ライフサイエンスコーパス: acrosomal

1 to exist as a homomer in the posterior post-acrosomal and neck regions of sperm and is probably link

2 er the arrival of the triggering signal, the acrosomal and plasma membranes dock at multiple sites an

3 with 0.2% Triton X-100 disrupted the plasma, acrosomal, and inner mitochondrial membranes, leaving ax

4 to regions appropriate for involvement with acrosomal biogenesis and exocytosis, as well as signalin

5 study, an actin filament atomic model in the acrosomal bundle has been refined by combining rigid-bod

6 The acrosomal bundle in the Limulus sperm has been shown to

7 For successful fertilization, the acrosomal bundle must penetrate through a 30 microm thic

8 f a primitive motile system, the actin-based acrosomal bundle of horseshoe crab sperm.

9 ctin filament cross-linked by scruin in this acrosomal bundle state deviates significantly from a per

10 We show that electron micrographs of acrosomal bundles in water are similar to bundles imaged

11 stimuli activate ARF6, which is required for acrosomal calcium efflux and the assembly of the membran

12 inositol 1,4,5-trisphosphate-dependent intra-acrosomal calcium release.

13 ocal NAADP concentrations with the efflux of acrosomal calcium, thereby ensuring complete fusion of t

14 ense along dorsal and ventral aspects of the acrosomal cap.

15 led to form large acrosomal granules and the acrosomal cap.

16 ing partners involving the oolemma and intra-acrosomal compartment during fertilization.

17 these chaperons to achieve vesiculation and acrosomal contents release.

18 g the release of sperm membrane vesicles and acrosomal contents, and SNARE antibodies inhibit both th

19 perm membranes, but also with the dispersing acrosomal contents.

20 tion of membrane vesicles and release of the acrosomal contents.

21 They are absent from the acrosomal crescent, but are present elsewhere over the s

22 N/+) cross, exhibited cataracts and aberrant acrosomal development indicating a failure to complement

23 he seminiferous tubules identified disrupted acrosomal development.

24 -binding molecules diffuse randomly over the acrosomal domain.

25 me-intact spermatozoa, it is likely that the acrosomal enzymes deform and lyse the oocytes.

26 In view of potentially harmful effects of acrosomal enzymes on embryo development, the removal of

27 form of PH-20 may result from the action of acrosomal enzymes, which could include proteases, glycos

28 roteins, and are not detected in sperm after acrosomal exocytosis (acrosome reaction).

29 Dyngo-4a, blocked the in vitro induction of acrosomal exocytosis by progesterone, but not by the cal

30 pecific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.

31 of many cells; for instance, mammalian sperm acrosomal exocytosis is essential for egg fertilization.

32 ylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC.

33 In this regard, acrosomal exocytosis is sensitive to pertussis toxin and

34 l media and appear to capacitate and undergo acrosomal exocytosis normally.

35 rations of 125I-ZPs not sufficient to induce acrosomal exocytosis revealed no differences in binding

36 ntaxin and VAMP localization and loss during acrosomal exocytosis support a role for these proteins i

37 -dependent pathways are operative in driving acrosomal exocytosis supports the concept that both NAAD

38 and a soluble form of PH-20 released during acrosomal exocytosis was also investigated.

39 unfertilized eggs, inducing sperm to undergo acrosomal exocytosis, and preventing sperm from binding

40 a pellucida) that binds sperm and stimulates acrosomal exocytosis, enabling sperm to penetrate the zo

41 Following acrosomal exocytosis, syntaxin and VAMP cosediment to de

42 During acrosomal exocytosis, the plasma membrane over the acros

43 rthermore, syntaxin-2, a protein involved in acrosomal exocytosis, was present in both raft and nonra

44 t of complex increases over 4-fold following acrosomal exocytosis.

45 gg's extracellular matrix and controls sperm acrosomal exocytosis.

46 adhesion molecule and as a secretagogue for acrosomal exocytosis.

47 tracellular matrix prior to the induction of acrosomal exocytosis.

48 w that this protein has an essential role in acrosomal exocytosis.

49 ation of trans-SNARE complexes and inhibited acrosomal exocytosis.

50 is recognized by sperm GalT I to facilitate acrosomal exocytosis.

