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1 its binding partner XRCC1, this interaction acts as a backup attempt to intercept the more error-pro
4 lial cells and pericytes encase the surface, acting as a barrier that regulates transport of molecule
6 gic synapse revealed that the cortical actin acts as a barrier for secretion of such large granules a
7 Here, we investigated whether glycosylation acts as a barrier to infection for other nonpermissive s
10 lack of standardized images at these stages acts as a barrier to the efficient and accurate represen
11 ligned PAA remained on the membrane support, acting as a beneficial barrier that prevented the acid-f
13 ed a lipophilic hydrogen bond donor that may act as a bioisostere of hydroxyl, thiol, or amine groups
15 lly, it alters the nucleosomal response, and acts as a brake on chromatin remodeling and gene regulat
16 in WT and Eed (-/-) TSCs suggests that PRC2 acts as a brake to prevent induction of transcribed gene
17 n the rice CCR4-NOT complex, and that OsCAF1 acts as a bridge between OsCCR4 and OsNOT1 in this compl
18 further reduced the capacity for the fen to act as a C sink by causing shifts in vegetation and thus
20 simulations indicate that the Glu361 residue acts as a catalytic base facilitating the hydride transf
21 hway, recognition of micronuclei by cGAS may act as a cell-intrinsic immune surveillance mechanism th
22 of talin rod subdomains has been proposed to act as a cellular mechanosensor, but so far evidence lin
24 together, these results suggest that Bcl11b acts as a central intrinsic regulator of mammary epithel
26 engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natur
27 e as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune
28 ermediates; (ii) the alpha-dicarbonyl tether acts as a chromophore enhancer, extending the conjugatio
29 or of the pigment, in which the chromate ion acts as a chromophore, is related to its chemical compos
33 proteins - known as the HS interactome - by acting as a co-receptor or alternative receptor for grow
35 gesting that SERCA2a 971-990 can potentially act as a common epitope for both T cells and B cells.
37 porter activity was observed, which possibly acted as a compensatory mechanism in the face of the ele
38 he data suggest that the C terminus of SPI-1 acts as a competitive inhibitor of target proteases as i
42 IL-1beta is produced by myeloid cells and acts as a critical mediator of host defense during infec
43 hough it has long been appreciated that p300 acts as a critical Notch coactivator, the mechanistic de
44 intaining cellular dNTP homeostasis but also acts as a critical regulator in innate immune responses
45 t for the first time that the primary cilium acts as a crucial sensor for electrical field stimulatio
50 ates nitric oxide (NO) in myeloid cells that acts as a defense mechanism to suppress invading microor
52 Here, we tested whether glycosylation also acts as a determinant of permissivity for ferret, hamste
53 Together these data indicate that MAX can act as a direct epigenetic sensor of E-box cytosine modi
57 the entorhinal cortex/CA1 region circuit by acting as a domain-specific postsynaptic target-recognit
58 ding domain but not the Rad50 binding domain acts as a dominant negative inhibitor of E2-dependent HP
59 1A mutation limits MAL glutathionylation and acts as a dominant negative, blocking the interaction of
60 ether, these observations suggest that D477G acts as a dominant-negative mutant of RPE65 that delays
61 on regulators) bound at a single DNA site to act as a dual regulator of cmr transcription and an acti
62 urnover is controlled by the circadian clock acting as a dynamic homeostat responding to sucrose sign
66 nal data now prove that the alkyne primarily acts as a four-electron donor ligand to the catalyticall
68 social categorization engages a network that acts as a functional bridge between dorsal attentional (
69 t the cell surface via sialylation, ST6Gal-I acts as a functional switch to divert signaling toward s
72 65T, which alters a DNA binding residue, and acts as a gain-of-function mutation enhancing cell survi
76 re we show how macromolecular force sensors, acting as a genome proxy, allow us to probe the pathways
77 oderm and mesoderm, whereas Wnt/beta-catenin acts as a genome-wide toggle between foregut and hindgut
79 express nitrous oxide reductase, potentially acting as a global sink for the greenhouse gas nitrous o
82 en synaptic partners, but how these proteins act as a group to specify a complex neural network is po
83 that stimulates RNA interference (RNAi) and acts as a growth inhibitor selectively in cancer but not
85 analyses show no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas th
89 both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell n
91 rs, with the Lewis acid component of the FLP acting as a hydride shuttle that enables alkyne 1,2-hydr
92 It was found that the difluoromethyl group acts as a hydrogen bond donor on a scale similar to that
94 Our results suggest that Oxtr(PBN) neurons act as a key node in the fluid satiation neurocircuitry,
97 ave shown that modification of histone H3K27 acts as a key molecular switch for activation or suppres
98 Our findings suggest that the Atlantic Ocean acts as a key pacemaker for the western Pacific decadal
99 ow the controlled talin rod domain unfolding acts as a key regulator of adhesion structure and functi
101 nsistent with the light chain-binding domain acting as a lever arm to amplify nucleotide-dependent mo
102 consistent with a model where the N terminus acts as a lever to support amphetamine-induced efflux by
104 , an active metabolite of dietary vitamin A, acts as a ligand for nuclear receptor transcription fact
106 influences glucose homeostasis and possibly acts as a link between the cardiovascular system and met
108 om land-based sources and rivers potentially act as a major transport pathway for all sizes of plasti
112 e document that the vitamin D receptor (VDR) acts as a master transcriptional regulator of autophagy.
