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1 al properties of the tissues that the forces act on.
2 strong (|N(e)s| > 10), with strong selection acting on 10-20% of synonymous sites in preferred codons
5 in mice that SSRIs impair motor function by acting on 5-HT2C receptors in the substantia nigra pars
7 elieved to occur when postoperative triggers act on a preexisting vulnerable substrate, but the under
8 time enabled us to estimate what force must act on a single motor to achieve the microtubule depolym
9 The pathways are heavily interconnected and act on a variety of common effectors that can lead to th
10 nzymes share a conserved structural fold but act on a wide range of substrates to catalyze reactions
11 disulfide-rich and well-structured peptides act on a wide range of targets such as ion channels, G p
12 tive frequency-dependent selection plausibly acted on a human disease susceptibility locus, a form of
13 ive DLVO-force and the shear and drag forces acting on a bacterium near collector surfaces in a DC el
14 efforts focus on identifying lead compounds acting on a molecular target associated with an establis
15 ary cells with the core 2 GlcNAc transferase acting on a mucin-type O-glycoprotein displayed increase
16 y expressed key regulator of cell signaling, acting on a number of cellular processes and components,
17 shot learning approach to predict the kinase acting on a phosphosite for kinases with no known phosph
18 how male finches perform courtship songs by acting on a region of the premotor cortex called HVC.
19 a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation
21 expression that predicts the magnetic force acting on a superparamagnetic bead based on the Karlqvis
22 docannabinoid 2-arachidonoyl glycerol (2-AG) acting on a TRPV (transient receptor potential vanilloid
23 uch as nutrients alter cellular behaviors by acting on a wide array of molecular sensors inside cells
25 th the hypothesis that fluctuating selection acts on a microdiverse cloud of strains, and this succes
28 ides that promote dauer entry of larvae also act on adult animals to attenuate expression of the insu
30 a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bo
31 However, it remained unclear whether SPARCL1 acts on all or on only a subset of synapses, induces fun
32 oreover, it remained unclear whether SPARCL1 acts on all synapses containing neurexins and neuroligin
35 viral replication and showed that selection acting on an interferon protein has increased the protei
36 ng selection across precipitation gradients, acting on ancestral cereal grain size regulators, underl
38 what we have described for miRNAs, including acting on apoptosis, M. leprae recognition and engulfmen
39 s of enzyme activity, particularly for those acting on arabinosyl- and galactosyl-rich pectin side ch
41 en receptor (TCR) by B cells, helper T cells act on B cells via CD40 ligand and secreted cytokines th
43 C 842 in Escherichia coli We found that PapP acts on beta-(1->3)-glucooligosaccharide acceptors with
44 ours, blood and lungs demonstrated that IL11 acts on bone-marrow-derived mesenchymal stromal cells, w
46 i-input control through small molecules that act on both feedback loops, and we find that changes to
49 acetate enhances innate immune responses by acting on both neutrophils and ILC3s through its cognate
50 arousal-related suppression in decision bias acts on both conservative and liberal biases, and genera
51 ase dual-specificity phosphatase 11 (DUSP11) acts on both host and virus-derived 5'-triphosphate RNAs
52 similar endogenous ligands, and agomelatine acts on both receptors, the receptors differ markedly in
54 independently estimated selection gradients acting on Camellia pericarp thickness with values simula
56 rthritic pain and disease development, CCL17 acts on CCR4(+) non-bone marrow-derived cells, and 3) fo
57 colytic cancer-associated fibroblasts (CAFs) acts on CD4(+) T cells, shaping T-cell polarization.
58 s by considering cell number regulation that acts on cell division rates such that the number of cell
59 al source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the
60 e sequences, we find that negative selection acting on central guanines of UTR pG4s is comparable to
63 n activation, with the majority predicted to act on CoA-linked substrates, thus expanding our knowled
64 ues who might be impaired, physicians should act on collegial concern as well as ethical and legal gu
65 rapidly identifying ALS/FTD suppressors that act on conserved pathways from invertebrates to vertebra
66 can and do arise from differential selection acting on conserved patterns of phenotypic integration.
