ライフサイエンスコーパス: action

1 dynamics suggesting a distinct mechanism of action.

2 A and leads to complete loss of canonical TH action.

3 h particular emphasis on their mechanisms of action.

4 presumably due to the different mechanism of action.

5 reward is paramount to performing an optimal action.

6 Pase or have poorly understood mechanisms of action.

7 5-HT2A receptors mediate a direct excitatory action.

8 ulation of visibility synchronized with hand action.

9 he blood stream to exert their physiological action.

10 rovide insight into nivolumab's mechanism of action.

11 dies to better define specific mechanisms of action.

12 urvivorship movement that demanded a call to action.

13 itional RIBE factors and their mechanisms of action.

14 ly altered, which indicated reduced androgen action.

15 during a window of limited oral antiplatelet action.

16 ch has both vasoconstrictive and natriuretic actions.

17 fficult to separate from their network-level actions.

18 to select rewarding images but not rewarding actions.

19 ions where choices are associated with motor actions.

20 easing trends of liver cancer for preventive actions.

21 at the uncertainty affects prioritization of actions.

22 metabolism and its use in understanding drug actions.

23 erpolarizing) of postsynaptic GABAA receptor actions.

24 uation to gradually select appropriate motor actions.

25 eness of marine- and land-based conservation actions.

26 of surfing and retraction; or (iv) sweeping actions.

27 als the satisfaction we expect from imminent actions.

28 hdrawal threshold revealed a full preventive action against transient mechanical hypersensitivity in

29 an be sufficiently explained in terms of IE2 action alone.

30 ed the data well, with measures of impulsive action and choice separating into two independent factor

31 11beta-HSD1 shapes endogenous GC action and is immunomodulatory.

32 ey modulator of mitochondrial signaling, its action and molecular basis remain unknown.

33 Here, we investigate their mechanism of action and show that mobile small RNAs generate sharply

34 RI-associated renal injury via mitochondrial actions and could represent a novel therapeutic strategy

35 ed compounds with more complex mechanisms of actions and improved efficacy.

36 ture, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingred

37 nd (c) bridge long-term dependencies between actions and rewards.

38 for maximal pol II pause release through SEC action, and loss of H3K9ac increases the pol II pausing

39 estoration typically the most cost-effective action; and (4) land protection should be prioritised if

40 rations and targeted delivery to the site of action appear possible, and most importantly, recognitio

41 at the parameters of anchored PKA holoenzyme action are much more restricted than originally anticipa

42 fluence on spatial choices when decision and action are temporally close, and that this choice effect

43 rapy, although its efficacy and mechanism of action are unclear.

44 els of adult fibrosis, but the mechanisms of action are unclear.

45 be attenuated when drugs with NHE inhibitory actions are given concomitantly.

46 ctions.SIGNIFICANCE STATEMENT Accurate motor actions are made possible by continuous communication be

47 tes, respectively, which suggests that their actions are mediated mainly by modulation of KCNQ1 pore

48 w rate of vegetation decline; (3) land-based actions are optimal when the ratio of marine ecosystem e

49 orking memory function, with many beneficial actions arising from D1R stimulation.

50 o be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte

51 Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input

52 pressing OFC projection neurons in selecting actions based on their consequences.

53 mly interleaved blocks of stimulus-based and action-based reinforcement learning (RL).

54 imicrobial stewardship standards demonstrate actions being taken at the national level to make qualit

55 eals remarkable conservation in mechanism of action between SVP genes of taxonomically distant plant

56 markedly reduced the capacity for prolactin action both in the MPOA and throughout the network.

57 people do not execute an average of planned actions but rather a single movement that optimizes moto

58 sence of 5-HT1BRs caused increased impulsive action, but not impulsive choice.

59 ignaling, both targets of photomorphogenesis action, but the organ developmental outcomes differ: whi

60 Our compounds displayed a diversity of action by acting either on extracellular M. tb bacterial

61 Remarkably, all these inflammatory actions by activated platelets were abrogated by lack of

62 thout mechanistic data, an endocrine mode of action cannot be determined.

63 particular, it is unknown whether different action categories follow a specific topographical organi

64 itotemporal, and frontal cortex that exhibit action category codes that are similar across viewing of

65 performed a behavioural task in which their action choices were motivated by the potential for eithe

66 series for potency and increased duration of action commensurate with inhaled or topical delivery res

67 by treatment with NitroSynapsin, a new dual-action compound related to the FDA-approved drug memanti

68 ation dictates the neural representations of actions computed in the brain.