114 that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein foldin
115 propose that NOTCH1 is atheroprotective and acts as a mechanosensor in adult arteries, where it inte
117 in the distal posterior mesenchyme, where it acts as a mediator of anterior to posterior (AP) pattern
118 , owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fis
119 y, these results provide evidence that ABHD5 acts as a metabolic tumor suppressor in PCa that prevent
123 ization results suggested that the inhibitor acted as a mixed type inhibitor by reducing both anodic
125 d by the soybean pathogen Phytophthora sojae acts as a modulator of histone acetyltransferase (HAT) i
126 aken together, our results suggest that cGMP acts as a modulator that enhances downstream signaling w
127 the expected peroxidase activity, AnPrx6 can act as a molecular chaperone in its dimeric state, contr
129 gher order folding of chromatin topology may act as a molecular-pathway independent code regulating g
131 echanistically, SAP opposed PD-1 function by acting as a molecular shield of key tyrosine residues th
134 ene expression in EHEC, we propose that DHMA acts as a molecular beacon to target pathogens to their
135 e propose that the assembled tripartite pump acts as a molecular bellows to propel substrates through
136 DAC3 as a regulator of WAT physiology, which acts as a molecular brake that inhibits fatty acid metab
139 inct transcription factors and show that AHR acts as a molecular switch for monocyte fate specificati
141 unpaired 2 (Upd2) in skeletal muscle, which acts as a myokine to control glucagon-like adipokinetic
142 d of H2O2, showing that FeS2 dissolution can act as a natural Fenton reagent, influencing the oxidati
144 Over longer timescales, CO2 release could act as a negative feedback, limiting progress of glaciat
146 cts the rewarding effects of cannabinoids by acting as a negative allosteric modulator of alpha7 nico
147 role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability an
150 he invasiveness of GBM cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibit
153 oparaphenylenes (CPPs) have the potential to act as a new class of ligands for coordination cages, me
154 on the effects of pyrazolo[4,3-c]quinolines acting as a new class of bacterial betaG-specific inhibi
155 d also suggest that the ARF-NRF2 interaction acts as a new checkpoint for oxidative stress responses.
156 e terminals supplying the subependymal zone, acts as a niche component to sustain the neurogenic pote
157 gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic response t
158 membrane serine proteinase (TTSP) matriptase acts as a novel initiator of cartilage destruction via t
159 We show Sox2 downregulates miR-452, which acts as a novel metastasis suppressor to directly target
160 in the regulation of biotin utilization and acts as a nuclear transcriptional coregulator of gene ex
161 s unusual regioselectivity in this reaction, acting as a nucleophile at the alpha-position to provide
162 e model also naturally explains how KaiA, by acting as a nucleotide exchange factor, can stimulate ph
163 s that show that the fluoride anion does not act as a one-electron reducing agent toward the NDI inve
164 Photoelectron spectroscopy confirms that Ag acts as a p-type dopant for PbSe QDs and infrared spectr
165 -oscillating hindbrain population (HBO) that acts as a pacemaker for ocular saccades and controls the
166 and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed
167 coevolution between constituent species, may act as a partially cohesive unit [8-11], resulting in on
170 simulation data suggested that the bulky Phe acts as a pawl that stabilizes the downward ratchet-like
171 t, two-domain multifunctional stress protein acting as a Phase II enzyme, activating cancer pro-drugs
172 uciferase reporter assays, a mutant that may act as a phosphomimetic, with a Y102-to-glutamate (E) mu
175 embrane and the cell wall of the growing tip acts as a piconewton force transducer that couples the i
176 ation of 1,8-diiodooctane, which we suggest, acts as a plasticiser to promote molecular mobility.
177 a multifunctional protein termed VP35, which acts as a polymerase cofactor, a viral protein chaperone
179 ated by all nuclear RNA polymerases, thereby acting as a positive modifier of global gene expression.
