosine 3',5'-cyclic monophosphate are exp

38 even when Kras is activated in a majority of acinar cells, ADM and subsequent development of PanINs i

39 llular Ca(2+) signals may protect pancreatic acinar cells against Ca(2+) overload, intracellular prot

40 icroscopy studies revealed modestly enlarged acinar cells and accumulated secretory granules in saliv

41 ymogen-containing subcellular compartment of acinar cells and activation of CTSD, CTSB, and trypsinog

42 ollagen I limited the lipolytic flux between acinar cells and adipocytes and prevented increases in a

43 cell (MPC) population that gives rise to pre-acinar cells and bipotent cells with ductal and islet en

44 x transcription factor complex of pancreatic acinar cells and critical to acinar cell fate specificat

45 on states of purified human alpha, beta, and acinar cells and found alpha cells exhibit intrinsic phe

46 nisms involved in regulating the function of acinar cells and in the loss of salivary gland function

47 , leading to activation of EGFR signaling in acinar cells and increased ADM.

48 ectly increased the activity of NF-kappaB in acinar cells and induced pancreatitis.

49 Moreover, Arg-II is mainly expressed in acinar cells and is upregulated with aging, which enhanc

50 scribed in considerable detail in pancreatic acinar cells and oocytes.

51 ofibrotic transforming growth factor-beta of acinar cells and pancreatic fibrosis were assessed by im

52 n cytoskeleton controls the reprogramming of acinar cells and regulates cell morphology in vivo and i

53 re to cigarette smoke increased ER stress in acinar cells and sensitized the pancreas to LPS-induced

54 ) that induce saliva secretion from residual acinar cells and the use of saliva substitutes.

55 sed to reflect the proliferative activity of acinar cells and their role in salivary gland homeostasi

56 causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancreatic functio

57 stablishment of a generic endocrine state in acinar cells, and also promotes delta-specification in t

58 y reduced CTSB and trypsinogen activation in acinar cells, and CTSD directly activated CTSB but not t

59 ted in activation of stellate cells, loss of acinar cells, and fibrosis, which are characteristics of

60 tabolism were measured in pancreatic tissue, acinar cells, and isolated mitochondria.

61 ules, expansion of ductal epithelia, loss of acinar cells, and the induction of pancreatic inflammati

62 Its deletion or inhibition regulates acinar cell apoptosis but not necrosis in two models of

63 Aberrant Ca(2+) signals within pancreatic acinar cells are an early and critical feature in acute

64 As a result, Ptf1a-deficient acinar cells are dramatically sensitized to KRAS transfo

65 Despite this requirement, how acinar cells are generated during organogenesis is uncle

66 tion, a loss and abnormal differentiation of acinar cells are observed.

67 Pancreatic acinar cells are reprogrammed to a "ductal-like" state d

68 We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells.

69 ) that induce saliva secretion from residual acinar cells as well as artificial salivary substitutes.

70 e known to induce aberrant Ca(2+) signals in acinar cells as well as nuclear translocation of NF-kapp

71 n regulating protein secretion by pancreatic acinar cells, as does Rab3D.

72 zymes, packaged into the zymogen granules of acinar cells, become activated and cause autodigestion.

73 IER3 expression was discrete in healthy acinar cells, becoming highly prominent in peritumoral a

74 This involves not only signalling in acinar cells but also in stellate cells.

75 ally give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5,

76 signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on stellate c

77 ates and enhanced oxidative and ER stress in acinar cells, but none of these effects is related to NF

78 Incubation of mouse and human acinar cells, but not HEK293 or COS7 cells, with iohexol

79 bone marrow chimeras, expression of BCL3 by acinar cells, but not myeloid cells, was required for re

80 Nicotine induced dedifferentiation of acinar cells by activating AKT-ERK-MYC signaling; this l

81 features of pancreatitis in EtOH-sensitized acinar cells by suppressing the adaptive unfolded protei

82 r TP53(f/f) specifically in adult pancreatic acinar cells by using a full-length pancreatic elastase

83 y, we examined the role of CD38 and cADPR in acinar cell Ca(2+) signals and acinar injury due to bile

84 f the Ca(2+) concentration inside pancreatic acinar cells ([Ca(2+)]i), due to excessive release of Ca

85 In summary, we demonstrate that acinar cell calcineurin is activated in response to Ca(2

86 We now show that acinar cells can be converted to delta-like and alpha-li

87 ning MIST1 activity in Kras(G12D)-expressing acinar cells can partially mitigate the transformation a

88 In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (AD

89 Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tu

90 developed various subtypes of PC, including acinar cell carcinoma, ductal adenocarcinoma, sarcomatoi

91 ng proximity of PTF1 and MIST1 in pancreatic acinar cell chromatin implies extensive collaboration, a

92 a was also suppressed in ex vivo cultures of acinar cell clusters isolated from mouse pancreas bearin

93 30 and 95%, respectively, in Cd38-deficient acinar cells compared with wild-type cells (p < 0.05).

