ライフサイエンスコーパス: action potential firing

1 stently exhibit reduced input resistance and action potential firing.

2 duction in Shaker increases the frequency of action potential firing.

3 lity and plays a critical role in modulating action potential firing.

4 cotrophs, leading to a sustained increase in action potential firing.

5 and-inducible, and reversible suppression of action potential firing.

6 ne properties occurs in vivo, in response to action potential firing.

7 transient increase in p(open) in response to action potential firing.

8 dition, beta1 is required for high-frequency action potential firing.

9 u potential capable of triggering repetitive action potential firing.

10 on, activation of AMPA or NMDA receptors, or action potential firing.

11 on by converting synaptic input to output as action potential firing.

12 kinetics that support high-frequency, narrow action potential firing.

13 cterized role in neurotransmitter-stimulated action potential firing.

14 difference to pain because of attenuation of action potential firing.

15 rapidly decreases in response to repetitive action potential firing.

16 ent forms of sodium current and to sustained action potential firing.

17 ion cues through modulation of their rate of action potential firing.

18 (2P) channel exhibit marked accommodation of action potential firing.

19 hR antagonist, and (3) tetrodotoxin to block action potential firing.

20 derlie the neuronal M current that regulates action potential firing.

21 hed, however there is a failure to establish action potential firing.

22 rease the speed and regularity of repetitive action potential firing.

23 lity of transmitter release during bursts of action potential firing.

24 hibited robust, spontaneous "pacemaker-like" action potential firing.

25 larizing currents and tetrodotoxin abolished action potential firing.

26 ity at -38 mV of -44 pA pF(-1) and supported action potential firing.

27 -activated cryptochrome to increase neuronal action potential firing.

28 es in interneurons that triggered repetitive action potential firing.

29 spikes that trigger and shape the pattern of action potential firing.

30 s to a degree that was sufficient to abolish action potential firing.

31 eceptors, which are activated in response to action potential firing.

32 erties and responded to kainate with intense action potential firing.

33 oportionately to synaptic integration during action potential firing.

34 g membrane potential below the threshold for action potential firing.

35 to activate nitric oxide synthase, increased action potential firing.

36 he resting potential and previous history of action potential firing.

37 as ET-1 induced a long-lasting abolition of action potential firing.

38 f sodium channels develops during repetitive action potential firing.

39 these effects of MF exposure evoke increased action potential firing.

40 n in the coupling of GABAA-R conductances to action potential firing.

41 volume remained constant during the repeated action potential firing.

42 tability and decreased temporal precision in action potential firing.

43 nous release contributes to the precision of action potential firing.

44 ial segment that was identified by analyzing action potential firing.

45 be switched between by brief periods of NGFC action potential firing.

46 ance, leading to a concomitant adjustment in action potential firing.

47 at resulted in nociceptor depolarization and action potential firing.

48 the muscle whereas GABAergic bursts suppress action potential firing.

49 activation enables excitable cells to adjust action potential firing.

50 in cellular depolarization and ganglion cell action potential firing.

51 ar calcium transients triggered by bursts of action potential firing.

52 ease in the stimulus threshold for the first action potential firing.

53 annels that are prominently activated during action potential firing.

54 alcium and is associated with an increase in action-potential firing.

55 ated ion channels, enabling light to control action-potential firing.

56 Ca(2+) imaging, we have observed hyperactive action-potential firing.

57 zation by the monosynaptic EPSP and multiple action potential firings.

58 d 63.5 +/- 3.9 ms) and a higher frequency of action potential firing (19.3 +/- 1.4 action potentials

59 as apparent across a wide frequency range of action potential firing (6-22 Hz) and dendritic excitati

60 2/7.3 at voltages close to the threshold for action potential firing (-60 mV) but generally had reduc

61 rization of cell membranes and inhibition of action potential firing, accompanied by a rapid inhibiti

62 racellular recording showed that concomitant action potential firing activity in putative GABAergic a

63 tes for the first 15-25 APs during bursts of action potential firing, after which it slows with incre

64 In striking contrast, high frequency action potential firing alone failed to trigger CREB pho

65 Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the select

66 reliably reproduce the observed increase in action potential firing and altered action potential wav

67 synaptic inputs, but does not require axonal action potential firing and backpropagation.