67 Our results show that the Reissner fiber acts on CSF-cNs and thereby contributes to establish bod
68 vely unexplored, and the selective pressures acting on CVB3 in the intestine are not well characteriz
70 acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of
71 dinones (TDZDs) are covalent inhibitors that act on cysteine residues to inhibit RGS4, RGS8, and RGS1
73 c acid (isoDCA) increased Foxp3 induction by acting on dendritic cells (DCs) to diminish their immuno
75 which is composed of two monostable modules acting on different cellular compartments and sharing sp
77 early in tumorigenesis; different mechanisms act on distinct genomic regions to drive DNA copy change
79 le mutants, suggesting that DH31 and PDF may act on DN1ps to regulate free-running rhythmicity in a h
82 role of chromatin as a barrier to processes acting on DNA and how chromatin proteins have diversifie
87 An oral compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at
88 are silenced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] together with the
94 This mechanical mode works as a common force acting on each optical mode, which, thus, enables the sy
95 hanistic pathways where macronutrients might act on either appetite or adipogenesis to cause weight g
96 sed on traditional cytotoxic agents does not act on either immune signaling pathways or BRAF mutation
98 rowth- and survival-promoting cytokines that act on epithelial cells, as well as fibrogenic and immun
104 M, an IL-6 family cytokine, which appears to act on fibroblasts to alter extracellular matrix product
106 n sites, enabling the molecular machinery to act on functionally significant information encoded in D
107 astic forces (drift or stochastic dispersal) act on fungal community assembly in leaves and roots ear
108 llergens elicit host production of mediators acting on G-protein-coupled receptors to regulate airway
110 ransmission in the brain is mediated by GABA acting on GABA(A) receptors (GABA(A)Rs), which provides
111 types(1,2), but the nature of selection that acts on gene expression and its role in adaptive evoluti
112 ramework to evaluate the evolutionary forces acting on genomic regions associated with human complex
113 th perceiving the gentlest detectable forces acting on glabrous skin and fine sensorimotor control.
114 -binding triad characteristic of CE4 enzymes acting on GlcNAc residues, differing from MurNAc deacety
119 allocation theory and propose that selection acts on heritable variation to optimize longevity in lig
121 chemicals are common in our environment and act on hormone systems and signaling pathways to alter p
122 clusion that Btl proteins are effectors that act on host DNA and play important but varied or possibl
124 nstrated, JG-98, a rhodocyanin compound that acts on Hsp70 but not its inactive structural analog JG-
125 and murine stroke and that AnxA1 is able to act on human platelets, suppressing classic thrombin-ind
126 viously unappreciated cellular circuits that act on human-infecting viruses and provides insight into
127 one that induces responses to stress through acting on hypothalamus to activate the sympathetic nervo
128 ercellular and extracellular traction forces acting on individual cells within an endothelial cell co
129 results indicate that the negative selection acting on individuals affected by schizophrenia in the g
134 mpathetic input suppresses colon motility by acting on intrinsic myenteric neurons, but the extent of
137 rphology is in turn a function of the forces acting on it and the mechanical properties of the nuclea
139 ogether, these findings indicate that 14-3-3 acts on keratin IFs and is involved in their reorganizat
140 improving our understanding of how selection acts on key floral traits in taxonomically diverse speci
141 to DNA, not much is known about how crowding acts on late initiation and promoter clearance steps, wh
145 e (1) widespread losses of degrading enzymes acting on lignin and cellulose, (2) co-option of genes p
147 e novel circuit-based information on how CCK acts on local astrocytes to regulate the key behavior of
149 ammation, basophil-derived interleukin-4 can act on lung-infiltrating monocytes causing aberrant expr
152 fferential expression of a novel lncRNA that acts on MAOA expression to regulate impulsive-aggressive
153 produce cardiovascular protective effects by acting on Mas receptor and is considered as a counter-re
154 viridis, to address the evolutionary forces acting on MHC diversity in populations with different bi
157 dition, we find pervasive negative selection acting on missense and nonsense mutations, except for mu
158 s that the strength of stabilizing selection acting on mRNA levels in a species is strongly associate
159 rates of dopaminergic neurons in the VTA by acting on mu-opioid receptors on RMTg neurons and their
164 hasic arousal, indicative of neuromodulators acting on multiple timescales, was mediated by its effec
165 r in ovaries and hemolymph are increased and act on nearby midgut progenitors inducing Ecdysone-induc
166 tumors, but not others, secrete factors that act on nearby nerves to augment nociception by producing
170 ocytes, can cross the blood-brain barrier to act on neurons in different brain regions, including tho
173 We further show that IL-17 can directly act on non-Th17 effector CD4+ T cells to induce suppress
175 s and modifications and chromatin regulators act on nucleosomes to regulate transcription is the subj
177 could increase pathological downstaging and act on occult micrometastatic disease, leading ultimatel
178 lation in mouse CD4(+) T cells, subsequently acting on oligodendrocytes to induce anxiety-like behavi
179 , we review how neural and vascular activity act on one another with regard to these two properties.
