ライフサイエンスコーパス: actin-binding protein

1 n cytoskeletal dynamics (e.g. RhoGTPases and actin binding proteins).

2 recruitment of vinculin, a tension-sensitive actin binding protein.

3 question of what makes the Tm coiled coil an actin binding protein.

4 ruited through an interaction with Filamin A actin-binding protein.

5 ed Ig binding to cofilin, a highly conserved actin-binding protein.

6 on achieved for a complex of F-actin with an actin-binding protein.

7 esis in many organisms depends on this small actin-binding protein.

8 predicted to have a similar fold, is a novel actin-binding protein.

9 g domains, is a novel ER membrane-associated actin-binding protein.

10 in increased levels of profilin1 (Pfn1), an actin-binding protein.

11 common than previously considered for other actin binding proteins.

12 present in a complex with cofilin and other actin binding proteins.

13 a region involved in the binding of several actin-binding proteins.

14 tr family of protein phosphatase 1 (PP1)-and actin-binding proteins.

15 e can be modulated by cooperative binding of actin-binding proteins.

16 less this aging effect is overcompensated by actin-binding proteins.

17 polymerization are regulated by a variety of actin-binding proteins.

18 ted interactions of both G- and F-actin with actin-binding proteins.

19 affected by the concentrations of actin and actin-binding proteins.

20 petition between drebrin and several other F-actin-binding proteins.

21 ytoskeleton, via transmembrane integrins and actin-binding proteins.

22 reased rate) has not been observed for other actin-binding proteins.

23 s encode other RBPs, translation factors and actin-binding proteins.

24 cess, requiring the activity of more than 75 actin-binding proteins.

25 ns that are specifically recognized by other actin-binding proteins.

26 led by a vast array of intricately regulated actin-binding proteins.

27 oskeleton are controlled by a large array of actin-binding proteins.

28 the coordinated action of different sets of actin-binding proteins.

29 he calcium-regulated gelsolin superfamily of actin-binding proteins.

30 cific member of the NETWORKED superfamily of actin-binding proteins.

31 This study reveals that actin-binding protein 1 (Abp1/HIP-55/SH3P7) is a negativ

32 nteract with the SH3 domain of Dictyostelium actin-binding protein 1 (dAbp1).

33 Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an imp

34 Recently, the mammalian actin-binding protein 1 (mAbp1; Hip-55, SH3P7, debrin-li

35 Mammalian actin-binding protein-1 (mAbp1) is an actin-binding prot

36 Mammalian actin-binding protein-1 (mAbp1) is an adaptor protein th

37 s the F-actin cross-linking protein filamin (actin-binding protein 120, abp120) in vivo.

38 ngs to a plant-specific superfamily (NET) of actin-binding proteins, (2) VAP27, a plant homolog of th

39 t to an association between cytoskeletal and actin-binding proteins, a mesenchymal or hybrid EMT phen

40 l lines was upregulation of cytoskeletal and actin-binding proteins, a signature shared with mesenchy

41 tes WH2 domain functions with those of the F-actin-binding protein Abp1.

42 were exactly mirrored by knockdown of the F-actin-binding protein Abp1.

43 Even though cells have multiple actin binding proteins (ABPs) that exist simultaneously

44 fect(s) of Ca(2+)-sensitive and -insensitive actin-binding proteins (ABPs) on PC2(iv) channel functio

45 Through interactions with various actin-binding proteins (ABPs), actin plays an active rol

46 [PI(4,5)P2], regulate the activities of many actin-binding proteins (ABPs), including profilin, cofil

47 cellular processes at discrete locations by actin-binding proteins (ABPs), including the formins and

48 first eukaryote known to lack all canonical actin-binding proteins (ABPs).

49 are connected to the actin cytoskeleton via actin-binding proteins (ABPs).

