ライフサイエンスコーパス: actin-binding domain

1 is a monomer with a functional C-terminal F-actin binding domain.

2 ATP:guanidino kinases, and an "actinin-type" actin binding domain.

3 tary homologous motifs or "repeats" near the actin binding domain.

4 ing inclusion of exon 16 within the spectrin/actin binding domain.

5 ent on the integrity of the carboxy terminal actin binding domain.

6 mature 4.1R mRNA encoding an intact spectrin-actin binding domain.

7 y the latter possessed a functional spectrin-actin binding domain.

8 as at least three and potentially a fourth F-actin binding domain.

9 ratio, every actin monomer contacts a Sac6p actin binding domain.

10 in mouse LSP1 are in the basic C-terminal F-actin binding domain.

11 isoforms having a fully functional spectrin-actin binding domain.

12 g random mutagenesis and shown to lie in the actin binding domain.

13 ound that the C-terminal half constitutes an actin binding domain.

14 of alternative splicing within the spectrin/actin binding domain.

15 t (PEVK), and, at the N-terminus, a unique F-actin-binding domain.

16 ith utrophin, which binds via one contiguous actin-binding domain.

17 to co-purifying actin through the N-terminal actin-binding domain.

18 ed by point mutations in the alpha-actinin-4 actin-binding domain.

19 an N-terminal kinase domain and a C-terminal actin-binding domain.

20 erminus of 3beta contains a Ca(2+)-dependent actin-binding domain.

21 phin through a specific interaction with its actin-binding domain.

22 f the rod domain, but retains the rod domain actin-binding domain.

23 in filaments directly via a carboxy terminal actin-binding domain.

24 calponin-homology domains that comprise the actin-binding domain.

25 ease severing requires the internal (I/L)WEQ actin-binding domain.

26 inding domain, but block interactions of the actin-binding domain.

27 encodes a new Filamin isoform that lacks the actin-binding domain.

28 s seen in myo2-66, a mutant defective in the actin-binding domain.

29 ated platelets within its conserved putative actin-binding domain.

30 inking proteins that share a conserved 27-kD actin-binding domain.

31 from BPAG1e in that it contains a functional actin-binding domain.

32 a dystrophin deleted for the majority of the actin-binding domain.

33 tion of a conserved threonine residue in the actin-binding domain.

34 on of the conserved threonine residue in the actin-binding domain.

35 both its membrane-remodeling domain and its actin-binding domain.

36 truncated LSP1 peptides and to define the F-actin binding domains.

37 (up to nine) and the fewest (two) predicted actin binding domains.

38 of human caldesmon containing the principal actin-binding domains.

39 st likely structural similarity within their actin-binding domains.

40 , and this bundling activity requires both F-actin-binding domains.

41 vely spliced so that each isoform has unique actin-binding domains.

42 ors together with proteins bearing predicted actin-binding domains.

43 nal role for a dystrophin protein that lacks actin-binding domains.

44 rophin-glycoprotein complex (DGC), but lacks actin-binding domains.

45 f each lobe that mutational data suggest are actin-binding domains.

46 se-causing missense mutations are located in actin-binding domain 1 (ABD1) of dystrophin.

47 xons 7 and 8 corresponding to the end of the actin-binding domain 1 and the N-terminal part of hinge

48 depolymerize F-actin, or the deletion of the actin binding domain (100-252 amino acids) of ACTN4Y265E

49 The crystal structure of the F-actin binding domain 2 of severin, the gelsolin homologu

50 The interaction between fimbrin ABD2 (actin binding domain 2) and F-actin is different from an

51 ified are predicted to contain an N-terminal actin binding domain, a long central triple helical coil

52 P-280, beta-filamin contains an NH2-terminal actin-binding domain, a backbone of 24 tandem repeats, a

53 ys 30 spectrin repeats, a modestly conserved actin-binding domain, a conserved membrane association d

54 ELF3 is characterized by an actin-binding domain, a long repeat domain, and a short

55 Tensin3 binds DLC1 through its actin-binding domain, a region that is missing in cten,

56 ort sequence containing LKKTETQ, the central actin-binding domain (aa 17-23) plus 1 additional amino

