ライフサイエンスコーパス: acne

1 fection, notably Propionibacterium acnes (P. acnes).

2 nterior cutaneous nerve entrapment syndrome (ACNES).

3 , which is the primary pathological event in acne.

4 which have associations with healthy skin or acne.

5 nce immune responses and the pathogenesis of acne.

6 ere age matched to 100 male controls without acne.

7 l isotretinoin for the standard patient with acne.

8 oral antibiotics are routinely used to treat acne.

9 excretion result in clinical improvement of acne.

10 lity of applying lupeol for the treatment of acne.

11 ealthy young women taking spironolactone for acne.

12 nd researched, yet poorly treated disease of acne.

13 scarring secondary to inflammatory or cystic acne.

14 for healthy women taking spironolactone for acne.

15 e a potential candidate for the treatment of acne.

16 ealthy young women taking spironolactone for acne.

17 y active molecules is important for treating acne.

18 t of normal human skin, is down-regulated in acne.

19 lesions and in the inflammatory response in acne.

20 for the treatment of refractory nodulocystic acne.

21 be an actionable target in the treatment of acne.

22 e deeper into microbial/host interactions in acne.

23 eta-mediated signalling in susceptibility to acne.

24 sterile arthritis, pyoderma gangrenosum, and acne.

25 s to modulate Th17-mediated diseases such as acne.

26 ect of retinoic acid, the main treatment for acne.

27 the skin microbiome can promote inflammatory acne.

28 up, 20% of patients had oily skin and 4% had acne.

29 ntibiotics commonly used in the treatment of acne.

30 hich may be due to increased abundance of P. acnes.

31 ain fatty acids known to be produced from C. acnes.

32 L-26 lacked antimicrobial potency against P. acnes.

33 sts and osteoclasts were infected by live C. acnes.

34 nes secreted molecules sufficient to kill P. acnes.

35 two [1%] of 159 given gefitinib) and rash or acne (15 [9%] patients given afatinib vs five [3%] of th

36 The P. acnes 16S rRNA gene was detectable in 4 of 15 carotid ar

37 r 4 drug-related adverse events were rash or acne (31 [10%] of 320 patients in the afatinib group vs

38 re likely to care for viral skin lesions and acne (3405 of 7287 visits [46.7%]), whereas in-person de

39 se events in the afatinib group were rash or acne (35 [14.6%] of 239 patients), diarrhoea (13 [5.4%])

40 elated grade 3-4 adverse events were rash or acne (37 [16%] of 229 patients in LUX-Lung 3 and 35 [15%

41 man-Gallwey scores of 8.6 vs 5.6, P = .001), acne (61.2% [164 of 268] vs 40.4% [19 of 47], P = .004),

42 tudy investigating prescribing practices for acne, a common dermatologic condition for which free sam

43 treatment for refractory severe nodulocystic acne.A true association between prior isotretinoin use a

44 towska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production

45 ential undesired effects and risks including acne, alopecia, reduced HDL cholesterol, increased trigl

46 including atopic dermatitis, psoriasis, and acne, among others.

47 ss-sectional study in 100 male patients with acne and 100 age-matched male controls without acne from

48 clinicians saw a total of 2770 patients with acne and 1516 patients with psoriasis in clinic, recordi

49 Acne and androgenic alopecia are prevalent but unreliabl

50 Oral tetracyclines are commonly used for acne and other conditions.

51 incorporated into practice to track patient acne and psoriasis outcomes over time, representing an o

52 physicians' billing sheets for patients with acne and psoriasis seen at a tertiary care center outpat

53 the hypothesis that patient scores for both acne and psoriasis would improve between the initial and

54 were collected from 52 and 103 patients with acne and psoriasis, respectively, within the larger samp

55 dinal PGA severity scores were collected for acne and psoriasis.

56 es elicits inflammation in early versus late acne and putative differences in the effects of IL-1alph

57 Prices of acne and rosacea medications increased a mean of 195%, a

58 data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitami

59 he Gram-positive bacterium Propionibacterium acnes and its potential association with biofilm structu

60 formation of resistance in Propionibacterium acnes and other bacteria, with clinical consequences.

61 Culture supernatants from C. acnes and other species of Cutibacteria inhibited S. epi

62 requiring helpers such as Propionibacterium acnes and Prevotella intermedia for stimulation, with be

63 onstrated that human monocytes respond to P. acnes and secrete mature IL-1beta partially via the NLRP

64 is the evidence for antibiotic resistance in acne, and how does resistance affect treatment?

65 logy, plastic surgery, scars, wound healing, acne, and isotretinoin was convened.

