ライフサイエンスコーパス: action

1 of plasma (AIP) suggesting its hypolipidemic action.

2 ing efficacy and minimal insulin sensitizing action.

3 nsport CQ away from its site of antimalarial action.

4 remain poorly defined in their mechanism of action.

5 targets and antibiotics with novel modes of action.

6 g transcript levels associated with glucagon action.

7 rstanding of sHSP structure and mechanism of action.

8 ze knowledge from the past to support future action.

9 ng that BCH070 acts via a novel mechanism of action.

10 ctually accomplish to support perception and action.

11 ge, including insecticides with new modes of action.

12 otein-1, suggesting a paracrine mechanism of action.

13 ld, was obtained from the principle of least action.

14 ot being met despite decades of conservation action.

15 multiple probabilistic outcomes of the same action.

16 hemozoin formation as a contributing mode of action.

17 lies, significantly expanding their scope of action.

18 of biological components regulating stomatal action.

19 the hydrophilic molecules to their sites of action.

20 tling with the urge to commit a non-rational action.

21 scale of online social interaction and joint action.

22 lasses of drugs with different mechanisms of action.

23 minimal impact on the recommended courses of action.

24 wn recent actions, and the outcomes of those actions.

25 raded changes without bursting near specific actions.

26 erns of movements with inferred common goals-actions.

27 our but rather carry information about prior actions.

28 te of aryl sulfonamides may have synergistic actions.

29 refer to people's explanations for their own actions.

30 nisms for the implementation of conservation actions.

31 ucoma therapies with durable and predictable actions.

32 n be beneficial based on their mechanisms of actions.

33 ctive injury response, modifying immune cell actions.

34 he acceptance of conservation and management actions.

35 ensive functions and excessive tissue damage actions.

36 s blocks in which they learned the values of actions.

37 thout comparisons across a range of possible actions.

38 ole in predicting future states given chosen actions.

39 ould rely on observing outcomes, rather than actions.

40 in myelin regeneration, including integrated actions across the oligodendrocyte and astroglial compar

41 th nematode ACC is a new nematicidal mode of action addressed by SPT, a well-known systemic insectici

42 ision (6); III) Influence the manual ongoing action: adjust (7), or stop the resident's manual activi

43 papaverine, a vasodilator, shows inhibitory action against various strains of influenza virus as wel

44 cted to be beneficial based on their mode of action and effects in wild-type or in other neurodegener

45 host parameters and to elucidate the mode of action and efficacy of REP 2139-Ca against HDV in 12 tre

46 mponents that can identify drug mechanism of action and enable prediction of long-term cell viability

47 employed to increase its stability, localise action and reduce dosage.

48 ur understanding of antibiotic mechanisms of action and resistance at inhibitory concentrations in th

49 tructure-activity relationship, mechanism of action and some research gaps has also been provided.

50 However, their precise mechanism of action and their physiological importance are still elus

51 se learning by learning associations between actions and egocentric representations of landmarks; and

52 ctions between local people and conservation actions and how to promote synergies between them.

53 s, further prompts to incorporate PKC family actions and interventions in this ecosystem, informed by

54 OVID-19 and explained possible mechanisms of actions and the therapeutic effects.

55 harms, which is seen as an inherently unfair action, and equality, which is a basic fairness principl

56 breast cancer cells, define its mechanism of action, and explore the therapeutic potential of unacyla

57 t regarding (2R,6R)-HNK's acute mechanism of action, and may inform novel antidepressant drug mechani

58 xpression underlies EPZ-6438 antitumorigenic action, and provide preclinical proof-of-principle evide

59 rn models that are parsimonious, tailored to action, and which avoid bad bootstraps and sub-optimal c

60 ces are accessing longer time scales, larger actions, and blind testing, enabling more of biology's s

61 nowledge, taking 15 small transplant-related actions, and pursuing transplant (waitlisting or LDKT ra

62 disease, potential diagnostic and preventive actions, and recommendations for prophylaxis and treatme

63 ning, i.e., simple reinforcement of rewarded actions, and the other is model-based learning, which co

64 d, the timing of the individual's own recent actions, and the outcomes of those actions.

65 drugs that target the generation (ACEIs) and actions (ARBs) of Ang II.

66 however, the mechanisms and tissue sites of action are incompletely defined.

67 he key role played by PZA, its mechanisms of action are not yet fully understood.

