ライフサイエンスコーパス: actinin

1 including DEB-1 (vinculin) and ATN-1 (alpha-actinin).

2 2 with the cytoskeletal linker protein alpha-actinin.

3 h observations of cells overexpressing alpha-actinin.

4 ected Z lines and were cross-linked by alpha-actinin.

5 networks crosslinked with palladin and alpha-actinin.

6 act expressed the cardiomyocyte marker alpha-actinin.

7 adhesions and binds to both actin and alpha-actinin.

8 is process in mutant cells depended on alpha-actinin.

9 tion contained syndecan-4, PIP(2), and alpha-actinin.

10 h other myosin isoforms and sarcomeric alpha-actinin.

11 -affinity complex with alphaCaMKII and alpha-actinin.

12 odilator-stimulated phosphoprotein and alpha-actinin.

13 n the Z-disk is the actin cross-linker alpha-actinin.

14 interaction with the actin crosslinker alpha-actinin.

15 ivation in the presence and absence of alpha-actinin.

16 s accumulate in the caps together with alpha-actinin.

17 mic domain of ICAM-2 binds directly to alpha-actinin.

18 -3 binding blocks its interaction with alpha-actinin.

19 ns of microbial pathogens or the human alpha-actinin 1 (HuACTN1) homolog.

20 show that perturbations to formin and alpha-actinin 1 activity selectively inhibited stress fiber as

21 vels of smn, cofilin 1, profilin 2 and alpha-actinin 1 did not affect smn morphant motor axon outgrow

22 which encodes the cytoskeletal protein alpha-actinin 1, in 10 of 239 consecutive probands with an inh

23 In this study, we assessed the role of alpha actinin-1 (ACTN1), one of the two alpha actinin isoforms

24 CLP36 interacted with both alpha-actinin-1 and -4 in breast cancer cells.

25 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein

26 cting with actin-cross-linking protein alpha-actinin-1 and increasing its affinity to filamentous act

27 EC1 ectodomain, or alternatively of an alpha-actinin-1 mutant that inhibits F-actin bundling, increas

28 Depletion of either alpha-actinin-1 or -4 inhibited breast cancer cell migration.

29 Time-lapse imaging reveals that alpha-actinin-1 puncta within actomyosin bundles move more qui

30 flet of the plasma membrane, including alpha-actinin-1, moesin, 14-3-3 protein zeta/delta, annexin A1

31 xpression and activation of moesin and alpha-actinin-1, which associate with actin filaments and the

32 rescued by the actin bundling protein alpha-actinin-1.

33 skeleton remodeling factors, including alpha-actinin-1.

34 s revealed its localization complementary to actinin-1.

35 ich a novel disease-causing variant in alpha-actinin 2 (ACTN2) was identified by next-generation sequ

36 evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to opt

37 sh can be rescued by overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafis

38 We have further demonstrated that alpha-actinin-2 competes with calcineurin for binding to calsa

39 een actn2 and actn3, the phenotypes of alpha-actinin-2 deficient zebrafish can be rescued by overexpr

40 gh-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore its fun

41 of other sarcomeric proteins including alpha-actinin-2, alpha-sarcomeric actin and tropomyosin were a

42 alpha-Actinin-2, which is differentially expressed in alpha-ac

43 d with dose-dependent up-regulation of alpha-actinin-2, z-band alternatively spliced PDZ-motif and my

44 ature stop codon in ACTN3 resulting in alpha-actinin-3 deficiency (the ACTN3 577XX genotype) is commo

45 l polymorphism (R577X) in ACTN3 causes alpha-actinin-3 deficiency in approximately 18% of the global

46 s no associated disease phenotype, but alpha-actinin-3 deficiency is detrimental to sprint and power

47 alpha-Actinin-3 deficiency occurs in approximately 16% of the

48 This suggests that alpha-actinin-3 deficiency reduces muscle performance at basel

49 Here, we have shown that alpha-actinin-3 deficiency results in increased calcineurin ac

50 Mechanistically, we show that alpha-actinin-3 deficiency triggers an increase in oxidative m

51 imary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to optimize their function

52 Here, we investigate the effects of alpha-actinin-3 expression level by comparing the muscle pheno

53 Loss of alpha-actinin-3 is associated with reduced power and enhanced

54 We show reduction in alpha-actinin-3 mRNA and protein in HET muscle compared with W

55 pression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafish or human.

