ライフサイエンスコーパス: actionable

1 tatements (descriptive) and recommendations (actionable).

2 ld not be limited to those deemed clinically actionable.

3 45 alarms among 100 children, 50 (0.5%) were actionable.

4 4% [95% CI, 8.0% to 11.0%]) were potentially actionable.

5 rs considered 52 (73%) of 71 visible cancers actionable.

6 BrM-acquired alterations that are clinically actionable.

7 f affected individuals harbored a clinically actionable aberration, including 62.7% with aberrations

8 he ability to profile each unique cancer for actionable aberrations by using high-throughput technolo

9 BRAF,HER2,RET,MET, andROS, did not reveal an actionable abnormality.

10 ns about those results that were potentially actionable according to a physician-reviewer.

11 scale), and actionability (actionable or not actionable according to whether the radiologists probabl

12 on and diarrhea etiology while not providing actionable adaptation strategies.

13 ant ABC-DLBCL cells in particular display an actionable addiction to BCL2.

14 95% CI, 2.1 to 17.5) and anticipating using actionable (adjusted OR, 2.46; 95% CI, 1.2 to 5.2) or po

15 OR, 2.46; 95% CI, 1.2 to 5.2) or potentially actionable (adjusted OR, 2.89; 95% CI, 1.1 to 7.9) test

16 sk genotypes, in addition to other suggested actionable adult-onset genetic conditions, opportunistic

17 ost individuals had at least one potentially actionable alteration (94.7%), with the median number of

18 el, and iCat recommendations were made if an actionable alteration was present, and an appropriate dr

19 ts, 317 (93.5%) had at least one potentially actionable alteration.

20 testing protocol, including the frequency of actionable alterations across tumor types, subsequent en

21 ve: To assess the feasibility of identifying actionable alterations and making individualized cancer

22 These include a number of clinically actionable alterations and mutations inactivating SWI-SN

23 in 76% of tumors, three times the number of actionable alterations detected by current diagnostic te

24 to 2,221 clinical cases revealed clinically actionable alterations in 76% of tumors, three times the

25 in all patients tested, including clinically actionable alterations in DNA damage repair genes and PI

26 This approach may identify actionable alterations in signal coordination that under

27 The most common actionable alterations leading to an iCat recommendation

28 4.7%), with the median number of potentially actionable alterations per patient being 2 (range, 0-13)

29 wever, only a small portion of patients with actionable alterations were actually enrolled onto genot

30 Actionable alterations, including novel RAC1 mutations,

31 nique somatic profile with pharmacologically actionable alterations, justifying the inclusion of noni

32 l portion of cisplatin-resistant GCTs harbor actionable alterations, which might respond to targeted

33 /670 (48%) of patients displayed potentially actionable alterations, with 241 patients possible candi

34 parisons and identify potentially clinically actionable alterations.

35 ed or refractory pediatric solid tumors have actionable alterations.

36 rs that 24 (37.1% [CI, 25.7% to 50.2%]) were actionable and 8 (12.6% [CI, 6.4% to 23.3%]) required ur

37 obvious (grade > 3) cancers and between the actionable and not actionable cancers.

38 and detecting two (25%) of eight missed not actionable and ten (38%) of 26 missed actionable cancers

39 ize genomic findings into robust, clinically actionable and widely accepted scoring systems as well a

40 Our work identifies a clinically actionable approach to overcome the T-cell-suppressive e

41 Our results suggest a quickly actionable approach to supporting conventional therapies

42 nts reveals patterns of issues that point to actionable areas for improvement.

43 sary to determine whether this measure is an actionable assessment of hospital quality, and, if so, h

44 hirty-five genes were considered potentially actionable based on their potential to be targeted with

45 We show that our methodology generates actionable biological hypotheses for up to 41% of diseas

46 ivation of HER3 in SCCHN and thus defines an actionable biomarker for interventions targeting HER3.

47 c NAB2-STAT6 inversion and a therapeutically actionable BRAF fusion, which may drive this specific ca

48 than plasma, allowing the identification of actionable brain tumour somatic mutations.

49 ese data identify Notch as a therapeutically actionable branch point of metabolic signaling at which

50 Visible cancers deemed actionable by at least three of five readers were analyz

51 whether any given guideline is memorable and actionable by the intended target audience.

