ライフサイエンスコーパス: action potential

1 ted by L-type Ca channel openings during the action potential.

2 pening resulting in the initial phase of the action potential.

3 can occur spontaneously or in response to an action potential.

4 of the sound-evoked auditory nerve compound action potential.

5 duce membrane depolarization and initiate an action potential.

6 cellular stores after the end of a preceding action potential.

7 ium current IKS that repolarizes the cardiac action potential.

8 ortant for the repolarization of the cardiac action potential.

9 here a single EPSP (quantum) can generate an action potential.

10 controls the repolarization phase of cardiac action potentials.

11 ere decomposed into discharges of motor unit action potentials.

12 d can lead to the unidirectional transfer of action potentials.

13 cytes and are responsible for shaping atrial action potentials.

14 ing frequency in human DRGs with spontaneous action potentials.

15 eshold potentials or during Ca(2+)-dependent action potentials.

16 synapse formation, and proper propagation of action potentials.

17 ellular Ca(2+) increase following a burst of action potentials.

18 voltage depolarizations, similar to metazoan action potentials.

19 g synaptic depolarization near threshold for action potentials.

20 g membrane potential required for generating action potentials.

21 ed current sink to depolarize Vm and trigger action potentials.

22 ccurs, allowing fast saltatory conduction of action potentials.

23 odes and exhibit noisy periodic sequences of action potentials.

24 ent (ICa) at subthreshold potentials between action potentials.

25 l population activity that is not evident in action potentials.

26 rdepolarization (AfD) that triggers myotonic action potentials.

27 timulation, enabling the sustained firing of action potentials.

28 myocytes and responsible for shaping atrial action potentials.

29 es of contractions, is controlled by cardiac action potentials.

30 primary cultures fired spontaneous bursts of action potentials.

31 ical properties and the ability to propagate action potentials.

32 myocytes display (1) significantly prolonged action potentials, (2) disrupted Ca(2+) cycling properti

33 has been proposed to be the main trigger for action potential activity in immature sensory inner hair

34 wavefront and is absent interictally or from action potential activity outside the wavefront territor

35 sting depolarizing potentials with bursts of action potentials after synaptic stimulation.

36 CNS) is required for saltatory conduction of action potentials along neuronal axons.

37 ckers of electroneutral Na(+) movement), the action potential amplitude consistently falls.

38 ns at action potential properties, including action potential amplitude in Kcnq2-null neurons.

39 cnq2 ablation unexpectedly leads to a larger action potential amplitude.

40 action potentials and [Ca(2+)]i transients, action potential and [Ca(2+)]i alternans, and bursting b

41 riness might release Ca(2+) later during the action potential and alter the cell-wide Ca(2+) transien

42 f ionic currents can destabilize the cardiac action potential and potentially trigger lethal cardiac

43 The effects of the mutations on human atrial action potential and rate dependence were investigated a

44 ical observations recapitulated the elevated action potential and repetitive firing phenotype.

45 ed rectifier is better able to stabilize the action potential and suppress pro-arrhythmic events than

46 They include normal action potentials and [Ca(2+)]i transients, action poten

47 Moreover, SK channels were activated by action potentials and affected the spike afterhyperpolar

48 ccurs on many levels, from the generation of action potentials and dendritic integration, to neuropep

49 l segment (AIS) is the site of initiation of action potentials and influences action potential wavefo

50 lance between excitatory inputs that trigger action potentials and inhibitory inputs that promote a s

51 We find that bursts of action potentials and local neuropeptide signals are bot

52 otropin-releasing hormone (GnRH) neurons via action potentials and neuromodulators.

53 mination showed severely low compound muscle action potentials and presynaptic impairment.

