ライフサイエンスコーパス: actinomycetemcomitans

1 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans).

2 AZM or 16 mug/mL AMX (equipotent against A. actinomycetemcomitans).

3 and leukotoxin A (LtxA) from Aggregatibacter actinomycetemcomitans.

4 = 6 mm, BOP, and ABL, except Aggregatibacter actinomycetemcomitans.

5 and 41 participants who were negative for A. actinomycetemcomitans.

6 y those testing positive for Aggregatibacter actinomycetemcomitans.

7 tis and/or the individual colonization of A. actinomycetemcomitans.

8 both wild-type and morC mutant strains of A. actinomycetemcomitans.

9 d significant phagocytic activity against A. actinomycetemcomitans.

10 eased colonization risk with Aggregatibacter actinomycetemcomitans.

11 ted from the oral bacterium, Aggregatibacter actinomycetemcomitans.

12 equence of a serotype b non-JP2 strain of A. actinomycetemcomitans.

13 ve implants, per group, with Aggregatibacter actinomycetemcomitans.

14 may be capable of phosphorylating AI-2 in A. actinomycetemcomitans.

15 is required for optimal biofilm growth by A. actinomycetemcomitans.

16 Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.

17 EmaA on the LPS biosynthetic machinery in A. actinomycetemcomitans.

18 Ns cope with an overwhelming infection by A. actinomycetemcomitans.

19 ved in biofilm formation and virulence of A. actinomycetemcomitans.

20 ycetemcomitans but not with S. oralis and A. actinomycetemcomitans.

21 of a trimeric autotransporter protein of A. actinomycetemcomitans.

22 re genes distinguished A. aphrophilus and A. actinomycetemcomitans.

23 ystem for AZM that may enhance killing of A. actinomycetemcomitans.

24 -producing organisms such as Aggregatibacter actinomycetemcomitans.

25 P for detection frequency of key pathogen A. actinomycetemcomitans.

26 ation between smoking and the presence of A. actinomycetemcomitans.

27 ormation, and periodontitis severity than A. actinomycetemcomitans.

28 is required for optimal biofilm growth by A. actinomycetemcomitans.

29 i, Streptococcus mutans, and Aggregatibacter actinomycetemcomitans.

30 l levels and prediabetes were as follows: A. actinomycetemcomitans, 2.48 (1.34, 4.58), P = 0.004; P.

31 The majority of the individuals carrying A. actinomycetemcomitans (80.1%) (P <0.001) and of the peri

32 th altered outer membrane morphology make A. actinomycetemcomitans a model organism for examining mem

33 leatum (a middle colonizer), Aggregatibacter actinomycetemcomitans (a late colonizer), and P. gingiva

34 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans), a capnophilic facultative anaero

35 Aggregatibacter actinomycetemcomitans, a periodontal pathogen, synthesiz

36 tx is a marker for presence of leukotoxic A. actinomycetemcomitans, a presence that may modify the di

37 terial complexes, and "high" Aggregatibacter actinomycetemcomitans (Aa) colonization.

38 ammatory response induced by Aggregatibacter actinomycetemcomitans (Aa) in human coronary artery endo

39 bacterial biofilm of Sg and Aggregatibacter actinomycetemcomitans (Aa) in terms of hydrogen peroxide

40 disease (PD) associated with Aggregatibacter actinomycetemcomitans (Aa) infection.

41 The oral pathogen Aggregatibacter actinomycetemcomitans (Aa) resides in infection sites wi

42 Aggregatibacter actinomycetemcomitans (Aa) was the only species found to

43 usobacterium nucleatum (Fn), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg

44 rphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), a

45 e, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypert

46 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans [Aa]), and divided into a cohort o

47 D superfamily of genes and that TadZ from A. actinomycetemcomitans (AaTadZ) forms a polar focus in th

48 A. actinomycetemcomitans activates the p38 mitogen-activate

49 ere the three-organism consortium (versus A. actinomycetemcomitans alone) was detected, the specifici

50 ences in serum IgG levels to Aggregatibacter actinomycetemcomitans among the four diagnostic categori

51 Aggregatibacter actinomycetemcomitans, an oral pathogen representative o

52 and in vitro colonization by Aggregatibacter actinomycetemcomitans, an organism highly associated wit

53 as a direct transcriptional activator in A. actinomycetemcomitans; an mlc deletion mutant reduces le

54 umina MiSeq platform was performed for 31 A. actinomycetemcomitans and 2 A. aphrophilus strains.