56 viduals, suggesting dose-dependency of alpha-actinin-3, while others have shown no difference between

57 , which is differentially expressed in alpha-actinin-3-deficient muscle, has higher binding affinity

58 Mutations in alpha-actinin 4 (ACTN4) are linked to familial forms of focal

59 ing affinity of the actin cross-linker alpha-actinin 4 (ACTN4) in cells modulates cytoplasmic mobilit

60 In this study, we demonstrated that alpha actinin 4 (ACTN4), an actin-cross-linking protein known

61 utations in the actin-binding protein, alpha-actinin 4 (ACTN4), are linked to focal segmental glomeru

62 units of the vacuolar ATPase, small GTPases, actinin 4, and, of special interest, components of the e

63 tegrin-linked kinase, laminin-521, and alpha-actinin 4.

64 mass spectrometric analysis identified alpha-actinin-4 (ACTN4) as an MTBP-interacting protein.

65 omodimeric actin cross-linking protein alpha-actinin-4 (ACTN4) during cell migration involves signali

66 in disease; for example, mutations in alpha-actinin-4 (Actn4), a dynamic actin cross-linking protein

67 alpha-Actinin-4 (ACTN4), a key regulator of the actin cytoskel

68 rther increased binding of MICAL-L2 to alpha-actinin-4 (ACTN4), a protein involved in GLUT4 transloca

69 Furthermore, a point mutation of alpha-actinin-4 (K255E) associated with FSGS failed to support

70 ng antibodies to a conserved domain of alpha-actinin-4 (present in both wild-type and mutant proteins

71 Functional silencing of alpha-actinin-4 abolished spine elongation and turnover stimul

72 We found that mechanical force induces alpha-actinin-4 and actin accumulation at the cell junction in

73 n-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein 2/3 complex subunit

74 ynaptopodin forms a complex containing alpha-actinin-4 and beta-catenin and interacts with myosin II,

75 lose correlation between the levels of alpha-actinin-4 and CLP36, which form a complex in normal podo

76 nhibited the complex formation between alpha-actinin-4 and CLP36.

77 by metabotropic signaling and identify alpha-actinin-4 as a critical effector of structural plasticit

78 Our study identified alpha-actinin-4 as a novel NHERF1 interaction partner and prov

79 ension-sensitive upstream regulator of alpha-actinin-4 as synaptopodin.

80 Actinin-4 associates with lamellipodia and has been impl

81 /CD2AP colocalizes with E-cadherin and alpha-actinin-4 at the apical junction in polarized Madin-Darb

82 ation of the podocyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modification

83 Genetic alterations of alpha-actinin-4 can cause podocyte injury through multiple mec

84 immunoprecipitation studies showed the alpha-actinin-4 carboxyl-terminal region specifically interact

85 Knockdown of alpha-actinin-4 decreased total junctional actin and inhibited

86 Knockdown of synaptopodin and alpha-actinin-4 decreases the strength of cell-cell adhesion,

87 Here we show that alpha-actinin-4 deficiency occurs in multiple human primary gl

88 s and provide an explanation as to how alpha-actinin-4 deficiency or mutations found in human patient

89 podocytes, treatment with C3a reduced alpha-actinin-4 expression and promoted ILK-dependent nuclear

90 te loss and changes in ILK, Snail, and alpha-actinin-4 expression.

91 upporting mechanisms involving loss-of-alpha-actinin-4 function in human glomerular diseases remains

92 Although a mechanism involving gain-of-alpha-actinin-4 function was well described and is responsible

93 To study the functions of actinin-4 in human keratinocytes, we used shRNA to gener

94 siRNA-mediated depletion of alpha-actinin-4 in human podocytes resulted in a marked reduct

95 Together, our data indicate a role for actinin-4 in regulating the steering mechanism of kerati

96 This function of alpha-actinin-4 in spine dynamics was underscored by gain-of-f

97 ound that silencing of either EWI-2 or alpha-actinin-4 increased cell infectivity.

98 Here alpha-actinin-4 induced spine head enlargement, a morphologica

99 The NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ubiquiti

100 Actinin-4 knockdown keratinocytes lack polarity, assembl

101 Additionally, two FSGS-associated alpha-actinin-4 mutations (R310Q and Q348R) inhibited the comp

102 tion with spinophilin, but not through alpha-actinin-4 or Arp3.