69 a situation first presents itself, stimulus-action contingencies and their relative value must be en

70 involves both predictive processes linked to action control, and retrospective 'sense-making' causal

71 Furthermore, similarity between different actions corresponded to the similarity between SPN ensem

72 rves within the pancreas slice, CCK cellular actions directly affected human acinar cells.

73 s, determining DAF-6/patched-related site of action during sensory-organ development.

74 e of reaction times when subjects perform an action (e.g., a reach-to-grasp pantomime) congruent with

75 sing such structures to infer a mechanism of action, especially in the case of membrane receptors whe

76 Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and

77 ent manner, indicating that the mechanism of action for NA in cell migration is evolutionarily conser

78 We also hope that it will be a call to action for the global tuberculosis community to make a s

79 ulates tau acetylation, a novel mechanism of action for this class of compounds.

80 parent confidence in the likely reward of an action, for instance, makes qualities of their evidence,

81 Here we report, at room temperature, lasing action from an optically pumped BIC cavity.

82 ikely the cause of the observed photovoltaic action from photoacid-modified membranes.

83 cidation of the mechanisms underlying folate action has been challenging.

84 The exact mechanism of its action has yet to be determined, but it does appear to h

85 Its detailed mode of action has, however, remained elusive.

86 Several mechanisms of action have been proposed, including thiol depletion and

87 The risk with this action, however, is seizure recurrence.

88 , thereby confirming an earlier mechanism of action hypothesis.

89 of factors involved in their biogenesis and action in Arabidopsis (Arabidopsis thaliana) has been de

90 es may knock down target genes and enrich T3 action in fat and liver.

91 epatic ILK deletion has no effect on insulin action in lean mice but sensitizes the liver to insulin

92 ine, for the 4D profiling of chemoconvulsant action in multiple brain regions.

93 ht-after molecular mechanisms that govern PG action in the cervix.

94 Here, we evaluated the role of prolactin action in the MPOA using complementary genetic strategie

95 determine the role of ILK in hepatic insulin action in vivo, male C57BL/6J ILK(lox/lox) mice were cro

96 ic receptor subtype, ACh exerts two opposing actions in cortical pyramidal neurons: transient inhibit

97 ly, underscoring the importance of household actions in influencing urban watershed nutrient budgets.

98 presence, functional role, and mechanisms of actions in prostate cancer (PCa)-the most common cancer

99 tudy suggests that additionally to its local actions in the AD brain, TNF-alpha can also indirectly m

100 can still show substantial adverse or lethal actions in the brain.

101 insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose tissue

102 uently encountered promiscuous mechanisms of action including inhibition of the QcrB subunit of the c

103 th distinct clinical durations and onsets of action (indacaterol, two indacaterol analogues, salmeter

104 , and this effect was stimulus dependent and action independent.

105 idal factors and the modes and mechanisms of action involved in nematode control by Paenibacillus pol

106 id homeostasis and arterial BP through renal actions involving increased GFR and vascular and tubular

107 Voluntary action is also accompanied by prominent rhythmic activit

108 Cellular specificity of dmd-3 action is ensured by its collaboration with non-sex-spec

109 actors, whereas the sex specificity of dmd-3 action is ensured by the hermaphrodite-specific transcri

110 However, a peripheral site of action is indicated by the ability of intravenous CGRP t

111 rrent paradigm that in vivo physiological TH action is mediated exclusively via regulation of gene tr

112 ut better understanding of this mechanism of action is needed.

113 Swift action is often required in the face of indeterminate se

114 This action is probably due to disengagement of Smc1-Smc3 hea

115 Promoting only participation in collective actions is not effective.

116 nverbal interpersonal coordination, or joint action, is a crucial element of social interaction, but

117 wever, mechanisms by which central serotonin action leads to fat loss remain unknown.

118 engagement in both projections during early action learning suggests potential learning-related in v

119 rstanding mechanistically their differential actions may advance our understanding of nervous system

120 regulation and cellular function, and their actions may be relevant to a variety of human diseases a

121 fication and elucidation of the mechanism of action (MoA) of hits from these noisy high-throughput sc

122 Here, we emphasise that these actions nonetheless represent a significant feature of t

123 report that reduced SMN function impacts the action of a pertinent microRNA and its mRNA target in MN

124 uring terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters i

125 onor splice site mutation, likely due to the action of a putative intronic splicing enhancer present

126 As the mechanism of action of ABMA is restricted to host-endosomal compartme

127 We propose that the primary mechanism of action of acylation is to control membrane curvature and

128 , disrupted glutamate homoeostasis, impaired action of antipsychotics, and development of antipsychot

129 s are protected from the potentially harmful action of apoptotic caspases is largely unknown.

