ライフサイエンスコーパス: actin polymerization

1 interest as they bind to G-actin and enhance actin polymerization.

2 bited neutrophil migration and intracellular actin polymerization.

3 ion, impairing N-WASP-driven Arp2/3-mediated actin polymerization.

4 domain but not the TOCA1 HR1 domain inhibits actin polymerization.

5 te smoke extract via oxidative disruption of actin polymerization.

6 supports memory by directly driving synaptic actin polymerization.

7 ulinum toxin substrate 1 GTPase activity and actin polymerization.

8 ation of T cell receptor-driven (TCR-driven) actin polymerization.

9 fectors such as N-WASP that induce localized actin polymerization.

10 bles microtubular transport, exocytosis, and actin polymerization.

11 enance of total actin levels and preserves F-actin polymerization.

12 contractility of smooth muscle by regulating actin polymerization.

13 5)P2 and PI(3)P in a curved vesicle triggers actin polymerization.

14 -regulation of a large number of genes after actin polymerization.

15 ntegrin activation by fibronectin to nuclear actin polymerization.

16 trosylation of cytosolic actin that enhances actin polymerization.

17 th micromolar affinities and weakly nucleate actin polymerization.

18 actin assembly proteins, formins, to sustain actin polymerization.

19 me, across multiple contexts, and depends on actin polymerization.

20 P-mediated molecular processes necessary for actin polymerization.

21 es the actin cortex rearward to facilitate f-actin polymerization.

22 and prolonged the effects of BDNF and TEA on actin polymerization.

23 suppresses UNC-73 function and, indirectly, actin polymerization.

24 ile myosin-II activity and not to elevated F-actin polymerization.

25 o hyperactivation of cofilin and inefficient actin polymerization.

26 e to ACh, and also inhibited contraction and actin polymerization.

27 , proliferation, autophagy, translation, and actin polymerization.

28 rocess akin to blebbing and is not driven by actin polymerization.

29 a permissive open conformation, speeding up actin polymerization.

30 Uptake was dependent on dynamin and actin polymerization.

31 elated protein 2/3 (Arp2/3) complex-mediated actin polymerization.

32 ange depends on strong synaptic activity and actin polymerization.

33 ependent, Abl/Src tyrosine kinase-mediated F-actin polymerization.

34 negative regulator of RhoGTPase activity and actin polymerization.

35 d that it regulates contraction by mediating actin polymerization.

36 bles microtubular transport, exocytosis, and actin polymerization.

37 Rho-kinase signaling pathways and stimulated actin polymerization.

38 ctic signal transduction network, as well as actin polymerization.

39 -readout, likely downstream of PCP-regulated actin polymerization.

40 nchymal cell motility is driven by polarized actin polymerization [1].

41 CLIP-170-mDia1 complexes promoted actin polymerization ~18 times faster than free-barbed-e

42 Blocking of actin polymerization abolished this process.

43 ssociated inverted formin-2 (INF2), a potent actin polymerization activator (mutations of which are a

44 Stimuli that promote actin polymerization allow for shuttling of MRTFs to the

45 These effects are due to Cyfip1's role in actin polymerization and are reversed by expression of a

46 ion as SRF coactivators, serve as sensors of actin polymerization and are sequestered in the cytoplas

47 rate the crucial role of Skap2 in regulating actin polymerization and binding of talin-1 and kindlin-

48 on effector protein that plays roles in both actin polymerization and caspase-3 activation in intesti

49 h in turn cooperates with Vav1 in regulating actin polymerization and CD28 signaling functions.

50 MEK/ERK signaling as well as disruption of F-actin polymerization and cell intercalation.

51 this network is required to link stimuli to actin polymerization and chemotactic motility and we dis

52 We define actin polymerization and contractility as target mechani

53 Pak inhibition suppressed actin polymerization and contraction in response to ACh,

54 ldrich syndrome protein (N-WASP) activation, actin polymerization and contraction in response to ACh.

55 axillin Ser273 phosphorylation and inhibited actin polymerization and contraction.

56 The primary drivers of yeast endocytosis are actin polymerization and curvature-generating proteins,

57 rotein-based network of 14 genes involved in actin polymerization and dendritic spine formation (nomi

58 cytoskeleton, which is regulated in part by actin polymerization and depolymerization.

