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1 when the agent was visibly constrained from acting.
2 t or whether he was visibly constrained from acting.
4 l an evolutionary young (~530,000 years) cis-acting 2.25-kb LTR retrotransposon insertion reducing ex
7 Bi(4)O(7) and Bi(3.33)(VO(4))(2)O(2) phases acting afterward as a conventional p-n junction, creates
9 2-arylvinylquinolines are identified as fast-acting agents that kill asexual blood-stage parasites at
12 ual comprises common and rare variants that, acting alone and in combination, confer risk of disease.
13 sidering the impact of chemical risk factors acting alone and in concert with genetic risk, and point
16 sychotomimetic compound, ketamine, is a fast-acting antidepressant and induces synapse formation.
17 anced with the advent of ketamine as a rapid-acting antidepressant and the development and refinement
19 aimed to compare to active placebo the rapid acting antidepressant properties of a broad range of sub
30 tained virologic response (SVR) after direct acting antiviral agents (DAAs) holds promise for reducin
33 Early HCV treatment with all-oral direct-acting antiviral combination therapy has been associated
34 n and ribavirin (PegIFN-RBV) plus one direct-acting antiviral in 53.4%, PegIFN-RBV in 34.5%, and sofo
35 ent suppression of RHV viremia with a direct-acting antiviral led to the priming of CD8 T cells with
37 ug use remains a barrier to accessing direct-acting antiviral treatment (DAA) for hepatitis C virus (
38 an implementation trial providing HCV direct-acting antiviral treatment in Melbourne, Australia, from
40 There is a lack of data on the use of direct-acting antivirals (DAA) on the risk of death and tumoral
42 r HCV-elimination by sofosbuvir-based direct-acting antivirals (DAAs) and addition of RBV improves NK
47 334 (30.2%) initiated treatment with direct-acting antivirals, and 29 090 (19.4%) achieved a sustain
49 packing of trans-acting Tyr(290) against cis-acting Arg(349) compels Arg(349) to maintain proper conf
50 e of the earliest targets of HIV-1 infection acting as a "Trojan horse," concealing the virus from th
51 tral player in physiology of CD8(+) T cells, acting as a barrier to prevent premature differentiation
52 productive maturation suggests that MKRN3 is acting as a brake on gonadotropin-releasing hormone (GnR
54 ty to counteract the ISR at its very core by acting as a competitive inhibitor of p-eIF2-eIF2B intera
55 artners, MtTT8 and MtWD40-1, as RH1, thereby acting as a competitor in the regulatory complex and exe
56 s found to display unprecedented reactivity, acting as a convenient and highly effective precursor fo
60 ex with an ABC-transporter (BceAB), together acting as a flux-sensor where signaling is proportional
61 the arid south, where the Andes are higher, acting as a genetic barrier between the sharply differen
62 unction in mouse models of beta-cell failure acting as a growth factor necessary for beta-cell adapta
64 upport binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme
65 Our results indicate that a TANGO1 ring, by acting as a linactant, stabilizes the open neck of a nas
67 be designed to bind alternating structures, acting as a mediator between the catalytic site and the
68 association between lutein esters formation acting as a metabolic sink during early stages of grain
69 echanotransduction of cells, and potentially acting as a molecular crosslinker for functional materia
70 le-stranded and high-frequency PTs with SspB acting as a nickase and possibly introducing nicks to fa
72 mary, our data imply a new function for TWD1 acting as a putative activator of ABCB-mediated auxin tr
73 h the first example of a neutral phosphinine acting as a rare bridging mu(2) -P-4e donor-ligand betwe
75 tant function in the central nervous system: acting as a sensory network, they detect neuronal activi
76 nds on its orientation with respect to a hub acting as a source, even if the link in question is seve
77 yrazinamide exerts antibacterial activity by acting as a target degrader, a mechanism of action that
78 rthermore, we identify a gene family, likely acting as a taxonomic marker for an unclassified species
80 any conifers include a torus-margo structure acting as a valve that prevents air from spreading betwe
81 ersibly transforms into the amorphous phase, acting as an active species to facilitate the interactio
82 clear envelope through its spectrin repeats, acting as an adaptor between nesprin-1alpha and Pcnt or
83 nclude that Ca(2+)-sensitive Syt1 oligomers, acting as an exocytosis clamp, are critical for maintain
85 es decorated with attractive surface patches acting as analogs of functional groups are used to assem
86 lecules with diverse functions, ranging from acting as antioxidants that prevent chronic diseases to
89 h nodes serving the upper respiratory tract, acting as both induction and effector site for mucosal i
90 ng a protometabolic pathway, with glyoxylate acting as both the carbon source and reducing agent.
91 cially when presented response-contingently, acting as conditioned reinforcers that bridge delays to
92 been suggested to promote immunogenicity by acting as danger signals recognized by dendritic cells (
93 2 with virus encoding beta-arrestin2 mutants acting as dominant-negatives markedly reduces tau-laden
95 ed as hotspots of marine life in the Azores, acting as feeding stations for top predators, including
96 e network of the endoplasmic reticulum (ER), acting as gatekeepers to the early secretory pathway, ye
98 n of interfaces and the modeling of peptides acting as inhibitors of protein-protein interactions.
