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2 he CARMA1-BCL10-MALT1 complex, wherein MALT1 acts as (a) a scaffold to recruit components of the cano
3 findings demonstrate the ability of eDNA to act as a barometer of disturbance and provide an exempla
4 ental function of an epithelial tissue is to act as a barrier, regulating interactions between the ex
5 tral player in physiology of CD8(+) T cells, acting as a barrier to prevent premature differentiation
6 phospholipids and lipopolysaccharide, which acts as a barrier and contributes to antibiotic resistan
11 y consensus in this region, which appears to act as a biased signaling switch, may predispose the AT1
16 t PrpS and PrsS, when expressed ectopically, act as a bipartite module to trigger a self-recognition:
17 se experiments demonstrate that FGF23-WT can act as a bivalent ligand of KLA in the cell membrane.
19 productive maturation suggests that MKRN3 is acting as a brake on gonadotropin-releasing hormone (GnR
20 nvasion by staphylococci, suggesting that Vn acts as a bridge between IsdB and host alpha(v)beta(3) i
21 mation regarding the potential for H(2) S to act as a bronchodilator in developing airways in the con
22 y in xylem resistance to embolism, which may act as a buffer against complete canopy death during pro
23 the sugar-decorated proteins and lipids that act as a buffer between the tumor and the ECM, which in
25 g depression front and its subsequent whelps act as a bumpy treadmill on which the ship would move ba
26 after a fire, during which the ecosystem can act as a C source for decades, as C emissions to the atm
29 ished role in charge photogeneration and can act as a capacitor, where adjacent free charges are held
31 AcrIIA1 uses its two-domain architecture to act as a "Cas9 sensor," tuning acr expression according
33 In the presence of suitable reactants, ROT-2 acted as a catalytic machinery catalyzing a click reacti
34 ur study reveals that nuclear-localized IPMK acts as a chaperone to inhibit LLPS of TFEB to negativel
35 to conform to irregular substrates, but also acts as a cheap building material to facilitate rapid gr
39 le S1 site binder, 4-aminobenzamidine (pAB), acted as a classical competitive inhibitor of PF-3688 cl
42 f transition metal hydroxides on graphene to act as a cocatalyst ensemble for efficient CO(2) photore
44 In the MB, Rutabaga (Rut) adenylate cyclase acts as a coincidence detector during associative condit
46 In mycobacteria, phosphatidylinositol (PI) acts as a common lipid anchor for key components of the
47 th the V280X variants, this mutation did not act as a compensatory mutant but, indeed, further reduce
49 del, we show that low-affinity binding sites act as a competitive reservoir in vivo from which transc
50 ty to counteract the ISR at its very core by acting as a competitive inhibitor of p-eIF2-eIF2B intera
51 for example, kainate receptors on which NMDA acts as a competitive antagonist, and high affinity homo
53 artners, MtTT8 and MtWD40-1, as RH1, thereby acting as a competitor in the regulatory complex and exe
59 icide residues on milkweed leaves that could act as a contributing factor when ingested as part of th
60 s found to display unprecedented reactivity, acting as a convenient and highly effective precursor fo
61 ane, smooth thickness variations in the film act as a correlated disordered potential, focusing the l
62 d catalytic activation, the chiral phosphate acts as a counterion for the Lewis acidic zinc ion, whic
63 ic platform, we discover that the system can act as a coupled oscillator, notably showing spontaneous
65 In addition to its barrier function, the NE acts as a critical signaling node for a variety of cellu
66 the extracellular matrix upon liver injury, acting as a cytokine stimulates the deposition of fibril
71 known to be activated in planta to SPT-enol acts as a developmental inhibitor of the free-living nem
72 PAS transcription factor Single-minded (Sim) acts as a direct target of Ftz-f1 to promote follicle ce
74 or the seasonal variation in GEP and further acted as a distinct mediator for temperature and radiati
76 that overexpression of the Spc110 C terminus acts as a dominant-negative mutant that titrates endogen