57 of the dystrophin molecule [from N-terminal actin binding domain (ABD) 1 through ABD2] bound actin f

58 to a ternary complex between the N-terminal actin-binding domain (ABD) and an adjacent helical neck

59 We show that the alphaE-catenin actin-binding domain (ABD) binds cooperatively to indivi

60 BK(Ca) channels contain a novel cytoplasmic actin-binding domain (ABD) close to the C terminus, cons

61 0 kDa cytoskeletal protein (consisting of an actin-binding domain (ABD) followed by 24 sequential rep

62 rea victoria and the 25 kDa highly conserved actin-binding domain (ABD) from the amino terminus of th

63 amplifies the function of the beta-spectrin actin-binding domain (ABD) in forming the spectrin-actin

64 r ataxia type 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of beta-III-spectrin causes h

65 We report that Ca(2+)-calmodulin binds the actin-binding domain (ABD) of FLNa and dissociates FLNa

66 he molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its association wit

67 ucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fol

68 These domains include an actin-binding domain (ABD), a plakin domain, a coiled co

69 at melanophilin, specifically its C-terminal actin-binding domain (ABD), is a target of PKA.

70 middle of the actin-binding interface of the actin-binding domain (ABD).

71 es of BMD, truncations within the N-terminal actin-binding domain (ABD1) typically decrease dystrophi

72 regulatory headpiece domain followed by two actin-binding domains (ABD1 and ABD2).

73 c subunits have N-terminal spectrin family F-actin binding domains (ABDs) and an elongated flexible s

74 Talin contains three actin-binding domains (ABDs).

75 sophila S2 cells, anillin lacking the entire actin-binding domain (ActBD) exhibits defective cortical

76 these two domains and whether the rod domain actin-binding domain alone can support a mechanically fu

77 usters with F-actin through an alpha-catenin actin-binding domain (alphaABD) dramatically extended cl

78 model transmembrane protein with a cytosolic actin-binding domain also exhibits the temperature-indep

79 to replace verprolin is dependent on its WH2 actin binding domain and a putative profilin binding dom

80 ithelium, is of interest both as a compact F-actin binding domain and as a model folded protein.

81 a flexible spacer between the amino-terminal actin binding domain and carboxyl-terminal membrane-asso

82 ti-parallel fashion through its C-terminal F-actin binding domain and delays dilution-induced F-actin

83 This segment is adjacent to the actin binding domain and is within the region of the bet

84 Deletion of the C-terminal actin binding domain and N-terminal Rab binding domain o

85 cted with filamin A constructs that lack the actin binding domain and that do not bind actin in vivo

86 om ocular isolates that contained up to four actin binding domains and as few as one tyrosine-rich re

87 Filamins are composed of an N-terminal actin-binding domain and 24 filamin-type immunoglobulin-

88 ouse SH3P7 protein, containing an N-terminal actin-binding domain and a C-terminal Src homology 3 dom

89 flanked in the sequence by the spectrin- and actin-binding domain and a domain containing the binding

90 ticulated-consisting of a globular catalytic/actin-binding domain and a long lever arm that may rotat

91 mACF7 contains a putative actin-binding domain and a plakin-like domain that are h

92 shed the interaction between the fragment of actin-binding domain and alpha-actin.

93 ough interactions between its NH(2)-terminal actin-binding domain and COOH-terminal EF-hand-GAS2 doma

94 rt a novel neural splice form that lacks the actin-binding domain and instead binds and stabilizes mi

95 We find that the actin-binding domain and membrane-association domain 1 (

96 aa, has structure/function activity via its actin-binding domain and numerous biological affects on

97 Shot interacts with the cortex through its actin-binding domain and recruits the microtubule minus-

98 clustered into four regions of the gene: the actin-binding domain and rod domain repeats 3, 10 and 14

99 the plakin repeats are inserted between the actin-binding domain and spectrin repeats, generating is

100 left that separates the active site from the actin-binding domain and that has been shown to move in

101 lly rescued by a transgene encoding only the actin-binding domain and the first six filamin repeats.

102 e preferred cleavage site occurs between the actin-binding domain and the proline-rich region, genera

103 tory intramolecular interactions between the actin-binding domain and the rest of alpha-catenin.