50 SM22 (or transgelin), an actin-binding protein abundant in vascular smooth muscle

51 We recently found that the F-actin-binding protein afadin is required for lumen conti

52 myosin isoforms may influence both access of actin-binding proteins along the actin filaments and the

53 The actin binding protein alpha-actinin is a major component

54 We show that the actin-binding protein alpha-actinin binds to the C-termi

55 Here we show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha

56 s-linking induced complex formation with the actin-binding protein alpha-actinin, linking membrane-bo

57 Mutations in ACTN4, the gene encoding the actin-binding protein alpha-actinin-4, are a cause of fa

58 Mutations in the ACTN4 gene, encoding the actin-binding protein alpha-actinin-4, are a rare cause

59 d the specific association of EWI-2 with the actin-binding protein alpha-actinin; this association wa

60 e Wnt-signaling protein beta-catenin and the actin-binding protein alpha-catenin.

61 plasmic tail of classical cadherins to the F-actin-binding protein alpha-catenin.

62 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin

63 N-termini of SK2 channels interact with the actin-binding proteins alpha-actinin2 and filamin A, res

64 Mutations in the actin-binding protein, alpha-actinin 4 (ACTN4), are link

65 Here we identify a Ca(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group

66 herin, beta-catenin, and the filamentous (F)-actin binding protein alphaE-catenin form a minimal cadh

67 The actin-binding protein alphaE-catenin may contribute to t

68 filaments is regulated by a diverse array of actin-binding proteins, among which is the Actin-Depolym

69 ement in these processes is mediated by many actin-binding proteins, among which the cofilin family p

70 Cofilin is an actin-binding protein and a major actin depolymerization

71 Cofilin-2, a small actin-binding protein and member of the AC protein famil

72 Additionally, we found that PMD1 is an actin-binding protein and that a functioning actin cytos

73 Although a large number of actin-binding proteins and their regulators have been id

74 he band 3 macrocomplex, CD47 associates with actin-binding proteins and we confirm that CD47 membrane

75 ude clathrin, clathrin-interacting proteins, actin binding proteins, and peripheral membrane proteins

76 viously observed that a membrane-associated, actin binding protein, annexin A2 (AnxA2), is up-regulat

77 The formin family of actin binding proteins are involved in nucleating MFs in

78 Actin and actin-binding proteins are incorporated into HIV-1 parti

79 These observations support the idea that actin-binding proteins are key elements of the molecular

80 Whereas several actin-binding proteins are known to be regulated by chan

81 Many actin-binding proteins are thought to be stimulus-respon

82 es was explored by examining the PIP(2)- and actin-binding proteins Arp2/3 and N-WASP.

83 RhoA stabilization by structurally unrelated actin-binding proteins as a conserved mechanism for regu

84 These genes encode numerous actin-binding proteins as well as actin.

85 alphaE-catenin is an actin-binding protein associated with the E-cadherin-bas

86 tion resulted in reduced Cdc12, F-actin, and actin-binding proteins at the CR, which in turn led to a

87 upon polymerization as well as with multiple actin binding proteins both in the monomeric and filamen

88 hemical and functional properties of diverse actin-binding proteins, both alone and in combination, h

89 Profilin 1 is a well studied actin-binding protein but how PFN1 mutations cause ALS i

90 ic events are choreographed by a plethora of actin-binding proteins, but the exact mechanisms are poo

91 We selected two vital Plasmodium berghei G-actin-binding proteins, C-CAP and profilin, in combinati

92 ng and binding assays that a fragment of the actin-binding protein caldesmon added to polymerizing ac

93 The actin-binding protein calponin has been previously impli

94 of constraints imposed by troponin or other actin-binding proteins, cannot be formulated, and thus o

95 We identify the endothelial actin-binding protein CD2-associated protein (CD2AP) as

96 Through the coordinated action of diverse actin-binding proteins, cells simultaneously assemble ac

97 In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT a

98 is known to initiate changes to the cortical actin-binding protein cofilin to stimulate the depolymer

99 Surprisingly, the actin-binding protein cofilin was excluded from some reg

100 We have also defined in the actin-binding protein cofilin-1 a link between PP2A, act

101 ments were hypersensitive to severing by the actin-binding protein cofilin.

