ライフサイエンスコーパス: actinonin

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1 ic versus endothermic) upon interaction with actinonin.

2 HsPDF bound to the peptidomimetic inhibitor actinonin (1.7 A) identified the substrate-binding site.

3 eased PDF expression level and resistance to actinonin, a known PDF inhibitor with antibacterial acti

4 The mode of antibacterial action of actinonin, a known PDF inhibitor, was also confirmed wit

5 We have identified actinonin, a naturally occurring antibacterial agent, as

6 Inhibition of bacterial PDF enzymes by actinonin, a naturally occurring antibacterial agent, ha

7 the high-affinity interaction of EcPDF with actinonin, a naturally occurring potent EcPDF inhibitor.

8 We show that actinonin, a peptidomimetic antibiotic that inhibits HsP

9 Actinonin, a specific peptide deformylase inhibitor, was

10 igned and synthesized 33 chemical analogs of actinonin; all of the molecules with potent activity aga

11 hroline and by the aminopeptidase inhibitors actinonin, amastatin, and leuhistin.

12 Shedding was abrogated using actinonin, an inhibitor for meprinalpha.

13 e inhibition of Staphylococcus aureus PDF by actinonin and BB-3497 is consistent with a recent report

14 Of note, actinonin and bestatin had no effect on TNFRII expressio

15 Actinonin and matlystatins are potent metalloproteinase

16 We used an innovative screen to identify actinonin as having a novel mechanism-of-action inhibiti

17 tive target for anticancer therapy by use of actinonin-based antibiotics.

18 of cell surface aminopeptidase N (APN) using actinonin, bestatin, or inhibitory peptides significantl

19 arison of the crystal structures of free and actinonin-bound EcPDF with the solution data suggests th

20 ata reveal that the formation of the PDF(Ec)-actinonin complex results in the transfer of one H(+) fr

21 nsation effect upon formation of the PDF(Ec)-actinonin complex.

22 on demonstrate that the unexpected target of actinonin in P. falciparum and Toxoplasma gondii is FtsH

23 The susceptibility of this strain to actinonin increases with decreased levels of PDF express

24 s Parkin onto mitochondrial subdomains after actinonin-induced mitochondrial proteotoxicity and that

25 ed levels of PDF expression, indicating that actinonin inhibits bacterial growth by targeting this en

26 A conservation of PDF-actinonin interaction across PDFs was observed.

27 Microbiological evaluation revealed that actinonin is a bacteriostatic agent with activity agains

28 lution studies establish that the potency of actinonin is enhanced by more than 2000-fold upon tighte

29 time- and dose-dependent manner; removal of actinonin led to a recovery of the membrane potential co

30 Median inhibitory concentrations (IC50) for actinonin of 73 +/- 16 and 100 +/- 14 nM were obtained i

31 Actinonin provides an excellent starting point from whic

32 veral plant species including Arabidopsis to actinonin resulted in chlorosis and severe reductions in

33 coli with the peptide deformylase inhibitor, actinonin, results in the expected (but previously unrep

34 Slow binding of actinonin to these enzymes is observed under steady-stat

35 binding of a naturally occurring antibiotic, actinonin, to the Ni(2+)-reconstituted recombinant form

36 Actinonin treatment of cells led to a tumor-specific mit

37 Actinonin was a tight binding competitive inhibitor (K(i

38 In animal models, oral or parenteral actinonin was well tolerated and inhibited human prostat

39 ate peptide analog inhibitor of collagenase, actinonin, was included in the reaction.

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