101 the synthesis of metal nanoparticles, often acting as reducing agents, solvents, and stabilizers.
102 xhibited a synergic effect with rhBMP-2/ACS, acting as suitable and viable carriers for vertical bone
103 it radio-frequency pulses, along with diodes acting as switches to control the resonance frequency of
104 ansmitter release to action potentials (APs) acting as the fast Ca(2+) release sensor and as the inhi
105 vival of beta-lactam susceptible bacteria by acting as the first line of defense against beta-lactam
106 These interacting processes result in N acting as the proximate limiting nutrient in most surfac
111 tters released by vagal afferents, glutamate acting at AMPA receptors and 5-HT acting at 5-HT(2A) rec
112 ostriatal afferents revealed that histamine, acting at H(3) receptors, negatively modulates corticost
114 oteins couple proximal stimuli to chromatin, acting at super-enhancer regulatory regions to direct ge
115 s phosphorylated, we propose that instead of acting at the time of rescue occurrence, CLIP-170 would
117 onchial epithelial cells, formoterol, a long-acting beta (2)-adrenoceptor agonist (LABA), enhanced th
119 ied on reliever therapy with as-needed short-acting beta-agonists (SABAs), while anti-inflammatory ma
123 g molecular mechanism through which dominant-acting calsequestrin mutations provoke lethal arrhythmia
125 tivity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural p
127 field gives rise to an electrophoretic force acting directly on a charged substrate but also indirect
128 lammatory Th17 cell differentiation program, acting directly on T cells in collaboration with STAT3-a
131 inflammatory cytokine production, with IRF5 acting downstream of Toll-like receptor 7 (TLR7) and, po
135 and heart attack) and many beta-adrenoceptor acting drugs are listed on the WHO Model List of Essenti
136 ddition, the antidepressant effects of rapid-acting drugs are thought to occur via inhibition of GABA
138 vestment in research and development of long-acting drugs with dual activity against HIV and HBV exis
142 of transcription and is associated with cis-acting elements, alternative splicing, and RNA-binding f
144 e the discovery and characterisation of endo-acting enzymes from prominent mucin-degrading bacteria t
147 luding the cis-regulatory elements and trans-acting factors that determine general de novo m(6)A depo
148 ervations do not account for the multiple co-acting factors that modulate GPP and RECO flux dynamics.
149 port a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis th
152 l drug rilpivirine was developed into a long-acting formulation (RPV LA) to improve adherence for pre
157 that a signaling pathway controlled by EPFL9 acting from the carpel wall through the LRR-receptor kin
159 allowed evolution of separate cis and trans acting functions, providing selective pressure to mainta
161 ncompass a structurally diverse group of cis-acting, gene regulatory elements found mostly in bacteri
162 pha-1,2-mannosidase (MANEA) is the sole endo-acting glycoside hydrolase involved in N-glycan trimming
163 from both the oral standard-of-care and long-acting groups, must have completed the 52-week comparati
165 We report here the creation of a uniquely acting HSP70 inhibitor (HSP70i) that targets multiple co
166 Treatment of PG typically starts with fast-acting immunosuppressive drugs (corticosteroids and/or c
167 tion followed by the addition of more slowly acting immunosuppressive drugs with superior adverse eve
173 e results indicate that bacterial infection, acting in part through the NPC, alters core clock gene e
174 s suggest a novel mechanism by which leptin, acting in the NTS, could potentiate gastrointestinal sat
175 ganic matter, benthic primary production) by acting in the opposite direction than the effects of red
176 hways, resulting in many bioactive molecules acting in various organs through different action mechan
179 the behavioural fluctuations exhibited by co-acting individuals does become aligned during the perfor
180 or HIV, were randomly assigned (3:1) to long-acting injectable cabotegravir (800 mg given three times
181 al phase pharmacokinetics and safety of long-acting injectable cabotegravir in participants included
185 vivo, daily administration of marketed long-acting insulin, glargine, resulted in fluctuating blood
187 nical studies showed non-inferiority of long-acting intramuscular cabotegravir and rilpivirine dosed
189 oncentrated in a small subset of hepatocytes acting like stem cells, located around the central vein
190 ion relationship, determining cis- and trans-acting lncRNAs in vivo, and generating new developments
194 tant alleles are eliminated via a dominantly-acting maternal effect combined with slower-acting stand
196 aceptive services, including short- and long-acting methods, are available, even in protracted crisis
198 BPP-specific Vgamma2Vdelta2 T cells are fast-acting, multi-functional, and protective during infectio
199 its putative function as a cotranslationally acting Nat, AtNAA50-EYFP localized to the cytosol and th
200 ar organ with a self-contained, autonomously acting nervous system, composed of 20 neurons that fall
201 in mice that SSRIs impair motor function by acting on 5-HT2C receptors in the substantia nigra pars
202 shot learning approach to predict the kinase acting on a phosphosite for kinases with no known phosph
203 how male finches perform courtship songs by acting on a region of the premotor cortex called HVC.