54 ed fast Ca(2+) buffering strength, shortened action potentials and reduced L-type Ca(2+) current cont

55 hat CaMPARI is effectively converted by both action potentials and subthreshold synaptic inputs, and

56 projecting PRL (PRL5/6) neurons fired fewer action potentials and this was associated with increased

57 e critical for the repolarization of cardiac action potentials and tune-spike frequency adaptation in

58 The effects of different data types (action potentials and unipolar or bipolar electrograms)

59 gy, i.e. how K(+) currents shape the cardiac action potential, and how their dysfunction can lead to

60 concentrations of odorants with barrages of action potentials, and their terminals have an extraordi

61 um after-hyperpolarizations; (iv) broadening action potentials; and (v) reducing spike clustering.

62 cause excessive prolongation of the cardiac action potential (AP) and lead to the development of ear

63 o the axon initial segment, which suppressed action potential (AP) excitability, particularly when AP

64 Measurement of action potential (AP) firing in Scn8a(N1768D/+) pyramida

65 Here, we provide strong evidence that during action potential (AP) firing, nerve terminals rely on th

66 orated into a model of the human ventricular action potential (AP) for investigation of QT interval c

67 Facilitated action potential (AP) generation, measured as higher fir

68 The shape of the presynaptic action potential (AP) has a strong impact on neurotransm

69 orrelated with altered Ca(2)(+)-handling and action potential (AP) prolongation.

70 Action potential (AP) shape is a key determinant of cell

71 In healthy mammalian hearts the action potential (AP) waveform initiates and modulates e

72 Action potential (AP)-induced Ca(2+) entry activates Ca(

73 contributes to repolarization of the cardiac action potential (AP).

74 detail and currently available mathematical action-potential (AP) models do not take into account ex

75 g the time relationship between postsynaptic action potentials (APs) and EPSPs.

76 of auditory brainstem circuits is guided by action potentials (APs) arising from the inner hair cell

77 These action potentials (APs) cause rapid closure of the trap

78 We optically mapped action potentials (APs) in excised rabbit hearts to test

79 rons.SIGNIFICANCE STATEMENT In most neurons, action potentials (APs) initiate in the axosomatic regio

80 and distant cells, and the time it takes for action potentials (APs) to reach their targets governs t

81 ines and can be activated by backpropagating action potentials (APs).

82 age-gated sodium channels (VGSC) would evoke action potentials (APs).

83 ac pacemaker cells by generating spontaneous action potentials (APs).

84 onal processes specialized for conduction of action potentials (APs).

85 , although the factors that control cellular action potentials are incompletely understood.

86 These action potentials are initiated and propagated by a sing

87 In fmr1(-/y) L2/3 neurons, action potentials are taller, faster and narrower.

88 C fibers conduct successive action potentials at progressively slower speeds, but th

89 We found that back-propagating action potentials (bpAPs) could elicit Ca(2+) release fr

90 ic Kv1-family potassium channels, leading to action potential broadening and increased calcium influx

91 d of multiple peaks, probably resulting from action potential bursts in single collaterals and variab

92 p, GTx (i) had almost no effect on the first action potential but markedly slowed repolarization of l

93 ctrically stimulated with the same number of action potentials, but with different inter-burst interv

94 sic outward rectification near threshold for action potentials by activation of voltage and Ca(2+) ga

95 sults demonstrate a delay in transmission of action potentials by the ganglion cells in regular canna

96 effects of TTX on C-fiber-mediated compound action potentials (C-CAPs) of proximal and distal periph

97 : Purkinje cells (PCs) generate two types of action potentials, called simple and complex spikes (SSs

98 ion and repolarization phases of the cardiac action potential can exhibit distinct time- and voltage-

99 Synaptic activity and action potentials can independently initiate significant

100 tween neighboring cells during the spread of action potentials, can induce a rapid decay of junctiona

101 were derived from human keratinocytes, their action potential characteristics determined, and their g

102 Action potentials clustered into high-frequency bursts p

103 or function scores (MFS) and compound muscle action potential (CMAP) decreased rapidly in SMA infants

104 velocity (MNCV) and reduced compound muscle action potentials (CMAP) in patients.