104 CryAB features a conserved actin-binding domain and, when attenuated, leads to clus

105 Arg has two distinct actin-binding domains and interacts physically and funct

106 Arg requires both its F-actin-binding domains and its MT-binding domain to rescu

107 ls show variation in the distance separating actin-binding domains and the angle of the alpha-actinin

108 phin constructs require the presence of both actin-binding domains and the C-terminal domain for full

109 d region that is predicted to be helical, an actin binding domain, and a region(s) that participates

110 d overall structure, including an N-terminal actin-binding domain, and a series of 20 immunoglobulin

111 associate with F-actin through a conserved F-actin-binding domain, and mutants defective for F-actin

112 tify C-terminal tyrosines, the fourth repeat actin-binding domain, and the N-terminal Arp2/3-binding

113 n binding proposed for fimbrin, the utrophin actin-binding domain appears to associate with actin in

114 Only the isoforms containing full-length actin binding domains are detectably expressed in the ne

115 All F-actin binding domains are located in the basic C-termina

116 Both of Arg's F-actin-binding domains are necessary and sufficient for t

117 ecule, which contain the calmodulin-like and actin binding domains, are held in distinctly different

118 BPAG1-n contains an actin-binding domain at its NH2 terminus and a putative

119 ed-coils, a leucine zipper, and a talin-like actin-binding domain at the COOH terminus.

120 kinases are known to contain filamentous (F)-actin-binding domains at their C termini, it is unclear

121 vitro and in vivo studies suggested that the actin-binding domain attenuated protein kinase A (PKA) p

122 Neurabin-I actin-binding domain bundled F-actin, promoted filopodia

123 rminal segment of smMLCK is connected to the actin-binding domain by a long, flexible tether.

124 ng domain (N-ABD) but retains the C-terminal actin-binding domain (C-ABD).

125 ains, at its extreme C terminus, a compact f-actin binding domain called "headpiece".

126 Point mutations in the actin-binding domain cause aberrant membrane ruffling an

127 Overexpression of the KASH domain or the actin-binding domain caused a dominant negative anchorag

128 nding domains but lacking the lever arms and actin-binding domains colocalized with markers of the tr

129 acids 535-636, which overlaps with the known actin-binding domains composed of the Xin repeats.

130 ontains an N-terminal calponin homology (CH)/actin-binding domain connected by a series of 24 immunog

131 Here, we report the NMR structure of the actin-binding domain contained in the cell adhesion prot

132 f nexilin and that the expressed fragment of actin-binding domain containing p.Q131E completely lost

133 e, LC2NT, a LC2 truncated mutant lacking the actin-binding domain, could not rescue Ca(v)2.2 surface

134 , which lies within a region of the spectrin-actin-binding domain critical for erythrocyte membrane s

135 NH(2)-terminal sequences corresponding to an actin binding domain defined by in vitro cosedimentation

136 cellular studies showed that an N-terminal F-actin-binding domain dictated neurabin I localization at

137 of one NrbI deletion mutant, containing the actin binding domain, dramatically increased the density

138 tantly, activation of DLC1 by tensin3 or its actin-binding domain drastically reduced the anchorage-i

139 Despite sharing homology through two shared actin binding domains, drebrin and mAbp1 have different

140 We overexpressed dystrophin's actin-binding domain (Dys-ABD), K8 and K19, as well as c

141 there is a crystal structure of the utrophin actin-binding domain, electron microscopy of the actin-b

142 the protein's functionally critical spectrin-actin binding domain, essential for maintenance of red c

143 midline attraction through its C-terminal F-actin binding domain (FABD) and (2) a kinase-dependent i

144 he c-Abl gene has the unique feature of an F-actin binding domain (FABD).

145 nase domains are joined via a linker to an F-actin-binding domain (FABD).

146 rminal 248 amino acids contained an apparent actin binding domain followed by 24 tandem repeats each

147 re 280-kDa proteins containing an N-terminal actin-binding domain followed by 24 characteristic repea

148 sslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgF

149 Human filamins are composed of an N-terminal actin-binding domain followed by 24 immunoglobulin-like

150 similar to spectrin and dystrophin, with an actin-binding domain followed by spectrin repeats.