205 what we have described for miRNAs, including acting on apoptosis, M. leprae recognition and engulfmen
206 acetate enhances innate immune responses by acting on both neutrophils and ILC3s through its cognate
210 which is composed of two monostable modules acting on different cellular compartments and sharing sp
212 are silenced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] together with the
214 llergens elicit host production of mediators acting on G-protein-coupled receptors to regulate airway
215 ransmission in the brain is mediated by GABA acting on GABA(A) receptors (GABA(A)Rs), which provides
216 ramework to evaluate the evolutionary forces acting on genomic regions associated with human complex
218 e (1) widespread losses of degrading enzymes acting on lignin and cellulose, (2) co-option of genes p
221 s that the strength of stabilizing selection acting on mRNA levels in a species is strongly associate
222 omodulators, intestinal secretagogues, drugs acting on opioid or 5-HT receptors, or minimally absorbe
224 l pigment epithelium can be damaged by light acting on photosensitizers like N-retinylidene-N-retinyl
225 Further, Fig4 is also a protein phosphatase acting on PIKfyve to stimulate its lipid kinase activity
226 -deficient member of the adenosine deaminase acting on RNA (ADAR) family, is competing with ADR-2 for
227 Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible for adenosine-to-inos
230 By quantifying multiple evolutionary forces acting on sPTB-associated regions, our approach improves
235 r3 in controlling the actin-dependent forces acting on the nuclear envelope to remodel nuclear shape,
236 thdrawal symptoms and drug cravings, despite acting on the same opioid receptors triggered by classic
238 i) ] is explained by a direct effect of P(i) acting on the SR Ca(2+) release channel, combined with t
239 By characterizing landscape-scale drivers acting on these interfaces, we demonstrate that socioeco
242 pectrometric analysis of their products when acting on well-defined chitosan polymers as substrates.
243 bers (OR 2.23 95% CI 1.75-2.83) and new long acting opioid prescriptions (OR 1.69, 95% CI 1.05-2.71).
246 gle, highly patchy protein when interactions acting over multiple length scales are exploited and pre
247 ameters of TLZ in humans, we designed a long-acting PEG~TLZ for humans that may be superior in effica
249 d by a regulatory network composed of a fast-acting positive feedback loop and a delayed negative fee
251 emonstrate that a single injection of a long-acting prodrug of the PARP inhibitor talazoparib in muri
254 me replicating evidence for rare-variant cis-acting protein quantitative trait loci for five genes, i
255 stitute for Brain Science; examining the cis-acting regulatory effect of SNPs on the ITIH3 expression
258 We describe the design and testing of a long-acting reservoir subcutaneous implant capable of releasi
260 HERV-K mRNA appears to be mediated by a cis-acting signal on the mRNA, the RcRE, and the protein Rec
261 We show the vital role played by mountains acting simultaneously as cradles and museums of tropical
262 s-cleavage at PHAS precursors, and these cis-acting sites were also variable among close species.
263 es microRNA390, contributing to reduce trans acting small interference Auxin Response Factor producti
264 ted that a short variant of the lncRNA Trans-acting small interference RNA3 (TAS3) increased its asso
265 -acting maternal effect combined with slower-acting standard negative selection, and rare functional
268 11% and 2%, respectively, who received long-acting therapy and in 4% and 1% who received oral therap
269 of 283 participants (2.1%) who received long-acting therapy and in 7 of 283 (2.5%) who received oral
270 absence of Hh by elimination of Cos2, likely acting through binding the CORD domain of Ci, or PKA, re
278 mainly exerted by intensified drought stress acting to offset the acceleration driven by CO(2) fertil
279 a concomitant overproduction of eicosanoids, acting to promote cell proliferation beyond a cell-auton
282 e Mel receptor MT(1) but not MT(2) A peptide acting to release free Gbetagamma also activates hSlo1 i
283 y and upon heptamerization, packing of trans-acting Tyr(290) against cis-acting Arg(349) compels Arg(
285 ght chain kinase (cMLCK), the primary kinase acting upon RLC, in the regulation of cardiomyocyte cont
288 , ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of the fly's molecula
289 LTB(4) was at least as effective as the long-acting variant that inhibited both C5 and LTB(4), preven
290 fficacious in mouse EAU models, and the long-acting variant that inhibited only LTB(4) was at least a
292 ecently reported an important role for Wnt5a acting via canonical and noncanonical signaling in spina
295 eld of subtype-selective GABA(A)R modulators acting via the BZD binding site and their potential clin
296 onstrated a physiological role for glucagon, acting via the GLP-1 receptor, in paracrine regulation o
297 of IL-9 critically depends on autocrine IL-3 acting via the sustained activation of STAT5 on the expr
298 vestigate the chlamydial response mechanisms acting when other amino acids become limiting, we tested
300 uals with dysplasia have no prior experience acting with hands, allowing us to control for hand motor