51 spermatogenesis defects, including deformed acrosomal formation, degenerative elongating spermatids

52 20 in mice results in cataracts and aberrant acrosomal formation, thus establishing bs and Tbc1d20 (Z

53 has been shown to affect sperm motility and acrosomal function, thereby altering fertility.

54 n of the round spermatid marker SP-10 in the acrosomal granule of germ cells of Bsg KO mice was detec

55 lei, but these vesicles failed to form large acrosomal granules and the acrosomal cap.

56 We find that the variability of the acrosomal growth curve can be explained by the salt and

57 Furthermore, acrosomal labeling was detected in mouse sperm prepared

58 entify oolemmal binding partner(s) for sperm acrosomal ligands, affinity panning was performed with m

59 Acrosomal localization of FNDC3A is observed in spermati

60 Consistent with an acrosomal localization, Gs reactivity is lost in acrosom

61 enerated Golgi-derived vesicles positive for acrosomal markers and attached to nuclei, but these vesi

62 Isolated acrosomal matrices are composed of a limited number of m

63 The guinea pig sperm acrosomal matrix is the dense core of the acrosome and i

64 and inner acrosomal membranes as well as the acrosomal matrix of ejaculated human sperm.

65 rtilization and support the concept that the acrosomal matrix plays an essential role in mediating th

66 e third and fourth modules of the guinea pig acrosomal matrix protein 67; but the formulation of gene

67 proacrosin is one of several proteins in the acrosomal matrix that retain acrosome reacted spermatozo

68 ogues and suggests that sp56 may function in acrosomal matrix-zona pellucida interactions during and

69 protein ZP3R/sp56, which is localized in the acrosomal matrix.

70 rotein (MCP; CD46) is expressed on the inner acrosomal membrane (IAM) of spermatozoa.

71 al vesicle fuses at multiple points with the acrosomal membrane (vesiculation) and syntaxin and VAMP

72 y-6/uPAR family that is exposed on the inner acrosomal membrane after the acrosome reaction.

73 erior part is intercalated between the inner acrosomal membrane and the nuclear envelope of the mamma

74 cence, indicating its retention on the inner acrosomal membrane following the acrosome reaction.

75 ZPBP2 were subfertile, demonstrated aberrant acrosomal membrane invaginations, and produced dysmorphi

76 MCP is expressed on the inner acrosomal membrane of human sperm, and Abs to CCP1 inhib

77 s to the identification of P-selectin on the acrosomal membrane of porcine sperm cells.

78 s only expressed in the eye and on the inner acrosomal membrane of spermatozoa.

79 tors, SAMP14, which is retained on the inner acrosomal membrane of the human spermatozoan following t

80 of exocytosis and through the action of the acrosomal membrane protein Snky.

81 at is necessary for the docking of the outer acrosomal membrane to the plasma membrane and subsequent

82 ealed that PSMA1-GFP copurifies with several acrosomal membrane-associated proteins (e.g., lactadheri

83 erm, and also endogenous PMCA4a on the inner acrosomal membrane.

84 (64 kDa) is present on the plasma and inner acrosomal membranes and gives rise to the soluble acid-a

85 P14 localized the protein to outer and inner acrosomal membranes as well as the acrosomal matrix of e

86 nd syntaxin driving the fusion of plasma and acrosomal membranes.

87 The BRD4 ring does not form in acrosomal mutant mice.

88 The 18-kDa protein coats the sperm acrosomal process and probably mediates fusion of the tw

89 ility of cysteine residues in scruin and the acrosomal process by chemical modification with (1,5-IAE

90 The chemical reactivities of cysteine in the acrosomal process implicate C837 at an actin-binding sit

91 In the acrosomal process of Limulus sperm, the beta-propeller p

92 The acrosomal process of the sea cucumber Thyone briareus ca

93 The acrosomal process of the sperm of the horseshoe crab (Li

94 but previous models have indicated that the acrosomal process of Thyone extends too rapidly for diff

95 It coats the acrosomal process where it is thought to mediate fusion

96 During activation of the Limulus sperm acrosomal process, actin filaments undergo a change in t

97 In contrast to soluble scruin, in the acrosomal process, C837 is completely unreactive while t

98 to support a finger of membrane known as the acrosomal process.

99 ne-enclosed apical projection reminiscent of acrosomal processes of invertebrate sperm.