180 re not yet known, we propose that these DUBs act on one or more factors that control period length of
181 omodulators, intestinal secretagogues, drugs acting on opioid or 5-HT receptors, or minimally absorbe
183 ge of different objects whose function is to act on other parts of the environment, and assign them t
185 Our present work reveals that M. morganii acts on P. mirabilis in a contact-independent manner to
186 ter understanding of the evolutionary forces acting on patterns of DNA methylation and suggest a role
187 iochemically characterize these enzymes that act on peptidoglycan because suitable peptidoglycan subs
188 l pigment epithelium can be damaged by light acting on photosensitizers like N-retinylidene-N-retinyl
189 Further, Fig4 is also a protein phosphatase acting on PIKfyve to stimulate its lipid kinase activity
191 play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular syst
196 s-promoting properties of chemotherapy drugs acting on rapidly proliferating hair matrix keratinocyte
199 ic RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide
200 -deficient member of the adenosine deaminase acting on RNA (ADAR) family, is competing with ADR-2 for
201 y inactive member of the Adenosine Deaminase Acting on RNA (ADAR) protein family, whose active member
202 Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible for adenosine-to-inos
207 igoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other prote
209 scription to nucleotide excision repair, and acts on RNA polymerases when elongation is impeded.
210 we show that ADAR2 (adenosine deaminase that acts on RNA), an RNA editing enzyme, is expressed outsid
212 k analysis predicts that NMIIA and NMIIB may act on similar pathways but through different regulators
213 the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and transiently-unpaired DNA
217 s of evidence suggest that natural selection acts on spatial memory in food-caching species [3-6].
222 By quantifying multiple evolutionary forces acting on sPTB-associated regions, our approach improves
224 ontrolled trial to investigate the effect of ACT on stress in patients with inflammatory bowel diseas
225 g with our discovery that positive selection acts on structural clusters, opens previously unexplored
226 g more likely to use digital tools to report/act on symptoms and seek testing, compared with African
227 er than impairing cytotoxicity, excess IL-18 acted on T lymphocytes to amplify their inflammatory res
230 may be the long-sought neuronal factor that acts on taste stem cells for maintaining taste tissue ho
231 the translational activators are believed to act on the 5'-untranslated regions of target mRNAs, but
232 s a family of methyltransferases, those that act on the amino groups of adenine or cytosine in DNA, h
233 nt's beliefs only when the agent was free to act on the ball and not when the agent was visibly const
235 e CLR-induced NF-kappaB, and molecules which act on the CLR family broadly and which directly regulat
240 emonstrates that the melanocortin system can act on the mesolimbic DA system to control feeding and o
243 n increased risk related to medications that act on the renin-angiotensin-aldosterone system in patie
244 1 and Stx2, which bind the same receptor and act on the same target but nonetheless differ in potency
245 terns suggest that although the 4 inhibitors act on the same target, they may have distinct effects o
247 tivated protein kinases (GCN2 and PERK) that act on the translational machinery to slow down protein
249 eative tool use-using objects in new ways to act on the world, achieve a goal, or solve a problem.
250 timulates intestinal phosphate absorption by acting on the active transcellular pathway mostly mediat
252 an angiotensin II (Ang II) receptor blocker acting on the Ang II type-1 receptor (AT1R) subtype, is
257 enging because of the wide range of forcings acting on the GBMD and because of the large range of sca
262 prey, revealed a self-recognition mechanism acting on the nematode surface, capable of distinguishin
263 r3 in controlling the actin-dependent forces acting on the nuclear envelope to remodel nuclear shape,
265 detaches RcopLS20 from DNA by preferentially acting on the RcopLS20 molecules involved in DNA looping
268 thdrawal symptoms and drug cravings, despite acting on the same opioid receptors triggered by classic
272 i) ] is explained by a direct effect of P(i) acting on the SR Ca(2+) release channel, combined with t
274 , consisting of distinct selective processes acting on the two antagonists during rapid and reciproca
275 gnostic pipeline to show that favipiravir is acting on the virus by revealing the mutation bias patte
276 using increased synthesis of xanthine, which acts on the brain and induces anxiety-like behaviors.
277 ultivariate analysis suggests that selection acts on the expression of photosynthesis genes(4,5), but
278 2 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysopho
280 vonol glycoside 4'-O-xylosyltransferase that acts on the second to last intermediate (MbA-XR(2)) in t
283 nt cause of cancer, and selecting drugs that act on these oncogenic kinases can lead to effective the
284 come available, the regulatory framework for acting on these data requires further optimization.
285 By characterizing landscape-scale drivers acting on these interfaces, we demonstrate that socioeco
286 nd we suggest that the environmental context acting on these predictors at a specific time point will
291 rging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tu
295 nerated reactive oxygen species (ROS), which acted on transient receptor potential cation channel sub
299 pectrometric analysis of their products when acting on well-defined chitosan polymers as substrates.
300 converting the kinase to a phosphatase that acts on Ypd1 to trigger HOG pathway activation and funga