68 Human actions are causing concurrent shifts in CO(2) , tempera

69 These two actions are known to alternate during tick engorgement.

70 Actions are needed to limit the incidence of, and to eff

71 is highlights that the ability to learn what actions are prosocial and choosing to perform helpful ac

72 The sensory consequences of our actions are thought to be predicted via sensorimotor int

73 Conservation actions are urgently needed to improve the status of fre

74 s not appear to translate to peoples' health actions, as MFW appears to have an inconsistent effect o

75 addiction, related to impaired goal-directed actions, as well as countervailing resilience systems im

76 the target mRNA than expected by independent action at each site.

77 esults support an autocrine mode of d-serine action at synapses.

78 in extracellular fluid, potentially enabling action at the cell surface.

79 s of time to decide when to initiate a given action at the end of an interval.

80 sm of these drugs can be attributed to their actions at ryanodine receptors.

81 injury and provides insight into its mode of action beyond a basic antibiotic.

82 This action buries ionic side chains away from the bulk water

83 detailed understanding of their mechanism of actions but also guides the design and selection of drug

84 frontal cortex has been linked to voluntary action, but an explanation of why decisions to act emerg

85 predictions of the specific consequences of actions, but how these are implemented in the brain is p

86 Thus, TMR in human sleep transcends global action by selectively promoting specific memories associ

87 We will discuss the modes of action by those drugs including inducing innate sensing

88 ession that result in distinct physiological actions by 1,25(OH)(2)D, which are disrupted by mutation

89 take inhibitors (SSRIs), initiate their drug actions by rapid elevation of serotonin, but they take s

90 For example, a learned sequence of words or actions can follow a common rule, which determines their

91 ling suggests that climate change mitigation actions can have substantial human health benefits that

92 to environmental cues to specifically shape action control.

93 describing their discovery and mechanism of action, coupled with emerging clinical data from patient

94 the body influence motivational feelings and action decisions.

95 by increasing the expression of genes whose action diminishes the efficacy of anti-cancer drugs.

96 tally shape the experience of watching joint actions, directly influencing how beautiful and enjoyabl

97 A DA neurons simultaneously encoded multiple actions (e.g., movement velocity, acceleration, distance

98 population code that allowed us to classify action exemplars irrespective of the visual format.

99 r results describe an oncogenic mechanism of action for ACVR1 mutations, and suggest therapeutic stra

100 Adults from the Look AHEAD trial (Action for Health in Diabetes) without prevalent HF were

101 One management action for reducing extinction risk is translocation of

102 a problem of dynamically coordinating their actions for achieving a joint goal.

103 the adjusted hazard rate for loss-of-license actions for surgeons who failed their first recertificat

104 They guide our future actions, form a scaffold for constructing the self, and

105 200 years ago, the molecular basis of opioid action has remained the subject of intense inquiry.

106 tion is essential for the execution of motor actions; however, the molecular mechanisms that give ris

107 iscriminate analytes with different modes of action (i.e. CdCl(2) toxicity versus ion pump inhibition

108 vels (BLLs) from drinking water Pb reduction actions (i.e., combinations of lead service lines [LSL]

109 sampled from a central spout with different actions (i.e., licking either a left or a right spout).

110 We filtered naturalistic action images to contain only LSF or HSF and measured be

111 By coupling light to therapeutic action, improved spatial and temporal selectivity can be

112 Insulin action in adipose tissue is crucial for whole-body gluco

113 h simulations, bepridil's more proarrhythmic action in adult cardiomyocytes compared to hiPSC-CMs cou

114 to serve as a feedback regulator of insulin action in control of liver metabolism.

115 (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome

116 data on domatinostat's efficacy and mode of action in MCC.

117 nto its cooperative interactions and mode of action in regulating cholesterogenesis.

118 h their secretion from islet cells and their action in the liver.

119 and indirectly hint at an IVIg mechanism of action in treating autoimmune diseases and allosensitiza

120 We present a model for UVR8 action in UV-B-acclimated plants growing in photoperiodi

121 However, the coupling of sounds and actions in nonhuman primates (and the availability of an

122 played anti-inflammatory and neuroprotective actions in rodent models of status epilepticus.

123 successfully traverse the space of possible actions in social situations, and the potential interven

124 further compelling evidence that these multi-action inhibitors are efficacious and more potent than s

125 This is surprising because antibiotic action involves many additional effects downstream of dr

126 use of insecticides with different modes of action is considered for resistance management.