59 at fragmentation of murine ovaries increases actin polymerization and disrupts Hippo signaling, leadi

60 While other Mena isoforms promote actin polymerization and drive membrane protrusion, we f

61 ed protein kinase 2 (MK2) pathway to promote actin polymerization and endothelial cell migration.

62 ling through c-Src and Cdc42, which modulate actin polymerization and filopodia formation via the Arp

63 signal-regulated kinase phosphorylation and actin polymerization and for L-Phe-induced Ca(2+)i mobil

64 method is then used to treat the dynamics of actin polymerization and force generation during endocyt

65 Second, ascorbate prevented actin polymerization and formation of stress fibers by r

66 tructures has been correlated with increased actin polymerization and global organization of the acti

67 PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation.

68 uired to enhance cytotoxicity, by increasing actin polymerization and granule polarization.

69 e protrusion, we find that Mena11a decreases actin polymerization and growth factor-stimulated membra

70 to IL-20 that manifested as modification of actin polymerization and inhibition of a broad range of

71 Cycling requires dynamic actin polymerization and is blocked by inhibitors of bot

72 genes.Trio is a RhoGEF protein that promotes actin polymerization and is implicated in the regulation

73 actin-related protein 2/3 (Arp2/3)-dependent actin polymerization and is involved in regulating the t

74 of constitutively active mutant ADF reduces actin polymerization and junctional protein disassembly,

75 Furthermore, actin polymerization and microtubules have been implicat

76 on peripheral blood neutrophils, as well as actin polymerization and migration.

77 ate plasma membrane tension toward polarized actin polymerization and migration.

78 letal organization by studying the effect of actin polymerization and nuclear rigidity on the diffusi

79 lonRI in processes that depend on stimulated actin polymerization and outward trafficking of REs.

80 e mediated by cytoskeletal changes involving actin polymerization and p38 mitogen-activated protein k

81 a phosphorylated state, thereby decreasing F-actin polymerization and preventing cell migration in a

82 n-binding protein that promotes formin-based actin polymerization and regulates numerous cellular fun

83 ytochalasin D (CytoD) and PP2, inhibitors of actin polymerization and Src activity, respectively.

84 nds and binds tropomyosins (TMs), regulating actin polymerization and stability.

85 y mDia1 and Fmnl3 as major factors enhancing actin polymerization and stabilizing E-cadherin at epith

86 moting actin depolymerization and localizing actin polymerization and the actin nucleation promotion

87 ctivation of ROCK/MLC signalling, persistent actin polymerization and the disassembly of junctional p

88 imary PIP3-stimulated Rac activator, whereas actin polymerization and the GTPase-activating protein A

89 ral protein A36 beneath the virus, enhancing actin polymerization and the spread of infection.

90 Mechanistically, actin polymerization and turnover have been shown to be

91 ith the important role of Pfn1 in regulating actin polymerization and various fundamental actin-based

92 is consistent with aura function promoting F-actin polymerization and/or stabilization.

93 , phosphatidylinositol-3-OH kinase, PAK1 and actin polymerization, and activated upon Cdc42 inhibitio

94 the smooth muscle cell cortex, via cortical actin polymerization, and by downstream smooth muscle ef

95 Indeed, increases in basal Ca(2+), actin polymerization, and IL-6 production are reversed i

96 ng, possibly through its ability to regulate actin polymerization, and inhibiting its activity could

97 S-2 activation, reactive species generation, actin polymerization, and MP production.

98 cium channels, protein kinase C, Rho-kinase, actin polymerization, and myocardin-related transcriptio

99 my1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver S

100 Inhibitors of tyrosine kinases, actin polymerization, and the phosphatidylinositol casca

101 ndent mb-KitL/c-kit clustering, anchorage, F-actin polymerization, and Tyr567-dependent cluster phosp

102 Remarkably, amounts and dynamics of actin polymerization are normal.

103 Inhibition of actin polymerization as well as myosin light chain kinas

104 clear magnetic resonance and the pointed-end actin polymerization assay, we find that leiomodin-2, a

105 dimeric capping protein (CAPZ), which blocks actin polymerization at barbed ends.

