ライフサイエンスコーパス: actinorhodin

1 the biosynthesis of the pigmented antibiotic actinorhodin.

2 oding biosynthetic enzymes of the antibiotic actinorhodin.

3 c activator for production of the antibiotic actinorhodin.

4 The activity of AtrA is also regulated by actinorhodin.

5 ation of dihydrokalafungin, the precursor of actinorhodin.

6 bld strain that overproduced the antibiotic actinorhodin.

7 the production of the polyketide antibiotic actinorhodin.

8 is completely deficient in the production of actinorhodin, a major S. coelicolor antibiotic.

9 Here we revisit the actinorhodins, a class that was first reported 70 years

10 e of actI-open reading frame 3 (encoding the actinorhodin ACP) to allow coexpression of acpP with the

11 revent the FAS ACP from substituting for the actinorhodin ACP, acpP was cloned in place of actI-open

12 enes regulating synthesis of the antibiotics actinorhodin (Act) and undecylprodigiosin (Red) identifi

13 olactones, yet overproduced two antibiotics, actinorhodin (Act) and undecylprodigiosin (Red), whereas

14 r chemically distinct antibiotics, including actinorhodin (Act) and undecylprodigiosin (Red).

15 ne cluster encoding the pigmented antibiotic actinorhodin (ACT) is present in the two closely related

16 Plasmid-encoded actinorhodin (act) ketosynthase/chain-length factor (KS/

17 The actinorhodin (act) minimal polyketide synthase (PKS) fro

18 N-terminal nor the C-terminal domain of the actinorhodin (act) or the griseusin (gris) ARO/CYC exhib

19 iol ester and thiol ether derivatives of the actinorhodin (act) PKS ACP from Streptomyces coelicolor

20 The wild-type apo-ACP from the actinorhodin (act) PKS of Streptomyces coelicolor (synth

21 the antibiotics undecylprodigiosin (Red) and actinorhodin (Act), respectively.

22 Polyketone mimetics are positioned on the actinorhodin acyl carrier protein (actACP) to probe the

23 c polyketides: the blue-pigmented antibiotic actinorhodin and a grey pigment associated with the spor

24 nd sporulation, overproducing the antibiotic actinorhodin and forming crenellated colonies in its abs

25 ction of the benzochromanequinone antibiotic actinorhodin and requires intact [2Fe-2S] clusters in So

26 se loci control synthesis of the antibiotics actinorhodin and undecylprodigiosin by regulating transc

27 Production of actinorhodin and undecylprodigiosin was abolished when a

28 n the clusters responsible for production of actinorhodin and undecylprodigiosin.

29 recocious hyperproduction of the antibiotics actinorhodin and undecylprodigiosin.

30 ntibiotic production (undecylprodigiosin and actinorhodin) and led on further incubation to increased

31 , and the ability to produce prodiginine and actinorhodin antibiotics.

32 nsional model of the Streptomyces coelicolor actinorhodin beta-ketoacyl synthase (Act KS) was constru

33 cM with different combinations of homologous actinorhodin biosynthesis genes did not result in the pr

34 described as a transcriptional activator of actinorhodin biosynthesis in S. coelicolor, is inhibited

35 ent monooxygenase involved in the antibiotic actinorhodin biosynthesis.

36 -ORF4, the pathway-specific activator of the actinorhodin biosynthetic gene cluster in S. coelicolor.

37 -specific activator gene actII-ORF4 from the actinorhodin biosynthetic gene cluster of Streptomyces c

38 E activity in a transcriptional fusion to an actinorhodin biosynthetic gene.

39 Abs- absA mutant strain, transcripts for the actinorhodin biosynthetic genes actVI-ORF1 and actI, and

40 otic gene cluster, reduced the production of actinorhodin, but had no detectable effect on the produc

41 functional aromatic natural products such as actinorhodin, frenolicin, tetracenomycin, and doxorubici

42 oduction of oxidatively rearranged enterocin-actinorhodin hybrid compounds as anticipated, suggesting

43 also inhibited production of the antibiotic actinorhodin, implicating c-di-GMP in the regulation of

44 ve a marked influence on the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2).

45 D were analyzed in vitro and in vivo for the actinorhodin KR (actKR).

46 We have investigated the role of the actinorhodin KS-CLF in priming, elongation, and terminat

47 (a) report on the kinetic properties of the actinorhodin minimal PKS, and (b) present further data i

48 These data indicate that actinorhodin, or a redox-active precursor, modulates Sox

49 lted in delayed production of the antibiotic actinorhodin, overproduction of undecylprodigiosin, and

50 dly, one of the enzymes for synthesis of the actinorhodin polyketide antibiotic appears to be located

51 Two cocrystal structures of actinorhodin polyketide ketoreductase (act KR) were solv

52 The cocrystal structures of actinorhodin polyketide ketoreductase (actKR) bound with

53 her with the other components of the minimal actinorhodin polyketide synthase (act PKS), resulting in

54 eptomyces coelicolor CH999 together with the actinorhodin polyketide synthase (PKS) gene cluster, whi

55 Hybridization with the actI probe from the actinorhodin polyketide synthase genes identified two cl

56 We show that gamma-actinorhodin possesses many of the requisite properties

57 ) and led on further incubation to increased actinorhodin production at high, but not low, cell densi

58 tation had no consistent or marked effect on actinorhodin production in either liquid- or agar-grown

59 Neither gene was essential for actinorhodin production or morphological development in

60 ptionally inactive state before the onset of actinorhodin production with the aim of designing decoy

61 m of gene SCO5812, deletion of which reduced actinorhodin production, confirming that experimental an

62 re efficacious than the others in increasing actinorhodin production.

63 potential repressor binding and so stimulate actinorhodin production.

64 RF4, the pathway-specific activator gene for actinorhodin production.

65 nto Sc bldA mutants restored sporulation and actinorhodin production.

66 on medium deficient in Mg2+ they overproduce actinorhodin, sporulate poorly and form crenellated colo

67 ne transporter and proteins with homology to actinorhodin-tailoring enzymes.