102 horylation levels of inhibitory sites of the actin-binding proteins cofilin and VASP, which are upstr

103 increased levels of inhibitory sites of the actin-binding protein, cofilin, and vasodilator-stimulat

104 ADF is one of the few actin-binding proteins conserved in apicomplexan parasit

105 e filamins (FLNs), which are multifunctional actin-binding proteins, consist of 24 Ig domains.

106 Michael and colleagues (2016) show that the actin binding protein Coronin plays a critical role in a

107 Further, we show that the F-actin binding protein cortactin binds the PLS and is req

108 RSV induced phosphorylation of the actin binding protein cortactin in a PKD-dependent manne

109 rylation of Y573 influences association of F-actin binding protein cortactin to MT1-MMP-positive endo

110 osome transport in vivo also depend on the F-actin-binding protein cortactin.

111 e GTPase dynamin 2 (Dyn2) and its associated actin-binding protein, cortactin (Cort).

112 sm that depends on the binding partner and F-actin-binding protein, cortactin.

113 anism linking a signaling intermediate to an actin-binding protein critical to T cell migration.

114 Importantly, the actin binding proteins Cyclase-Associated Protein and Ac

115 or binding to F-actin and represents a novel actin-binding protein domain.

116 est whether HSP in adulthood depends on an F-actin binding protein, drebrin A, mice deleted of the ad

117 nhanced green fluorescent protein (EGFP) and actin-binding protein-EGFP (Abp1-EGFP) fluorescence.

118 resistant form of one of these proteins, the actin-binding protein elongation factor 1 alpha 1 (EF1al

119 These actin-binding proteins enhance the disassembly of actin

120 polarized actomyosin network, and the Shroom actin-binding protein enhances myosin contractility loca

121 Vinculin is filamentous (F)-actin-binding protein enriched in integrin-based adhesio

122 We show that the actin-binding protein epidermal growth factor receptor p

123 Overexpression of the actin-binding protein espin causes elongation of stereoc

124 Furthermore, the actin binding protein ezrin relocated from the plasma me

125 29 differentially expressed spots, including actin-binding protein ezrin and its interaction partner,

126 The actin-binding protein Ezrin and the activator protein 1

127 lasting clusters that are enriched with the actin-binding protein ezrin and with clathrin.

128 cently that Ras activation also requires the actin-binding proteins ezrin, radixin, and moesin.

129 In double mutants the muscle-specific actin binding protein Filamin Ca is up-regulated.

130 Here we identify the actin-binding protein filamin A (FLNA) as a central mech

131 Here, we report that the actin-binding protein filamin A (FlnA) physically intera

132 The actin-binding protein filamin A (FLNa) regulates neurona

133 ain (C-tail) also has a binding site for the actin-binding protein filamin A (FLNA); it is not known

134 Here we show that the actin-binding protein filamin A is essential for the act

135 suggests that mechanical strain through the actin-binding protein filamin A leads to increased linka

136 main of meckelin directly interacts with the actin-binding protein filamin A, potentially at the apic

137 The actin-binding protein filamin links membrane receptors t

138 The human actin-binding protein filamin-A (also known as ABP-280)

139 using RNAi techniques that knockdown of the actin-binding protein filamin-A (FLNa) severely impaired

140 s only 40 years ago that the first nonmuscle actin-binding protein, filamin, was identified and chara

141 The actin-binding protein filamins (FLNs) are major organize

142 i14 (retinoic acid induced protein 14) is an actin binding protein first identified in the liver, hig

143 In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and prof

144 sting dynamics has been linked to regulatory actin-binding protein function, filament assembly and fr

145 own that villin, an epithelial cell-specific actin-binding protein functions as an anti-apoptotic pro

146 ving to modulate cell migration and named it actin-binding protein G (AbpG); this 971-amino acid (aa)

147 The decreases in expression of ACTB, and the actin-binding protein gene TB10, suggest changes in cyto

148 We show that the actin-binding protein h3/acidic calponin associates with

149 the biochemical properties of fission yeast actin-binding proteins has been done with skeletal muscl