94 aB (based on nuclear translocation of p65 in acinar cells) compared with controls.

95 and thus transforms our understanding of the acinar cell compartment as a pool of equipotent secretor

96 In isolated mouse pancreatic acinar cells, CRAC channels were activated by blocking C

97 Acinar cell damage and dysfunction cause malnutrition an

98 s to the role of trypsin activation in early acinar cell damage but not in the inflammatory response

99 risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase

100 1, die perinatally due to massive pancreatic acinar cell death, precluding investigation of the effec

101 so activates ER stress pathways that promote acinar cell death.

102 of CTSB affected apoptotic but not necrotic acinar cell death.

103 ownstream of trypsin activation that lead to acinar cell death.

104 s; therefore, we investigated its effects on acinar cell dedifferentiation, regeneration, and metapla

105 pment via down-regulation of Gata6 to induce acinar cell dedifferentiation.

106 is associated with chronic pancreatitis and acinar cell dedifferentiation.

107 Immunohistochemical stains demonstrate an acinar cell defect but normal islet cells.

108 Atg7(Deltapan) mice exhibit severe acinar cell degeneration, leading to pancreatic inflamma

109 is only minimal and transient in the early, acinar cell-dependent phase of pancreatitis and much gre

110 At the final stage of acinar cell development, the absence of NR5A2 affects th

111 Loss of acinar cell differentiation also drives pancreatic cance

112 Numb is an important regulator of acinar cell differentiation and viability during metapla

113 ression of transcription factors that affect acinar cell differentiation suggested that acinar cells

114 tis, with pathways involved in inflammation, acinar cell differentiation, and cell junctions being sp

115 ption of acinar morphogenesis and incomplete acinar cell differentiation.

116 little is known about their contribution to acinar cell differentiation.

117 equired to establish and maintain pancreatic acinar cell differentiation.

118 d to regulate multiple signaling pathways in acinar cells during cerulein-induced pancreatitis.

119 cells in the pancreas, yet the source of new acinar cells during homeostasis remains unknown.

120 onfocal microscopy in freshly isolated mouse acinar cells during perifusion with the bile acid taurol

121 Zymogen secretory granules in pancreatic acinar cells express two vesicle-associated membrane pro

122 cent lineage-tracing studies have shown that acinar cells expressing mutant Kras(G12D) are induced to

123 -regulation of genes that promote the mature acinar cell fate is required to reduce injury associated

124 x of pancreatic acinar cells and critical to acinar cell fate specification and differentiation.

125 ature activation of digestive enzymes within acinar cells, followed by necrosis and inflammation.

126 EM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the lumen.

127 ce KLF5 activity might reduce progression of acinar cells from ADM to PanIN and pancreatic tumorigene

128 calcineurin activation, we infected primary acinar cells from mice with an adenovirus expressing the

129 Acinar cells from monkey lacrimal glands were cultured w

130 Accordingly, conditioned medium of isolated acinar cells from old WT (not Arg-II(-/-)) mice contains

131 ta was also significantly increased in human acinar cells from patients with acute/recurrent pancreat

132 I) lectin has been used to label and isolate acinar cells from the pancreas.

133 lular and molecular mechanisms that maintain acinar cell function and whose dysregulation can lead to

134 pression of proteins critically relevant for acinar cell function.

135 cinar-to-ductal metaplasia (ADM), pancreatic acinar cells give rise to pancreatic intraepithelial neo

136 , had higher levels of NF-kappaB activity in acinar cells, greater levels of inflammation, and more s

137 C-S), known to induce Ca(2+) oscillations in acinar cells, had only minor effects on stellate cells i

138 generation and maintenance of exocrine gland acinar cells have not yet been established.