103 These findings demonstrate that alpha-actinin-4 plays an important role in coupling actin nucl

104 alpha-Actinin-4 specifically localized to sites of actin incor

105 nge requiring the C-terminal domain of alpha-actinin-4 that binds to CaMKII, an interaction we showed

106 point mutation at lysine 255 in human alpha-actinin-4 to glutamate increases the binding affinity re

107 /alpha-actinin-4 interaction increased alpha-actinin-4 ubiquitination and decreased its expression le

108 alpha-Actinin-4, an actin cross-linking protein, was identifie

109 HERF3 and another ligand such as NHE3, alpha-actinin-4, and PKCalpha, promoting formation of NHE3 mac

110 ding those of podocin, nephrin, neph1, alpha-actinin-4, and vimentin.

111 ne, encoding the actin-binding protein alpha-actinin-4, are a rare cause of autosomal dominant famili

112 a(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group 1 mGluR-interacting partner

113 -actinin-4-CLP36 complex, like loss of alpha-actinin-4, markedly reduced the level of CLP36 in podocy

114 ocyte proteins including synaptopodin, alpha-actinin-4, nephrin, JAM4, and beta-catenin.

115 on prevents junctional accumulation of alpha-actinin-4, vinculin, and actin.

116 studies reveal a critical role of the alpha-actinin-4-CLP36 complex in podocytes and provide an expl

117 f the CLP36 level or disruption of the alpha-actinin-4-CLP36 complex significantly inhibited RhoA act

118 Inhibition of the alpha-actinin-4-CLP36 complex, like loss of alpha-actinin-4, m

119 Intercellular tension also induces alpha-actinin-4-dependent recruitment of vinculin to the cell

120 In actinin-4-knockdown keratinocytes, focal contact area is

121 nail and downregulation of nephrin and alpha-actinin-4.

122 o, including diminished proteolysis of alpha-actinin-4.

123 d a global linear staining pattern for alpha-actinin-4.

124 of infected cells and association with alpha-actinin-4.

125 vitro actin assembly assay identified alpha-actinin-4/focal segmental glomerulosclerosis 1 (FSGS1) a

126 ractions between the EF-hand domain of alpha-actinin (Act-EF34) and peptides derived from palladin an

127 nd located in the last intron of the alpha 1 Actinin (Actn1) gene.

128 alpha-Actinins (ACTNs) are a family of proteins cross-linking

129 Alpha actinins (ACTNs) are known for their ability to modulate

130 gy, and expressed the MEC markers SMA, alpha-actinin, adenylate cyclase II, and vimentin.

131 ating or titrating actin cross-linkers alpha-actinin Ain1 and fimbrin Fim1 in live cells, we reveal t

132 The T. vaginalis alpha-actinin amino acid sequence and the sequences of the epi

133 to detect any of the epitopes or other alpha-actinin amino acid sequences.

134 zed accumulation of actin, myosin, and alpha-actinin and a complete loss of myofibrillar organization

135 Confocal imaging after actinin and Cx-43 specific immunostaining showed extensi

136 PLM synaptogenesis was independent of alpha-actinin and ENA-VASP, both of which bind to the N-termin

137 alpha-Actinin and Ena/VASP proteins bind to the stress fiber r

138 on of key sarcomeric proteins, such as alpha-actinin and filamin C, and is essential for maintenance

139 strates, including the z-disc proteins alpha-actinin and filamin C.

140 arkedly attenuated degradation of both alpha-actinin and filamin C.

141 in, other cytoplasmic proteins such as alpha-actinin and filamin can directly interfere with talin-me

142 lar understanding of the mechanisms of alpha-actinin and filamin catch-bonding behavior.

143 successfully predicted which mammalian alpha-actinin and filamin paralogs would be mechanoaccumulativ

144 motors and actin cross-linkers such as alpha-actinin and filamin, accumulate in response to internall

145 of actin association in both wild-type alpha-actinin and in the K225E mutant.

146 lates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and

147 eropositive in response to trichomonad alpha-actinin and its truncated protein (ACT-P2) (positive con

148 IP6K1 physiologically associates with alpha-actinin and localizes to focal adhesions.

149 mislocalization of the Z-disk proteins alpha-Actinin and muscle LIM protein 84B.