106 the contribution of myosin contraction, and actin polymerization at bundles' terminals when the prod

107 ds on F-actin, but the mechanisms regulating actin polymerization at cell-cell junctions remain poorl

108 e we investigated a role for formin-mediated actin polymerization at cell-cell junctions.

109 ntiated NB4 cell migration and intracellular actin polymerization at concentrations seen during acute

110 wn is the mechanism triggering INF2-mediated actin polymerization at ER-mitochondria intersections.

111 s myosin II-derived force inhibits vectorial actin polymerization at focal adhesions through AMPK-med

112 oduced by dysregulation of Rac1's control of actin polymerization at glutamatergic synapses.

113 tor SopE, we recapitulated Rho GTPase-driven actin polymerization at model phospholipid membrane bila

114 sidues, in particular tyrosine 421, promotes actin polymerization at newly-forming invadopodia, promo

115 tochastic simulations of force generation by actin polymerization at obstacles coated with actin "nuc

116 a length by transporting cargos that control actin polymerization at stereocilia tips.

117 rotein complex, which has been implicated in actin polymerization at synapses, a process thought to b

118 arbed ends of F-actin, traveling to sites of actin polymerization at the cell periphery [4].

119 tion or blockade on T cells caused defective actin polymerization at the contact site with APC, alter

120 Cortical retrograde flow resulting from actin polymerization at the edges is shown to be modulat

121 abarti et al. demonstrate that INF2 mediates actin polymerization at the endoplasmic reticulum (ER),

122 is eliminated there is negligible effect on actin polymerization at the immunological synapse, leadi

123 formin (FMN)-type actin nucleators initiate actin polymerization at vesicular membranes necessary fo

124 Actin polymerization-based protrusion increases tension

125 Here we show that efficient control of actin polymerization-based protrusion requires an additi

126 ata suggest that the Arp2/3 complex-mediated actin polymerization brings two opposing membranes into

127 s also exhibit a normal initial magnitude of actin polymerization but fail to polarize actin assembly

128 lators that target the FH2 domain to inhibit actin polymerization, but little is known about how thes

129 Mechanoactivation of the AT1 R stimulates actin polymerization by a protein kinase C-dependent mec

130 tin filament length regulator that repressed actin polymerization by binding to monomeric actin.

131 setting established that RHAMM stabilized F-actin polymerization by controlling ROCK signaling.

132 otide exchange factor (RhoGEF) Trio promotes actin polymerization by directly activating the small GT

133 timulated phosphoprotein (VASP) can catalyze actin polymerization by elongating actin filaments.

134 Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the

135 Liprin-alpha3 regulates actin polymerization by lowering the regulatory potency

136 Cells can control actin polymerization by nucleating new filaments or elon

137 Previously, perturbation of actin polymerization by pathogens was shown to activate

138 confirm this hypothesis for mDia1 dependent actin polymerization by stretching a single-actin filame

139 force for constriction is thought to involve actin polymerization by the ER-anchored isoform of the f

140 Inhibition of actin polymerization by these agents enhanced colocaliza

141 Additionally, applied force from actin polymerization can bypass the instability by induc

142 supports a general mechanism where localized actin polymerization can coordinate activation of the co

143 Force produced by actin polymerization can generate traction across the pl

144 Small-molecule inhibition of actin polymerization can remove potential danger signals

145 t activates the small GTPase, cdc42, and the actin polymerization catalyst, neuronal Wiskott-Aldrich

146 the absence of CD37 in neutrophils impaired actin polymerization, cell spreading and polarization, d

147 We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbin

148 the actin-related proteins 2 and 3 (ARP2/3) actin polymerization complex member N-WASP.

149 ntrast, jasplakinolide, a drug that enhances actin polymerization, consolidates the cytoskeleton netw

150 rodents and that the loss of mTORC2-mediated actin polymerization contributes to age-associated memor

151 n-related transcription factor (MRTF), a Rho/actin polymerization-controlled coactivator of serum res

152 Conversely, conditions that favor actin polymerization de-repress MRTFs and activate SRF-d

153 The regulation of EAAT2 expression involves actin polymerization-dependent activation of the transcr

154 epaired by recruitment of new material in an actin polymerization-dependent manner.