150 Profilin1 (Pfn1), a ubiquitously expressed actin-binding protein, has an indispensable role in migr

151 In plants, several actin binding proteins have been implicated in remodelin

152 he ezrin, radixin and moesin (ERM) family of actin-binding proteins have been implicated in several a

153 Nuclear actin and actin-binding proteins have been shown to contribute to

154 Many actin-binding proteins have been shown to possess multip

155 etitive and cooperative interactions between actin binding proteins help define their associations wi

156 es of actin filaments is finely regulated by actin-binding proteins; however, the underlying mechanis

157 t pools of alphaE-catenin, an E-cadherin and actin binding protein, identified a membrane-associated

158 , PC3 cells do not express alpha-catenin, an actin binding protein in the cadherin complex.

159 subset of nuclear intermediate filament and actin binding proteins in epithelial cells.

160 t instability, leaving uncertain the role of actin-binding proteins in controlling dynamics.

161 nical cues control the activities of various actin-binding proteins in different cellular, developmen

162 This behavior is comparable to that of actin-binding proteins in reconstituted filamentous acti

163 n-interacting proteins, actin filaments, and actin binding proteins, in a highly ordered and regulate

164 ing that its role, and perhaps that of other actin binding proteins, in growth cone motility is subst

165 y reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibres by blocking

166 which beta-III-spectrin, and likely similar actin-binding proteins, interact with actin, and how thi

167 ied profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and neurot

168 Villin is a tissue-specific, actin-binding protein involved in the assembly and maint

169 tropomyosin additionally controls access of actin-binding proteins involved in cytoskeletal actin fi

170 Drebrin A, an actin-binding protein, is a key regulatory element in sy

171 Tropomyosin (TM), an essential actin-binding protein, is central to the control of calc

172 Vinculin, an actin-binding protein, is emerging as an important regul

173 Cortactin, an actin-binding protein, is essential for cell growth and

174 LSP1, a F-actin-binding protein, is expressed in hematopoietic cel

175 ebulette), a member of the nebulin family of actin-binding proteins, is a newly identified component

176 The Kelch repeats interact directly with the actin-binding protein Lasp-1 in membrane ruffles at the

177 F-actin) and regulates its interactions with actin-binding proteins like myosin by moving between thr

178 a missense mutation in FLNA (Filamin A), an actin-binding protein located at Xq28, mutations in whic

179 tide hydrolysis, ions, and a large number of actin-binding proteins, make actin a critical player in

180 uniform, as neither vinculin nor LIM-domain actin-binding proteins match the boundaries of cadherin

181 ural plasticity of actin, suggest that other actin-binding proteins may also induce large but differe

182 Gelsolin, a multifunctional actin-binding protein, mediates cell death involving the

183 lant-specific Networked (NET) superfamily of actin-binding proteins, members of which localize to the

184 We find that the actin-binding protein, Moesin, is essential for NB proli

185 ral membrane proteins (Clmn, Nckap1) and one actin-binding protein (Mpp5) that link F-actin to the pl

186 Here, we identify the actin-binding protein myristoylated alanine-rich C-kinas

187 o and in vivo, but little is known about the actin-binding proteins necessary to mediate this respons

188 The actin-binding protein nonmuscle tropomyosin (Tm) provide

189 a process closely involving a host of other actin-binding proteins, notably the actin-related protei

190 linositol 3,4,5-trisphosphate-interacting, F-actin-binding protein, participates in actin rearrangeme

191 that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1al

192 The actin-binding protein plastin 3 (PLS3) has been identifi

193 Actin filaments and associated actin binding proteins play an essential role in governi

194 Filamentous actin and associated actin binding proteins play an essential role in governi

195 Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell mig

196 Coronins make up a large class of actin-binding proteins previously shown to inhibit Arp2/

197 assembly factors, we found that the small G-actin binding protein profilin directly inhibits Arp2/3

198 uces the expression of the gene encoding the actin-binding protein profilin 1.

199 Previously, we showed that the actin-binding protein profilin-1 (pfn) plays a role in a

200 The actin-binding protein profilin-1 (Pfn1) inhibits tumor g

201 e found that siRNA-mediated silencing of the actin-binding protein profilin-1 in cancer cells caused

202 more stretches of polyproline that bind the actin-binding protein profilin.