127 f the aquaporin-2 (AQP2) water channel. This action is widely accepted to be associated with cAMP-med

128 sire is translated into the decision that an action is worth taking at any particular point in time i

129 ify conditions that might require management actions is quite high and, in many respects, represents

130 co-localize, and be explained by simple mass action kinetics, and more likely to contain proteins wit

131 sts: Those who receive incentives view their actions less positively due to the perceived incompatibi

132 ts of the visuomotor system guide daily hand actions, like reaching for and grasping objects.

133 we propose that beat anticipation relies on action-like processes consisting of precisely patterned

134 organismal metabolism by controlling insulin action, lipolysis, and mitochondrial respiration to cont

135 The velocity of actions made in response to cues prospectively triggered

136 useful, for example, when multiple stimulus-action mappings must be retained and used.SIGNIFICANCE S

137 The mechanism of action may be through compound binding to A kinase ancho

138 The action mechanisms revealed by the biochemical and struct

139 s acting in various organs through different action mechanisms.

140 rn and consider the harmful consequences our actions might have for others.

141 sible responses to the COVID-19 pandemic: no action, mitigation for 6 months, suppression for 2 month

142 Understanding the mechanism of action (MOA) of bioactive chemicals in terms of targeted

143 therapeutic compounds with unknown modes of action (MoAs), and the resulting uncertainties can lead

144 Interestingly, these predictive action models were used comparably at a sensorimotor lev

145 ebate about the efficacy and mechanism(s) of action of "TTFields" by better isolating the effects of

146 becomes further dysbiotic by the synergistic action of bacterial communities.

147 The scale and mechanism of antidepressant action of BoNT is unclear and maybe hypothetically attri

148 w that isothiocyanate formation requires the action of BT2158 and either BT2156 or BT2157 in vitro.

149 m Synechocystis sp. PCC6803 to elucidate the action of Ca(2+) and peripheral proteins.

150 and understanding the precise mechanisms of action of cancer-related proteins and their diverse role

151 sducers of signals from GPCRs, mediating the action of countless natural stimuli and therapeutic agen

152 ese molecules are rapidly inactivated by the action of dipeptidyl peptidase IV (DPP-4) which limits t

153 ming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way.

154 ific role of Pole in DNA replication and the action of extrinsic correction systems that remove Pole

155 n and DNA damage that may be mediated by the action of HDAC and PP1CC, respectively.

156 resistance is mediated, in part, through the action of IL-17A, IL-17F, and IL-17AF heterodimer throug

157 in guinea pigs, as well as investigating the action of IRL201104 on human cells in vitro.

158 Understanding the mechanism of action of methotrexate could be instructive in the appro

159 k in which filament sliding is driven by the action of motor proteins.

160 situation similar, but not identical, to the action of NAE endocannabinoids in animal systems.

161 tion-associated noise trends implicating the action of natural selection.

162 ssential genes, which is consistent with the action of negative selection.

163 eractions captured uncover the early mode-of-action of NIN-LIKE PROTEIN 7 (NLP7), a master regulator

164 al a key role and an epigenetic mechanism of action of NONO in regulation of TET1-targeted neuronal g

165 jacent loci and safeguard the specificity of action of promoters and enhancers towards their targets

166 ly, we found that the simulated mechanism of action of RUTI and INH are in good alignment with the re

167 thesis and investigation of the mechanism of action of some bis(styryl)pyrazoles, demonstrating their

168 ia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the e

169 d, which was induced by an unusual predatory action of the capsule on specific imine constituents.

170 s study aimed to investigate the myorelaxant action of the Dysphania ambrosioides essential oil (EODa

171 nderstanding of the structure and mechanical action of the NER machinery.

172 ver, little is known about the exact mode of action of the serotonin metabolite and the possible inte

173 Here we investigate the mode-of-action of the small, rationally designed synthetic antif

174 tics have provided insight into the modes of action of these drugs on the GABA(A) receptor.

175 , studies on the regulation and mechanism of action of these lncRNAs are in their infancy.

176 Understanding the mode of action of these non-protein regulators has been an inten

177 s evaluated, which clearly showed a synergic action of TMZ and GEM.

178 This decrease is due to acute and reversible action of TNF-alpha and is not associated with increased

179 D receptor (VDR) that mediates the cellular actions of 1,25(OH)(2)D.

180 electively protecting against the pathologic actions of Abeta in AD.SIGNIFICANCE STATEMENT Elevated l

181 Although extravascular actions of AngII have been suggested, a direct effect of

182 The authors determined the actions of both RvE1 and RvD1 on LTB4-induced responses

183 DEI was ignited by synergistic actions of constructing nanoheterojunctions and creating

184 We assessed actions of fibroblast growth factor receptor (FGFR) 2 in

185 an, or value so much as, my knowledge of the actions of great people, acquired by long experience in

186 key NMDAR subunit, GluN2B, implicated in the actions of ketamine.