139 orm crucial functions in food digestion, and acinar cell homeostasis required for secretion of digest

140 The loss of acinar cell homeostasis, differentiation, and identity i

141 ys a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pa

142 , necrosis, acinar-to-ductal metaplasia, and acinar-cell hypertrophy; this led to tissue atrophy and

143 works that control pancreatic MPC expansion, acinar cell identity, duct morphogenesis and generation

144 tify a critical role for PDX1 in maintaining acinar cell identity, thus resisting the formation of pa

145 Lacrimal acinar cells immunoreacted with GCDFP-15 and CK7, wherea

146 pecialized phenotype of the adult pancreatic acinar cell in vivo Transcriptome sequencing and chromat

147 s required for normal function of pancreatic acinar cells in adult mice.

148 lonal expansion of terminally differentiated acinar cells in all major salivary glands.

149 rified fatty acids (NEFAs) and adipokines on acinar cells in culture.

150 ovel strategy for generating and maintaining acinar cells in culture.

151 receptor expression in pancreatic ductal or acinar cells in normal or diabetic human pancreas is cha

152 s in stellate cells compared to the adjacent acinar cells in pancreatic lobules; whereas taurolithoch

153 b resulted in premature dedifferentiation of acinar cells in response to injury due to administration

154 genesis, and a lack of differentiated mucous acinar cells in submandibular and sublingual glands.

155 at Lfng is uniquely expressed in a subset of acinar cells in the adult pancreas.

156 gglutinin (PNA) have a specific affinity for acinar cells in the mouse pancreas, with minimal affinit

157 Maintaining the identity of acinar cells in the pancreas could help to prevent the d

158 eted expression of activated K-ras to mature acinar cells in the pancreas induces the spontaneous dev

159 activation of KRAS in normal, untransformed acinar cells in the pancreatic tissues of mice resulted

160 cytes and pancreatic beta-cells, but not the acinar cells, in a high glucose-dependent manner.

161 We measured DeltaPsim in mouse pancreatic acinar cells incubated with ethanol alone and in combina

162 Addition of NETs and histones to acinar cells induced formation of trypsin and activation

163 mmary, bile-induced NF-kappaB activation and acinar cell injury are mediated by calcineurin, and a me

164 hibitory peptide prevented bile acid-induced acinar cell injury as measured by lactate dehydrogenase

165 ce that insulin directly protects pancreatic acinar cell injury induced by bona fide pancreatitis-ind

166 Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic

167 mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+)

168 eatitis (AP) suggest a strong association of acinar cell injury with cathepsin B-dependent intracellu

169 FK506 prevented activation of NF-kappaB and acinar cell injury.

170 activation only at concentrations that cause acinar cell injury.

171 In conclusion, Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults

172 n of PanINs by enabling dedifferentiation of acinar cells into duct-like cells that are susceptible t

173 y because of postnatal de-differentiation of acinar cells into duct-like cells.

174 cked the irreversible transition of exocrine acinar cells into pancreatic preneoplastic ductal lesion

175 substrate p62/SQSTM1 in stressed Kras(G12D) acinar cells is associated with PDAC development and mai

176 intense inflammatory signaling mechanisms in acinar cells is crucial to the pathogenesis of pancreati

177 e intracellular Ca(2+) signals in pancreatic acinar cells is largely unknown.

178 overexpression of this factor in developing acinar cells is sufficient to repress acinar differentia

179 ne were also evaluated in primary pancreatic acinar cells isolated from wild-type, nAChR7a(-/-), Trp5

180 t acinar cell differentiation suggested that acinar cells lacking ATF3 maintain a mature cell phenoty

181 Our data demonstrate that lacrimal acinar cells lacking Orai1 do not exhibit SOCE following

182 In cytokine-treated acinar cells, lacritin stimulated protein secretion as m

183 In cultured monkey acinar cells, lacritin stimulated tear protein secretion

184 on, driven by cell-cell interactions between acinar cells, leukocytes, and resident fibroblasts.

185 esponse to lipopolysaccharide in vivo and in acinar cell-like AR42J cells in vitro.

186 ses in mouse and human primary acini and the acinar cell line AR42J.

