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1 utations and the neural representations they act on.
2 according to how that sensory information is acted on.
3 we screened libraries to find compounds that act on a cell-based fluorescence sensor of ppGalNAc-T3 b
6 gs suggest that ATP-dependent RNA ligase may act on a specific set of 3'-adenylated RNAs to regulate
8 ingle miRNA can control an entire process by acting on a crucial mediator; however, this is a quite e
10 lts illustrate a mechanism by which cocaine, acting on a key neuromodulation pathway, modifies the co
12 a more general framework, mechanical forces acting on a molecular system can strongly modify its rea
13 of CD mutations as a result of neutral drift acting on a small population of active hematopoietic ste
16 is-like toxin demonstrates that this protein acts on a known toxin substrate but displays distinct an
17 ted K63-linkage-specific ubiquitin machinery acts on a major postsynaptic scaffold to regulate synaps
20 CLEASES (SDNs) initiate miRNA degradation by acting on AGO1-bound miRNAs to cause their 3' truncation
21 r with smoke and other environmental stimuli acts on airways epithelial cells to induce neutrophil ch
26 The UbiD family of reversible decarboxylases act on aromatic, heteroaromatic, and unsaturated aliphat
28 the negative effects of Tau in AD and FTD by acting on autophagy, providing a rationale for therapeut
31 is less clear which of the many WNT proteins act on bone or where these WNTs act in the skeleton; how
34 rons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine re
35 e between excitation and inhibition and tACS acts on both excitatory and inhibitory cortical neurons.
36 bronchial mucosal production of IL-17A which acts on bronchial epithelial cells directly and in conce
37 structural features, which identify enzymes acting on bulky substrates as a distinct subgroup of the
39 blic health concern and cannabis is known to act on central neurotransmission, studying the retinal g
41 e demonstrate that the channel gating, which acts on chordotonal stretch receptor neurons, is based o
43 chromosomal DNA via several mechanisms that act on chromatin-associated proteins and provide a rich
44 ajor increase in the frequency of adaptation acting on coding and regulatory changes genome-wide.
45 become a major target for natural selection acting on colour and pattern variation in this group of
46 ing question is whether the antOFC and vlPFC act on common or distinct downstream targets to regulate
49 n atypical class I (di)terpene synthase that acts on CPP to produce the abietane olefin miltiradiene,
51 acean Gammarus pulex and four toxicants that act on different targets (diazinon, propiconazole, 4,6-d
52 ts of reward seeking and action selection by acting on different functional networks of PFC neurons t
53 DA mediates opposing patterns of behavior by acting on different receptors within the same terminal r
55 t carry-over toxicity occurs among chemicals acting on different targets and when exposure is several
57 onents is distinctive for its versatility in acting on diverse incompatible DNA end configurations co
62 anosized system cannot be merely incremented acting on doping, since other parameters come into play.
64 A editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs pred
65 is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-conta
66 xhibited elevated circulating estradiol (E2) acting on E2-responsive tissue/cells such as macrophages
67 ship, which differs from purifying selection acting on each mimetic pattern, indicates that predator
68 IL-1beta, which inhibits B lymphopoiesis by acting on early lymphoid progenitors, S100A9 inhibits B
71 ric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist bind
73 We asked whether the presence of kin might act on energy allocation, a central aspect of life-histo
74 , the gut microbiota produces molecules that act on enteric neurons to influence gastrointestinal mot
75 ther activates ILC2s to secrete IL-13, which acts on epithelial crypt progenitors to promote differen
76 l alpha2 -adrenoceptors, although serotonin, acting on facilitatory spinal 5-HT3 receptors, influence
77 Our hypothesised role of predatory selection acting on females to generate both extreme sexual size d
78 the septum, our findings indicate that FtsEX acts on FtsA to promote divisome assembly and to coordin
81 and the antimalarial drug artemether, which acts on GABAergic pathways, can drive pancreatic cells w
82 rtemether-lumefantrine (AL), relative to non-ACTs on gametocyte clearance and transmission interrupti
83 to novel environments, allowing selection to act on genes that have evolved in multiple genetic backg
85 sts that immunomodulatory drugs can directly act on glomerular epithelial cells or 'podocytes', the c
86 Bacteroides EstA, a sialate O-acetylesterase acting on glycosidically linked sialylate-O-acetylestera
87 (RGS) proteins RGS7 and RGS11 that directly act on Go and two adaptor subunits: RGS Anchor Protein (
90 -receiving cells, we found that SHH does not act on hair follicles, adipocytes, endothelial cells, an
91 inhibitors as possible drug candidates that act on hematopoiesis and the niche to prevent transforma
93 cted to hemorrhage or EPO therapy, that ERFE acts on hepatocytes to suppress hepcidin, and that the r
94 spite abundant examples of natural selection acting on heritable traits, conclusive evidence for cont
96 T2A1 (encodes a sulfoconjugation enzyme that acts on hydroxysteroids and cholesterol-derived sterol b
97 metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal meta
99 erences in the tendency to seek stimulation, act on impulse, and engage in substance use are correlat