52 roof-of-principle data identify mutp53 as an actionable cancer-specific drug target.

53 ed not actionable and ten (38%) of 26 missed actionable cancers (P = .33).

54 ) cancers and between the actionable and not actionable cancers.

55 they are considered drivers and potentially actionable (category 1-2); however, treatment was guided

56 h a library of useful resources and a simple actionable checklist of recommendations.

57 HBs harbor multiple SSTR subtypes that offer actionable chemo-therapeutic strategy for management of

58 Both approaches yielded reliable and actionable clinical information on the Salmonella outbre

59 ork for the translation of genomic data into actionable clinical strategies for targeted patient ther

60 these advances have not been translated into actionable clinical tools, and the language of brain cir

61 Actionable contrast was achieved between tumor tissue an

62 Thus, TRX1 is an actionable CRPC therapeutic target through its protectio

63 ployed surveillance capability now generates actionable data in one-tenth the time of manual filter c

64 Our analysis provides exploratory actionable data on the overall effect sizes and strength

65 ing stage, with the main goals of generating actionable data that will inform clinical decision makin

66 er the opportunities for deriving clinically actionable decisions that have the potential to compleme

67 sis and tumor biology; these aberrations are actionable (defined as having the potential to affect ma

68 her, our data indicate that SCLC displays an actionable dependence on ATR/CHK1-mediated cell cycle ch

69 confirms the potential to create clinically actionable diagnostics for lung cancer.

70 how this new knowledge can lead to medically actionable discoveries of pathobiology.

71 are with the goal of accelerating clinically-actionable discoveries.

72 'nDRIVE revealed many potentially clinically actionable driver genes.

73 being used at an increasing rate to identify actionable driver mutations that can inform therapeutic

74 h might be improved by the identification of actionable driver mutations.

75 d lung cancers defines RET rearrangements as actionable drivers in patients with lung cancers.

76 share common molecular subtypes with similar actionable drivers to improve precision therapy.

77 Actionable drivers were detected in 64% of lung adenocar

78 ade bladder tumors was conducted to identify actionable drug targets, which are defined as genomic al

79 efulness as a resource for mining clinically actionable drug targets.

80 and that thermodynamic poise information is actionable during network reconciliation.

81 These findings identify a clinically actionable, epigenetic cause of cetuximab resistance.

82 The time to first diagnosis of a clinically actionable event was compared in patients who were follo

83 M is safe and allows more rapid detection of actionable events compared with conventional monitoring

84 tion for the earlier diagnosis of clinically actionable events compared with traditional transtelepho

85 te pacemaker interrogation follow-up detects actionable events that are potentially important more qu

86 e mean time to first diagnosis of clinically actionable events was earlier in the Remote arm (5.7 mon

87 Identifying actionable factors explaining long-term graft survival d

88 esponses in relation to outcome and leads to actionable findings for translational research.

89 anagement was feasible, revealed potentially actionable findings in 46% of patients, and was associat

90 WES identified diagnostic and/or potentially actionable findings in nearly 40% of newly diagnosed ped

91 udy has yet estimated the number of expected actionable findings per individual; therefore, we classi

92 e CAD system correctly marked 37 (71%) of 52 actionable findings read as negative in previous screeni

93 Forty-two patients (46%) had actionable findings that changed their cancer management

94 Proportion of patients with potentially actionable findings, results of clinical actions based o

95 ated M. tuberculosis mutation data to reveal actionable findings.

96 d a program of research designed to deliver "actionable" findings-genomic results that 1) reveal fund

97 orize visible cancers as either threshold or actionable FN findings.

98 efine levels of viremia and viruria that are actionable for additional testing or intervention.

99 ulates tumor progression in ways that may be actionable for therapy or prevention.

100 lly valuable' findings even if not medically actionable-for instance, findings that help corroborate

101 ill provide medicine with an informative and actionable framework that enables objective clinical ass

102 we are to derive more complex, nuanced, yet actionable frameworks that help us to plan better polici

103 al conditions, we should also acquire highly actionable functional information by perturbing-for exam

104 e sensitive and robust methods for detecting actionable gene fusions in lung cancer and could provide

105 result in the expression of therapeutically actionable gene fusions.