66 ited robust bactericidal activity against P. acnes, and complete breaches in the bacterial cell envel

67 irulence organisms such as Propionibacterium acnes are the most common culprit organisms, and treatme

68 Using acne as a model disease, we investigated the determinant

69 We found that acne-associated P. acnes phylotypes induced 2- to 3-fold

70 hat was expressed at least 10-fold higher in acne-associated phylotypes and a cell surface hydrolase

71 The CC18 C. acnes ATCC6919 isolate could survive intracellularly for

72 We hypothesized that the C. acnes bacteria recovered at the time of revision shoulde

73 strated that laboratory-grown cultures of P. acnes biofilms were susceptible to induction of a biofil

74 ive treatment option for hormonally mediated acne but can cause hyperkalemia.

75 onstrated potent and selective killing of P. acnes but not against human skin cells in vitro.

76 role in the treatment of moderate-to-severe acne, but only with a topical retinoid, benzoyl peroxide

77 Algorithm-based treatment of acne by primary care clinicians may eliminate unnecessar

78 These results demonstrate that P. acnes can infect the carotid arteries of humans with ath

79 dant skin-resident microbe Propionibacterium acnes can influence cytokine expression from human seboc

80 putative-associated loci in a further 2,063 acne cases and 1,970 controls.

81 When monocytes were stimulated with live P. acnes, caspase-1 and caspase-5 gene expression was upreg

82 Propionibacterium acnes, causative agent of chronic prostatitis possibly c

83 tivity, as treatment with Pentobra killed P. acnes cells and caused leakage of intracellular contents

84 Recent work revealed that P. acnes clinical isolates can be classified into distinct

85 The clade of 11 C. acnes clinical isolates was determined by MLST.

86 y increasing resistance of Propionibacterium acnes clinical isolates.

87 tobramycin (by 5-7 logs) against multiple P. acnes clinical strains.

88 At 3-month follow-up, 14.6% of the acne cohort was graded as effectively clear, compared wi

89 6 S. epidermidis-colonized screws; n = 26 C. acnes-colonized screws (covering all three main subspeci

90 Other skin phenotypes such as acne, color and skin cancers are also being investigated

91 a of 1116 patients suspected and treated for ACNES consistently showed the presence of the following

92 echanisms at play in skin diseases including acne continue to be made.

93 common component in cosmetics and commercial acne creams as well as being a first-line chemotherapeut

94 Both short chain fatty acids and C. acnes culture supernatant also increased sensitivity of

95 der that features comedones and inflammatory acne cysts in localized, linear configurations.

96 crobial richness, depletion of Cutibacterium acnes, Dermacoccus and Methylobacterium species, individ

97 biofilm bacteria within all samples, with P. acnes detectable in 4 samples.

98 arlier age at pubic hair, axillary hair, and acne development comparing unexposed with those prenatal

99 e 3D printing technology to manufacture anti-acne devices with salicylic acid.

100 rmatology clinic identified patients with an acne diagnosis at a dermatology visit in the past 3 mont

101 aerococcus, Peptoniphilus, Propionibacterium acnes, Dorea, and Ruminococcus and reduced proportions o

102 to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrat

103 cations for RPE-related eye diseases and the acne drug isotretinoin (a retinoid cycle inhibitor) are

104 secutive patients who received the diagnosis ACNES during evaluation at the SolviMax Center of Excell

105 Internet-based acne education using automated counseling was not superi

106 egarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and

107 e airborne microorganisms, Propionibacterium acnes, Escherichia coli, Acinetobacter lwoffii, Lactobac

108 ally significant improvement of inflammatory acne following three treatments given 1-2 weeks apart.

109 new explanations about the development of C. acnes foreign-body infections.

110 Cutibacterium acnes (formerly Propionibacterium acnes) is recognized a

111 ne and 100 age-matched male controls without acne from a dermatology outpatient department of a terti

112 rimary care clinicians to dermatologists for acne from January 2014 through March 2015 were reviewed

113 dual severity groups according to the Global Acne Grading System and were age matched to 100 male con

114 planted, and intravitreal cultures showed P. acnes growth after 5 days.

115 immune response targeting Propionibacterium acnes has a significant role in its pathogenesis.

116 Sequencing of C. acnes has been proposed as a potential rapid diagnostic

117 e microaerophylic organism Propionibacterium acnes has shown consistent association with prostate can

118 ogical manifestations, mainly represented by acne, hirsutism, and alopecia.

119 sulin resistance and metabolic syndrome with acne in male patients is lacking.

120 hese observations suggest the presence of C. acnes in a diverse microbial community with S. epidermid

121 ectus sheath block, may allow for diagnosing ACNES in patients with chronic abdominal pain.

