ライフサイエンスコーパス: acne

1 excretion result in clinical improvement of acne.

2 lity of applying lupeol for the treatment of acne.

3 ealthy young women taking spironolactone for acne.

4 nd researched, yet poorly treated disease of acne.

5 scarring secondary to inflammatory or cystic acne.

6 for healthy women taking spironolactone for acne.

7 e a potential candidate for the treatment of acne.

8 ealthy young women taking spironolactone for acne.

9 y active molecules is important for treating acne.

10 lesions and in the inflammatory response in acne.

11 for the treatment of refractory nodulocystic acne.

12 e deeper into microbial/host interactions in acne.

13 eta-mediated signalling in susceptibility to acne.

14 sterile arthritis, pyoderma gangrenosum, and acne.

15 s to modulate Th17-mediated diseases such as acne.

16 to assess the clinical relevance of IL-17 in acne.

17 the bacterium linked to the pathogenesis of acne.

18 retinoin is the most effective treatment for acne.

19 idely prescribed medication for nodulocystic acne.

20 ntly accompanied by pyoderma gangrenosum and acne.

21 e natural history, subtypes, and triggers of acne.

22 ntial mechanism for its long-term effects on acne.

23 which have associations with healthy skin or acne.

24 nce immune responses and the pathogenesis of acne.

25 ere age matched to 100 male controls without acne.

26 l isotretinoin for the standard patient with acne.

27 oral antibiotics are routinely used to treat acne.

28 L-26 lacked antimicrobial potency against P. acnes.

29 nes secreted molecules sufficient to kill P. acnes.

30 sts and osteoclasts were infected by live C. acnes.

31 hich may be due to increased abundance of P. acnes.

32 two [1%] of 159 given gefitinib) and rash or acne (15 [9%] patients given afatinib vs five [3%] of th

33 The P. acnes 16S rRNA gene was detectable in 4 of 15 carotid ar

34 r 4 drug-related adverse events were rash or acne (31 [10%] of 320 patients in the afatinib group vs

35 re likely to care for viral skin lesions and acne (3405 of 7287 visits [46.7%]), whereas in-person de

36 se events in the afatinib group were rash or acne (35 [14.6%] of 239 patients), diarrhoea (13 [5.4%])

37 elated grade 3-4 adverse events were rash or acne (37 [16%] of 229 patients in LUX-Lung 3 and 35 [15%

38 man-Gallwey scores of 8.6 vs 5.6, P = .001), acne (61.2% [164 of 268] vs 40.4% [19 of 47], P = .004),

39 of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a sk

40 tudy investigating prescribing practices for acne, a common dermatologic condition for which free sam

41 level and genome level of Propionibacterium acnes, a dominant skin commensal, between 49 acne patien

42 treatment for refractory severe nodulocystic acne.A true association between prior isotretinoin use a

43 towska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production

44 ential undesired effects and risks including acne, alopecia, reduced HDL cholesterol, increased trigl

45 ss-sectional study in 100 male patients with acne and 100 age-matched male controls without acne from

46 clinicians saw a total of 2770 patients with acne and 1516 patients with psoriasis in clinic, recordi

47 Acne and androgenic alopecia are prevalent but unreliabl

48 s of isotretinoin are effective for treating acne and decreasing relapse rates without increasing adv

49 Oral tetracyclines are commonly used for acne and other conditions.

50 incorporated into practice to track patient acne and psoriasis outcomes over time, representing an o

51 physicians' billing sheets for patients with acne and psoriasis seen at a tertiary care center outpat

52 the hypothesis that patient scores for both acne and psoriasis would improve between the initial and

53 were collected from 52 and 103 patients with acne and psoriasis, respectively, within the larger samp

54 dinal PGA severity scores were collected for acne and psoriasis.

55 es elicits inflammation in early versus late acne and putative differences in the effects of IL-1alph

56 Prices of acne and rosacea medications increased a mean of 195%, a

57 data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitami

58 strain-based resolution of Propionibacterium acnes and its association with the common teenage malady

59 he Gram-positive bacterium Propionibacterium acnes and its potential association with biofilm structu

60 formation of resistance in Propionibacterium acnes and other bacteria, with clinical consequences.

61 requiring helpers such as Propionibacterium acnes and Prevotella intermedia for stimulation, with be

62 onstrated that human monocytes respond to P. acnes and secrete mature IL-1beta partially via the NLRP

63 is the evidence for antibiotic resistance in acne, and how does resistance affect treatment?

64 logy, plastic surgery, scars, wound healing, acne, and isotretinoin was convened.