106 This study sought to identify actionable gene targets by selective targeting of the mo

107 ion on their pro-tumourigenic behaviour, but actionable generalised conclusions have been scarce.

108 Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures.

109 of the American College of Medical Genetics actionable genes identified a pathogenic BRCA2 mutation

110 n changes (<2-fold or >2-fold) in clinically actionable genes including gains of FGFR4 (n = 6 [30%]),

111 ment in which the suitability of potentially actionable genes, that could eventually become drug targ

112 M commonly acquire alterations in clinically actionable genes, with metastasis-acquired ERBB2/HER2 al

113 harbor deleterious variants in 76 clinically actionable genes.

114 ls through combinatorial therapies targeting actionable genes.

115 9%) had at least one mutation in potentially actionable genes.

116 h factor receptor (EGFR) are the most common actionable genetic abnormalities yet discovered in lung

117 lioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted th

118 Actionable genetic alterations included 25 EGFR mutation

119 d medicine will require tools to distinguish actionable genetic alterations within the complex geneti

120 based on family history may miss clinically actionable genetic changes with established implications

121 t panel for their association with medically actionable genetic conditions possibly undiagnosed in ad

122 To identify therapeutically actionable genetic dependencies in SS, we performed a se

123 an expert panel as associated with medically actionable genetic disorders that may be undiagnosed in

124 stigating the role of treatments targeted at actionable genetic mutations in bladder cancer.

125 certain cases, WGS will identify clinically actionable genetic variants warranting early medical int

126 increasing number of potentially clinically actionable genetic variants, using smaller samples obtai

127 om white patients with respect to clinically actionable genomic alterations and suggest that clinical

128 o define the prevalence and co-occurrence of actionable genomic alterations in patients with high-gra

129 cations in mTORC2-specific genes as the only actionable genomic alterations, suggesting a distinct ro

130 y-one percent of tumors harbored potentially actionable genomic alterations.

131 lly valid, medically important and medically actionable genomic findings (for example, pathogenic var

132 ht a more sensitive approach for identifying actionable genomic lesions that may be infrequently muta

133 medicine approaches, by helping to identify actionable genomic markers and subgroups of patients who

134 Proportion of clinically actionable germline mutations detected by universal tumo

135 ce analysis using a multigene panel detected actionable germline variants in 6 patients (5%).

136 with them in ways that promote disclosure of actionable health information.

137 stance tests that are able to provide timely actionable HIV resistance data at individual, population

138 Molecular alterations were potentially actionable in 28 of 135 patients (21%).

139 tom-level insight that is potentially highly actionable in drug design.

140 ations that are potentially pharmaceutically actionable in rare cancers.

141 nes that affect about 80 medications and are actionable in the clinic.

142 w driver mutation in LCH that is potentially actionable in the clinic.

143 rticipant had 2 autosomal dominant medically actionable incidental findings (unrelated to retinopathy

144 mate of the burden of adult onset, medically actionable incidental findings expected from exome seque

145 There were 95 medically actionable incidental findings in genes unrelated to the

146 ossibility of being informed about medically actionable incidental findings.

147 All 9 patients and families with actionable incidental genetic findings agreed to genetic

148 aling pathway, since they provide clinically actionable information as negative predictors of benefit

149 oint-of-care (POC) diagnostics provide rapid actionable information for patient care at the time and

150 mputational methods are essential to extract actionable information from raw sequencing data, and to

151 in search of somatic genetic alterations for actionable information has become routine practice in cl

152 The interpretation of this data to extract actionable information is one of the keys to developing

153 on of genome-scale variation into clinically actionable information is still in its infancy; neverthe

154 This cohort study provides clinically actionable information that could impact treatment decis

155 lted depends on the amount of perceived new, actionable information that is consistent with the objec

156 ed with other related analyses, will provide actionable information that will shape policy makers' th

157 tery (PA) pressures provides clinicians with actionable information to help further optimize medicati

158 rovide caregivers with reliable, immediately actionable information to identify whether there is a ne

159 ality of hospice care is still needed before actionable information will be available to guide the ch

160 iseases), specific analytic methods, and how actionable information will differ based on the disease

161 stems with capacity to provide effective and actionable information.