151 isoform (betaIVSigma1 spectrin) includes an actin-binding domain, followed by 17 spectrin repeats, a

152 though cten is shorter and does not have the actin-binding domain found in other tensins, analysis of

153 g of actin have been generated by fusing the actin-binding domain from an actin-interacting protein t

154 transient and stable expression of the talin actin-binding domain fused to the C-terminus of the gree

155 calponin homology domains that comprise the actin-binding domain have a closed conformation at one e

156 ow that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the cor

157 tinin - which serve as spacers between their actin-binding domains - have provided important insights

158 Myosin V is biomolecular motor with two actin-binding domains (heads) that take multiple steps a

159 the cytoskeleton: their sequences include an actin-binding domain homologous to that found in calponi

160 sing two dominant negative polypeptides: the actin-binding domain III of EF1alpha and the EF1alpha-bi

161 ponin homology motif which functions as an F-actin binding domain in members of the spectrin, filamin

162 These results establish the location of an F-actin binding domain in native talin, demonstrate that d

163 , and that interaction may be mediated by an actin binding domain in subunit B of the enzyme.

164 aMKIIbeta binding depended upon a putative F-actin binding domain in the variable region of CaMKIIbet

165 econd, previously uncharacterized internal F-actin-binding domain in Arg.

166 s via a previously unknown phospho-regulated actin-binding domain in Ent1 and the THATCH domain in Sl

167 s shown an important role for the C-terminal actin-binding domain in proliferation and transformation

168 of the MyBP-C sequence identifies a possible actin-binding domain in the Pro-Ala-rich sequence found

169 This bimodal mechanism requires two separate actin-binding domains in Crn1.

170 ded a small "dimer initiation" site near the actin binding domain is present.

171 We found that the VASP-F-actin binding domain is required for the recruitment of

172 Unlike full-length talin, the C-terminal f-actin binding domain is unable to nucleate actin polymer

173 f of the protein containing the Arp2/3 and F-actin binding domains is necessary and sufficient for sp

174 The actin-binding domain is between the modular PDZ and LIM

175 The FLNA actin-binding domain is essential for the suppression of

176 domain I-deletions indicates that an intact actin-binding domain is not essential, although it does

177 n ACTN4 isoform, ACTN4 (Iso), that loses its actin-binding domain is still capable of potentiating a

178 Of the eight domains in alpha-actinin, the actin-binding domain is the most highly conserved.

179 hila ortholog Filamin/cheerio that lacks the actin-binding domain, is here shown to govern the growth

180 domain 1 (CH1), within the filamin A (FLNa) actin-binding domain, is the minimal fragment sufficient

181 p7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated

182 a "mini-dystrophin," lacking one of the two actin-binding domains, is less effective than dystrophin

183 tain a Fes/CIP4 homology (FCH) domain and an actin-binding domain-like sequence.

184 idarum, and C. caviae harbor between 1 and 4 actin binding domains located in the C-terminal half of

185 The functionality of the actin binding domains located near the N terminus was co

186 In this report, we demonstrate that the actin-binding domain, located between amino acids 561 an

187 Using two independent actin-binding domains, mAbp1 binds to actin filaments wi

188 An actin-binding domain maps to the LKKAET hexapeptide loca

189 vity: when unphosphorylated, dematin's two F-actin binding domains move independent of one another pe

190 se mutant Dyn1-K44A and the loss-of-function actin binding domain mutant Dyn1-K/E.

191 Dyn1 actin binding domain mutant inhibits filopodial formatio

192 trigger the disease occur in the N-terminal actin binding domain (N-ABD or ABD1).

193 ave been determined, of which the N-terminal actin-binding domain (N-ABD or ABD1) is of particular in

194 isoform of 29 kDa that lacks the N-terminal actin-binding domain (N-ABD) but retains the C-terminal

195 We find that Ig repeats 9-15 contain an F-actin-binding domain necessary for high avidity F-actin

196 Deletion of the actin binding domain of Bcr-Abl (Bcr-AbI-AD) dramaticall

197 The actin binding domain of drebrin decreases the intrastran

198 actin complex, which can be formed via the F-actin binding domain of either protein.