68 atic MORs in POMC neurons robustly inhibited action potential firing and Ca(2+) activity despite dese

69 and temporal profile of inhibition of axonal action potential firing and dendritic spike generation.

70 lication of Abeta to cortical slices induced action potential firing and enhanced excitatory postsyna

71 , do not display a tuft, and exhibit regular action potential firing and little sag.

72 rent (I(A)) plays an active role in neuronal action potential firing and may contribute to modulating

73 iminated by tetrodotoxin--a drug that blocks action potential firing and network activity--or by anta

74 3/Nav1.7 interaction reduced the heat-evoked action potential firing and nociceptive behavior.

75 This hyperpolarization was not triggered by action potential firing and not accompanied by an increa

76 al ganglia circuitry, changes in the rate of action potential firing and pattern of activity in the g

77 osition persisted after chronically blocking action potential firing and postsynaptic receptors but w

78 m-activated potassium (SK) channels regulate action potential firing and shape calcium influx through

79 , thereby establishing a direct link between action potential firing and somatic [Ca2+]i in light-sti

80 ng [Ca(2+)](o) with enhanced conductance and action potential firing and strongly elevated [Ca(2+)](i

81 ward current and resulting sADP may modulate action potential firing and subsequent GnRH release.

82 ing in membrane depolarization and increased action potential firing and subsequent stimulation of in

83 in vitro development suggest that changes in action potential firing and synaptic activity may be sec

84 tion of neuronal excitability, the timing of action potential firing and synaptic integration and pla

85 ransient biochemical events such as neuronal action-potential firing and RhoA activation in growth co

86 izing resting membrane potential, increasing action potential firing, and facilitating responses to s

87 tial, decreased GnRH neuron excitability and action potential firing, and hyperpolarized membrane pot

88 Similarly, the sodium currents and action potential firing are also impaired in the GABAerg

89 Plateau depolarizations and bursts of action potential firing are thought to depend on the mat

90 e delayed rectifier currents, which regulate action potential firing, are encoded by heteromeric Kv2

91 These data identify temporal kinetics of action potential firing as critical components regulatin

92 duced by hyperosmolarity, high potassium, or action potential firing at 30 Hz to produce synaptic dep

93 rpolarization and permitted accommodation of action potential firing at frequencies greater than arou

94 e majority of Re neurons exhibit spontaneous action potential firing at rest.

95 IPSPs gave rise to a rebound excitation and action potential firing at the termination of the burst.

96 er functioning of synapses during repetitive action potential firing, because deficiencies in this pr

97 nd noninvasive optical means for controlling action potential firing, but the genes encoding these ch

98 ding Ca(2+) spike frequencies resulting from action potential firing, but this has not been investiga

99 and inflammatory pain; (2) sanshool inhibits action potential firing by blocking voltage-gated sodium

100 li were either single shocks to mimic normal action potential firing by cortical neurons or high-freq

101 We report that sustained action potential firing by CWCs evokes endocannabinoid r

102 olarized the cell by 11-14 mV, and inhibited action potential firing by increasing the threshold curr

103 Inhibiting CN neuron action potential firing by local application of the gamm

104 the period of enhanced glutamate release and action potential firing by postsynaptic neurons.

105 at the axonal initial segment and regulates action potential firing by setting the density of the ax

106 Last, we modeled action potential firing by simulating eight currents dir

107 ll as its influence on Na channel gating and action potential firing, by studying cultured cerebellar

108 During action potential firing, calcium signals in basal dendri

109 vironmental stimuli, coded in the pattern of action potential firing, can be very sensitive to the te

110 P)-sensitive component of I(h) and abolished action potential firing caused by an elevation of cAMP i

111 Cholesterol modulation of BK channels alters action potential firing, colonic ion transport, smooth m

112 ater use-dependent inactivation, and reduced action potential firing compared with wild-type cells.

113 maturation of resting membrane potential and action potential firing, decreased synaptic activity and

114 at these subtle alterations in the timing of action potential firing differentially regulates hundred

115 ntaneous activity, with correlated bursts of action potential firing dominating network activity.

116 ed muscle membrane and the failure of muscle action potential firing during challenge with agents kno

117 e to the resting potential, reduced delay to action potential firing during depolarizing current inje

118 , increases both duration of the upstate and action potential firing during the upstate.