162 Patients with clinically actionable inherited mutations whose genetic test result

163 th patient survival differences and provides actionable insights for treating breast tumors.

164 help uncover novel biological and clinically actionable insights into carcinogenesis.

165 These results provide actionable insights that can be rapidly translated into

166 method that uses proteomics data to produce actionable insights to increase biofuel production.

167 ns were taken in 23 of the 91 (25%) based on actionable integrative clinical sequencing findings, inc

168 textualization (understanding the data), and actionable interpretation (real-time use of the data to

169 aling axes in patients with ALL and identify actionable kinase targets for the development of therape

170 bility to discover clinically meaningful and actionable knowledge across highly heterogeneous biomedi

171 Potentially clinically actionable (likely pathogenic [LP] or pathogenic [P]) ve

172 s essential for developing more specific and actionable messages on tea for consumers.

173 ion and potentially identify therapeutically actionable, metastasis-specific genomic aberrations.

174 ns acquired in BrM could identify clinically actionable metastatic dependencies.

175 We view effective coverage as a relevant and actionable metric for tracking progress towards achievin

176 This actionable molecular addiction to functional PARP1 signa

177 nd 70% of iCCA patients harbour at least one actionable molecular alteration (FGFR2 fusions, IDH1/2,

178 Feasibility, the frequency of actionable molecular alterations, the effect on decision

179 and Measures: Feasibility, the frequency of actionable molecular alterations, the effect on decision

180 e and drug resistance, the identification of actionable molecular targets by studying leukaemic cell

181 gnificant knowledge gap exists in clinically actionable molecular targets in Li-Fraumeni syndrome (LF

182 orming potential of adult OPCs and reveal an actionable multiphasic reactivation process that turns s

183 CI, 1.3 to 2.74 years), and those without an actionable mutation (1.85 years; 95% CI, 1.61 to 2.13 ye

184 A locally actionable mutation (i.e., available targeted treatment

185 The concept of an "actionable mutation" is considered within a model of clo

186 However, the same 'actionable mutation' impacts distinct context-specific g

187 y of targeted therapies showed theoretically actionable mutations (i.e., mutations for which targeted

188 quences of somatic mutations and identifying actionable mutations and the related drug responses curr

189 (17.5%; 95% CI, 15.3%-19.9%) had clinically actionable mutations conferring cancer susceptibility, i

190 GS) panel that identifies RAS/BRAF and other actionable mutations could also reliably identify tumors

191 y being applied to rapidly assess clinically actionable mutations in tumor biopsies in a cost-effecti

192 psy specimen revealed adenocarcinoma with no actionable mutations present.

193 a of personalized medicine; however, lack of actionable mutations presents a significant hurdle.

194 feasible and subsets of patients may harbor actionable mutations that could potentially impact thera

195 er pharmacogenomics (KNMPx), for identifying actionable mutations that rewired signaling networks and

196 Eighty-three patients (11%) with potentially actionable mutations went on genotype-matched trials tar

197 rgent evolution' means that the majority of 'actionable mutations' in tumor specimens are absent with

198 rgeted therapies' that are directed towards 'actionable mutations', these mutations should be conside

199 identifies several prevalent and potentially actionable mutations, including activating mutations of

200 Most melanomas had potentially actionable mutations, most in components of the mitogen-

201 ile past efforts have identified a number of actionable mutations, the bulk of genetic risk remains h

202 heterogeneity of ovarian cancer and identify actionable mutations.

203 cimens in an attempt to identify potentially actionable mutations.

204 o patient phenotype and incidental medically-actionable mutations.

205 r patients with defined genotypes containing actionable mutations.

206 nerability for TNBCs lacking therapeutically actionable mutations.

207 cal sequencing studies for the detection of 'actionable' mutations and copy number alterations to gui

208 -70% of all solid tumors harbor potentially 'actionable' mutations that can be exploited for patient

209 monstrate PU-H71 affinity capture identifies actionable networks that may help design rational combin

210 n the definition of clinical trials to match actionable oncogenic signatures with personalized therap

211 Multiple actionable opportunities exist to improve communication

212 ion and pre discharge planning may represent actionable opportunities to optimize patient adherence a

213 Its causes are frequently serious or actionable or both and are usually identified.

214 ous on a 10-point scale), and actionability (actionable or not actionable according to whether the ra

215 r human microbiome studies to translate into actionable outcomes for health, meta-analysis of reprodu

216 Early findings point to actionable outcomes of microbiome-wide association studi

217 % in other cancer-related genes, and 8% with actionable pathogenic germline alterations.