78 y system is composed of a polymeric NP which acts as a drug depot encapsulating cationic polymer/nucl
80 FOXM1 also upregulated ZEB1, which could act as a feedback inhibitor of FOXM1, and caused the tra
81 reveal a potential pathogenic mechanism that acts as a feedback loop contributing to the progression
84 sults show that amino acids 93-111 in SNAP25 act as a flexible molecular spacer that ensures efficien
85 ator (orchestrating task changes), while CON acted as a flexible switcher (switching specific regions
87 ex with an ABC-transporter (BceAB), together acting as a flux-sensor where signaling is proportional
88 Here, we show for the first time that C1q acts as a functional hNSC ligand, inducing intracellular
89 complex mechanism that explains how RGMs can act as a functionality-changing switch for two structura
91 rall, these data demonstrate that Folliculin acts as a gatekeeper that maintains separation of blood
92 fore, aBNST GABAergic nociceptin neurons may act as a gateway to feeding behavior by connecting AgRP
94 innate immune signalosomes, but whether HRI acts as a general sensor of proteotoxicity in the cytoso
95 upport the hypothesis that hybridization can act as a generative force in macroevolutionary diversifi
96 the arid south, where the Andes are higher, acting as a genetic barrier between the sharply differen
98 ylated genomes, we show that CHG methylation acts as a greater transcriptional regulator than CG meth
100 ms that high dietary taurine supplementation acted as a growth promoter and concurrently improved sig
101 unction in mouse models of beta-cell failure acting as a growth factor necessary for beta-cell adapta
103 me and the hyphal apical dome (HAD) where it acts as a GTPase-activating protein for FgRab8 which is
106 s secreted by surrounding mesenchymal cells, acts as a guidance cue to orchestrate this epithelial pa
110 a complex network of passive components that acts as a high-pass filter to distort and attenuate the
111 n together, our findings suggest that ringer acts as a hub for microtubule regulators that relays cel
112 that aberrant expression of IGFBP2 in cancer acts as a hub of an oncogenic network, integrating multi
114 upport binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme
118 ine nucleotide exchange factor (RhoGEF) TRIO acts as a key regulator of neuronal migration, axonal ou
120 In the proposed working model, optineurin acts as a key regulator to link inhibition of KRAS signa
122 the active site, and a side chain crafted to act as a latch to inhibit turnover by fastening down the
123 e more dissimilar, increased virulence might act as a limiting factor preventing onward transmission.
124 Our results indicate that a TANGO1 ring, by acting as a linactant, stabilizes the open neck of a nas
125 d to the ER for cleavage by gamma-secretase, acts as a lipid-sensing peptide that forms regulatory DR
128 Our data show that telomere dysfunction acts as a major regulator of HNF4alpha during hepatocyte
133 ng serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell u
134 rming lithium metal anodes, because they can act as a mechanical barrier to avoid unwanted dendritic
138 k if shifts in a child's field of view (FOV) act as a mediator between symptoms of attention deficit
139 be designed to bind alternating structures, acting as a mediator between the catalytic site and the
140 sed cells, where the nanoassembly presumably acts as a mediator for cell-cell communication (bicellul
141 Runt-related transcription factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and
143 association between lutein esters formation acting as a metabolic sink during early stages of grain
144 on initially interferes with photosynthesis, acting as a metabolic threshold switch mechanism that we
145 nt miR-1291 agent, we revealed that miR-1291 acts as a metabolism modulator in pancreatic carcinoma c
147 inement factors of ~5 x 10(10) Such a cavity acts as a mid-infrared nanoantenna, which is efficiently
148 ment performed via an ancillary qubit, which acts as a minimally invasive probe that detects absent q
151 Furthermore, we found evidence that MESM acts as a Mn-selective ionophore, and we observed that i
152 fied LITTLE NINJA (LNJ), a microProtein that acts as a modulator of jasmonic acid (JA) signaling.