130 The coordinated action of both pathways is required to ensure efficient

131 The therapeutic action of capsaicin treatment in patients with idiopathi

132 Thus, the combined action of CCT chaperonin with that of TRIP13 ATPase prom

133 can expect that the efficiency of protective action of CRISPR-Cas systems against different viruses s

134 aken together, we propose that the concerted action of DDK, Polo-like kinase, and CDK1 promotes effic

135 ocated in the 2nd extracellular loop, in the action of decanoic acid but not of 3,3'-diindolylmethane

136 The mechanism of action of DEXxDSy was assessed.

137 replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofre

138 nings, the dysfunction of CFTR in CF and the action of drugs that repair CFTR gating defects.

139 ious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) .

140 table, and apparently not susceptible to the action of efflux pumps.

141 mics were used to determine the mechanism of action of ER-beta and its ligands.

142 method of the mammary gland where the direct action of estrogens can be tested during embryonic days

143 tidases act first followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpe

144 vative was unexpectedly obtained through the action of Fe(2+) on a dynamic library of imines generate

145 We incorporated sites of action of four drugs (palbociclib, gemcitabine, paclitax

146 l pathway and hence reversing the inhibitory action of Foxp3 on RORgammat activity.

147 te accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its

148 nositide 3-kinase in mediating the metabolic action of glucocorticoids.

149 yte glycoprotein (MOG)35-55 The mechanism of action of GM-CSF in EAE is poorly understood.

150 In contrast, there was very little agonist action of I942 towards EPAC2 or protein kinase A (PKA).

151 n degree, partly explaining the mechanism of action of local hyperthermia to treat viral warts.

152 al neurons and their targets, a key locus of action of many drugs, and highly vulnerable to dysfuncti

153 subunit is highly dynamic in controlling the action of methyl farnesoate through temporal variation i

154 rrectly identified the accepted mechanism of action of nifedipine, a calcium-channel blocker clinical

155 eal the mechanisms underlying the behavioral action of NPS, and present a chain of evidence that the

156 small pseudoislets depends upon the combined action of paracrine factors, such as insulin and somatos

157 study sheds light into the as yet unrevealed action of PFOS on lipid mediators in affecting testicula

158 ly kinase inhibitor PP2, indicating that the action of pilocarpine on endogenous M3R is biased toward

159 action with hydrosilanes under the catalytic action of potassium tert-butoxide alone.

160 ased on these findings, we conclude that the action of PZA is entirely independent of RpsA and trans-

161 ecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activati

162 udy is to discuss the potential mechanism of action of rifaximin, a minimally absorbed antibiotic.

163 activity is controlled by the combinatorial action of several regulatory proteins.

164 ens; however, the identification and mode of action of T6SS effector proteins that mediate this prote

165 and is reabsorbed in the renal tubule by the action of the apical sodium-dependent phosphate transpor

166 extracytoplasmic domains requiring the dual action of the co-translational Sec and post-translationa

167 Action of the exogenous enzyme on the dye results in flu

168 the toroidal moment of the vortex under the action of the field.

169 The proposed mechanism of action of the modifiers includes proton transfer reactio

170 with most damaging agents is reduced by the action of the mucociliary apparatus and by formation of

171 s ubiquitylation of its Mcm7 subunit and the action of the p97 ATPase.

172 mation in neighboring cells by the enzymatic action of the released endolysin.

173 that Mad2 is released from MCC by the joint action of the TRIP13 AAA-ATPase and the Mad2-binding pro

174 us allowing for compensatory and independent action of these circuits.

175 The action of these peptides likely relies on tight coupling

176 ics, which might explain the chemopreventive action of this drug indicating that tag diversity may be

177 her extend it by incorporating the potential action of tRNS.

178 e provide evidence for non-canonical mode of action of Wnt5a and its regulation over genes associated

179 hat species rapidly interconvert through the action of ZDHHC16 and the Acyl Protein Thioesterase APT2

180 To uncover the mechanism of action of ZnO NPs on CT activity, here we used classical

181 Npt2a in alphaKL-null mice supporting direct actions of cKL in the absence of mKL.

182 r nutrient ingestion and is critical for the actions of dipeptidyl peptidase 4 inhibitors that enhanc

183 These depletions identified differential actions of ILP7 and ILP8 in lipid homeostasis and ovaria

184 lly, collective behavior must arise from the actions of individual cells.