119 Cholinergic bursts concur with facilitated action potential firing, elevated cytosolic [Ca(2+)] and

120 chanical threshold by 50% and increasing the action potential firing elicited by a P2X2/3 agonist to

121 Although the patterns of action potential firing elicited in this cell population

122 while changes in the rate and statistics of action-potential firing encode information about the ens

123 The structure of action potential firing evoked at the break of hyperpola

124 simulated EPSPs enhanced the rate of ongoing action potential firing, evoked by somatic simulated EPS

125 enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstine

126 terminations of multiple cable parameters in action potential-firing fibres including Rin and lambda

127 both receptor types leads to an increase in action potential firing frequency and a rise in the intr

128 ntial upstroke velocity but markedly reduced action potential firing frequency in intracardiac neuron

129 g potential and is an important modulator of action potential firing frequency in many excitable cell

130 yperpolarization and a dramatic reduction of action potential firing frequency in rat sympathetic neu

131 relevant concentrations, ranolazine reduced action potential firing frequency of hippocampal neurons

132 onic GS967-treatment had no impact on evoked action potential firing frequency of interneurons, but d

133 d its stable analogue exendin-4 increase the action potential firing frequency of MCs by decreasing t

134 ransient increase followed by a reduction in action potential firing frequency recorded from GABAergi

135 TRH increased the action potential firing frequency recorded from GABAergi

136 KII inhibition suppresses glucose-stimulated action potential firing frequency.

137 in input resistance, impedance amplitude and action-potential firing frequency across the somato-apic

138 harge in isolated brainstem preparations and action potential firing from CO2 -sensitive neurons in b

139 ticonvulsant lamotrigine selectively reduced action potential firing from dendritic depolarization, w

140 We recorded action potential firing from the terminals of individual

141 ecordings (n = 42) revealed that patterns of action potential firing generated by concerted somatic a

142 voltage-gated Na(+) channels responsible for action potential firing have specialized mechanisms that

143 risation (6.6 +/- 0.5 mV) and an increase in action potential firing in 41/50 (82%) neurones.

144 CCh depolarized and evoked action potential firing in a fraction of PCs and increas

145 Y) evokes rapid depolarization and increased action potential firing in a subset of circadian and aro

146 FGF14 is required for spontaneous and evoked action potential firing in adult Purkinje neurons, there

147 However, dopamine altered action potential firing in an extremely rapid (<1s) and

148 f GABA depolarized beta-cells and stimulated action potential firing in beta-cells exposed to glucose

149 neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pat

150 creased the probability of SR input to drive action potential firing in CA1 pyramidal neurons, which

151 ) mice, making it nearly impossible to evoke action potential firing in CA2 pyramidal neurons.

152 PACAP stimulation did not evoke action potential firing in chromaffin cells but did caus

153 se of proinflammatory neuropeptides from and action potential firing in cutaneous nociceptors.

154 probably to influence the precise timing of action potential firing in either individual or ensemble

155 s heat stimuli could not evoke the sustained action potential firing in FGF13-deficient DRG neurons.

156 electively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals.

157 frequencies rapidly and reversibly increased action potential firing in HA cells, an effect that was

158 functional properties of hNav1.5 and alters action potential firing in heterologous expression syste

159 to LTP induction during synaptically driven action potential firing in hippocampal CA1 pyramidal neu

160 s have severely impaired sodium currents and action potential firing in hippocampal GABAergic inhibit

161 with these behavioral results, CNO decreased action potential firing in isolated sensory neurons from

162 ng sequentially both synaptic potentials and action potential firing in large populations of DGCs, we

163 llow rapid and dynamic control of OSN-driven action potential firing in MCs through changes in gap ju

164 n is the transformation of synaptic input to action potential firing in mitral and tufted (M/T) cells

165 ordings showed that OH cell firing inhibited action potential firing in most MCH neurons, an effect t

166 High-frequency, but not low-frequency, action potential firing in myelinated CA1 axons of the h

167 c pain is therefore initiated by HCN2-driven action potential firing in Na(V)1.8-expressing nocicepto

168 cium dyes and allowed visualization of tonic action potential firing in neurons and high resolution f