100 s evolve by mutations and epigenetic changes acting on individuals in a population; tumors evolve by
101 I first consider the constraints and drivers acting on influenza A virus reassortment, including the
102 eir effects on the central nervous system by acting on ion channels, most notably pentameric ligand-g
106 Although much is known about how serotonin acts on its cellular targets, how serotonin release is r
107 Here we show that melatonin time-dependently acts on its receptors in the PT to alter splicing of vas
110 n came the recognition that the enzymes that act on lipid substrates residing in or on membranes and
113 ic modulation may contribute to attention by acting on local cortical microcircuits to decorrelate sp
114 males and reveal a molecular mechanism that acts on local medial prefrontal cortex (mPFC) circuits t
115 of density-dependence and sexual antagonism acting on loci within the arginine vasopressin-oxytocin
116 re, we demonstrated that gonococcal AmiC can act on macromolecular PG to liberate cross-linked and no
117 layers, as well as the spin transfer torques acting on magnetisation regions with spatial gradients,
118 o uncover TRUB1 and PUS7 as the two key PUSs acting on mammalian mRNA and to computationally model th
120 cytokine thymic stromal lymphopoietin (TSLP) acting on mast cells to generate PGD2 and facilitate tis
122 mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diphosphate (MVAPP) to produce IPP wh
123 nventional antidepressant medications, which act on monoaminergic systems, display significant limita
125 tide 1 (GLP-1) receptor agonists (GLP-1-RAs) act on multiple tissues, in addition to the pancreas.
126 nthesized in the periphery and in the brain, acting on multiple receptors to regulate gene transcript
127 We, therefore, conclude that mavacamten acts on multiple stages of the myosin chemomechanical cy
128 o the substantia nigra pars reticulata (SNr) act on muscarinic acetylcholine receptor subtype 4 (M4)
129 investigation reveals that Msd specifically acts on mutagenic nucleobases such as 5-azacytosine and
130 impacts programs governing myelination, and acts on myelinating oligodendrocyte (OL) cells across th
131 genitors, S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inf
135 re opportunity to test the effect of warming acting on natural ecosystems is by investigation of heat
137 e.g., PPS, the area around the body used to act on nearby objects, through a reaching-distance task.
139 eria are capable of producing molecules that act on neurons and affect essential aspects of host phys
140 ocytes, and release 'gliotransmitters' which act on neurons and vascular smooth muscle, led to the id
141 nterleukin 18, an anorexigenic cytokine, can act on neurons of the bed nucleus of the stria terminali
142 hesis that IL-18 can decrease food intake by acting on neurons of the bed nucleus of the stria termin
143 ell proliferation and differentiation and by acting on neurons to enhance dendritic arbor elaboration
145 N-lambda was elicited by enteric viruses and acted on neutrophils to decrease oxidative stress and in
146 the strengths of selection and genetic drift acting on newly incorporated genetic elements in viral g
148 Understanding where and how these compounds act on NMDA receptors should aid in designing better the
154 and other animals must monitor, approach and act on objects that are associated with variable or unkn
156 rnative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, wit
159 blood flow (via shear stress) or hypoxia, to act on P2 receptors on endothelial cells to produce nitr
160 cond kinase, CDC-Like Kinase 2 (CLK2), which acts on PAGE4 and hyperphosphorylates it at multiple S/T
164 le is known about the extrinsic signals that act on planarian stem cells to modulate rates of neuroge
165 tors are considered primary selective agents acting on plant traits, and thus variation in the streng
166 to be due principally to selective pressure acting on pollen morphogenesis because of its implicatio
168 is consistent with the expectations of drift acting on populations founded by small numbers of indivi
170 over the DLPFC has fast excitatory effects, acting on prefrontal and striatal transmissions, and the
171 ization signal to Sis1, indicating that Cur1 acts on prions via its previously reported ability to re
173 that peripherally derived endocrine signals act on receptors in hippocampal neurons to reduce (lepti
175 ae and skeletal deformities in adult, mainly acting on reducing ER cisternae size and favoring collag
176 n language occurs when one modality (vision) acts on representations of a second modality (audition).
177 ection of HMGB1 accelerates tissue repair by acting on resident muscle stem cells, hepatocytes, and i
179 overed motif present in several enzymes that act on ribosomally synthesized and post-translationally
181 hysiological responses in signalling modules acting on RLC phosphorylation and force responses, proba
182 d muscarinic responses in signalling modules acting on RLC phosphorylation are different from pharmac
184 e temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and trans-regula
185 entous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believed to lack
186 n-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene, occurs in 30-50% of MM patie
187 the catalytic domain of Adenosine Deaminase Acting on RNA (ADAR2) that deaminates A to inosine (I) r
189 -binding domain of human adenosine deaminase acting on RNA 1 (ADAR1, hZalphaADAR1), as confirmed by C
190 editing, we do show that adenosine deaminase acting on RNA 1 and 2 and fibrillarin negatively influen
192 inase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts in mammalian cells.