155 ive of involvement in cell-cell adhesion and actin polymerization-dependent processes.

156 driven) vs proplatelet branching (Arp2/3 and actin polymerization-driven).

157 -Aldrich syndrome protein (N-WASP)-activated actin polymerization drives extension of invadopodia and

158 prisingly, a possibility that unextinguished actin polymerization drives neurite outgrowth in the pre

159 beta-catenin with N-cadherin is regulated by actin polymerization during contractile activation.

160 Any disruption to actin polymerization dynamics will render the parasite i

161 can be applied to studying the integrity of actin polymerization dynamics.

162 on of increased coat rigidity and force from actin polymerization enables robust vesiculation even at

163 pharmacologically boosting either mTORC2 or actin polymerization enhances LTM.

164 sphorylation attenuates MCP1-induced HASMC G-actin polymerization, F-actin stress fiber formation, an

165 sphorylation, cortactin-WAVE2 interaction, G-actin polymerization, F-actin stress fiber formation, an

166 ortactin interaction with WAVE2, affecting G-actin polymerization, F-actin stress fiber formation, an

167 s singled out the actin cytoskeleton and the actin polymerization factor, the Arp2/3 complex, as top

168 ssembly, previous studies suggest that other actin polymerization factors, such as formins, may parti

169 Without talin or actin polymerization, few early adhesions form, but expr

170 ynamics, but the mechanisms steering nascent actin polymerization for cell-cell adhesion initiation a

171 palmitoylation is essential for normal spine actin polymerization, for spine-specific structural plas

172 e found to be microtubule associated, making actin polymerization from microtubule-associated platfor

173 These foci are a nidus for vigorous actin polymerization, generating long filaments spurting

174 ated that N-WASP is required for localized F-actin polymerization, GLUT4 vesicle translocation, and g

175 icate that the cyto-D treatment blocking the actin polymerization has a dominant effect at the large

176 x and branched actin networks soften it, but actin polymerization has no effect on cortex stiffness.

177 e pinch-off stage, however, where additional actin polymerization helps break off the vesicle.

178 uss here the propagation of forces caused by actin polymerization, highlighting simple configurations

179 onsistent with HSPB7's inhibitory effects on actin polymerization, HSPB7 KO mice had longer actin/thi

180 dynamin oligomerization and thus, increases actin polymerization, improved renal health in diverse m

181 Whether talin ABDs regulate actin polymerization in a constitutive or regulated mann

182 lsive force comparable to that provided by f-actin polymerization in a lamellipod.

183 lves activation of RhoA signaling leading to actin polymerization in dendritic spines.

184 d LIMK-dependent cofilin phosphorylation and actin polymerization in dendritic spines.

185 We specifically explore the role of actin polymerization in determining both the height and

186 depolymerizing factor (ADF) causes sustained actin polymerization in ECs, whereas EC-targeted overexp

187 and bundled F-actin filaments and inhibited actin polymerization in in vitro actin assays.

188 t dynamin oligomerization and thus increased actin polymerization in injured podocytes, was sufficien

189 bl-related gene (Arg) activation, leading to actin polymerization in invadopodia, extracellular matri

190 risingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integ

191 sits that attractive guidance cues stimulate actin polymerization in neuronal growth cones whereas re

192 This change triggers otherwise-forbidden actin polymerization in primary cilia, which excises cil

193 in light chain phosphorylation at Ser-19 and actin polymerization in response to contractile activati

194 tion of the cytoskeleton involving increased actin polymerization in response to Rho-associated kinas

195 osphorylation of Vav1, Rac activation, and F-actin polymerization in SCF-treated BMMCs.