105 In the presence of ouabain, the action potential collapses.

106 channel isoforms exert differential roles in action potential conduction along the axonal membrane of

107 contribution of TTX-s and TTX-r channels to action potential conduction in different axonal compartm

108 e nodes of Ranvier are essential regions for action potential conduction in myelinated fibers.

109 >/=1 Hz) results in a progressive slowing of action potential conduction velocity, which manifests as

110 onal dendrites, which can generate dendritic action potentials (DAPs) in vitro, which can profoundly

111 ensity of stimulation or the total number of action potentials delivered.

112 be very sensitive to the temporal nature of action potential delivery rather than the intensity of s

113 within the EC and in this way, constrain non-action potential-dependent and action potential-dependen

114 constrain non-action potential-dependent and action potential-dependent spontaneous release as well a

115 Antagonists of GABA or VIP signaling or action potentials did not disrupt circadian synchrony in

116 thranilic acid (MONNA), inhibited CQ-induced action potential discharge at itch nerve terminals and b

117 responses to capsaicin (2 mum) and reducing action potential discharge from colonic afferent nerves.

118 EAAT2 block also augmented action potential discharge in chemosensitive nTS neurons

119 The CQ-induced action potential discharge was largely absent in phospho

120 ecreased PV+ IN excitability, as assessed by action potential discharge.

121 ed animals in vivo with corresponding longer action potential duration (APD) in cardiomyocytes incuba

122 dium currents leading to prolongation of the action potential duration and an increased propensity to

123 130G-CALM2, as shown by the normalization of action potential duration and Ca(2+)/CaM-dependent inact

124 with DMSO, concentration-dependent prolonged action potential duration and effective refractory perio

125 l mapping, whole-cell patch clamp to measure action potential duration and ionic currents, and quanti

126 ction mutations had heterogeneous effects on action potential duration and promoted early-after-depol

127 rse SGK1's effects on NaV1.5 and shorten the action potential duration in induced pluripotent stem ce

128 Gain-of-function mutations shortened the action potential duration in single cells, and stabilise

129 model, acute interstitial edema exacerbated action potential duration prolongation and produced EADs

130 ial effects of leptin involve restoration of action potential duration via normalization of transient

131 s associated with a dramatic prolongation of action potential duration with evidence of arrhythmic ac

132 brafish resulted in shortening of the atrial action potential duration, a hallmark of AF.

133 educed phase 0 upstroke slope, and prolonged action potential duration.

134 on-recovery intervals (a surrogate for local action potential duration; median, 275 versus 241 ms; P=

135 sion and hERG currents (IhERG) and shortened action-potential duration (APD).

136 Optical mapping was used to measure action potential durations (APDs) in the presence of the

137 Conduction velocities were higher and action potential durations were significantly longer in

138 channel critical for shortening ventricular action potentials during high beta-adrenergic tone.

139 e increased firing thresholds and diminished action potential dynamic range.

140 These imaging experiments revealed action potentials, dynamic aspects of dendritic integrat

141 out mice, we show that IHCs fire spontaneous action potentials even in the absence of ATP-dependent i

142 We demonstrate action potential evoked calcium signals in mammalian tib

143 ed the rheobase, and increased the number of action potentials evoked by a depolarizing current at 2X

144 on enabled the afferent to reliably generate action potentials evoked by single AMPA-dependent EPSPs.

145 to the regulation of synaptic efficacy, and action potential-evoked and spontaneous neurotransmissio

146 on a molecular level.SIGNIFICANCE STATEMENT Action potential-evoked and spontaneous neurotransmissio

147 y improving calcium buffering, or decreasing action potential-evoked calcium influx.

148 In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is prin

149 els (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release.

150 ium channels (VACCs) is the major trigger of action potential-evoked synaptic release.

151 Action potential-evoked vesicle fusion comprises the maj

152 Diuretics reduce the rate of action potential fall in the presence of ouabain.

153 reliably reproduce the observed increase in action potential firing and altered action potential wav

154 atic MORs in POMC neurons robustly inhibited action potential firing and Ca(2+) activity despite dese

155 3/Nav1.7 interaction reduced the heat-evoked action potential firing and nociceptive behavior.