185 Here we investigate the antidepressant actions of inhibitors of monoacylglycerol lipase (MAGL),

186 GIRK channels mediate the actions of inhibitory brain neurotransmitters.

187 lamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP

188 aim of the current study was to compare the actions of midazolam and 1-hydroxymidazolam on network a

189 n both humans and songbirds is linked to the actions of sex steroid hormones during ontogeny but also

190 We hypothesized that cell-specific actions of Smad3 regulate repair and remodeling in the i

191 HCV subverts the antiviral actions of these miRNAs by dampening their expression in

192 in the RvT pathway, reversed the protective actions of these statins on both joint and systemic infl

193 tely, but WGS may prompt additional clinical actions of unclear value.

194 using siRNA restored fluticasone repressive action on chemokine production and its ability to induce

195 egradation as an important target of insulin action on glucose homeostasis.

196 tochondrial biogenesis primarily through its action on Nrf2, and is the first drug demonstrated to in

197 Moreover, in contrast to their action on other known carbohydrates, both KCl and NaCl a

198 al lesions as long as the toxins exert their action on the epithelium.

199 Given its selective action on the omega1 subtype of the gamma-aminobutyric a

200 Because of its inhibitory action on the reproductive axis in other vertebrates, we

201 ry was demonstrated to be by both the direct action on virus particles and the interference on the ho

202 lopes, suggesting that the isoboles for drug actions on ion channel function are not linear.

203 types distinguish themselves by differential actions on lipid and glucose homeostasis.

204 raventricular nucleus (PVN) are mediated via actions on local OXT neurons in male Wistar rats.

205 oral effects of drugs of abuse through their actions on the mesocorticolimbic system.

206 ee independent and synergistic mechanisms of action, only one of which requires d-Ala-d-Ala/d-Ala-d-L

207 ng a different aspect of recognizing others' actions or emotions from body cues.

208 focus on a complex task and inhibit unwanted actions or interfering information (i.e., inhibitory con

209 atterns, post-perturbation completion of the action, or their performance in a reward-based learning

210 ogen-induced scratching may involve sites of action other than the primary afferent terminals.

211 We find that the inhibitor fasudil enhances action-outcome memory, resulting in goal-directed behavi

212 In tasks involving the recognition of actions, patients showed a general increase in reaction

213 s show that the dPul plays a primary role in action planning as opposed to visual processing, that it

214 Facilitated action potential (AP) generation, measured as higher fir

215 or function scores (MFS) and compound muscle action potential (CMAP) decreased rapidly in SMA infants

216 p, GTx (i) had almost no effect on the first action potential but markedly slowed repolarization of l

217 In the presence of ouabain, the action potential collapses.

218 dium currents leading to prolongation of the action potential duration and an increased propensity to

219 uisitely sensitive to the temporal nature of action potential firing patterns.

220 stently exhibit reduced input resistance and action potential firing.

221 ntly decreased the reliability of the second action potential in each burst of activity.

222 d with CA1 PNs, which is sufficient to drive action potential output from CA2 but not CA1.

223 th L-type Ca(2+) channel activity during the action potential plateau, as well as by the increase of

224 ld inhibit further Ca(2+) release during the action potential plateau.

225 oltage-activated potassium currents near the action potential threshold as well as by enhanced recrui

226 f excitatory post synaptic currents near the action potential threshold.

227 ynaptic potentiation induced by postsynaptic action potential trains.

228 aintained by a positive feedback between the action potential upstroke and SCR.

229 ng of the fast initiation and propagation of action potential within single neurons, and validate the

230 gy, i.e. how K(+) currents shape the cardiac action potential, and how their dysfunction can lead to

231 within the EC and in this way, constrain non-action potential-dependent and action potential-dependen

232 constrain non-action potential-dependent and action potential-dependent spontaneous release as well a

233 ortant for the repolarization of the cardiac action potential.

234 uroscience is understanding how sequences of action potentials ("spikes") encode information about se

235 These action potentials (APs) cause rapid closure of the trap

236 We found that back-propagating action potentials (bpAPs) could elicit Ca(2+) release fr

237 projecting PRL (PRL5/6) neurons fired fewer action potentials and this was associated with increased

238 In fmr1(-/y) L2/3 neurons, action potentials are taller, faster and narrower.

239 sults demonstrate a delay in transmission of action potentials by the ganglion cells in regular canna

240 In addition, action potentials in fmr1(-/y) neurons were significantl

241 rrent-clamp revealed GnRH neurons fired more action potentials in response to current injection durin

242 polarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular neurons re

243 hyperpolarized, or by postsynaptic trains of action potentials in the absence of presynaptic stimulat

244 The excitatory events that trigger myotonic action potentials in the absence of stabilizing ClC-1 cu

245 ular level, the occurrence of irregular-type action potentials of PMCA1(cko) atrial myocytes increase

246 Although action potentials propagate along axons in an all-or-non

247 Action potentials, taking place over milliseconds, are t

248 ical properties and the ability to propagate action potentials.