154 echanotransduction of cells, and potentially acting as a molecular crosslinker for functional materia
158 d Boc Together, these data indicate that BOC acts as a multi-functional regulator of HH signaling dur
159 evidence in a metazoan of a PDGF/VEGF ligand acting as a myokine that regulates systemic lipid homeos
161 all matrix surrounding male gametophytes and acts as a natural protector of pollen grains against var
162 or the PIN2 asymmetry during gravitropism by acting as a negative regulator of the cell-surface signa
163 F)-alpha-induced protein 8 (TNFAIP8 or TIPE) acts as a negative mediator of apoptosis via inhibition
165 We demonstrate here that LACCASE2 (LAC2) acts as a negative regulator of lignin deposition in roo
166 difficult to determine whether those regions act as a net sink or source because of the large spread
167 ucleus-derived neural stem cells/progenitors acted as a neuronal relay to reconnect supraspinal cente
168 e food intake and has recently been shown to act as a neurotrophic factor to control the development
169 ow that continuous flow has the potential to act as a new enabling technology for asymmetric synthesi
171 le-stranded and high-frequency PTs with SspB acting as a nickase and possibly introducing nicks to fa
172 ss, and the simulations demonstrate that CA9 acts as a nonlinear [Formula: see text] equalizer at any
174 arker genes in prostate epithelial cells and acts as a novel mediator in prostate stem/progenitor cel
175 nd demonstrated that the expression of FABP5 acts as a novel positive regulator of ST2 expression in
176 sertion within the catalytic domain of PfCCT acts as a nuclear localization signal and its deletion d
179 that single-stranded RNA of bacterial origin acts as a PAMP and activates NOS2 by engaging TLR-7.
182 p of phosphatidic acid enables this lipid to act as a pH biosensor as changes in its protonation stat
184 nce that spindles during overnight sleep may act as a physiological mechanism for the restructuring o
186 t dopamine D1 receptors in the dentate gyrus act as a pivotal mediator of antidepressant actions in m
190 We found that NAS directly binds IDO1 and acts as a positive allosteric modulator (PAM) of the IDO
191 tes in proximity of the antenna region, NADH acts as a positive allosteric modulator by enhancing bot
193 time is one of these behaviors that can also act as a postzygotic barrier to reproduction and allow t
196 nections is not only important for ENSO, but acts as a primary mechanism to filter (e.g. reddening) t
197 tion or maternal immune activation (MIA) may act as a primer for multiple genetic and environmental f
198 s of a small protein termed VPg or 3B, which acts as a primer in the replication of foot-and-mouth di
199 Set3C histone deacetylase scaffold Snt1 can act as a prion that drives the emergence and transgenera
201 te that CRISPR-mediated Myd88 repression can act as a prophylactic measure against septicaemia in bot
202 have previously reported that (R,S)-ketamine acts as a prophylactic against stress when administered
205 d, yet they are infectious, allowing them to act as a protein-based epigenetic element: a prion [SMAU
206 While triethanolamine (TEOA) was expected to act as a proton acceptor to ensure the sacrificial behav
209 mary, our data imply a new function for TWD1 acting as a putative activator of ABCB-mediated auxin tr
211 plex into two separate domains, one of which acts as a quencher for the light-harvesting complexes.
212 h the first example of a neutral phosphinine acting as a rare bridging mu(2) -P-4e donor-ligand betwe
213 fone that inhibits growth of tumor cells and acts as a RAS mimetic by binding to Ras binding domains
215 membrane-located GRP78 has been reported to act as a receptor binding to the active form of alpha(2)
218 ytoplasmic actin network (the actin mesh) to act as a regulator of flow speeds to counteract the recr
219 Besides initiating chondrogenesis, SOX9 acts as a regulator of cellular metabolism by suppressin
220 that the putative HSP-90 co-chaperone CHP-1 acts as a regulator of EGFR trafficking in C. elegans.
222 genome, in which one of the FluPol molecules acts as a replicase while the other initiates the assemb
224 CD8(+) T cell reprogramming into T(SCM) that acts as a reservoir for effector T cells with potent the
226 this study reveals that the nuclear envelope acts as a reservoir, maintaining COP1 poised for action.