156 in vitro development suggest that changes in action potential firing and synaptic activity may be sec

157 e majority of Re neurons exhibit spontaneous action potential firing at rest.

158 at these subtle alterations in the timing of action potential firing differentially regulates hundred

159 onic GS967-treatment had no impact on evoked action potential firing frequency of interneurons, but d

160 s heat stimuli could not evoke the sustained action potential firing in FGF13-deficient DRG neurons.

161 llow rapid and dynamic control of OSN-driven action potential firing in MCs through changes in gap ju

162 n IO neurons, leading to markedly diminished action potential firing of IO neurons in TMEM16B knockou

163 uisitely sensitive to the temporal nature of action potential firing patterns.

164 posure led to an increase in the single-unit action potential firing rate in vivo in VTA dopamine neu

165 vironmental stimuli, coded in the pattern of action potential firing, can be very sensitive to the te

166 maturation of resting membrane potential and action potential firing, decreased synaptic activity and

167 stently exhibit reduced input resistance and action potential firing.

168 in cellular depolarization and ganglion cell action potential firing.

169 latform to rapidly generate large numbers of action-potential firing mDA neurons after 25 days of dif

170 double-projecting vCA1 neurons also induced action potential firings in the mPFC neurons that projec

171 frontal cortex of fmr1(-/y) mouse fired more action potentials for a given stimulus compared with wil

172 tability, responding with a higher number of action potentials for a given stimulus, in fmr1(-/y) mic

173 exhibiting an increased input resistance and action potential frequency, as well as a reduced medium

174 (VGlut2)], and cultures exhibited increased action potential frequency.

175 lar recordings to investigate how comparably action potentials from gastrocnemius and soleus are repr

176 al recordings, we find that back propagating action potentials fully invade spines, that excitatory p

177 a shorter period should increase the pulse's action-potential-generating effectiveness by increasing

178 nd across a range of distances, and promotes action potential generation and synchronous firing.

179 characteristic region and thus, the site of action potential generation are of particular importance

180 elinated and operates at the upper limits of action potential generation frequency and speed observed

181 This scenario may be relevant to action potential generation in certain sensory neurons,

182 which operate at the physiological limit of action potential generation, precision, and speed.

183 the resting membrane potential and impaired action potential generation.

184 The amplitude of the supramaximal compound action potential gets larger on warming, whereas in the

185 In the atria, age-associated changes in the action potential have been documented.

186 A (Dopamine And Neural Activity), to measure action potentials (high frequency) and local-field oscil

187 rdepolarization" that can in turn trigger an action potential if the excitation threshold is reached.

188 When measuring or simulating IKs during an action potential, IKs was not different during a physiol

189 An action potential in a motor nerve triggers an action pot

190 ction potential in a motor nerve triggers an action potential in a muscle cell membrane, a transient

191 ntly decreased the reliability of the second action potential in each burst of activity.

192 ntly decreases the reliability of the second action potential in each burst of epileptiform activity.

193 Although all dopamine neurons fire action potentials in a pacemaker pattern in the absence

194 eurons and their target cells by propagating action potentials in a saltatory manner.

195 or, ASAP1, which can monitor rapid trains of action potentials in cultured neurons.

196 Bath-applied ProTx II suppressed spontaneous action potentials in DRG neurons occurring in rats with

197 NaV1.3 was not only critical for generating action potentials in EC cells, but it was also important

198 In addition, action potentials in fmr1(-/y) neurons were significantl

199 NAcSh FSIs compared with MSNs and triggered action potentials in FSIs preceding BLA-mediated activat

200 dependent on Na(+) channels, suggesting that action potentials in granule cells function to coordinat

201 izes membrane potential (Vm) and can trigger action potentials in isolated myocytes.