249 um after-hyperpolarizations; (iv) broadening action potentials; and (v) reducing spike clustering.

250 ochastic system, we use the stochastic least-action principle to derive the entropy production and it

251 ct monkeys shifted their choice to whichever action produced the higher-value food; monkeys with cros

252 theoretical models of how the brain selects actions, regulates movement initiation and execution, an

253 However, its mechanisms of action remain poorly understood.

254 heir two C2 domains, but their mechanisms of action remain unclear.

255 dopamine reuptake, the specific mechanism of action remains obscure.

256 signaling pathway, although its mechanism of action remains unclear.

257 metastatic melanoma, yet their mechanism of action remains unclear.

258 ever, the specific antipruritic mechanism of action remains unclear.

259 types of human cancer, but the basis for its actions remains obscure.

260 the relevance of this to pharmacotherapeutic actions remains unresolved.

261 ales) whether the visuomotor object-directed action representation system that includes left-hemisphe

262 ment of the value of items available and the actions required to obtain them.

263 ppocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherw

264 e that nigrostriatal dopamine biases ongoing action selection.

265 within the striatum is integral to efficient action-selection during foraging.SIGNIFICANCE STATEMENT

266 ically in learning the value of stimuli, not actions.SIGNIFICANCE STATEMENT Reinforcement learning mo

267 ing the early receptor current amplitude and action spectra between WT and the Opn4-expressing Drosop

268 memory effect is further supported by IR-MS action spectroscopy and ab initio calculations.

269 ionization mass spectrometry, absorption and action spectroscopy in the UV and IR regions, and microw

270 Concordance of the course of action, strength of recommendation, and quality of evide

271 ng contributions to SAR development, mode of action studies, and eventually medicinal chemistry.

272 direct human modification of streams through actions such as water abstraction is likely to further e

273 New drugs with novel mechanisms of action, such as cardiac myosin activators, are under inv

274 be highly sensitive to androgen-regulated AR action, such as NOV and ST6GalNAc1, were markedly altere

275 ay-based initial studies on the mechanism of action suggest that compound 8 blocks translation.

276 Mensacarcin's unique mode of action suggests that it may be a useful probe for examin

277 ed with other animals, to make decisions for action that are related to future goals, or at least fre

278 d, in our preparation, prioritize courses of action that lead to greater rewards.

279 minance motives that underpin ideologies and actions that ultimately sustain group-based hierarchy.

280 the Ebola epidemic, I recommend four sets of actions that would make the humanitarian system relevant

281 OP-r selectivity, extremely long duration of action) that limit translation to human studies.

282 ease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of

283 ucators to acknowledge inequalities and take action to address them.

284 e gain spectrum curve) and switch the lasing action to another mode.

285 ), which can directly and globally modify ER action to attenuate tumor growth.

286 clamp, reaffirming that the site of insulin action to control EGP is extrahepatic.

287 ing and tracking combined with a therapeutic action to different diseases sites and organs).

288 modulators offer an alternative mechanism of action to traditional alpha1-adrenergic ligands, yet the

289 ines, and fundamentally different management actions to restore populations.

290 strategies by which animals execute precise actions using sparse motor networks, we imaged the activ

291 ng in parallel with a system for more direct action-value learning.

292 RL models-namely, "actor/critic" models and action-value-learning models (e.g., the Q-learning model

293 Dopamine neuron synaptic actions vary across the striatum, involving variations n

294 This inhibitory action was not associated with overt circadian rhythmici

295 Eu(3+)'s and Sm(3+)'s action was tested on single RyR1 channels reconstituted

296 r those that did, the recommended courses of action were 98.2% concordant.

297 easing hormone (GHRH) and their mechanism of action were investigated in diabetic retinopathy (DR).

298 ated in vitro and in vivo, and mechanisms of action were suggested.

299 rcumstance in rats by designing a task where actions were consistently rewarded but probabilistically

300 cked the effects of exogenous 2-AG and their actions were prevented by inhibiting the 2-AG-synthesizi