187 learned about the mechanisms describing the actions of lenabasum.

188 l signaling that underlie the antidepressant actions of NMDAR-positive modulation vs. NMDAR blockade.

189 The actions of norepinephrine are profoundly altered by recr

190 he current work we show that the profibrotic actions of TGF-beta are mediated, at least in part, thro

191 This suggests that the collective actions of the Australian public and government authorit

192 specific and physiologically relevant tissue actions of TRPV4, stretch-independent responses, and und

193 4+ T cells themselves, but not through their action on CD8+ T cells or APC.

194 h defect according to the European Concerted Action on Congenital Anomalies and Twins (EUROCAT) class

195 at hepatic steatosis might impair glucagon's action on hepatic amino acid metabolism and lead to hype

196 Delayed or lack of action on implementation would push back the timeline to

197 the possible physiological importance of GH action on PVH neurons.

198 ssible that coronavirus has an idiosyncratic action on receptors involved in chemosensitivity to oxyg

199 uoxetine restores the efficacy of fluoxetine actions on D1 receptor expression and behavioral respons

200 nxiety and depression-like behaviors through actions on mitochondrial and MSN structure and function.

201 population representations of targeted motor actions on single trials, we developed an optical method

202 ulations in goals and kinematics of observed actions on the brain response, but little research has e

203 fetal anthropometry could result from direct actions on the fetus and/or placenta.

204 One approach to learning action-oriented models is to learn online in the presenc

205 as may be adaptive for efficient learning of action-outcome contingencies, above and beyond fostering

206 resented in VR influence the body schema and action performance.

207 scientific literature and formulation of an action plan to address the issue from different perspect

208 rough parietal multisensory areas to frontal action planning areas.

209 lysis, (iii) constructive feedback, and (iv) action planning.

210 nding organisations to develop and implement action plans for prevention, health care, and research t

211 initiated brushing habits, and the types of actions post-brushing.

212 Atrial action potential (AP) morphology was altered in Akita mi

213 several electrophysiological changes such as action potential (AP) prolongation (~50%), reduced L-typ

214 of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca(2+) signals.

215 ed hearts, there were no differences in mean action potential duration (APD(80)) between groups; howe

216 sodium channel expression, I(Na) and atrial action potential duration were reduced and potassium cha

217 AF burden, restored I(Na), I(Ca,L), I(Kur), action potential duration, and reversed atrial fibrosis

218 We have demonstrated that shortened action potential duration, slow conduction and triggered

219 hat activation of OXTRs in the CeL increased action potential firing frequency recorded from neurons

220 C14 decreases outward currents and increases action potential firing in hippocampal neurons.

221 ht into the mechanism that produces rhythmic action potential firing in SCN.

222 Circadian oscillations in spontaneous action potential firing in the suprachiasmatic nucleus (

223 alcium responses have the capacity to encode action potential frequency and number in all compartment

224 ver, siRNA knockdown did not directly affect action potential morphology.

225 equency and number in all compartments, with action potential number being preferentially encoded.

226 ion component of spikelets (a synapse-evoked action potential passively propagating from electrically

227 5 inhibitor olomoucine affected the compound action potential recorded in the spinal nerves, as well

228 cal neurons from both patients had prolonged action potential repolarization.

229 during the repolarization phase of a cardiac action potential that can trigger fatal ventricular arrh

230 ecreased the current required to generate an action potential through PAR(2) Inhibitors of adenylyl c

231 calcium ion flux indicating occurrence of an action potential, this paper demonstrates that an applic

232 ted ion channels involved in the ventricular action potential.

233 on and physiologic shortening of the cardiac action potential.

234 ke neural Ca(2+) events were consistent with action-potential-independent spontaneous glutamate relea

235 STATEMENT Auditory information is encoded by action potentials (APs) phase-locked to sound frequency

236 s, immature OHCs elicited spontaneous Ca(2+) action potentials (APs), but only during the first few p

237 ase their content independent of presynaptic action potentials (APs).

238 hannels effectively measure the frequency of action potentials and convert it into Na(+) current avai

239 The duration of the action potentials and the QT interval were significantly

240 Action potentials are a key component of neuronal commun

241 c nerves, but causes transient activation of action potentials at the onset of the blocking current.

242 Ex vivo, single action potentials evoked alkalinizing pH transients of o

243 Action potentials propagate through long axons to their

244 quires axons not only to faithfully transfer action potentials to distant synaptic regions but also t

245 cell types that are not expected to support action potentials, but definitive data were lacking.