150 Furthermore, alpha-actinin and myosin minifilaments turned over significant

151 ntrolled by zyxin and binding partners alpha-actinin and p130Cas, but not vasodilator-stimulated phos

152 The interaction between alpha-actinin and palladin, two actin-cross-linking proteins,

153 ependent growth, co-precipitation with alpha-actinin and production of localized and disseminated tum

154 Cas and two other adhesion molecules, alpha-actinin and talin, were also significantly slower in the

155 A single interaction of alpha-actinin and titin turns out to be surprisingly weak if f

156 ecificity between the scaffold protein alpha-actinin and various ligands, which appears to require an

157 ocal stress fiber damage, whereas both alpha-actinin and VASP independently contribute to limiting st

158 tment of the actin regulatory proteins alpha-actinin and VASP to compromised stress fiber zones.

159 s filaments with desmin and also binds alpha-actinin and vinculin.

160 ffold protein (actin), a cross-linker (alpha-actinin), and a motor (myosin).

161 ins), adherens junctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV), were

162 its C-terminal SH3 domains in an ATN-1(alpha-actinin)- and ALP-1(ALP/Enigma)-dependent manner, where

163 s alpha-smooth muscle actin, vimentin, alpha-actinin, and adenylyl cyclase II.

164 re, we show that non-muscle myosin II, alpha-actinin, and filamin accumulate to mechanically stressed

165 eparated by the actin bundling protein alpha-actinin, and is mechanically coupled to noncontractile d

166 mutant ZASP interact with alpha-actin, alpha-actinin, and myotilin.

167 verexpression of the actin crosslinker alpha-actinin, and rheology measurements reveal that changes i

168 ulations with the K237E mutant chicken alpha-actinin--and evaluate the mechanism of alpha-actinin bin

169 lso serves as a molecular scaffold for alpha-actinin, another key actin crosslinker.

170 unofluorescence staining with the anti-alpha-actinin antibody (a z-line marker) showed that nearly al

171 ArgBP2gamma binding to alpha-actinin appears to underlie its ability to localize to s

172 alpha-Actinins are actin-binding proteins that can be broadly

173 Although alpha-actinins are better known to cross-link actin filaments

174 s, such as actin-titin cross-links via alpha-actinin, are sufficient to maintain Z-disk stability des

175 These findings identify epitopes of alpha-actinin as candidate serodiagnostic targets and suggest

176 ro experiments of motility assays with alpha-actinins as molecular force sensors.

177 embryos results in the accumulation of alpha-actinin associated with severely impaired contractile fu

178 nts and the muscle-specific isoform of alpha-actinin at the PM of differentiated myotubes.

179 ion, changing spacing and alignment of alpha-actinin bands due to increase in proteolytic activity of

180 ses, myosin band spacing decreases and alpha-actinin bands form.

181 inding site residues are similar to an alpha-actinin binding motif previously suggested for the compl

182 We map a small alpha-actinin binding region in ArgBP2 (residues 192-228) that

183 actinin--and evaluate the mechanism of alpha-actinin binding to actin.

184 ted here was to evaluate the impact of alpha-actinin binding to ICAM-2 on the phenotype of NB tumor c

185 reatic cancer, does not interfere with alpha-actinin binding.

186 Furthermore, mutations inhibiting the alpha-actinin-binding activity abolished the ability of CLP36

187 pressing ICAM-2 variants with modified alpha-actinin-binding domains differed from cells expressing I

188 ressed variants of ICAM-2 with mutated alpha-actinin-binding domains, and compared the impact of ICAM

189 We show that the actin-binding protein alpha-actinin binds to the C-terminal surface targeting motif

190 The calmodulin-like domain of alpha-actinin binds to the Z-repeats of titin.

191 n the formation of distinct fascin- or alpha-actinin-bundled domains.

192 soluble and interacted with sarcomeric alpha-actinin by coimmunoprecipitation, while alpha-synemin an

193 Regulation of alpha-actinin by IP6K1 requires its kinase activity.

194 reduction of cardiac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and cardiac t

195 Knockdown of alpha-actinin causes aberrant rigidity sensing, loss of CUs, l

196 ow in an in vitro assay that talin and alpha-actinin compete for binding to beta3 integrins, but coop

197 It has been shown that alpha-actinin competes with talin for binding to the cytoplasm

198 actin cytoskeleton by talin, and then alpha-actinin competes with talin to bind beta3 integrins.

199 on of CLP36 or disruption of the CLP36-alpha-actinin complex in breast cancer cells substantially inh

200 Our data suggest that the EWI-2-alpha-actinin complex is involved in the regulation of the act

201 n, tropomyosin, troponins) and Z-band (alpha-actinin) components and promotes their degradation.

202 vity with robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha/beta-

203 ter protein, ArgBP2, is a component of alpha-actinin containing stress fibers and inhibits migration.