169 Nav1.7 mutation could induce high-frequency action potential firing in nociceptive neurons and that

170 The rate of action potential firing in nociceptors is a major determ

171 rpolarizes membrane potential and suppresses action potential firing in OX neurons in mouse hypothala

172 The precise inhibition affected action potential firing in PCs in two distinct ways.

173 Moreover, the timing of action potential firing in PNs is not phase-locked to os

174 This conductance is sufficient to drive action potential firing in response to acid stimuli, is

175 freshly isolated DRG neurons showed reduced action potential firing in response to current injection

176 Importantly, EtOH inhibited interneuron action potential firing in response to KA-R activation b

177 med that such hyperpolarization enhances RGC action potential firing in response to subsequent depola

178 ct of carbachol on inhibition of spontaneous action potential firing in sinoatrial node cells.

179 entiation that does not require postsynaptic action potential firing in the axon.

180 -mediated sPSC frequency and the decrease in action potential firing in the GnRH cells.

181 sensory neurons (SNs) via the interaction of action potential firing in the SN coupled with the relea

182 rons, and PACAP was further shown to augment action potential firing in these cells.

183 sticity of ionic currents leads to increased action potential firing in vitro and increased strength

184 Blocking action potential firing in vitro increased presynaptic e

185 enhanced fear memory consolidation and drove action potential firing in vitro.

186 double-projecting vCA1 neurons also induced action potential firings in the mPFC neurons that projec

187 mining the shape, duration, and frequency of action-potential firing in excitable cells.

188 both necessary and sufficient for sustained action-potential firing in tactile afferents.

189 vation caused prolonged inhibition (>9 s) of action-potential firing in thalamic projection neurons o

190 Possible modulators of action potential firing include the HCN ion channels, wh

191 tic sites on the rate and pattern of ongoing action potential firing is determined using multisite wh

192 rons is potentiated and hypocretin-1-induced action potential firing is facilitated, potentially expl

193 The probability of synaptically evoked action potential firing is increased during DSI under cu

194 uring the circadian cycle, but the effect on action potential firing is modulated by postsynaptic pro

195 ane excitability, to maintain consistency of action potential firing, is critical for stable neural c

196 ouse extensor digitorum longus (EDL) fibres, action potential firing leads to substantial changes in

197 latform to rapidly generate large numbers of action-potential firing mDA neurons after 25 days of dif

198 ing prolonged, complex trains of presynaptic action potential firing (mean frequency, 48 Hz).

199 eads to increased sodium current (I(Na)) and action potential firing, mimicking the response by these

200 In addition, MCH suppressed action potential firing MSNs through K(+) channel activa

201 Because action potential firing occurs only during the depolariz

202 f synaptic inhibition triggered by transient action potential firing of a single thalamic relay neuro

203 hreshold, GRP-induced Ca(2+) transients, and action potential firing of GRPR(+) neurons.

204 n IO neurons, leading to markedly diminished action potential firing of IO neurons in TMEM16B knockou

205 required to cause half-maximal depression of action potential firing of neocortical neurons in cultur

206 Finally, we found that repetitive action potential firing of PFC pyramidal neurons suppres

207 rdings show that cannabidiol reduces overall action potential firing of striatal neurons.

208 cluding KCNQ2/3 channels, and attenuated the action potential firing of superior cervical ganglion ne

209 d single CCK cells could transiently inhibit action potential firing of synaptically coupled PV cells

210 ity of these lines for precisely controlling action-potential firing of GABAergic, cholinergic, serot

211 t optogenetic activation of phasic and tonic action-potential firing of NR neurons during memory acqu

212 les different wavelengths of light to switch action potential firing on and off.

213 nergic signaling does not interfere with the action potential firing pattern, pharmacological ablatio

214 ritic processes that transformed the ongoing action potential firing pattern, promoting action potent

215 mEC were preferentially affected, such that action potential firing patterns in dorsal mEC-SCs were

216 e voltage-gated Na and K currents define the action potential firing patterns of parasympathetic card

217 were used for stimulating and inhibiting the action potential firing patterns of SH-SY5Y human neurob

218 uisitely sensitive to the temporal nature of action potential firing patterns.

219 role in regulating membrane excitability and action potential firing patterns.