65 Certain strains were highly associated with acne, and other strains were enriched in healthy skin.

66 ited robust bactericidal activity against P. acnes, and complete breaches in the bacterial cell envel

67 of depression; 36.2% carried a diagnosis of acne; and 6% had pilonidal disease.

68 irulence organisms such as Propionibacterium acnes are the most common culprit organisms, and treatme

69 Using acne as a model disease, we investigated the determinant

70 We found that acne-associated P. acnes phylotypes induced 2- to 3-fold

71 hat was expressed at least 10-fold higher in acne-associated phylotypes and a cell surface hydrolase

72 The CC18 C. acnes ATCC6919 isolate could survive intracellularly for

73 strated that laboratory-grown cultures of P. acnes biofilms were susceptible to induction of a biofil

74 ive treatment option for hormonally mediated acne but can cause hyperkalemia.

75 onstrated potent and selective killing of P. acnes but not against human skin cells in vitro.

76 role in the treatment of moderate-to-severe acne, but only with a topical retinoid, benzoyl peroxide

77 Algorithm-based treatment of acne by primary care clinicians may eliminate unnecessar

78 These results demonstrate that P. acnes can infect the carotid arteries of humans with ath

79 putative-associated loci in a further 2,063 acne cases and 1,970 controls.

80 When monocytes were stimulated with live P. acnes, caspase-1 and caspase-5 gene expression was upreg

81 Propionibacterium acnes, causative agent of chronic prostatitis possibly c

82 ere found to induce the disruption of the P. acnes cell membrane, providing a mechanism for the bacte

83 tivity, as treatment with Pentobra killed P. acnes cells and caused leakage of intracellular contents

84 Recent work revealed that P. acnes clinical isolates can be classified into distinct

85 The clade of 11 C. acnes clinical isolates was determined by MLST.

86 y increasing resistance of Propionibacterium acnes clinical isolates.

87 tobramycin (by 5-7 logs) against multiple P. acnes clinical strains.

88 At 3-month follow-up, 14.6% of the acne cohort was graded as effectively clear, compared wi

89 Other skin phenotypes such as acne, color and skin cancers are also being investigated

90 d superior antimicrobial activity against P. acnes compared with BP alone while demonstrating less to

91 echanisms at play in skin diseases including acne continue to be made.

92 common component in cosmetics and commercial acne creams as well as being a first-line chemotherapeut

93 der that features comedones and inflammatory acne cysts in localized, linear configurations.

94 biofilm bacteria within all samples, with P. acnes detectable in 4 samples.

95 e 3D printing technology to manufacture anti-acne devices with salicylic acid.

96 rmatology clinic identified patients with an acne diagnosis at a dermatology visit in the past 3 mont

97 aerococcus, Peptoniphilus, Propionibacterium acnes, Dorea, and Ruminococcus and reduced proportions o

98 to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrat

99 cations for RPE-related eye diseases and the acne drug isotretinoin (a retinoid cycle inhibitor) are

100 Internet-based acne education using automated counseling was not superi

101 egarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and

102 ally significant improvement of inflammatory acne following three treatments given 1-2 weeks apart.

103 new explanations about the development of C. acnes foreign-body infections.

104 Cutibacterium acnes (formerly Propionibacterium acnes) is recognized a

105 ne and 100 age-matched male controls without acne from a dermatology outpatient department of a terti

106 rimary care clinicians to dermatologists for acne from January 2014 through March 2015 were reviewed

107 festations, such as pyoderma gangrenosum and acne fulminans, predominated.

108 eported P. acnes strains and comparing 71 P. acnes genomes, we identified potential genetic determina

109 dual severity groups according to the Global Acne Grading System and were age matched to 100 male con

110 planted, and intravitreal cultures showed P. acnes growth after 5 days.

111 immune response targeting Propionibacterium acnes has a significant role in its pathogenesis.

112 e microaerophylic organism Propionibacterium acnes has shown consistent association with prostate can

113 ogical manifestations, mainly represented by acne, hirsutism, and alopecia.

114 Overall, acne in 32.7% of patients in the study relapsed at 12 mo

115 Because inflammatory acne in children and adolescents carries a high psycholo

116 sulin resistance and metabolic syndrome with acne in male patients is lacking.

117 ylococci in 6.0% (27/448), Propionibacterium acnes in 4.7% (21/448), and Pseudomonas aeruginosa in 3.

118 5%CI, 0.10-0.80;P = .02) and for sex and non acne indication (OR, 0.28; 95%CI, 0.10-0.79; P = .02).

119 P. acnes induced key inflammasome genes including NLRP1 and

120 ts as demonstrated by suppression of some P. acnes-induced chemokines.