100 permatid differentiation markers such as the acrosomal protein SP-10 display remarkable testis- and g

101 Abalone sperm lysin is a 16 kDa acrosomal protein used by sperm to create a hole in the

102 In mammals, the sperm acrosomal protein zonadhesin is a rapidly evolving molec

103 pecific mouse SP-10 gene, which codes for an acrosomal protein, revealed that its proximal promoter a

104 formed with mouse oocyte lysates using sperm acrosomal protein, SLLP1 as a target.

105 Abalone sperm lysin is a 16-kDa acrosomal protein, which nonenzymatically and species se

106 The two acrosomal proteins arose by a gene duplication followed

107 Salt and water fluxes during the acrosomal reaction and the nonideality of the cytoplasm

108 udy investigates the striking example of the acrosomal reaction in the sea cucumber Thyone, whose fil

109 cs of an active actin spring that powers the acrosomal reaction of the horseshoe crab (Limulus polyph

110 filopodia could possibly be observed in the acrosomal reactions of the sea cucumber Thyone, and the

111 lpha1E but not alpha1C, the remainder of the acrosomal region also is labeled.

112 binding sites showed a colocalization at the acrosomal region and that treatment of spermatozoa with

113 ng endogenous Rab3A-GTP and Rab27-GTP in the acrosomal region of human sperm.

114 ed in the cytoplasm of spermatocytes and the acrosomal region of round, elongating and elongated sper

115 sporter that is exclusively expressed in the acrosomal region of spermatozoa; it is about 62% similar

116 Localization of suREJ3 to the acrosomal region provides the first suggestion for the r

117 permatids, FNDC3A is largely absent from the acrosomal region with immunostaining being localized to

118 is present in human sperm, localizes to the acrosomal region, and is required for calcium and diacyl

119 led that Atp6v0a2 is mainly expressed in the acrosomal region.

120 extended to a broad area covering the entire acrosomal region.

121 d the TSSK2 kinase localized in the tail and acrosomal regions of mouse epididymal sperm, while TSSK2

122 Acrosomal release is triggered upon sperm adhesion to th

123 on is crucial for mammalian sperm to acquire acrosomal responsiveness during capacitation.

124 t concentrated zona protein binding over the acrosomal ridge and acquire this binding in the corpus r

125 m head, concentrated in a thin band over the acrosomal ridge.

126 fic membrane metalloproteinase, SAS1B (Sperm Acrosomal SLLP1 Binding), was identified as a SLLP1 bind

127 The mammalian acrosomal sperm protease proacrosin plays a role in fert

128 g FACS to simultaneously evaluate viability, acrosomal status, and complement deposition, we found th

129 condense their nuclei, acquire flagellar and acrosomal structures, and shed a significant amount of t

130 hat the Golgi apparatus is cast off from the acrosomal vesicle and migrates toward the sperm tail in

131 Imaging of the acrosomal vesicle and the Golgi apparatus in live rhesus

132 The abalone spermatozoon has a large acrosomal vesicle containing two proteins of 16 kDa and

133 r CMTRos and LysoTracker DND-26 detected the acrosomal vesicle from its formation through spermatid d

134 mal exocytosis, the plasma membrane over the acrosomal vesicle fuses at multiple points with the acro

135 Fusion of the plasma membrane with the acrosomal vesicle membrane at multiple points (vesiculat

136 , a tissue-specific protein found within the acrosomal vesicle of all mammalian spermatozoa, is a mul

137 We show that, like the acrosomal vesicle of mammalian sperm, MOs undergo acidif

138 matozoa with NAADP resulted in a loss of the acrosomal vesicle that showed typical properties describ

139 ies and induced to undergo exocytosis of the acrosomal vesicle with great synchrony.

140 ogenesis: the nucleus, the mitochondria, the acrosomal vesicle, and the Golgi apparatus.

141 n round spermatids, it is localized over the acrosomal vesicle, as confirmed by using polyclonal anti

142 elease the contents of a single vesicle, the acrosomal vesicle, exposing the membrane destined to fus

143 erm contain a single exocytotic vesicle, the acrosomal vesicle, whose contents are exposed during the

144 hereby ensuring complete fusion of the large acrosomal vesicle.

145 exclusively to the plasma membrane over the acrosomal vesicle.

146 ze to the plasma membrane covering the sperm acrosomal vesicle.