204 network consisting of actin filaments, alpha-actinin cross-linking proteins, and non-muscle myosin II

205 constituted actin networks formed with alpha-actinin crosslinks.

206 The data suggest the presence of alpha-actinin-dependent and alpha-actinin-independent mechanis

207 sistently, we find opposite effects of alpha-actinin depletion and expression of mutants on substrate

208 Surprisingly, only one-fourth of alpha-actinin dimers were bound to two actin filaments.

209 in domains are densely packed, whereas alpha-actinin domains consist of widely spaced parallel actin

210 tin cross-linking proteins, fascin and alpha-actinin, during the first steps of structure assembly.

211 epletion of the focal adhesion protein alpha-actinin enhances force generation in initial adhesions o

212 Finally, alpha-actinin enters NAs periodically and in clusters that tra

213 and the range of levels of identity of alpha-actinin epitopes with HuACTN1 was 0% to 50%.

214 Comparison of the T. vaginalis alpha-actinin epitopes with proteins in data banks, such as Tr

215 n cytoskeleton, bundle-like sarcomeric alpha-actinin expression, higher pacing beat rate at lower thr

216 disrupting nonfocal adhesion proteins (alpha-actinin, F-actin, and myosin II) and subcellular organel

217 ial adhesion and force generation) and alpha-actinin for integrin binding.

218 Expression of an alpha-actinin fragment containing the integrin binding domain,

219 demonstrate that calmodulin displaces alpha-actinin from their shared binding site on alpha11.2 upon

220 Disruption of alpha-actinin function by dominant-negative or small hairpin R

221 ch contains orthologoues of each human alpha-actinin gene, including duplicated copies of actn3.

222 ng a deletion of the single C. elegans alpha-actinin gene.

223 that shares actin-binding domains with alpha-actinin had a strong inhibitory effect on PC2(iv) channe

224 nt sarcomeres that are cross-linked by alpha-actinin homodimers.

225 ctivity and is more dynamic than human alpha-actinin HsACTN4.

226 Our results suggest that alpha-actinin impairs integrin signaling by both undermining t

227 mponent of the Z-disc (about 1 per 400 alpha-actinin) important for myofibrillar development and mech

228 results may shed light on the role of alpha-actinin in cellular mechanotransduction and focal adhesi

229 Palladin coexists with alpha-actinin in stress fibers and focal adhesions and binds t

230 of densin results in reduced levels of alpha-actinin in the brain and selective reduction in the loca

231 was seen for alpha6beta1-integrin and alpha-actinin in U2OS.

232 alpha-actinins in particular are the major actin crosslinkers

233 The actin-bundling protein alpha-actinin increased PC2(iv) channel function in the presen

234 resence of alpha-actinin-dependent and alpha-actinin-independent mechanisms, and indicate that the in

235 odel for NA assembly whereby transient alpha-actinin-integrin complexes help nucleate NAs within the

236 re we directly observe that fascin and alpha-actinin intrinsically segregate to discrete bundled doma

237 The actin binding protein alpha-actinin is a major component of focal adhesions found in

238 alpha-Actinin is a promiscuous cross-linker, linking filaments

239 alpha-Actinin is abundant by E19, suggesting that it is a core

240 alpha-Actinin is an actin cross-linker and may act as a mechan

241 alpha-Actinin is an essential actin cross-linker involved in c

242 The interaction with alpha-actinin is blocked by CaMKII autophosphorylation at Thr-

243 te that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non

244 The cytoskeletal protein alpha-actinin is shared between these two force-producing syst

245 with force generation, suggesting that alpha-actinin is the main link transmitting force between inte

246 lpha actinin-1 (ACTN1), one of the two alpha actinin isoforms expressed in keratinocytes, in skin cel

247 r hydrophobic residues, common to many alpha-actinin ligands.

248 our to six layers of links, presumably alpha-actinin, linking antiparallel overlapping ends of the ac

249 rmation with the actin-binding protein alpha-actinin, linking membrane-bound CD13 to the cytoskeleton

250 nts within the Z-band is devoid of any alpha-actinin links and is likely to be the location of cappin

251 When mixed, fascin and alpha-actinin mutually exclude each other by promoting their o

252 g protein (ZASP)/Cypher interacts with alpha-actinin, myotilin, and other Z-disc proteins via the PDZ

253 omen and men that were unreactive with alpha-actinin (negative control sera) failed to detect any of

254 to pure palladin or pure [Formula: see text]-actinin networks.