121 tralizing antibodies completely inhibited P. acnes-induced IL-17 production.

122 ssion by small interfering RNA attenuated P. acnes-induced IL-1beta secretion.

123 uggest that NO-np can effectively prevent P. acnes-induced inflammation by both clearing the organism

124 inflammatory properties as they inhibited P. acnes-induced inflammatory cytokine production in human

125 Propionibacter acnes-induced intracutaneous inflammation showed no diff

126 The mechanism of P. acnes-induced NLRP3 activation and subsequent IL-1beta s

127 in D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th17 differentiation.

128 Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood monon

129 Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR

130 Propionibacterium acnes induction of inflammatory responses is a major eti

131 EN mutation carriers presented with comorbid acne inversa (AI), an inflammatory hair follicle disorde

132 Acne is a multifactorial inflammatory skin disease with

133 Use of topical and systemic antibiotics for acne is associated with formation of resistance in Propi

134 ealthy young women taking spironolactone for acne is equivalent to the baseline rate of hyperkalemia

135 ealthy young women taking spironolactone for acne is unclear.

136 Propionibacterium acnes is a known cause of postneurosurgical meningitis;

137 he Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota an

138 In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1,

139 Propionibacterium acnes is a skin commensal bacterium that contributes to

140 portunistic human pathogen Propionibacterium acnes is composed of a number of distinct phylogroups, d

141 ACNES is hardly ever considered in the differential diag

142 Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous

143 ibacterium acnes (formerly Propionibacterium acnes) is recognized as a pathogen in foreign-body infec

144 When applied to 312 P. acnes isolates previously characterized by MLST and repr

145 t detailed population genetic analysis of P. acnes isolates recovered from paired lesional and non-le

146 possible association, and they conclude that acne itself may be responsible for an apparent correlati

147 eement between PGA and PtGA scores was good (acne, kappa = 0.68; psoriasis, kappa = 0.70).

148 At baseline, the mean (SD) total acne lesion count was not significantly different betwee

149 Improvement in the mean (SD) acne lesion count was not significantly different betwee

150 The primary outcome was the total acne lesion count.

151 within human skin is monitored throughout an acne lesion development over 7 days.

152 es has a critical role in both initiation of acne lesions and in the inflammatory response in acne.

153 L-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effe

154 Finally, in acne lesions, mature caspase-1 and NLRP3 were detected a

155 Grade 3 or 4 acne-like rash (in 209 of 785 patients [27%] vs four of

156 mon in the sulindac-erlotinib group, with an acne-like rash observed in 87% of participants receiving

157 Common grade 3/4 adverse events included acne-like rash, neutropenia, and fatigue.

158 gnment because of the expected occurrence of acne-like rash--a class effect of EGFR antibodies--that

159 tis (24% [19 of 79] and 31% [12 of 39]), and acne-like skin lesions (22% [17 of 79] and 5% [2 of 39])

160 reatment with a prescription topical or oral acne medication after a course of isotretinoin) or retri

161 Because current acne medications have various side effects, investigatin

162 brand-name medications, and the mean cost of acne medications prescribed per office visit nationally

163 five medicinal plants to explore alternative acne medications.

164 Postadolescent male patients with acne more commonly have insulin resistance.

165 he United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132).

166 rium species (n = 15), and Propionibacterium acnes (n = 19) isolates; all of these isolates were reco

167 a day in the dose-escalation phase (grade 3 acne [n=1] and intolerable grade 2 mucosal inflammation

168 Short-term adverse events-acne, night sweats, increased weight, and altered mood a

169 To date, the direct impact of C. acnes on bone cells has never been explored.

170 We showed a direct impact of C. acnes on bone cells, providing new explanations about th

171 various P. acnes strains in association with acne or health.

172 [20%]), fatigue (81 [13%] vs 74 [20%]), and acne or rash (52 [8%] vs one [<1%]).

173 ers, were not prescribed treatment for their acne, or did not have an active telephone number.

174 mentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can functi

175 ith AgP, Actinomyces oris, Propionibacterium acnes, P. aeruginosa, Staphylococcus aureus, and Strepto

176 (Th17) cells induced by healthy (PH) versus acne (PA) skin-associated P. acnes strains are currently

177 in agreement with our conclusion that the P. acnes pan-genome is closed.

178 sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome (OMIM 604416) is a rare autosomal d

179 new insights into the microbial mechanism of acne pathogenesis and suggests probiotic and phage thera

180 role in formation of sebum, a key factor in acne pathogenesis.