180 the Arabidopsis MYB107 transcription factor acts as a positive regulator controlling suberin biosynt
181 is study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcript
182 Therefore, our study supports that 38u might act as a potent and specific AEP inhibitor useful for ca
183 to heterologous transactivation domains can act as a potent guide RNA sequence-directed inducer or r
187 targeted delivery of GD1a to MS lesions may act as a potential novel molecular tool to boost maturat
188 egates in MS lesions, ganglioside GD1a might act as a potential novel therapeutic tool to selectively
190 by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diver
191 It was concluded that external immunity acts as a powerful selective force for virulence evoluti
193 differences in DNA methylation of autosomes act as a primary driver of sex differences that are foun
194 rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche
198 t increase in albumin oxidation, and albumin acts as a pro-oxidant; this promotes oxidative stress an
199 presence of replication protein A (RPA), MRN acts as a processivity factor for Exo1, retaining the ex
201 g that utilizing sand mixed with biochar can act as a promising biofilter capable of protecting natur
202 , in large part because positive mood states act as a protective buffer against otherwise aversive ex
205 ts reveal a mechanism by which lncRNA MALAT1 acts as a proto-oncogene in hepatocellular carcinoma, mo
210 channel function for TRPM8 that unexpectedly acts as a Rap1 GTPase inhibitor, thereby inhibiting endo
211 ning 3 (NLRP3) inflammasome activation often acts as a rate-limiting step in regulating critical cell
212 te that the [4Fe4S] cluster in Pol delta can act as a redox switch for activity, and we propose that
215 e show that the small GTPases Cdc42 and RhoA act as a regulatory circuit downstream of the MK-specifi
217 to promoting Th1 effector commitment, T-bet acts as a repressor in differentiated Th1 cells to preve
219 ETV4, which is induced by FGF signalling and acts as a repressor of ZRS activity, interacts with the
221 diated activation of the calcineurin pathway acts as a rheostat to shape both the phenotype and effec
227 ucleolar phosphoprotein nucleophosmin (NPM1) acts as a scaffold for PIDD and is essential for PIDDoso
231 ) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (
233 hat this post-translational modification may act as a signal for the selective recognition by the mac
235 ng, the GPCR-family protein Smoothened (Smo) acts as a signal transducer that is regulated by phospho
240 trial microbes.The extent to which the ocean acts as a sink and source of airborne particles to the a
245 ed changes in behavior have the potential to act as a source of information, so that stressed individ
246 ing with human CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of no
248 d the MT surface independently from Hec1 and acts as a stabilizer of both MTs and KT-MT interactions.
251 dicating that the North China cratonic crust acts as a strong resistance to the northward growth of t
252 topological arrangement of skull bones might act as a structural constraint, predisposing some articu
253 as activators of basal bud initiation, SPL4 acts as a suppressor for the formation of both aerial an
254 Here we report that a polyaromatic capsule acts as a supramolecular matrix for the mass determinati
256 roduced to replace other heteroatoms and can act as a surrogate of functional groups such as olefin a
257 ddressing these questions, we find that VEGF acts as a survival factor in growth plate chondrocytes d
261 he hyperactivated Wnt/beta-catenin signaling acts as a switch to induce epithelial to mesenchymal tra
263 e sea, and that the STE has the potential to act as a temporal storage or even sink for terrigenous a
266 melanopsin is required for thermo-reception, acting as a thermo-opsin that ultimately feeds the local
268 nd gamma-amino-alpha,beta-unsaturated esters acting as a three-atom component to construct indoline u
269 ass, alpha-(1'-fluoro)vinyllysine is seen to act as a time-dependent, irreversible inactivator of lys
270 propose an orthogonalization operator which acts as a time-varying weighting in the morphological re
271 eolysis suggests that the cleavage event may act as a timing switch in the regulation of early versus
272 CT is a critical initial diagnostic test and acts as a tool to identify patients who should undergo s
273 nd their canonical stop site and that TOP1MT acts as a topological barrier and regulator for mtDNA tr
274 y, in RNA-seq and ChIP-seq experiments, EBF3 acted as a transcriptional regulator, and mutant EBF3 ha
275 apical meristems of vrs3 suggested that VRS3 acts as a transcriptional activator of the row-type gene
277 regulating myelination and propose that Shp2 acts as a transient brake to the developmental myelinati
279 s observations, we suggest that CENP-F might act as a transporter of mitochondria and other cellular
280 n the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylated protein functi
281 between dividing and differentiating cells, acting as a trigger for this developmental transition, t
282 to CRISPR interference, CRISPR-Cas does not act as a true immunity system that saves the infected ce
284 d other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (S
286 of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic e
287 r development in many cancer types, TGF-beta acts as a tumor suppressor, whereas in the advanced stag
291 findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology.
292 s that the competitive network may therefore act as a unifying link between diversity and function, p
293 ected MCM translocation into double hexamers acts as a unifying mechanism for the establishment of bi
296 sults suggest that the random walk model can act as a useful predictive tool for describing the evolu
299 rcles one DNA strand and excludes the other, acting as a wedge with an external DNA unwinding point d
300 the Spemann organizer of Xenopus embryos and acts as a Wnt antagonist to promote notochord formation
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