246 seizure, while penumbral tissue shows stable action potentials, in keeping with the "dual territory"

247 With bursts of action potentials, we found that calcium responses have

248 scale, enabling the resolution of individual action potentials.

249 reement is intended to solve this collective action problem, but is likely insufficient.

250 EU Marie Sklodowska-Curie Actions programme.

251 ons included the Triple A (Adolescent Asthma Action) programme and a peer-led camp based on the Power

252 l processes are based on interfacial protein action, ranging from cellular communication to immune re

253 seen as a dynamic feedback loop that couples action, reaction, and internal cognitive processes acros

254 ous plantar sensation can be used to acquire action-related information during challenging locomotor

255 anterograde tracing, we show that the motor-action-related topographical organization of the striatu

256 However, their structures and mechanisms of action remain unclear, hampering drug development.

257 ver, the mechanisms of these tissue-specific actions remain unclear.

258 as recently discovered, but its mechanism of action remains poorly understood.

259 hastening modifier signal whose mechanism of action remains uncertain but does not involve an amino a

260 as up to 15% and 60% of total transglucanase action, respectively, and peaked in aging, strengthening

261 Because the combination of these actions results in Grp1 being recruited preferentially t

262 Adaptive behavior is influenced by prepotent action-reward and inaction-avoid loss Pavlovian biases.

263 o 2050, to identify endogenously the control actions, sectors, and locations that most cost-effective

264 stic environment and develop models of their action selection across exploration and hunting.

265 uggest that gaze dynamics play a key role in action selection during challenging visuomotor behaviors

266 interactions with brain-wide activity drive action selection is less understood.

267 secting umbrellas including decision-making, action selection, perceptual categorization, and attenti

268 pects of the mechanism-that is, its critical action site and relationship with geometry.

269 spectrometry, deuterium labeling, and UV/Vis action spectroscopy.

270 tubule nucleation pathways and their mode of action still need to be identified.

271 al cascade supports a physiological model of action-stopping, and partitions it into subprocesses tha

272 lymeric arabinoxylan while their synergistic actions successfully modified its structure reflecting i

273 cooperativity between proteins enables fast actions, supra-linear responses, and long-lasting molecu

274 LPS, our data reveal a distinct mode of LPS action that, through the disruption of the early coordin

275 environment are often critical for selecting actions that achieve desired goals.

276 e citizens, employees, and customers to take actions that are good for them or for society (e.g., ene

277 Cooperation in Science and Technology (COST) Actions that can help facilitate inter-, multi-, and tra

278 n agent behaves rationally-that is, it takes actions that optimize its subjective reward according to

279 tibiotics have many different 'mechanisms of action' that converge to irreversible lethal effects.

280 example, physics has the Principle of Least Action; the Principle of Minimum Power Dissipation, also

281 TIR) domain exerts its pro-neurodegenerative action through NADase activity(9,10).

282 translocation of UBQLN2, may facilitate its action to clear intranuclear, aggregated disease protein

283 uestion of how these motors coordinate their action to ensure smooth and fast transport along the fla

284 lin response to offset the defect in insulin action to maintain normal glucose tolerance.

285 whereas instructive stimuli inform about the action to perform.

286 ailed understanding of contribution of motor actions to sensing is needed to understand even seemingl

287 r the ways humans engage in social epistemic actions, to guide each other's attention, prediction, an

288 s have the potential to drive more ambitious action toward climate targets than governments, thus dri

289 The intervention consisted of 4 key actions: training of health care professionals on nutrit

290 Two modes of action underlie these effects.

291 egocentric representations of landmarks; and action values from either system are weighted by the rel

292 oups, mainly according to their mechanism of action: VEGF inhibitors or anti-angiogenic agents, EGFR

293 unds (H(2)S(n)), that exert their biological actions via cysteine S-sulfhydration of target proteins.

294 re examined in vitro, and their mechanism of action was preliminarily investigated.

295 plant cell walls and showed that CXE and MXE action was up to 15% and 60% of total transglucanase act

296 rming in-depth analysis of its mechanisms of action, we showed that this miRNA specifically inhibits

297 ological agents with different mechanisms of action, which could help guide clinical decision making

298 reward circuitry in ketamine's mechanism of action, which may be particularly relevant for understan

299 ffolding and concentrating it at its site of action while maintaining it in an "off" state until the

300 he cmA as a common denominator of anxiolytic action, with only OXT inducing large-scale connectivity