181 that may contribute to either homeostasis or acne pathogenesis.

182 le for inflammasome-mediated inflammation in acne pathogenesis.

183 acnes, a dominant skin commensal, between 49 acne patients and 52 healthy individuals by sampling the

184 ing cells were present in skin biopsies from acne patients but not from normal donors.

185 al subjects, peripheral blood monocytes from acne patients expressed significantly higher levels of T

186 In acne patients, the microbiome composition at the species

187 ive surgical procedure for pain reduction in ACNES patients who failed to respond to a conservative r

188 es of propionibacteria and Propionibacterium acnes phage in healthy skin.

189 On the other hand, P. acnes phylotypes associated with healthy skin induced 2-

190 We found that acne-associated P. acnes phylotypes induced 2- to 3-fold higher levels of I

191 ur data provide insight into how specific P. acnes phylotypes influence immune responses and the path

192 Comparative proteomic analysis of P. acnes phylotypes revealed a differential expression of s

193 um, while perturbation of this domain during acne progression is often accompanied by loss of K79.

194 lthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis.

195 Clinical examination, Global Acne Rating System, National Cholesterol Education Progr

196 The complexity of multidrug acne regimens may add to this problem but, to our knowle

197 nds in the skin which define the etiology of acne-related problems.

198 te comparative genetic analyses in future P. acnes research.

199 A total of 180 patients with acne resistant to other treatments were enrolled.

200 itzpatrick skin types I through V and facial acne scarring were enrolled.

201 nology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen

202 technologic advancement in the treatment of acne scarring.

203 ermatologists separately rated participants' acne scars based on standard digital photographs obtaine

204 healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled.

205 , there was improvement in the appearance of acne scars over time compared with the control group, wi

206 Treatment of facial acne scars with a diffractive lens array and 755-nm pico

207 smetic applications including acne vulgaris, acne scars, skin rejuvenation and hair growth, and for t

208 e device, thereby reducing the appearance of acne scars.

209 r to standard-website education in improving acne severity and quality of life.

210 drome did not differ significantly among the acne severity groups.

211 C. acnes significantly decreased the resorption ability of

212 ing maintained or adopted a recommended anti-acne skin care regimen.

213 oup maintained or adopted a recommended anti-acne skin care routine compared with the standard-websit

214 P. acnes stimulated expression of key Th17-related genes, i

215 Supernatants from P. acnes-stimulated PBMCs were sufficient to promote the di

216 atrix metalloproteinase (MMP)-9 levels in P. acnes-stimulated THP-1 cells.

217 r induction of TLR-2 expression following P. acnes stimulation.

218 e composition at the species level and at P. acnes strain level was more diverse than in healthy indi

219 ine of an early-colonizing Propionibacterium acnes strain similar to SK137 and the proliferation of n

220 blasts and osteoclasts than CC18 and CC28 C. acnes strains (p </= 0.05).

221 By sequencing 66 previously unreported P. acnes strains and comparing 71 P. acnes genomes, we iden

222 thy (PH) versus acne (PA) skin-associated P. acnes strains are currently unknown.

223 ting that more than 50% of Propionibacterium acnes strains are resistant to topical macrolides, makin

224 potential genetic determinants of various P. acnes strains in association with acne or health.

225 strain-specific Th17 clones and show that P. acnes strains induce Th17 cells of varied phenotype and

226 in microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health

227 Overall, our data suggest that P. acnes strains may differentially modulate the CD4(+) T-c

228 CC36 C. acnes strains were significantly less internalized by os

229 es in determining virulence properties of P. acnes strains, and some could be future targets for ther

230 earch participants as compared with 73.9% of acne studies and 91.7% of eczema studies.

231 The catalogued data and the public P. acnes Sybil database provide a solid foundation for gene

232 yogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome (PAPA syndrome) is an autoinflammatory dis

233 proach for developing antibiotics against P. acnes that are effective in cutaneous environments.

234 analysis of 90 genomes of Propionibacterium acnes that represent the known diversity of the species.

235 hough antibiotics are a common treatment for acne, the difficulties inherent to effective antimicrobi

236 activity in vitro against Propionibacterium acnes, the bacterium linked to the pathogenesis of acne.

237 Isotretinoin, an effective anti-acne therapy, is a known teratogen that is strictly regu

238 ns other than acne vulgaris, and concomitant acne therapy.

239 istopathological analysis of human patients' acne tissues after applying lupeol for 4 weeks demonstra

240 t links the skin bacterium Propionibacterium acnes to the condition.

241 27 patients (50.2%) were not on prescription acne treatment at the time of dermatology referral.