122 d the magnitude of the immune response to P. acnes in the murine dermis by controlling neutrophil rec

123 5%CI, 0.10-0.80;P = .02) and for sex and non acne indication (OR, 0.28; 95%CI, 0.10-0.79; P = .02).

124 P. acnes induced key inflammasome genes including NLRP1 and

125 ts as demonstrated by suppression of some P. acnes-induced chemokines.

126 ssion by small interfering RNA attenuated P. acnes-induced IL-1beta secretion.

127 uggest that NO-np can effectively prevent P. acnes-induced inflammation by both clearing the organism

128 The mechanism of P. acnes-induced NLRP3 activation and subsequent IL-1beta s

129 in D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th17 differentiation.

130 Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood monon

131 Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR

132 Five of the 17 rats in the C. acnes inoculated group were culture positive at euthanas

133 EN mutation carriers presented with comorbid acne inversa (AI), an inflammatory hair follicle disorde

134 elopment of Alzheimer's disease and familial acne inversa in humans.

135 adenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disorder, which

136 Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder ch

137 s that drive inflammatory gene expression in acne-involved pilosebaceous epithelial cells are still u

138 Acne is a multifactorial inflammatory skin disease with

139 Use of topical and systemic antibiotics for acne is associated with formation of resistance in Propi

140 ealthy young women taking spironolactone for acne is equivalent to the baseline rate of hyperkalemia

141 Although acne is the most common human inflammatory skin disease,

142 ealthy young women taking spironolactone for acne is unclear.

143 ACNES is a clinical diagnosis as no functional testing o

144 Propionibacterium acnes is a known cause of postneurosurgical meningitis;

145 In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1,

146 Propionibacterium acnes is a skin commensal bacterium that contributes to

147 portunistic human pathogen Propionibacterium acnes is composed of a number of distinct phylogroups, d

148 However, it is well-known that C. acnes is not clonal on the skin of most individuals.

149 Cutibacterium acnes is one of the most common bacterial species on hum

150 Cutibacterium acnes is the most common bacterium associated with perip

151 Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous

152 ibacterium acnes (formerly Propionibacterium acnes) is recognized as a pathogen in foreign-body infec

153 Given that multiple subtypes of C. acnes isolates are present on and around the skin pilose

154 Clonality of C. acnes isolates from deep specimens from a potential peri

155 to consider whether further assessment of C. acnes isolates from the same joint should be performed a

156 When applied to 312 P. acnes isolates previously characterized by MLST and repr

157 t detailed population genetic analysis of P. acnes isolates recovered from paired lesional and non-le

158 le samples that were culture positive for C. acnes, isolates from each sample were subjected to full

159 eement between PGA and PtGA scores was good (acne, kappa = 0.68; psoriasis, kappa = 0.70).

160 btilis group, Corynebacterium, Cutibacterium acnes, Lactobacillus, and Micrococcus), PPA and NPA rang

161 At baseline, the mean (SD) total acne lesion count was not significantly different betwee

162 Improvement in the mean (SD) acne lesion count was not significantly different betwee

163 The primary outcome was the total acne lesion count.

164 within human skin is monitored throughout an acne lesion development over 7 days.

165 resembled the transcriptional profile of an acne lesion.

166 es has a critical role in both initiation of acne lesions and in the inflammatory response in acne.

167 L-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effe

168 Finally, in acne lesions, mature caspase-1 and NLRP3 were detected a

169 y cutaneous adverse reactions, most commonly acne-like eruptions.

170 skin disorder characterized clinically with acne-like lesions in apocrine gland-bearing skin, follic

171 Grade 3 or 4 acne-like rash (in 209 of 785 patients [27%] vs four of

172 mon in the sulindac-erlotinib group, with an acne-like rash observed in 87% of participants receiving

173 gnment because of the expected occurrence of acne-like rash--a class effect of EGFR antibodies--that

174 in this environment, we hypothesized that C. acnes may influence biofilm formation of S. epidermidis.

175 Because current acne medications have various side effects, investigatin

176 brand-name medications, and the mean cost of acne medications prescribed per office visit nationally

177 five medicinal plants to explore alternative acne medications.

178 Postadolescent male patients with acne more commonly have insulin resistance.

179 luded muscle-related symptoms, diarrhea, and acne, most of which were mild in severity.

180 he United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132).

181 a day in the dose-escalation phase (grade 3 acne [n=1] and intolerable grade 2 mucosal inflammation

182 Short-term adverse events-acne, night sweats, increased weight, and altered mood a

183 ve protein levels that were classified as C. acnes ODRI would be considered contaminations when accou

184 To date, the direct impact of C. acnes on bone cells has never been explored.

185 We showed a direct impact of C. acnes on bone cells, providing new explanations about th

186 dermidis coexists with abundant Cutibacteria acnes on healthy human skin and does not typically form

187 l skin bacteria but was effective against C. acnes on pig skin and on mice.