203 As test molecules, we selected the actin-binding proteins profilin and actin-depolymerizing

204 Conversely, how different sets of actin-binding proteins properly sort to distinct actin f

205 ated by phosphorylation of the transporters, actin binding proteins (radixin and myristoylated alanin

206 sm by which caldesmon, and potentially other actin-binding proteins, regulates the interactions of ac

207 alpha-Catenin (alpha-cat) is an actin-binding protein required for cell-cell cohesion.

208 The role of synaptopodin (SP), an actin-binding protein residing in dendritic spines, in s

209 Filamins are a family of actin-binding proteins responsible for diverse biologica

210 chemotactic responses, we identified a novel actin-binding protein serving to modulate cell migration

211 or ectopic apical constriction driven by the actin-binding protein Shroom and during embryonic wound

212 Finally, we show that the actin-binding protein Shroom3 is crucial for the mainten

213 striction of ectoderm cells triggered by the actin-binding protein Shroom3.

214 Actin-binding protein sorting is critical for the self-o

215 Because Asef2 interacts with the F-actin-binding protein spinophilin, which localizes to sp

216 Importantly, other actin-binding proteins such as fimbrin and espin show hi

217 Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to p

218 Mammalian profilin is a small actin binding protein that catalyzes the exchange of nuc

219 Synaptopodin, an actin binding protein that is important in maintaining p

220 Dystrophin is an actin binding protein that is thought to stabilize the c

221 Tropomyosin is a coiled-coil actin binding protein that stabilizes the filament, prot

222 mical targets of LIMK2 belong to a family of actin binding proteins that are potent modulators of act

223 Filamins are actin binding proteins that contribute to cytoskeletal i

224 In the course of studying actin binding proteins that regulate the organization of

225 the coordinated action of a large number of actin binding proteins that reorganize the actin cytoske

226 lphaE-catenin is an allosterically regulated actin-binding protein that binds the cadherin.beta-caten

227 at alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cad

228 Coronin is a conserved actin-binding protein that co-functions with ADF/cofilin

229 Talin is a major actin-binding protein that controls both the inside-out

230 Filamin A (FLNa) is an actin-binding protein that cross-links F-actin into netw

231 malian actin-binding protein-1 (mAbp1) is an actin-binding protein that has been implicated in regula

232 Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the re

233 ADD1 (adducin-1) is an actin-binding protein that has been shown to play import

234 Twinfilin 2a (Twf2a) is a small actin-binding protein that inhibits actin filament assem

235 Cofilin is a key actin-binding protein that is critical for controlling t

236 Fascin is an actin-binding protein that is present predominantly in f

237 MARCKS is an actin-binding protein that modulates vascular endothelia

238 Similarly, filamin A (FLNa), an actin-binding protein that participates in cell attachme

239 Fascin is an evolutionarily conserved actin-binding protein that plays a key role in forming f

240 Afadin is a Rap-regulated, actin-binding protein that promotes cadherin complex ass

241 PFN1 is a small actin-binding protein that promotes formin-based actin p

242 Caldesmon is an actin-binding protein that regulates actomyosin interact

243 Filamin A (FLNa) is an actin-binding protein that regulates cell motility, adhe

244 rough its association with tropomyosin 4, an actin-binding protein that regulates sealing dimensions

245 Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the my

246 e identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive prope

247 Spectrin is a membrane-associated actin-binding protein that, like neurofilament, has been

248 alpha-Actinins are actin-binding proteins that can be broadly divided into

249 depolymerizing factors (ADFs) are a group of actin-binding proteins that contribute to reorganization

250 Eukaryotes have several highly conserved actin-binding proteins that crosslink filamentous actin

251 Tropomyosins are widespread actin-binding proteins that influence numerous cellular

252 lutionarily conserved, modular, multidomain, actin-binding proteins that organize the actin cytoskele

253 Filamins are actin-binding proteins that participate in a wide range

254 cortex is a thin layer of actin, myosin, and actin-binding proteins that subtends the membrane of ani