199 tively charged cluster of amino acids in the actin binding domain of Mlph, suggesting that Mlph acts

200 Using an Arp2/3 complex that is fused to the actin binding domain of WASP, we confirm that the NPF-in

201 ylation on CaD are located in the myosin and actin binding domains of CaD and that Tyr-27 is the majo

202 its amino terminus with high homology to the actin binding domains of conventional spectrins.

203 The N-terminal acidic and F-actin binding domains of cortactin were both necessary t

204 g factor homology (ADFH) and charged/helical actin binding domains of drebrin and mAbp1 are sufficien

205 motif (LKKNFMES) within the 10 kDa spectrin-actin-binding domain of 4.1R plays a critical role in bi

206 These results show that the actin-binding domain of Abl enhances leukemia developmen

207 termined that CRP1 associates with the 27-kD actin-binding domain of alpha-actinin.

208 Although the C-terminal F-actin-binding domain of alpha-catenin has been shown to

209 The C-terminal actin-binding domain of alpha-catenin has no influence o

210 The function of the actin-binding domain of alpha-catenin, alphaABD, includi

211 Because the actin-binding domain of alpha-E-catenin is necessary for

212 E-catenin in the autoinhibited state and the actin-binding domain of alphaN-catenin.

213 Previous in vivo studies identified the actin-binding domain of drebrin (DrABD), which causes th

214 The functional significance of the actin-binding domain of dystrophin, the protein lacking

215 the interaction of the cytokeratins with the actin-binding domain of dystrophin.

216 Site-directed mutagenesis of the actin-binding domain of eNOS replacing leucine and trypt

217 C (epsilonV1-2) and a peptide (ABP) from the actin-binding domain of epsilonPKC (epsilon(223-228)).

218 ther immobilized CLIC-5A or the C-terminal F-actin-binding domain of ezrin and that actin polymerizat

219 on is observed independently of the proposed actin-binding domain of HIV-1.

220 aper, we demonstrate that the NH(2)-terminal actin-binding domain of mACF7 is functional both in vivo

221 Using the green fluorescent protein-tagged actin-binding domain of mouse talin, we found a dynamic

222 stent with these findings, a mutation in the actin-binding domain of Myo2p, a class V unconventional

223 that corresponds topologically to the major actin-binding domain of myosin.

224 The actin-binding domain of Shot directly interacts with Act

225 the first time that variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effac

226 n-dependent PK 5 (Cdk5) (Ser-17), within the actin-binding domain of spinophilin.

227 -94 and Ser-177, that are located within the actin-binding domain of spinophilin.

228 uires RhoA and actin polymerization, and the actin-binding domain of STARS is necessary and sufficien

229 e, we report the structure of the C-terminal actin-binding domain of talin, the core of which is a fi

230 nic mouse model of FHC with mutations in the actin-binding domain of the alpha-myosin heavy chain (My

231 icted 518-kD polypeptide has homology to the actin-binding domain of the dystrophin family at the ami

232 y conserved evolutionarily, localizes to the actin-binding domain of the perinatal myosin head, and i

233 putative serine phosphorylation site in the actin-binding domain of UNC-115.

234 We present the structure of the actin-binding domain of utrophin in complex with F-actin

235 construct actin filaments decorated with the actin-binding domain of utrophin, which contains two cal

236 lexible linker or if it was replaced with an actin-binding domain of utrophin.

237 We constructed mice that lack the actin-binding domain of WIP (WIPDeltaABD mice).

238 Mutations in the actin-binding domain of ZASP-LDeltaex10, but not other i

239 ponin homology domains and is related to the actin-binding domains of a superfamily of proteins inclu

240 Both beta-cat- and actin-binding domains of alpha-cat are required to inhib

241 nal domain to wedge apart the membrane and F-actin-binding domains of ezrin.

242 conserved surface patches near the putative actin-binding domains of fascin, which conformational dy

243 We showed that the actin-binding domains of nesprin 1 were dispensable, whe

244 mino acid sequences highly homologous to the actin-binding domains of two known F-actin binding prote

245 complex, and the effect of the alpha-catenin actin-binding domain on beta-catenin association.