202 r, chronic restraint stress induces bursting action potentials in LHb neurons, which are abolished by

203 um channels are critical for supporting fast action potentials in neurons; even mutations which cause

204 demonstrate robust single-trial detection of action potentials in organotypic slice cultures.

205 cell EPSPs evoked in response to mitral cell action potentials in rat (both sexes) brain slices.

206 Cardiac myocytes normally initiate action potentials in response to a current stimulus that

207 rrent-clamp revealed GnRH neurons fired more action potentials in response to current injection durin

208 Finally, bushy cells fired fewer action potentials in response to evoked synaptic activit

209 MNTB neurons and induced extra postsynaptic action potentials in response to presynaptic firing.

210 SS conducting polymer microwires to modulate action potentials in single cells.

211 urons to provide clear detection of neuronal action potentials in single trials.

212 in the forward-sideslip direction and fires action potentials in spike bursts as well as single spik

213 polarizations (AHPs) generated by repetitive action potentials in supraoptic magnocellular neurons re

214 These currents are capable of eliciting action potentials in the absence of glutamatergic curren

215 hyperpolarized, or by postsynaptic trains of action potentials in the absence of presynaptic stimulat

216 The excitatory events that trigger myotonic action potentials in the absence of stabilizing ClC-1 cu

217 , Notch induces global changes in the atrial action potential, including a reduced dVm/dtmax.

218 Furthermore, action potential-independent glutamate release was regul

219 rotransmission within chemical synapses, but action potential-independent spontaneous neurotransmissi

220 nal input resistance and increased firing of action potentials, indicating an enhanced excitability.

221 positive synapses) and severe alterations in action potential-induced presynaptic Ca(2+) transients (

222 rate DADs of sufficient amplitude to trigger action potentials is not fully understood.

223 fferents that transduce sensory stimuli into action potentials is poorly understood.

224 irements of a circuit, yet how the timing of action potentials is tuned presynaptically to match thes

225 cking the transient Na(+) current underlying action potentials, is an inefficient approach.

226 hanced contractility, and more physiological action potential kinetics.

227 p experiments to determine the regulation of action potential morphology in guinea pig ventricular my

228 e, which causes involuntary firing of muscle action potentials (myotonia), producing muscle stiffness

229 m channels are clustered and regeneration of action potentials occurs, allowing fast saltatory conduc

230 e the use of these microwires to control the action potentials of cardiomyocytes, showing that the ce

231 ular level, the occurrence of irregular-type action potentials of PMCA1(cko) atrial myocytes increase

232 We found that action potentials of small-diameter rat DRG neurons show

233 ides a unique mechanism for rapid control of action potentials on the millisecond timescale.

234 ion induced either by postsynaptic trains of action potentials or by pairing postsynaptic hyperpolari

235 s with the plasma membrane in response to an action potential, or spontaneously in the absence of sti

236 d with CA1 PNs, which is sufficient to drive action potential output from CA2 but not CA1.

237 pping of HFpEF hearts demonstrated prolonged action potentials (P<0.05) and multiple reentry circuits

238 n of the membrane voltage during the cardiac action potential, passing potassium ions outward to repo

239 th L-type Ca(2+) channel activity during the action potential plateau, as well as by the increase of

240 ld inhibit further Ca(2+) release during the action potential plateau.

241 and show stronger reverse use dependency of action potential prolongation.

242 Although action potentials propagate along axons in an all-or-non

243 Modeling action potentials propagating along axons, we showed tha

244 ining fetal CFs exhibited higher velocity of action potential propagation and contractile force ampli

245 his may explain the occurrence of defects in action potential propagation at the level of single T-tu

246 Neither action potential propagation failure nor depressed Ca(2+

247 Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons.

248 ters the intrinsic neuronal excitability and action potential properties of L2/3 pyramidal neurons, a

249 2 ablation are accompanied by alterations at action potential properties, including action potential

250 ious stimulus is encoded by the frequency of action potentials relayed by nociceptive C fibers to the

251 ain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic

252 1 (hERG1) channels is a major determinant of action potential repolarization in the human ventricle.