55 ing 41 participants who were positive for A. actinomycetemcomitans and 41 participants who were negat

56 cin-loaded PMNs killed significantly more A. actinomycetemcomitans and achieved shorter half-times fo

57 A. actinomycetemcomitans and AL were frequently found in Gh

58 e strongest predictor of both presence of A. actinomycetemcomitans and AL.

59 wild-type mice were orally infected with A. actinomycetemcomitans and analyzed for bacterial coloniz

60 a are reported concerning the presence of A. actinomycetemcomitans and attachment loss (AL) in sub-Sa

61 several bacteria, including Aggregatibacter actinomycetemcomitans and Caulobacter crescentus.

62 lacZ transcriptional fusions in wild-type A. actinomycetemcomitans and DeltaihfA and DeltaihfB mutant

63 ted on days 0, 2, and 4 with Aggregatibacter actinomycetemcomitans and divided into groups (n = 5) th

64 ssion models, subgingival colonization of A. actinomycetemcomitans and F. nucleatum/periodonticum was

65 chain reaction, and culture detection of A. actinomycetemcomitans and microcomputed tomography quant

66 omitans in BL and (ii) the association of A. actinomycetemcomitans and other microbes in their relati

67 gival plaque samples for the detection of A. actinomycetemcomitans and P. gingivalis in each of the 1

68 A. actinomycetemcomitans and P. gingivalis quantities in sa

69 The counts of A. actinomycetemcomitans and P. gingivalis were significant

70 n the groups were seen after 3 months for A. actinomycetemcomitans and P. gingivalis, and after 12 mo

71 respectively, developed multiple CFUs for A. actinomycetemcomitans and P. gingivalis.

72 Aggregatibacter actinomycetemcomitans and Parvimonas micra (Pm) showed a

73 study, the aim is to measure Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis amoun

74 Different serotypes of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis have

75 tion in periodontopathogenic Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis viabi

76 inst the periodontopathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis with

77 3 and PCT5 were dominated by Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, resp

78 A. actinomycetemcomitans and Staphylococcus species do not

79 The prevalence of Aggregatibacter actinomycetemcomitans and Staphylococcus species was ver

80 full activity and modification of LtxA in A. actinomycetemcomitans and that modification is important

81 vides a comprehensive genomic analysis of A. actinomycetemcomitans and the closely related nonpathoge

82 frequency of JP2 and non-JP2 genotypes of A. actinomycetemcomitans and the presence of AL in Ghanaian

83 thensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus

84 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis in p

85 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis.

86 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans), and Porphyromonas gingivalis.

87 of the periodontal pathogen Aggregatibacter actinomycetemcomitans, and a commensal Streptococcus par

88 trains antagonistic toward P. gingivalis, A. actinomycetemcomitans, and F. nucleatum was found to be

89 of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum were

90 a: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum.

91 , GI, total bacterial load, T. forsythia, A. actinomycetemcomitans, and GCF volume.

92 idence of the association of Aggregatibacter actinomycetemcomitans, and its highly leukotoxic JP2 gen

93 The PCR-positive triad, P. gingivalis, A. actinomycetemcomitans, and P. intermedia, was associated

94 s of Parvimonas micra, Filifactor alocis, A. actinomycetemcomitans, and Peptostreptococcus sp. human

95 icantly greater amounts of P. gingivalis, A. actinomycetemcomitans, and T. forsythia than never-smoke

96 Streptococcus, Actinomyces, A. actinomycetemcomitans, and total anaerobic counts were e

97 valis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and total bacterial load were det

98 rulence of the oral pathogen Aggregatibacter actinomycetemcomitans, and we previously showed that lsr

99 of S. gordonii with P. gingivalis or with A. actinomycetemcomitans are more pathogenic in animal mode

100 Eighty participants with Aggregatibacter actinomycetemcomitans-associated moderate to advanced pe

101 The carrier status of A. actinomycetemcomitans at the individual level was determ

102 PRP interfered with P. gingivalis and A. actinomycetemcomitans attachment and enhanced exfoliatio

103 and Mk2(-/-) mice were treated with live A. actinomycetemcomitans bacteria at the midsagittal suture