196 1a can dampen membrane protrusion and reduce actin polymerization in the absence of other Mena isofor

197 therapeutic effect is reversed by inhibiting actin polymerization in the CD36(+/+) macrophages, suppo

198 ex, and therefore suggest a role for nuclear actin polymerization in the context of cellular adhesion

199 ures that can mitigate the effect of Pfn1 on actin polymerization in vitro As a further proof-of-conc

200 CRC cell viability, survival, migration and actin polymerization in vitro.

201 f MKL1 expression in MZMs led to defective F-actin polymerization, inability to clear ACs, and, event

202 Our results show that myosin II activity and actin polymerization increase cortex tension and intrace

203 ollicular fluid constituent known to promote actin polymerization, increased the conversion of globul

204 These results demonstrate that actin polymerization independently stimulates the dynami

205 a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase Cbe

206 Interfering with actin polymerization, inhibiting Arp2/3 complex, knockin

207 les E-cadherin to the actin cytoskeleton, or actin polymerization inhibitors similarly attenuated DR4

208 wth of neuronal processes in the presence of actin polymerization inhibitors.

209 Interestingly, we observe nuclear actin polymerization into dynamic filaments upon cell sp

210 Actin polymerization is a universal mechanism to drive p

211 Rac-dependent actin polymerization is activated by a guanine nucleotid

212 se results indicate that formin-based linear actin polymerization is critical for the formation and m

213 We conclude that actin polymerization is indispensable for neurite elonga

214 Consistently, actin polymerization is inhibited at sites of CynA accum

215 Actin polymerization is involved in endocytosis in varyi

216 Moreover, we found that the region of actin polymerization is located at the base of the endoc

217 hat Drp1 binds actin filaments directly, and actin polymerization is necessary for mitochondrial Drp1

218 Branched actin polymerization is necessary for the biogenesis of

219 Actin polymerization is required for tension generation

220 ons remain as to how force generated through actin polymerization is transmitted to the plasma membra

221 During CME in yeast, actin polymerization is triggered and coordinated by a s

222 ngle actin filament elongation, we show that actin polymerization kinetics at both filament ends are

223 d raise concerns about the interpretation of actin polymerization kinetics based solely on protein de

224 Integrins and actin polymerization largely regulate this transfer.

225 Reduced actin polymerization leads to destabilized endothelial j

226 This perturbation of actin polymerization leads to systemic autoinflammation

227 The branched actin polymerization machinery acts subsequently to prom

228 Signals at the leading edge recruit actin polymerization machinery to promote membrane protr

229 oting invadopodium maturation and consequent actin polymerization, matrix degradation, and invasive m

230 ovide new insights into how Arp2/3-dependent actin polymerization modulates both Kv3.3 activity and i

231 as an effector of WASP-mediated control over actin polymerization, mutations in protein components of

232 Inhibiting actin polymerization, myosin IIA, or the formin INF2 red

233 from Tmods, acting as powerful nucleators of actin polymerization, not capping proteins.

234 to membrane and microtubule (MT) and promote actin polymerization nucleation.

235 nd actin depolymerization, whereas increased actin polymerization offers protective effects and incre

236 otein coat, membrane tension, and force from actin polymerization on bud formation.

237 the timing of type 1 myosin recruitment and actin polymerization onset during CME.

238 The LTP deficit was rescued by promoting actin polymerization or by KIBRA expression.

239 Drugs inhibiting actin polymerization or myosin IIA activation prevented

240 Although actin polymerization or myosin-II activity individually

241 A secondary, weak, actin polymerization pathway is triggered via an NPY mot

242 sin D indicate that SHFV does not hijack the actin polymerization pathway.

243 genes involved in the small GTPase-dependent actin polymerization pathway.

244 SRC, VAV1, p38MAPK, IKKalpha/beta, RAC, and actin polymerization pathways.

245 its signaling pathway, leading to defective actin polymerization, platelet activation, and shape cha

246 that the final steps of extravasation, where actin polymerization plays an important role, are impair

247 Actin polymerization powers membrane deformation during

248 e ovaries with muM Jasplakinolide (JASP), an actin polymerization-promoting cyclic peptide, or sphing

249 olve actin polymerization, we tested whether actin polymerization-promoting drugs could promote YAP t

250 EL, following early endosomal sorting by the actin polymerization-promoting WASH complex.

251 ners of CRB3 in the testis were the branched actin polymerization protein Arp3, and the barbed end-ca

252 of Arp3 (actin-related protein 3, a branched actin polymerization protein) and palladin (an actin bun

253 that both proteins are involved in explosive actin polymerization, pseudopod formation, and cell migr

254 hanistically, this phenomenon is mediated by actin polymerization, Rac1 activation, and alphaIIbbeta3

255 s in the model: substrate adhesion strength, actin polymerization rate, myosin contractility, and the

256 y1 to formins, leading to a length-dependent actin polymerization rate.