246 It contains two actin-binding domains, one containing the talin-like I/L

247 The 4.1 spectrin-actin binding domain or NuMA binding C-terminal domain p

248 Other isoforms lack all or part of the actin binding domains or are truncated and contain a dif

249 ion deficient nuclei assembled when spectrin-actin-binding domain or NuMA-binding C-terminal domain p

250 ion protein, consisting of GFP fused to an F-actin binding domain, overlaps with GFP-PHPKB in the tim

251 ptides with low homology or variant spectrin-actin binding domain peptides that were incapable of bin

252 However, control variant spectrin-actin-binding domain peptides incapable of binding actin

253 In contrast, overexpression of the actin-binding domain plus spectrin repeat domain acts as

254 tinin-4 and E3KARP, which occurs through the actin-binding domain plus spectrin repeat domain of alph

255 croM at 25 degrees C, 20 times stronger than actin-binding domain produced by thermolysin digestion o

256 Each of utrophin's actin-binding domains promotes resilience in actin, whil

257 ACTN2 c.683T>C (p.Met228Thr), located in the actin-binding domain, proved to be the only mutation ful

258 ains, including a pair of alpha-actinin-like actin binding domains; regions of homology to plakins at

259 hPIV1 and one domain that is similar to the actin-binding domain required for budding induced by M p

260 Recombinant actin-binding domain (residues 2-269) binds actin filame

261 aE-catenin mutant lacking the modulation and actin-binding domains restores cadherin-dependent cell-c

262 It therefore appears that actin binding domains separated on the dystrophin molecu

263 , which has a sequence similar to that of an actin-binding domain, significantly reduced release of t

264 ant lacking the C-terminal calponin homology actin-binding domain stimulates actin branch formation b

265 n or coexpression of CaMKIIbeta carrying its actin-binding domain strongly modulated CaMKII diffusion

266 The open and closed conformations of the actin-binding domain suggests flexibility that may under

267 zation with Tarp is dependent on two novel F-actin binding domains that endow the Tarp effector with

268 ain and the cargo adapter Mlph, which has an actin-binding domain that acts as a tether, are sensitiv

269 hylogenetic analyses of the highly conserved actin-binding domain that alpha-actinin 2 was the first

270 Domain analysis of TARP identified an actin-binding domain that bears structural and primary a

271 inds directly to actin filaments via a novel actin-binding domain that defines a superfamily of thirt

272 structed a minispectrin heterodimer from the actin-binding domain, the EF domain, and 4 adjacent spec

273 rrowed to a region that does not include the actin-binding domain, the PDZ domain, or the coiled-coil

274 nd carboxyl-terminal ends, which include the actin-binding domain, the Src homology 2 (SH2) domain, a

275 Since IQGAPs harbor a potential actin binding domain, they could play roles in the Cdc42

276 ation domain (called the KASH domain) and an actin-binding domain; this structure was conserved with

277 -iLID can be used to temporally recruit an F-actin binding domain to MT plus ends and cross-link the

278 ne-rich domain and the binding of the VASP-F-actin binding domain to the side of growing filaments is

279 degrees C the rate constants for recombinant actin-binding domain to bind to (0.8-2.7 microM-1 s-1) a

280 damental role of CH domains as a widely used actin-binding domain underlines the necessity to underst

281 ains two inseparable villin headpiece-like F-actin binding domains (VI, VII).

282 was deleted (triangle upSH2), the C-terminal actin-binding domain was deleted (triangle upABD), or ki

283 nsable, whereas nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viabili

284 The three actin binding domains were identified as amino acids 1-1

285 Remarkably, PLS3 mutants lacking both actin-binding domains were still able to rescue motor ax

286 ly, human filamins are dimers composed of an actin-binding domain with 24 immunoglobulin (Ig)-like re

287 a-actinin by blocking the interaction of the actin-binding domain with actin filaments.

288 Conversely, filamin that shares actin-binding domains with alpha-actinin had a strong in

289 In contrast, profilin that shares actin-binding domains with gelsolin, significantly incre

290 er, the exact numbers and locations of the F-actin binding domains within LSP1 are not clearly define

291 igate the significance of the C-terminal Abl actin-binding domain within Bcr/Abl p190 in the developm