104 A. actinomycetemcomitans binding to SHA was irreversible an

105 The trimeric adhesin EmaA of A. actinomycetemcomitans binds to collagen and is modified

106 sults describe a novel animal model where A. actinomycetemcomitans biofilm was established in vitro o

107 Viable A. actinomycetemcomitans biofilm was successfully establish

108 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans)-biofilm colonizing titanium impla

109 gingivalis grew with Veillonella sp. and A. actinomycetemcomitans but not with S. oralis and A. acti

110 s aureus, S. epidermidis and Aggregatibacter actinomycetemcomitans, but not by A. pleuropneumoniae se

111 an AMX at enhancing phagocytic killing of A. actinomycetemcomitans by neutrophils.

112 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Campylobacter rectus, Fusobacter

113 clustered into eight groups: Aggregatibacter actinomycetemcomitans, Campylobacter spp., Capnocytophag

114 Gram-negative Aggregatibacter actinomycetemcomitans can be distinguished (based on the

115 Aggregatibacter aphrophilus, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenell

116 rom the periodontal pathogen Aggregatibacter actinomycetemcomitans causes extensive damage to gingiva

117 Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that the

118 Here, we demonstrate that A. actinomycetemcomitans Cdt kills proliferating and nonpro

119 A. actinomycetemcomitans cells rapidly lost viability at ev

120 A. actinomycetemcomitans cells were highly sensitive to eve

121 th differing constellations of genes, the A. actinomycetemcomitans clades may have evolved distinct a

122 In vivo, A. actinomycetemcomitans colonized HA within 6 h and thus c

123 bility of mast cells against Aggregatibacter actinomycetemcomitans compared with macrophages is evalu

124 (Rv) and isogenic smooth (Sv) variants of A. actinomycetemcomitans cultured in half-strength and full

125 ocytes after exposure to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt)

126 es following exposure to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt)

127 In vitro, A. actinomycetemcomitans desorbed from BECs and transferred

128 Sixteen of 63 subjects with A. actinomycetemcomitans developed BL (the other 47 subject

129 pport, and pathogens such as Aggregatibacter actinomycetemcomitans display resource partitioning to f

130 eptococci, the oral pathogen Aggregatibacter actinomycetemcomitans displays enhanced resistance to ki

131 The periodontal pathogen Aggregatibacter actinomycetemcomitans displays on the bacterial surface

132 and nine small regulatory RNAs (sRNAs) in A. actinomycetemcomitans during planktonic and biofilm grow

133 Prevalence and levels of Aggregatibacter actinomycetemcomitans, Eikenella corrodens, and Fusobact

134 ast cells and macrophages, incubated with A. actinomycetemcomitans, either opsonized or not, with dif

135 at a low concentration range regulated by A. actinomycetemcomitans enhanced the biofilm formation.

136 Ts from Haemophilus ducreyi, Aggregatibacter actinomycetemcomitans, Escherichia coli, and Campylobact

137 Aggregatibacter actinomycetemcomitans establishes a tenacious biofilm th

138 um implants were inoculated in vitro with A. actinomycetemcomitans, establishing a biofilm for 1 to 3

139 In this environment, A. actinomycetemcomitans faces numerous host- and microbe-d

140 se H and fumarate reductase are important A. actinomycetemcomitans fitness determinants in vivo.

141 points over 7 h to assess the transfer of A. actinomycetemcomitans from teeth or BECs to HA.

142 defined medium, approximately 14% of the A. actinomycetemcomitans genes were differentially regulate

143 genes accounted for 14.1% to 23.2% of the A. actinomycetemcomitans genomes, with a majority belonging

144 Only A. actinomycetemcomitans grew after 36 h when peg biofilms

145 developed BL (the other 47 subjects with A. actinomycetemcomitans had no BL).

146 Patients who were positive for A. actinomycetemcomitans had no specific benefit from amoxi

147 A. actinomycetemcomitans IHFalpha and IHFbeta were expresse

148 trongest association with the presence of A. actinomycetemcomitans in all subjects and in the subgrou

149 every 6 months to assess (i) the role of A. actinomycetemcomitans in BL and (ii) the association of

150 ient mutant KDP128, and live Aggregatibacter actinomycetemcomitans In contrast, infection of miR-155

151 JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in the Ghanaian adolescent populat

152 One patient was positive for A. actinomycetemcomitans in the three types of samples.

153 ir periodontal status and the presence of A. actinomycetemcomitans in their oral cavity.