253 rate, which is key to hERG's role in cardiac action potential repolarization.

254 s, S1 region mutations would reduce both the action potential repolarizing current passed by Kv11.1 c

255 he distaste for Ca(2+), and Ca(2+)-activated action potentials required several members of the varian

256 n the experimentally observed variability in action potential shape and macroscopic conduction, and t

257 the regular pacemaker-like spiking pattern, action potential shape, and most of the membrane propert

258 c activities, ablation of Slc26a6 results in action potential shortening.

259 r Purkinje cells (PCs) generate two types of action potentials, simple and complex spikes.

260 They exhibit two distinct types of action potential: simple spikes and complex spikes.

261 bellar cortex and fire two distinct types of action potential: simple spikes and complex spikes.

262 The sensory nerve action potentials (SNAPs) remained dispersed and areas r

263 by the millisecond-scale timing patterns of action potentials (spike timing).

264 In afferent sensory neurons, trains of action potentials (spikes) encode stimulus intensity wit

265 latencies and precision of the first evoked action potentials (spikes) in hair-cell afferent neurons

266 uroscience is understanding how sequences of action potentials ("spikes") encode information about se

267 tly improve the amplitude of compound muscle action potential starting at 14 days postinjury.

268 operties with the vertebrate nervous system: action potentials, synaptic transmission, neuropeptides,

269 Action potentials, taking place over milliseconds, are t

270 perpolarizations (AHPs) following a train of action potentials that are critical to shaping the firin

271 f SK channels results in a depolarisation of action potential threshold along with an increase in its

272 oltage-activated potassium currents near the action potential threshold as well as by enhanced recrui

273 ng the basal membrane potential close to the action potential threshold during hormonal demand.

274 tween the resting potential and the neuronal action potential threshold explains why NaV1.9 mutations

275 f excitatory post synaptic currents near the action potential threshold.

276 ls are crucial for proper propagation of the action potential through excitable tissues.

277 ing OLs (pre-OLs) can generate Nav1.2-driven action potentials throughout postnatal development to ea

278 evealed that application of AUT00063 reduced action potential timing variability and improved tempora

279 ly, axonal varicosity initiation can trigger action potentials to antidromically propagate to the som

280 rate over large spatial scales by using fast action potentials to link GABA release at many different

281 ynaptic potentiation induced by postsynaptic action potential trains.

282 , the inflammatory reflex, is dependent upon action potentials transmitted to the reticuloendothelial

283 ane potential, and decreasing the latency of action potentials triggered by depolarization.

284 6 mV), approximately 90% of Re neurons fired action potentials, typically continuously at approximate

285 aintained by a positive feedback between the action potential upstroke and SCR.

286 ynchronization of Ca(2+) releases during the action potential upstroke, waiting times of SCR events a

287 led the surface-recorded amplitude of soleus action potentials was 6% of that of gastrocnemius and di

288 itiation of action potentials and influences action potential waveform, firing pattern, and rate.

289 rease in action potential firing and altered action potential waveform.

290 Patches exhibited ventricular-like action potential waveforms and uniform electrical conduc

291 To investigate, compound action potentials were made, from dorsal roots isolated

292 Gastrocnemius action potentials were more likely detected for greater

293 nization of Ca wave initiation and triggered action potentials were observed in HF hearts and computa

294 (Nav) channels play a key role in generating action potentials which leads to physiological signaling

295 We captured local field potentials and action-potentials while mice engaged in unrestricted beh

296 r cortex, pyramidal cells have long duration action potentials, while in the macaque, some pyramidal

297 from layer II/III pyramidal neurons revealed action potential widening that could account for enhance

298 rapid time response of hVOS imaging revealed action potentials with high temporal fidelity, and enabl

299 ate dorsal root ganglia neurons and generate action potentials with visible light via the optocapacit

300 ng of the fast initiation and propagation of action potential within single neurons, and validate the

301 onsible for the initiation and conduction of action potentials within primary afferents.