188 [20%]), fatigue (81 [13%] vs 74 [20%]), and acne or rash (52 [8%] vs one [<1%]).

189 ers, were not prescribed treatment for their acne, or did not have an active telephone number.

190 Cutibacterium acnes orthopedic device-related infections (ODRIs) range

191 cterial infection, notably Propionibacterium acnes (P. acnes).

192 (Th17) cells induced by healthy (PH) versus acne (PA) skin-associated P. acnes strains are currently

193 in agreement with our conclusion that the P. acnes pan-genome is closed.

194 new insights into the microbial mechanism of acne pathogenesis and suggests probiotic and phage thera

195 le for inflammasome-mediated inflammation in acne pathogenesis.

196 role in formation of sebum, a key factor in acne pathogenesis.

197 that may contribute to either homeostasis or acne pathogenesis.

198 ing cells were present in skin biopsies from acne patients but not from normal donors.

199 In acne patients, the microbiome composition at the species

200 es of propionibacteria and Propionibacterium acnes phage in healthy skin.

201 On the other hand, P. acnes phylotypes associated with healthy skin induced 2-

202 We found that acne-associated P. acnes phylotypes induced 2- to 3-fold higher levels of I

203 ur data provide insight into how specific P. acnes phylotypes influence immune responses and the path

204 Comparative proteomic analysis of P. acnes phylotypes revealed a differential expression of s

205 lthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis.

206 Clinical examination, Global Acne Rating System, National Cholesterol Education Progr

207 The complexity of multidrug acne regimens may add to this problem but, to our knowle

208 nds in the skin which define the etiology of acne-related problems.

209 te comparative genetic analyses in future P. acnes research.

210 itzpatrick skin types I through V and facial acne scarring were enrolled.

211 nology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen

212 technologic advancement in the treatment of acne scarring.

213 ermatologists separately rated participants' acne scars based on standard digital photographs obtaine

214 healthy adults (age range, 20-65 years) with acne scars on both sides of the face were enrolled.

215 , there was improvement in the appearance of acne scars over time compared with the control group, wi

216 Treatment of facial acne scars with a diffractive lens array and 755-nm pico

217 smetic applications including acne vulgaris, acne scars, skin rejuvenation and hair growth, and for t

218 e device, thereby reducing the appearance of acne scars.

219 r to standard-website education in improving acne severity and quality of life.

220 drome did not differ significantly among the acne severity groups.

221 C. acnes significantly decreased the resorption ability of

222 ing maintained or adopted a recommended anti-acne skin care regimen.

223 oup maintained or adopted a recommended anti-acne skin care routine compared with the standard-websit

224 Supernatants from P. acnes-stimulated PBMCs were sufficient to promote the di

225 e composition at the species level and at P. acnes strain level was more diverse than in healthy indi

226 blasts and osteoclasts than CC18 and CC28 C. acnes strains (p </= 0.05).

227 thy (PH) versus acne (PA) skin-associated P. acnes strains are currently unknown.

228 ting that more than 50% of Propionibacterium acnes strains are resistant to topical macrolides, makin

229 strain-specific Th17 clones and show that P. acnes strains induce Th17 cells of varied phenotype and

230 in microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health

231 Overall, our data suggest that P. acnes strains may differentially modulate the CD4(+) T-c

232 CC36 C. acnes strains were significantly less internalized by os

233 Cutibacterium (previously Propionibacterium) acnes strains, and compare outcomes with non-inoculated

234 earch participants as compared with 73.9% of acne studies and 91.7% of eczema studies.

235 bited biofilm formation and, similarly to C. acnes supernatant, reduced polysaccharide synthesis by S

236 The catalogued data and the public P. acnes Sybil database provide a solid foundation for gene

237 proach for developing antibiotics against P. acnes that are effective in cutaneous environments.

238 analysis of 90 genomes of Propionibacterium acnes that represent the known diversity of the species.

239 hough antibiotics are a common treatment for acne, the difficulties inherent to effective antimicrobi

240 Isotretinoin, an effective anti-acne therapy, is a known teratogen that is strictly regu

241 ns other than acne vulgaris, and concomitant acne therapy.

242 istopathological analysis of human patients' acne tissues after applying lupeol for 4 weeks demonstra

243 perate with the skin commensal Cutibacterium acnes to induce IL-36gamma in keratinocytes via the comb

244 t links the skin bacterium Propionibacterium acnes to the condition.