242 Some patients may not complete acne treatment because 1 or more of their medications we

243 The frequency of primary nonadherence to acne treatment has not been well characterized.

244 Primary adherence to an acne treatment regimen is better when only 1 treatment i

245 cords of patients who were primarily seeking acne treatment were reviewed for isotretinoin exposure.

246 Terms related to acne treatment, isotretinoin, and diagnostic procedures

247 sal of recommendations for antibiotic use in acne treatment.

248 s were queried via telephone regarding which acne treatments they obtained.

249 s probiotic and phage therapies as potential acne treatments to modulate the skin microbiota and to m

250 Taken together, our results indicate that P. acnes triggers a key inflammatory mediator, IL-1beta, vi

251 phylogroups, including those associated with acne (type IA1).

252 lus species (type IV), and Propionibacterium acnes (type V).

253 with PCOS, there were minimal differences in acne types and distribution between the women meeting vs

254 d for treatment of moderate-to-severe facial acne, using unblinded and blinded assessments of disease

255 keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic dermatitis," "alopecia ar

256 ed biofilms, and these dispersion-induced P. acnes VP1 biofilms showed increased expression of mRNAs

257 Acne vulgaris (acne) is a common inflammatory disorder o

258 Acne vulgaris (AV) affects most adolescents, and of thos

259 erium that contributes to the development of acne vulgaris and other infections.

260 The pathophysiology of acne vulgaris depends on active sebaceous glands, implyi

261 Acne vulgaris is a nearly universal cutaneous disease ch

262 Acne vulgaris is a nearly universal cutaneous inflammato

263 Acne vulgaris is the most common skin disorder affecting

264 atologist for a primary initial diagnosis of acne vulgaris or rosacea in 2010.

265 ral minocycline 200mg daily for treatment of acne vulgaris since 16 years old.

266 ntact, and seborrheic dermatitis), 0.29% for acne vulgaris, 0.19% for psoriasis, 0.19% for urticaria,

267 oneedles for cosmetic applications including acne vulgaris, acne scars, skin rejuvenation and hair gr

268 otretinoin therapy for conditions other than acne vulgaris, and concomitant acne therapy.

269 In comparison, acne vulgaris, bacterial skin diseases, urticaria, pruri

270 athogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia.

271 analyzed resulting data: eczema, psoriasis, acne vulgaris, pruritus, alopecia areata, decubitus ulce

272 all relevant studies of isotretinoin use in acne vulgaris.

273 lighted as a dominant etiological factor for acne vulgaris.

274 be a well-tolerated, effective treatment for acne vulgaris.

275 tion is necessary for treating patients with acne vulgaris.

276 re centrally involved in the pathogenesis of acne vulgaris.

277 d be developed as an effective treatment for acne vulgaris.

278 ising therapeutic agent for the treatment of acne vulgaris.

279 l factor contributing to the pathogenesis of acne vulgaris.

280 s frequently prescribed for the treatment of acne vulgaris.

281 s association with the common teenage malady acne vulgaris.

282 ealthy young women taking spironolactone for acne was calculated.

283 cost of prescriptions at an office visit for acne was conservatively estimated to be 2 times higher (

284 p, 97.4% of the patients reported that their acne was improved.

285 Although the prevalence of acne was increased among women with PCOS, there were min

286 Acne was predominately associated with type IA(1) clonal

287 P. acnes was found to be highly sensitive to all concentrat

288 of 15 carotid artery samples, and viable P. acnes was one among 10 different bacterial species recov

289 To harness these characteristics to target acne, we used an established nanotechnology capable of g

290 aged at least 13 years with mild to moderate acne were eligible for participation.

291 s, other skin and subcutaneous diseases, and acne were in the top 10 most prevalent diseases worldwid

292 ents older than 18 years with a diagnosis of ACNES were randomized to undergo a neurectomy or a sham

293 and proteolytic extracellular enzymes by P. acnes were shown to increase in iron-induced dispersed b

294 that although the relative abundances of P. acnes were similar, the strain population structures wer

295 hylococcus epidermidis and Propionibacterium acnes, were identified in bacteriologically investigated

296 sess the risk of IBD mainly in patients with acne with and without isotretinoin exposure.DESIGN, SETT

297 ted most of the major pathogenic features of acne with desired physicochemical traits.

298 There is a need to treat acne with effective alternatives to antibiotics to reduc

299 ib (16 [4%] vs none), and of grade 3 rash or acne with erlotinib (23 [6%] vs 41 [10%]).

300 ld male with de novo meningitis caused by P. acnes with metastatic melanoma as the only identified ri