187 Thus, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a

188 We confirmed PTF1a/TRIP12 interaction in acinar cell lines and in co-transfected HEK-293T cells.

189 Acinar cells make up the majority of all cells in the pa

190 1R signaling in mice reflects an increase in acinar cell mass, without changes in ductal compartments

191 ng with exocrine defects, including impaired acinar cell maturation, the mutant mice exhibited substa

192 The proliferative capacity of differentiated acinar cells may prove critical in the implementation of

193 ritin, a glycoprotein secreted from lacrimal acinar cells, may function as an autocrine factor to sti

194 addition, Slug attenuated TGF-alpha-induced acinar cell metaplasia to ductal structures and TGF-alph

195 This suggests Notch1 deletion renders acinar cells more susceptible to formation of K-ras-indu

196 However, in the acinar cell, Munc18c's functions in exocytosis and homeo

197 However, NEFAs, but not adipokines, caused acinar cell necrosis.

198 This was associated with reduced acinar cell necrosis.

199 At study end, Ki-67-positive (proliferating) acinar cell number did not change, compared with baselin

200 in produced not only a dramatic reduction in acinar cell numbers, but also a significant reduction in

201 tion of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall

202 protein necessary for autophagy, in salivary acinar cells of Atg5(f/f);Aqp5-Cre mice.

203 ibitor of kappaB kinase (IKK)2 in pancreatic acinar cells of mice.

204 Pancreatic acinar cells of patients with CP have increased levels o

205 in the developing ductal, serous, and mucous acinar cells of salivary glands.

206 secretion of bicarbonate-rich fluid from the acinar cells of the pancreas that accumulates within the

207 ease-activated Ca(2+) currents in pancreatic acinar cells offers remarkable protection against Ca(2+)

208 directly via G protein-coupled receptors on acinar cells or through inflammatory cells.

209 scription factor Mist1, which is critical to acinar cell organization, significantly attenuated Kras(

210 In acinar cells, our study demonstrates an age-associated A

211 n PSCs and their better studied neighbouring acinar cells (PACs) and found complete separation of Ca(

212 tested in freshly isolated murine pancreatic acinar cells (PACs) to determine inhibition of toxin-ind

213 nnabinoid receptor subtype 2 (CB2R) prevents acinar cell pathogenesis in animal models of acute pancr

214 Epithelial pancreatic acinar cells perform crucial functions in food digestion

215 f the pancreas and in the maintenance of the acinar cell phenotype.

216 ying this Ca(2+)-dependent generation of the acinar cell phenotype.

217 s model, we studied the role of Hes1 in both acinar cell plasticity and pancreatic regeneration after

218 Acinar cells play an essential role in the secretory fun

219 Pancreatic acinar cells possess very high protein synthetic rates a

220 Acinar cells prepared from the pancreas of rats or mice

221 approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB1R-knockout (KO)

222 ATA6 and promoting differentiation toward an acinar cell program.

223 Furthermore, oncogenic KRAS did not induce acinar cell proliferation, but did sustain the prolifera

224 delayed recovery of the pancreas and reduced acinar cell proliferation.

225 ppear to be excellent lectins for pancreatic acinar cell purification.

226 Kras(G12D)-expressing acinar cells rapidly underwent ADM in 3D culture, formin

227 s based predominantly on self-duplication of acinar cells, rather than on differentiation of stem cel

228 xpression, and ectopic expression of KLF4 in acinar cells reduces acinar lineage- and induces ductal

229 okinin analogue cerulein and interfered with acinar cell regeneration.

230 We investigated acinar cell replacement during homeostasis, growth, and

231 ing, followed by a chase period, showed that acinar cell replacement is not driven by the differentia

232 oses to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal meta

233 Acinar cell responses to the muscarinic agonist carbacho

234 rly stage, short-term processes that involve acinar cell responses.

235 Kras activation in Mist1(+) adult acinar cells resulted in brisk PanIN formation, whereas

236 transcriptional program in normal pancreatic acinar cells, resulting in acinar-ductal metaplasia, a d

237 n addition, inhibiting let-7b and miR-495 in acinar cells results in similar effects to those found i

238 Transcriptome analysis of single acinar cells revealed the existence of a minor populatio

239 not been studied in CP, although pancreatic acinar cells seem to be especially vulnerable to ER dysf

240 dies of this disorder focus on the damage to acinar cells since they are assumed to be the primary ta

241 Acinar cell-specific expression of knocked-in Cre recomb

242 Mice with acinar cell-specific expression of Kras(G12D) were cross

243 We studied mice with acinar cell-specific expression of KrasG12D (LSL-Kras/El

244 Alcohol exposure exacerbated acinar cell-specific production of transforming growth f

245 )) via Cre(ERTM) recombinase regulated by an acinar cell-specific promoter (Ptf1a).

246 ed mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion.

247 Perturbation of pancreatic acinar cell state can lead to acinar-to-ductal metaplasi

248 in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-alpha.

249 educed caspase-3 activation and apoptosis in acinar cells stimulated with the intestinal hormone chol

250 last several months, the convergent roles of acinar cell stress, autophagy and proinflammatory signal

251 identified the presence of a progenitor-like acinar cell subpopulation.