245 27 patients (50.2%) were not on prescription acne treatment at the time of dermatology referral.

246 Some patients may not complete acne treatment because 1 or more of their medications we

247 The frequency of primary nonadherence to acne treatment has not been well characterized.

248 Primary adherence to an acne treatment regimen is better when only 1 treatment i

249 Terms related to acne treatment, isotretinoin, and diagnostic procedures

250 sal of recommendations for antibiotic use in acne treatment.

251 s were queried via telephone regarding which acne treatments they obtained.

252 s probiotic and phage therapies as potential acne treatments to modulate the skin microbiota and to m

253 Taken together, our results indicate that P. acnes triggers a key inflammatory mediator, IL-1beta, vi

254 phylogroups, including those associated with acne (type IA1).

255 lus species (type IV), and Propionibacterium acnes (type V).

256 with PCOS, there were minimal differences in acne types and distribution between the women meeting vs

257 that short-chain fatty acids produced by P. acnes under environmental conditions that favor fermenta

258 d for treatment of moderate-to-severe facial acne, using unblinded and blinded assessments of disease

259 keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic dermatitis," "alopecia ar

260 ed biofilms, and these dispersion-induced P. acnes VP1 biofilms showed increased expression of mRNAs

261 Acne vulgaris (acne) is a common inflammatory disorder o

262 Acne vulgaris (AV) affects most adolescents, and of thos

263 erium that contributes to the development of acne vulgaris and other infections.

264 cently developed to treat moderate to severe acne vulgaris by directly delivering the combination of

265 The pathophysiology of acne vulgaris depends on active sebaceous glands, implyi

266 Acne vulgaris is a nearly universal cutaneous disease ch

267 Acne vulgaris is a nearly universal cutaneous inflammato

268 Acne vulgaris is the most common skin disorder affecting

269 ral minocycline 200mg daily for treatment of acne vulgaris since 16 years old.

270 ntact, and seborrheic dermatitis), 0.29% for acne vulgaris, 0.19% for psoriasis, 0.19% for urticaria,

271 oneedles for cosmetic applications including acne vulgaris, acne scars, skin rejuvenation and hair gr

272 otretinoin therapy for conditions other than acne vulgaris, and concomitant acne therapy.

273 athogenesis of many skin conditions, such as acne vulgaris, hirsutism, and androgenic alopecia.

274 analyzed resulting data: eczema, psoriasis, acne vulgaris, pruritus, alopecia areata, decubitus ulce

275 microbiome can be useful as a biotherapy for acne vulgaris.

276 uman skin and can promote the common disease acne vulgaris.

277 all relevant studies of isotretinoin use in acne vulgaris.

278 lighted as a dominant etiological factor for acne vulgaris.

279 be a well-tolerated, effective treatment for acne vulgaris.

280 tion is necessary for treating patients with acne vulgaris.

281 re centrally involved in the pathogenesis of acne vulgaris.

282 d be developed as an effective treatment for acne vulgaris.

283 ising therapeutic agent for the treatment of acne vulgaris.

284 ass antibiotic approved for the treatment of acne vulgaris.

285 contribute to the common human skin disease acne vulgaris.

286 ealthy young women taking spironolactone for acne was calculated.

287 cost of prescriptions at an office visit for acne was conservatively estimated to be 2 times higher (

288 Although the prevalence of acne was increased among women with PCOS, there were min

289 Acne was noted as a treatment-related adverse event in 1

290 P. acnes was found to be highly sensitive to all concentrat

291 of 15 carotid artery samples, and viable P. acnes was one among 10 different bacterial species recov

292 To harness these characteristics to target acne, we used an established nanotechnology capable of g

293 aged at least 13 years with mild to moderate acne were eligible for participation.

294 s, other skin and subcutaneous diseases, and acne were in the top 10 most prevalent diseases worldwid

295 Up to four different subtypes of C. acnes were observed in the deep tissues of a single pati

296 and proteolytic extracellular enzymes by P. acnes were shown to increase in iron-induced dispersed b

297 ted most of the major pathogenic features of acne with desired physicochemical traits.

298 There is a need to treat acne with effective alternatives to antibiotics to reduc

299 ib (16 [4%] vs none), and of grade 3 rash or acne with erlotinib (23 [6%] vs 41 [10%]).

300 ld male with de novo meningitis caused by P. acnes with metastatic melanoma as the only identified ri

301 E12) that selectively inhibited growth of C. acnes with potency greater than antibiotics commonly use

302 tients, 5 (45%) had different subtypes of C. acnes within the deep tissues even though the colony mor