255 Unusually for F-actin binding proteins, the DNGR-1 ligand binding domain

256 Devoid of all known canonical actin-binding proteins, the prevalent parasite Giardia l

257 Vinculin is an actin-binding protein thought to reinforce cell-cell and

258 Filamin B (FlnB) is an actin-binding protein thought to transduce signals from

259 cient wound healing, but the contribution of actin-binding proteins to contraction of the extracellul

260 ical mechanisms that target distinct sets of actin-binding proteins to distinct actin filament popula

261 ipid bilayer coupled via membrane-associated actin-binding proteins to dynamic actin filaments and my

262 nt, controlling the spatiotemporal access of actin-binding proteins to specialized actin networks.

263 logy (MudPIT) showed that the recruitment of actin-binding proteins to these Las17-derived actin netw

264 Furthermore, we identified PHACTR1, an actin-binding protein, to be positively regulated by TGF

265 ing edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFbeta rec

266 iated muscle contraction is regulated by the actin binding proteins tropomyosin and troponin.

267 yotic cells express multiple isoforms of the actin-binding protein tropomyosin that help construct a

268 are predicted to be remote homologues of the actin-binding protein tropomyosin.

269 onstitution system to test roles for the key actin-binding proteins tropomyosin, capping protein, and

270 chemoresistance by a direct targeting of the actin-binding protein twinfilin 1, which promotes epithe

271 P), the Rac GTPases MIG-2 and CED-10 and the actin binding protein UNC-115 (abLIM) are dedicated UNC-

272 his study demonstrates the various ways that actin-binding proteins use physical properties to tune t

273 eletal and muscle functions are regulated by actin binding proteins using a variety of mechanisms.

274 In this study we show the multifunctional actin-binding protein vasodilator-stimulated phosphoprot

275 requires that this reaction be regulated by actin-binding proteins via allosteric effects on the act

276 the cytoskeleton in IECs via changes in the actin-binding proteins VIL1 and GSN.

277 y reported that the epithelial cell-specific actin-binding protein villin directly associates with ph

278 s F-actin-severing activity, the microvillar actin-binding protein villin drives both apical microvil

279 y, we demonstrated that Jak3 interacted with actin-binding protein villin, thereby facilitating cytos

280 We studied the actin-binding proteins villin 1 (VIL1) and gelsolin (GSN

281 localization is specific to Fascin, as other actin-binding proteins, Villin and Profilin, do not exhi

282 dy, we show that in mouse B lymphocytes, the actin binding protein vinculin localizes to the ring-sha

283 alphaE-catenin also binds to the F-actin-binding protein vinculin, which also appears to be

284 l change that exposes a cryptic site for the actin-binding protein vinculin.

285 The SRF target gene and actin-binding protein, vinculin, is sufficient to overco

286 Because vinculin (VCL) is an actin-binding protein, we asked whether it participates

287 Subsequently many other nonmuscle actin-binding proteins were identified and characterized

288 Palladin is a key cytoskeletal actin binding protein whose normal function is to enable

289 chemical analysis revealed CORO1C, another F-actin binding protein, whose direct binding to PLS3 is d

290 to-inhibited and found in a complex with the actin-binding protein WIP.

291 Drebrin is an actin filament (F-actin)-binding protein with crucial roles in neuritogene

292 Synaptopodin is another actin-binding protein with a more restricted expression

293 Filamin A (FLNA) is an actin-binding protein with a well-established role in th

294 Cofilin, a small actin-binding protein with F-actin severing activities,

295 Srv2/CAP is a conserved actin-binding protein with important roles in driving ce

296 Tropomyosins comprise a large family of actin-binding proteins with critical roles in diverse ac

297 y to study the association kinetics of seven actin-binding proteins with G-actin.

298 sizes of the interfaces formed by the seven actin-binding proteins with G-actin.

299 -plastin synthesis and the functions of this actin-binding protein, with a special interest in chemor

300 esses and require the activities of multiple actin-binding proteins working in concert.