252 (saliva-facing) membranes of salivary gland acinar cells, suggesting a dual role of this transporter

253 -gamma did not cause LDH leakage from monkey acinar cells, suggesting a higher tolerance against thes

254 more extensive necrosis in both stellate and acinar cells than TLC-S alone.

255 pathway; this could be a mechanism by which acinar cells that express activated KRAS become suscepti

256 inar specific partner Rbpjl, so that the few acinar cells that form do not complete differentiation.

257 operties of the ion-transporting pathways in acinar cells that might account for the differences amon

258 salivary glands is due to the impairment of acinar cells, the major glandular cells of protein, salt

259 The transdifferentiation of pancreatic acinar cells to a ductal phenotype (acinar-to-ductal met

260 fa, and Pdx1, directly reprograms pancreatic acinar cells to beta-cells.

261 ous work demonstrating in vivo conversion of acinar cells to beta-like cells by viral delivery of exo

262 the conversion of terminally differentiated acinar cells to beta-like cells.

263 actors whose combinatorial actions reprogram acinar cells to distinct islet endocrine subtypes in viv

264 trast, TGF-beta1 efficiently converted human acinar cells to duct-like cells (AD) in a SMAD-dependent

265 tor Snail (Snai1) can cooperate with Kras in acinar cells to enhance ADM development, the contributio

266 We investigated the ability of injured acinar cells to generate pancreatic fibrosis in acute pa

267 As studying the transition of acinar cells to metaplastic ductal cells in vivo is comp

268 ound shifts in PDX1 chromatin occupancy from acinar cells to PDA.

269 ts that prevent conversion of differentiated acinar cells to proliferative ductal progenitors.

270 lls connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for the

271 We exposed mouse and human acinar cells to the radiocontrast agent iohexol (Omnipaq

272 elimination of Numb causes dedifferentiated acinar cells to undergo apoptosis, and this is not mitig

273 in the ductal cell layer and/or in surviving acinar cells, to drive transcellular flux of interstitia

274 y antagonizing the metaplastic conversion of acinar cells toward a ductal fate capable of responding

275 in vivo conversion of adult mouse pancreatic acinar cells toward beta cells, we show that induced bet

276 ical role for ATF3 as a key regulator of the acinar cell transcriptional response during injury and m

277 An adipocyte and acinar cell Transwell coculture system, with or without

278 Notably, these effects were recapitulated in acinar cells treated with a pharmacological inhibitor of

279 hat GRP78 could exert a protective effect on acinar cells under stress, as during PDAC development.

280 rylation of rpS6 was increased in pancreatic acinar cells upon implantation of the chemical carcinoge

281 st-induced Ca(2+) oscillations in pancreatic acinar cells using multiple experimental approaches with

282 eltapan)) caused spontaneous and progressive acinar cell vacuolization and death, interstitial fibros

283 Since CEL is expressed mainly in pancreatic acinar cells, we asked whether we could find structural

284 ing 3D explant culture of primary pancreatic acinar cells, we show that PKD1 acts downstream of TGFal

285 transgenic mice expressing Slug and Kras in acinar cells were generated.

286 eata and primary acinar cells were isolated; acinar cells were incubated with an inhibitor of p110alp

287 Freshly isolated mouse acinar cells were infected for 24 h with an adenovirus e

288 Rat pancreatic acinar cells were isolated by collagenase digestion and

289 Acinar cells were isolated from the tissues and the effe

290 Pancreata and primary acinar cells were isolated; acinar cells were incubated

291 Moreover, PNA-purified acinar cells were less contaminated with mesenchymal and

292 ajor apical Cl(-) efflux pathway in salivary acinar cells, were significantly greater in PG compared

293 ment of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechan

294 ocess involves activation of YAP1 and TAZ in acinar cells, which up-regulate JAK-STAT3 signaling to p

295 lasia (ADM), a process that replaces damaged acinar cells with duct-like structures.

296 ncubation of AR42J or primary mouse or human acinar cells with MKC-3946 reduced expression of XBP1s,

297 Better methods for purifying human or mouse acinar cells without the need for genetic modification a

298 Thus, we show that acinar cells, without exogenously introduced factors, ca

299 mbination strategy in adult mouse pancreatic acinar cells (Yap1fl/fl;Tazfl/fl;Ela1-CreERT2).

300 Acinar cell zymogen granules (ZG) express 2 isoforms of