255 e propose that the reduced motility of alpha-actinin null is due to abnormal dense bodies that are le

256 aveolin, Rab5a in early endosomes, and alpha-actinin, often in relationship to cortical actin.

257 d with zyxin variants that lack either alpha-actinin or Ena/VASP-binding capacity display compromised

258 se results also suggest that the zyxin/alpha-actinin/p130Cas module may ensure that motile cells in a

259 also showed that composite networks of alpha-actinin/palladin/actin behave very similar to pure palla

260 CLANs and to ascertain the presence of alpha-actinin, PIP(2), and syndecan-4 within them.

261 have demonstrated that the sarcomeric alpha-actinins play a role in the regulation of calcineurin si

262 alpha-Actinin plays a critical role in restoration of actin in

263 Specifically, alpha-actinin plays distinct roles in regulating alphaIIbbeta3

264 Furthermore, we showed that alpha-actinin promote talin association with beta1-integrin by

265 Once adhesions have matured, alpha-actinin recruitment correlates with force generation, su

266 al ABPs, such as cortactin, myosin, or alpha-actinin, regulate leukocyte extravasation by controlling

267 d that the interplay between talin and alpha-actinin regulates signal transmission via controlling th

268 alpha-Actinin regulates the immune synapse formation and is re

269 In contrast, alpha-actinin remained nearly unchanged in both samples.

270 it distinct responses, with myosin and alpha-actinin responding to dilation, and filamin mainly react

271 The molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its assoc

272 IP6K1 deletion disrupts alpha-actinin's intracellular localization and function.

273 ation trajectory is generated in which alpha-actinin's vinculin-binding site swings out of the rod do

274 n myotubes induced a loss of actin and alpha-actinin sarcomeric organization, whereas CHC depletion i

275 In intact cells, alpha-actinin selectively stabilizes CaMKII association with G

276 be, in which the cross-linking protein alpha-actinin SpAin1 bundles the actin filament network.

277 filaments of mixed polarity like other alpha-actinins, SpAin1 has lower bundling activity and is more

278 Cortexillins I-III are members of the alpha-actinin/spectrin subfamily of Dictyostelium calponin hom

279 We conclude that alpha-actinin stabilizes Ca(V)1.2 at the plasma membrane and t

280 that a highly seropositive reaction to alpha-actinin suggests exposure to T. vaginalis.

281 A model, based on the structure of alpha-actinin, suggests that the EF domain modulates the funct

282 r, we found evidence that palladin and alpha-actinin synergistically modify network viscoelasticity.

283 g of vinculin and, to a lesser extent, alpha-actinin, talin, and filamin, to phosphomimetic Cav1Y14D

284 show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha to F-actin in cells by bindi

285 orces on matrices, unveiling a role of alpha-actinin that is different from its well-studied function

286 muscles exhibit normal localization of alpha-actinin, the nebulin M1M2M3 domain, Tmod3, and cytoplasm

287 Force transmitted through alpha-actinin then triggers adhesion maturation.

288 f EWI-2 with the actin-binding protein alpha-actinin; this association was regulated by PIP2.

289 encing phosphorylation of both FAK and alpha-actinin through its product 5-IP7.

290 how that Ca(2+)-independent binding of alpha-actinin to CaMKII differentially modulates the phosphory

291 The binding of alpha-actinin to CaMKII is Ca(2+)-independent and activates th

292 ent actin-bundling proteins fascin and alpha-actinin to distinct networks is an intrinsic behavior, f

293 nterlace with perijunctional actin and alpha-actinin to form a continuous belt of muscle-like sarcome

294 ajor mechanosensitive pathway in which alpha-actinin triggers adhesion maturation by linking integrin

295 Deletion of IP6K1 abolishes alpha-actinin tyrosine phosphorylation, which is known to be r

296 in A, non-muscle myosin IIA, clathrin, alpha-actinin, vimentin, actin, caldesmon, myosin IC, and anne

297 Sarcomeric alpha-actinin was equally abundant in the EOMs at all stages.

298 is correlated with a third component, alpha-actinin, which upon CRISPR knockout led to reduced plasm

299 Specific 15-mer peptide epitopes of alpha-actinin with low to no identity with other proteins were

300 p52 is required for the association of alpha-actinin with the flight muscle Z-disc, and for normal sa

301 results suggest a model where multiple alpha-actinin/Z-repeat interactions cooperate to ensure long-t