257 om 0.5 to 10 pN can drastically speed up the actin polymerization rate.

258 protrusion waves are due to fluctuations in actin polymerization rates and that overexpression of VA

259 in as bait to recruit and phosphorylate host actin polymerization-regulating proteins, including the

260 dulating integrin activation and controlling actin polymerization) remain largely unknown.

261 gers local Rac-GTP hydrolysis, thus reducing actin polymerization required for filopodia formation.

262 Further, we find that this force-promoted actin polymerization requires torsionally unconstrained

263 Cytochalasin-D, to inhibit beta-integrin or actin polymerization, respectively, significantly reduce

264 Depleting Mena or disrupting actin polymerization resulted in Golgi fragmentation.

265 nitiation, proximally localized Mwh inhibits actin polymerization resulting in polarized activation o

266 Spreading-induced nuclear actin polymerization results in serum response factor (S

267 Here, we show that INF2-mediated actin polymerization stimulates a second mitochondrial r

268 n assays, live-cell imaging of motility, and actin polymerization studies to confirm a role for CD13

269 an actin anti-capping protein that promotes actin polymerization, switches highly adherent keratocyt

270 Jasplakinolide-induced actin polymerization synergizes with TGFbeta to facilita

271 courses and the effects of interventions on actin polymerization: the surprising increase in the pea

272 he downstream Rho GTPase effectors mediating actin polymerization through Arp2/3 nucleation, Wiskott-

273 We previously showed that actin polymerization through ER-bound inverted formin 2

274 extracellular matrix interaction to nuclear actin polymerization through the LINC complex, and there

275 of endocytic sites is essential for allowing actin polymerization to drive membrane invagination.

276 Cdc42p initiates actin polymerization to facilitate membrane tethering; R

277 Does cytosolic pressure facilitate f-actin polymerization to push the leading edge of a cell

278 ction is important to transduce the force of actin polymerization to the membrane to drive successful

279 lly inhibit and thereby polarize Rac1-driven actin polymerization to the protrusions of migratory fib

280 IG-2, which function redundantly to polarize actin polymerization upstream of the WAVE complex and WA

281 at CD73-generated adenosine induces cortical actin polymerization via adenosine A1 receptor (A1R) ind

282 ical role at the SF-FA junction by promoting actin polymerization via free barbed end generation and

283 Kv3.3 activity and its ability to stimulate actin polymerization via Hax-1.

284 ecruitment of Nck, activation of N-WASP, and actin polymerization via the Arp2/3 complex.

285 Strikingly, inhibition of actin polymerization was found to be sufficient to recap

286 Actin polymerization was required for neurite outgrowth,

287 t not myosin light chain phosphorylation and actin polymerization, was reduced by the expression of t

288 opography can unidirectionally bias internal actin polymerization waves and that cells move with the

289 use these damaging procedures likely involve actin polymerization, we tested whether actin polymeriza

290 RhoA activity, cofilin phosphorylation, and actin polymerization were completely suppressed by prote

291 Chemokine-induced migration and actin polymerization were defective in the T cells, B ce

292 sed by TGF-beta/Smads, GPCR/Rho signals, and actin polymerization, whereas GPCR/cAMP signals and acti

293 Mena interacts with GRASP65 to promote local actin polymerization, which facilitates Golgi ribbon lin

294 in complex and unravel that FURIN promotes F-actin polymerization, which has previously been shown to

295 f the cytoskeletal protein HS1, along with F-actin polymerization, which resulted in rapid receptor i

296 mplex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular p

297 es microtubule organization as inhibition of actin polymerization with a low dose of latrunculin A di

298 Inhibition of actin polymerization with cytochalasin-D, but not inhibi

299 The inhibition of actin polymerization with latrunculin in Rictor KO B cel

300 rts a novel, G-actin-dependent regulation of actin polymerization within spine heads.