193 study, we identify adenosine deaminase that acts on RNA 3 (ADAR3) as an important regulator of Q/R s
194 RNA editing mediated by adenosine deaminase acting on RNA1 (ADAR1) promotes cancer progression and t
195 d and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specifi
198 re of forces, in static and dynamic regimes, acting on sealed abdominal aortic aneurysms, with refere
199 We explored the possibility that DA may act on separate networks of PFC neurons that are modulat
200 litate diverse aspects of decision making by acting on separate networks of prefrontal neurons that i
201 iepileptic activity can be mimicked by drugs acting on serotonin signalling pathways e.g. trazodone a
203 together, our findings indicate that GmCLV1A acts on shoot architecture, whereas GmNARK, functions in
204 Here we found that donor hematopoietic cells act on sinusoidal endothelial cells and induce host bloo
205 nsferase (GNMT), a member of the family that acts on small metabolites as the substrate, catalyzes me
207 potent and selective CBP/p300 inhibitor that acts on specific cancer cell lines, in particular malign
211 oth positive and negative diffusible signals act on stem and/or progenitor cells leads to the appeara
212 process that supports learning and memory by acting on synapses through poorly understood molecular m
215 Thus, protons could evoke pruriception by acting on TDAG8 to regulate TRPV1 activation with its me
216 studies show that August temperatures, which act on the adult stage, are linked to range change.
217 by which peripheral and central immune cells act on the brain to affect stress-related neurobiologica
218 ion to acting at the cell membrane, AMPs may act on the cell wall, inhibit protein folding or enzyme
219 minantly found in mycobacterial species that act on the commercially important s-triazine class of co
224 t carry out epigenetic protein modifications act on the p53 protein and its splice variants in stem a
225 monstrate that SoxC genes (Sox4, 11, and 12) act on the progenitor-to-postmitotic transition to imple
227 respect to each other, suggesting that they act on the same pathway, linking chemotherapy to a thera
228 A C-terminal reductase, TclS, can optionally act on the substrate peptide, yielding MP1, and is shown
229 cting directly on cancer cells, it must also act on the tumour stroma for effective rejection of larg
232 he identification of compounds that directly acted on the orthosteric sites for endogenous ligands.
233 nd the ecological context in which selection acted on the risk-related behavior of the organism of in
235 the material permittivity can be designed by acting on the amplitude and delay of the two fields.
236 arises from the interplay of external forces acting on the body and internally generated movements.
237 in activates translation of the COX1 mRNA by acting on the COX1 5'-UTR, and, in addition, it interact
238 es in acidic conditions has been achieved by acting on the electronic character of the substituent at
241 ies of positive allosteric modulators (PAMs) acting on the human alpha7 nicotinic acetylcholine recep
243 voked responses, indicating that rather than acting on the nerves within the pancreas slice, CCK cell
244 the balance between kinases and phosphatases acting on the NLRP3 PYD is critical for NLRP3 activation
248 ), generated by natural and sexual selection acting on the same trait, maintains mimicry polymorphism
252 sibility to myc-epitopes we show that forces acting on the transmembrane segment produce loose cluste
253 gle, but well-predicted by rotational forces acting on the whisker: both during touch and free-air wh
257 e also disclosed that protein overload first acts on the expression of the cubilin-amnionless (CUBAM)
259 re generated by the electric body force that acts on the free charge induced by the mismatch of ferro
261 od-brain barrier (BBB) to the brain where it acts on the hypothalamus receptors to control appetite a
263 d products of phospholipase A2 activity that acts on the membrane phospholipids, including the phosph
264 ms, whereas 5-HT produced by the NSM neurons acts on the MOD-1 receptor in AIY neurons to promote low
266 outer membrane-associated BoMan26B initially acts on the polysaccharide galactomannan, producing comp
268 DNA editing process (VDJ recombination) that acts on the surface receptor gene each time a new immune
270 uced by the bacterium Clostridium botulinum, act on their hosts by a high-affinity association to two
279 for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the ori
280 ound signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures
281 variation, as well as the natural selection acting on this variation that drives adaptation to envir
282 rovide an example of how biochemical signals act on tissue-level mechanics to drive organogenesis, an
283 uctures, a process called corticogenesis, by acting on transcriptional activity of numerous genes.
285 esponse function of a tunable logic AND gate acting on two promoters in heterogeneous cell population
286 F-alpha are upstream molecules by which CD40 acts on ULK1 and Beclin 1 to stimulate autophagy and kil
288 nzyme displays excellent enantioselectivity, acts on various ketones, and is particularly active on p
290 plain this invokes a Lorentz force mechanism acting on vestibular endolymph that acts to stimulate se
291 into the differential evolutionary pressures acting on virus subtypes, which can manifest into landsc
292 iral RNA sequence and/or an RNA modification act on viruses lacking ExoN activity.IMPORTANCE CoVs enc
293 utamate receptor 2 (mGluR2) signaling, which acts on voltage-gated calcium channels in SACs, selectiv
296 aints establish the magnitude of wave forces acting on wetland erosion that must be included in ecosy
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