154 ight into metabolic pathways required for A. actinomycetemcomitans in vivo fitness.

155 tially regulated in vivo, suggesting that A. actinomycetemcomitans in vivo metabolism is distinct fro

156 f the opportunistic pathogen Aggregatibacter actinomycetemcomitans in vivo.

157 ipopolysaccharide (LPS) from Aggregatibacter actinomycetemcomitans in wild-type (WT) and SP/ON-null C

158 , T. denticola, and T. forsythia, but not A. actinomycetemcomitans, in subgingival plaque.

159 e antibodies induced by P. gingivalis and A. actinomycetemcomitans include anti-phosphorylcholine (al

160 egative periodontal pathogen Aggregatibacter actinomycetemcomitans include serotype a, b, and c strai

161 Oral infection with A. actinomycetemcomitans increased LF levels in periodontal

162 Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans, increased GCF-IL-1beta levels, an

163 Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans induce remarkable IgG responses th

164 d LFKO(-/-) mice were more susceptible to A. actinomycetemcomitans-induced alveolar bone loss, with d

165 regulation of chemokine signaling during A. actinomycetemcomitans-induced inflammation and bone loss

166 Aggregatibacter actinomycetemcomitans-induced localized aggressive perio

167 tudy is to evaluate the role of LF during A. actinomycetemcomitans-induced periodontitis.

168 xide synthase (iNOS) in a murine model of A. actinomycetemcomitans-induced periodontitis.

169 and nitrogen intermediates in periodontal A. actinomycetemcomitans infection and progression to perio

170 hat NADPH oxidase is important to control A. actinomycetemcomitans infection in the murine oral cavit

171 by the periodontal pathogen Aggregatibacter actinomycetemcomitans, inhibits the proliferation of cul

172 the Gram-negative bacterium Aggregatibacter actinomycetemcomitans is a fibrillar collagen adhesin be

173 Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that

174 Aggregatibacter actinomycetemcomitans is a Gram-negative commensal bacte

175 Aggregatibacter actinomycetemcomitans is a human pathogen that produces

176 eukotoxin (Ltx) expressed by Aggregatibacter actinomycetemcomitans is a powerful exotoxin, which can

177 Aggregatibacter actinomycetemcomitans is an opportunistic pathogen that

178 Gram-negative facultative Aggregatibacter actinomycetemcomitans is an oral pathogen associated wit

179 Aggregatibacter actinomycetemcomitans is associated with aggressive peri

180 nfirmatory evidence that the detection of A. actinomycetemcomitans is associated with IL-6 genetic fa

181 by the periodontal pathogen Aggregatibacter actinomycetemcomitans is dependent upon autoinducer-2 (A

182 Aggregatibacter actinomycetemcomitans is hypothesized to colonize throug

183 Aggregatibacter actinomycetemcomitans is implicated in localized aggress

184 e we show that the expression of QseBC in A. actinomycetemcomitans is induced by AI-2 and that induct

185 Aggregatibacter actinomycetemcomitans is the main periodontopathogen of

186 illonella sp. strain PK1910, Aggregatibacter actinomycetemcomitans JP2, and Fusobacterium nucleatum A

187 inhibit biofilm formation by Aggregatibacter actinomycetemcomitans, Klebsiella pneumoniae, Staphyloco

188 atum (middle colonizer), and Aggregatibacter actinomycetemcomitans (late colonizer).

189 Aggregatibacter actinomycetemcomitans leukotoxin (LtxA) is a major virul

190 a, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans levels in subgingival plaque were

191 ans outer membrane protein 29 (Omp29) and A. actinomycetemcomitans lipopolysaccharide (LPS) were inje

192 by periodontal injection of Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS), while si

193 by periodontal injection of Aggregatibacter actinomycetemcomitans LPS.