220 o cells in these subregions led to different action potential firing patterns.

221 phs display highly heterogeneous spontaneous action-potential firing patterns and their resting membr

222 Action potential firing probability was reliably phase-l

223 ypophysial nerve terminals and increased the action potential firing probability.

224 dynamically regulates membrane excitability, action potential firing properties, and long term potent

225 This tonic inhibition strongly modifies action potential firing properties.

226 vely regulate resting membrane potential and action potential firing properties.

227 or prolonged application of capsaicin, their action potential firing quickly adapted.

228 dent membrane depolarization, an increase in action potential firing rate and decrease in amplitude o

229 MMW stimulation significantly increased the action potential firing rate in oocytes coexpressing vol

230 posure led to an increase in the single-unit action potential firing rate in vivo in VTA dopamine neu

231 gs, we found that TRH robustly increased the action potential firing rate of these neurones.

232 ibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very

233 pond to dopamine with a severe depression in action potential firing rate, while pyramidal neurons do

234 r nociceptors from Trpa1(-/-) mice exhibited action potential firing rates 50% lower than those in wi

235 Neuronal intrinsic properties control action potential firing rates and serve to define partic

236 Action potential firing rates are diminished owing to sl

237 tified TRPM7 blocker FTY720 has no effect on action potential firing rates of wild-type SAN cells.

238 electrical coupling of neurons and increased action potential firing rates.

239 subunits may affect temporal integration of action potential firing rates.

240 ibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding

241 ) concentrations (100 pm) to 100 nm enhanced action potential firing, reduced afterhyperpolarizing po

242 provement in neurite outgrowth and increased action potential firing relative to injected isolated ce

243 During action potential firing, resonance of the spike output m

244 Investigation of action potential firing shows that Scn1b null DRG neuron

245 In contrast, under active, action potential firing states, ACh excited c-ACs, but i

246 These cells exhibited periods of spontaneous action potential firing that generated high-amplitude fl

247 P can be induced by patterns of postsynaptic action potential firing that occur in these cells in viv

248 During repetitive action potential firing the maintenance of synaptic tran

249 During action potential firing, the rate of synapsin dissociati

250 ated synaptic potentials reach threshold for action potential firing, the signal propagates leading t

251 eased Na channel availability may facilitate action potential firing, these results suggest a mechani

252 uts can cause persistent changes in rates of action potential firing, through a mechanism that remain

253 itized colonic sensory neurons by increasing action potential firing to current injection and depolar

254 c neurons must maintain occasional bursts of action-potential firing to attract and keep synaptic con

255 e specific for KA-Rs, as EtOH did not affect action potential firing triggered by AMPA receptor-media

256 Action potential firing triggers transmitter release fro

257 rent injection induced irregular patterns of action potential firing up to a frequency of 440 Hz with

258 Furthermore, enhanced action potential firing was only observed upon concurren

259 Although axonal action potential firing was required to trigger persiste

260 r action potentials, however, the pattern of action potential firing was shaped by the distribution o

261 t Ca2+ influx through VGCCs, activated after action potential firing, was the primary source for ligh

262 Finally, from the action potential firing, we estimated that </=19 odorant

263 nd motoneuron ability to generate repetitive action potential firing were examined.

264 oncentrations and the fractional decrease in action potential firing when GABA(A)-Rs were blocked in

265 raised the ICMS current intensity to induce action potential firing whereas the agonist 8-OH-DPAT ha

266 interfere with thermally induced changes in action potential firing, whereas loss of trpv1 abolished

267 or the implementation of this cooperation is action potential firing, which begins in the axon, but w

268 tained plateau depolarizations and bursts of action potential firing, which resembled cortical UP and

269 urons showed deficits in sodium currents and action potential firing, which were rescued by a Nav1.1

270 arlier peak times and consequently generated action potential firing with shorter latencies than ipsi

271 a2+ responses could be blocked by preventing action potential firing with tetrodotoxin.

272 (lLNvs) in Drosophila melanogaster increase action potential firing within seconds in response to li

273 nce the same activity pattern in response to action potential firing within the parent presynaptic ne

274 ones, serotonin abolished the rhythmicity of action potential firing without affecting spike frequenc

275 je neurons attenuates spontaneous and evoked action potential firing without measurably affecting the