230 We determine that metal ion uptake does not act as a rigidification element but as a switch redistri
231 as correlated with reduced survival time and acted as a robust biomarker for poor prognosis in glioma
232 that NLRP3 can be activated by flagellin to act as a "safety net" to maintain inflammasome activatio
234 These data support a model whereby TRIM14 acts as a scaffold between TBK1 and STAT3 to promote pho
235 ental data demonstrated the feedback loop to act as a scalable converter of unimodal (population-wide
236 g cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activatin
239 ally warms the climate; however, BC can also act as a seed for cloud particles, which may offset much
240 mental CO(2) inhibits brain activity and has acted as a selection pressure to reduce GABAergic tone,
242 is a potent viral inhibitor and that it can act as a sensor by including a fluorescent output to rep
244 ggregation directly to antibiotic resistance acts as a sensor for the innate (un-accelerated) aggrega
246 tant function in the central nervous system: acting as a sensory network, they detect neuronal activi
247 the microenvironment at the synthetic niche acts as a sentinel by reflecting both progression and re
249 xpression to Fgf genes (SEF), is proposed to act as a signaling hub that negatively regulates mitogen
250 that the activity of the tyrosine kinase ITK acts as a signaling catalyst that accelerates the rate o
251 iated protein newly identified in the heart, acts as a significant mediator of cardiac protection aga
252 ene-1,4,5,8-bis(dicarboximide), and found to act as a simultaneous molecular dopant and morphology-ad
253 w a new, air-stable bimetallic scaffold that acts as a single-chromophore photocatalyst for hydrogen-
254 FeS(s)(m) mediated demethylation of DMHg may act as a sink for DMHg, and a potential source of MMHg,
256 related to the sharp inhomogeneity exist and act as a source of geomagnetic pulsations, but direct ev
257 boundary cells form at segment borders that act as a source or regulator of neuronal differentiation
258 nds on its orientation with respect to a hub acting as a source, even if the link in question is seve
259 Accordingly, in full-length Bs-FtsZ, the CTL acts as a spacer that spatially separates the CTP sticke
260 we can conclude that the carotenoid does not act as a spring that, releasing its internal strain, ind
261 textbook model of the polymerase holoenzyme acting as a stable complex coordinating the replisome, t
266 base-off Cbls, as verified by its ability to act as a strong inhibitor of bacterial adenosyltransfera
267 activity (a(w) 0.11-0.74) showed that water acts as a strong plasticiser decreasing the T(gs) (-16.4
270 These data suggest that SARS-CoV-2 S may act as a superantigen to trigger the development of MIS-
271 The crucial technique is to use the silica, acting as a support and ligand, to modify the cobalt spe
272 acrophage-targeted polyciprofloxacin prodrug acts as a surprisingly effective pre-exposure prophylact
274 terminal actin-binding site of leiomodin can act as a "swinging gate" allowing limited actin polymeri
276 o this motif, and INCENP T59 phosphorylation acts as a switch preventing MKLP2 binding in metaphase.
277 vealed that this short variant of TAS3 might act as a target mimic that captures microRNA390, contrib
278 yrazinamide exerts antibacterial activity by acting as a target degrader, a mechanism of action that
279 rthermore, we identify a gene family, likely acting as a taxonomic marker for an unclassified species
280 reduces the thermodynamic energy barrier by acting as a template for further self-assembly and resul
281 nd critical role of ALKBH5 in AML that might act as a therapeutic target of specific targeting LSCs.
283 a (CCAAT/enhancer-binding protein-alpha) can act as a transcription factor to trigger the expression
284 ATP or ADP, and which is essential for it to act as a transcriptional repressor but is dispensable fo
286 e LIFR is upregulated by nuclear EGFR, which acts as a transcriptional regulator, directly binds to t
289 e of the earliest targets of HIV-1 infection acting as a "Trojan horse," concealing the virus from th
290 EBV-encoded miRNA, namely EBV-miR-BART6-3p, acts as a tumor suppressor by inhibiting metastasis and
291 ceptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung
295 any conifers include a torus-margo structure acting as a valve that prevents air from spreading betwe
296 ive cloud column formed over the volcano and acted as a 'volcanic freezer' containing ~3 x 10(9) kg o
300 ded RNA derived from these retroelements may act as a Zalpha-domain ligand that triggers the activati