194 or alternatively that the start codon of A. actinomycetemcomitans lsrA has been incorrectly annotate

195 e previously showed that the Aggregatibacter actinomycetemcomitans lsrACDBFG and lsrRK operons are re

196 vels of systemic immunoreactivity against A. actinomycetemcomitans Ltx are associated with decreased

197 f murine mast cells as phagocytes against A. actinomycetemcomitans, mainly in the absence of opsoniza

198 A. actinomycetemcomitans migrated from BECs to HA in vivo a

199 HA in vivo and to SHA in vitro; however, A. actinomycetemcomitans movement from teeth and SHA to BEC

200 Detection frequency of Aggregatibacter actinomycetemcomitans (MT4/MSP: 42%/36%), Porphyromonas

201 Seventy-one A. actinomycetemcomitans-negative and 63 A. actinomycetemco

202 itans positive for teeth only, and 3 were A. actinomycetemcomitans-negative controls) had two mandibu

203 No A. actinomycetemcomitans-negative subjects developed BL.

204 All 5 subjects with A. actinomycetemcomitans on BECs showed transfer of A. acti

205 itans to HA was not seen in subjects with A. actinomycetemcomitans on teeth only.

206 Cs stimulated with different serotypes of A. actinomycetemcomitans or P. gingivalis is TLR2 or TLR4 d

207 Cs stimulated with different serotypes of A. actinomycetemcomitans or P. gingivalis is Toll-like rece

208 f infection (MOI) of 10(2) with different A. actinomycetemcomitans or P. gingivalis serotypes in the

209 en DCs were stimulated with serotype b of A. actinomycetemcomitans or serotype K1 of P. gingivalis, h

210 in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviat

211 Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29)

212 The counts of A. actinomycetemcomitans (P <0.001), P. gingivalis (P = 0.0

213 etween smoking status and the presence of A. actinomycetemcomitans (P <0.001).

214 sponse to the challenge by two strains of A. actinomycetemcomitans (P = 0.018 and P = 0.046).

215 ctively 60%, 62%, and 40% of subjects had A. actinomycetemcomitans, P. gingivalis, and both bacteria

216 All targeted periodontal pathogens (A. actinomycetemcomitans, P. gingivalis, T. forsythia, or C

217 A. actinomycetemcomitans, P. gingivalis, T. forsythia, P. i

218 signaling in chemokine regulation during A. actinomycetemcomitans pathogenesis.

219 At 5 weeks after infection, A. actinomycetemcomitans persisted at significantly higher

220 nomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, and Pr

221 esence and quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis (Pg), Ta

222 ntify periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Campylo

223 nce of Campylobacter rectus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

224 olymerase chain reaction for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

225 ue samples were analyzed for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

226 determined total bacterial, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

227 titative bacterial counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

228 esence and quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannere

229 essed at baseline, including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Trepone

230 For Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Trepone

231 Thirteen volunteers (5 were A. actinomycetemcomitans positive for buccal epithelial cel

232 epithelial cells [BECs] and teeth, 5 were A. actinomycetemcomitans positive for teeth only, and 3 wer

233 e following factors (interaction effect): A. actinomycetemcomitans-positive or -negative at baseline,

234 Being A. actinomycetemcomitans-positive or -negative did not chan

235 A. actinomycetemcomitans-negative and 63 A. actinomycetemcomitans-positive periodontally healthy sub

236 On a subject level, pooled data from A. actinomycetemcomitans-positive subjects who remained hea

237 eptococcus and Actinomyces species, while A. actinomycetemcomitans-positive subjects with BL had high

238 o study the host response to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

239 inhibitory concentration for Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

240 nhance their ability to kill Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

241 Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

242 esponse to Escherichia coli, Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

243 factors on the detection of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

244 e in a bacterial solution of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

245 s were screened, sampled for Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

246 globulin G (IgG) antibody to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinom

247 s (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans [previously Actinobacillus actinom

248 of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Eikenella

249 nomycetemcomitans [previously Actinobacillus actinomycetemcomitans], Prevotella intermedia, Tannerell

250 Aggregatibacter actinomycetemcomitans produces a repeats-in-toxin (RTX)

251 We report that A. actinomycetemcomitans promoted biofilm formation of S. p

252 These results demonstrate that A. actinomycetemcomitans promotes the S. parasanguinis biof

253 he Escherichia coli LsrB and Aggregatibacter actinomycetemcomitans RbsB proteins that bind AI-2.

254 Aggregatibacter actinomycetemcomitans resists killing by neutrophils and

255 While it is clear that A. actinomycetemcomitans responds to precise cues that allo

256 ling of S. parasanguinis co-cultured with A. actinomycetemcomitans revealed a significant decrease in

257 e conclude that detecting the presence of A. actinomycetemcomitans, S. parasanguinis, and F. alocis t

258 A. actinomycetemcomitans secretes a protein toxin, leukotox

259 ociated with increased systemic levels of A. actinomycetemcomitans-specific immunoglobulins and incre

260 uggest that antibody to RANKL can inhibit A. actinomycetemcomitans-specific T cell-induced periodonta

261 constructed a hyper-leukotoxin producing A. actinomycetemcomitans strain and identified a terminator

262 We report the first genome sequence of an A. actinomycetemcomitans strain isolated from an Old World

263 Opsonized A. actinomycetemcomitans strain Y4 was incubated with the i

264 A. actinomycetemcomitans strains can produce high or low le

265 A. actinomycetemcomitans strains expressing EmaA with the i

266 The genetic heterogeneity among A. actinomycetemcomitans strains has been long recognized.

267 Aggregatibacter actinomycetemcomitans strains that express cytolethal di

268 At vulnerable sites, A. actinomycetemcomitans, Streptococcus parasanguinis, and

269 human oropharyngeal pathogen Aggregatibacter actinomycetemcomitans synthesizes multiple adhesins, inc

270 s (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, or Prevotel

271 from the separation of A. aphrophilus and A. actinomycetemcomitans through gain and loss of genes and

272 upregulate known biofilm determinants of A. actinomycetemcomitans to contribute to biofilm formation

273 Transfer of A. actinomycetemcomitans to HA was not seen in subjects wit

274 ycetemcomitans on BECs showed transfer of A. actinomycetemcomitans to HA.

275 BECs are a likely reservoir for A. actinomycetemcomitans tooth colonization.

276 We identified 691 A. actinomycetemcomitans transcriptional start sites and 21

277 -/-) mice compared to Mk2(+/+) mice after A. actinomycetemcomitans treatment.

278 ive periodontitis-associated Aggregatibacter actinomycetemcomitans triggered a type I IFN response fo

279 nctionally active in Escherichia coli and A. actinomycetemcomitans using truncated PhoA and Aae chime

280 lity to grow in biofilms is essential for A. actinomycetemcomitans virulence, strains that were defic

281 The overall carrier rate of A. actinomycetemcomitans was 54.4%, and the highly leukotox

282 ytic ability of murine mast cells against A. actinomycetemcomitans was confirmed.

283 The presence of A. actinomycetemcomitans was demonstrated in vascular, bloo

284 A. actinomycetemcomitans was detected by polymerase chain r

285 Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans was examined using the agar overla

286 ia, Treponema denticola, and Aggregatibacter actinomycetemcomitans was identified by polymerase chain

287 A. actinomycetemcomitans was significantly associated with

288 rom the periodontal pathogen Aggregatibacter actinomycetemcomitans, was conjugated to an anti-human C

289 pression and influences biofilm growth of A. actinomycetemcomitans, we first defined the promoters fo

290 To determine the function of ltxC in A. actinomycetemcomitans, we generated an ltxC mutation in

291 Although no ncRNAs have been reported in A. actinomycetemcomitans, we propose that they are likely i

292 Lower levels of Aggregatibacter actinomycetemcomitans were observed in the PDT and SRP p

293 reptococcus constellatus, or Aggregatibacter actinomycetemcomitans, were resistant in vitro to doxycy

294 Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, were similarly reduced.

295 nst the periodontal pathogen Aggregatibacter actinomycetemcomitans when the bacteria were added to th

296 veloped one colony forming unit (CFU) for A. actinomycetemcomitans, whereas zero of 10 samples develo

297 letion of 530 bps in a primate isolate of A. actinomycetemcomitans, which produced leukotoxin equival

298 ptococcal metabolite hydrogen peroxide by A. actinomycetemcomitans, which stimulates a genetic progra

299 desorption, transfer, and reattachment of A. actinomycetemcomitans wild-type and mutant strains to BE

300 is to determine if patients positive for A. actinomycetemcomitans with moderate to advanced periodon