218 e 100 interrogated sudden death genes hosted actionable pathogenic mutations for more than one third

219 A clinically actionable pathogenic or likely pathogenic variant was i

220 for African descent) of the high-penetrance actionable pathogenic or likely pathogenic variants in a

221 African ancestry, we classified potentially actionable pathogenic single-nucleotide variants (SNVs)

222 ngs per individual; therefore, we classified actionable pathogenic single-nucleotide variants in 500

223 Three of these 21 decedents had a clinically actionable, pathogenic mutation (CALM2-F90L, CALM2-N98S,

224 e pivotal switch of a novel broad-acting and actionable pathway controlling EGFR signaling, and drivi

225 ecule Nrp2 as the pivotal switch of a novel, actionable pathway driving EGFR upregulation and resista

226 ce, the Nek6-Hsp72 module represents a novel actionable pathway for selective targeting of cancer cel

227 Here we identify a pharmacologically actionable pathway that controls cellular clearance via

228 elet reactivity, there are relatively little actionable pharmacogenetic data with antiplatelet agents

229 ation appears to be a common and potentially actionable phenotype in both patients and animal models.

230 In addition, we find potentially clinically actionable PI3K signalling mutations in 16% of cases.

231 s of the scientific crowd into practice with actionable plans.

232 policy (translation of high-level goals into actionable policies, open and transparent accountability

233 rovide a more accurate, and potentially more actionable, portrayal of where and why children are stil

234 te patient response to therapy, a clinically actionable prediction, and find that patients that are c

235 rmation in real-time to make what amounts to actionable predictions or estimates about future outcome

236 gulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 axis.

237 with an emphasis on pathways and potentially actionable proteins, provides a framework for determinin

238 inform the development of an informative and actionable quality indicator.

239 ection and structured peer review leading to actionable quality interventions.

240 ave organized our recommendations to address actionable questions concerning the entire spectrum of c

241 a multicomponent study designed to generate actionable recommendations to reduce Army suicides and i

242 Seven actionable recommendations were proposed for considerati

243 stored in electronic health records to offer actionable recommendations.

244 mmon blood pathogens, and enables clinically actionable results to be released much earlier than with

245 Potentially actionable results were disclosed to participants.

246 ant isolates, providing early and clinically actionable results.

247 More broadly, these findings illuminate an actionable roadmap to a more general and automated appro

248 orted adverse safety incidents (class I) and actionable safety findings (class II), conditioned on pa

249 -) HNSCC is another indicator of potentially actionable sequence variants for targeted therapy.

250 archers by enabling the return of clinically actionable sequencing results to research participants i

251 of XAF1, XIAP and SRD5A1 as a predictive and actionable signature for CRPC.

252 lated drug associations for known clinically actionable somatic genetic alterations and identified ne

253 iver gene mutation in all patients including actionable somatic mutations in ATM and MTOR.

254 lated interest in tailoring therapies toward actionable somatic mutations.

255 atient and their translation into clinically actionable strategies remain major hurdles.

256 ves, these measures are unlikely to identify actionable strategies to improve outcomes, but they coul

257 resistance to immunotherapy are elucidated, actionable strategies to prevent or treat them may be de

258 In this review we survey the landscape of 'actionable' structural variants in cancer and identify p

259 nd visualization of tumor variants and their actionable subsets.

260 This actionable synergistic interaction is validated using xe

261 to help authors perform and report valid and actionable systematic reviews.

262 de important functional information to guide actionable target and biomarker discovery.

263 ate that the VEGF-Nrp1 signalling axis is an actionable target for treating CMT2D.

264 disposition and represents a therapeutically actionable target with potential clinical relevance.

265 lasma cell biology will likely yield as many actionable targets as mapping the genomic landscape of t

266 ive rise to oncogenic gene fusions can offer actionable targets for cancer therapy.

267 s and stratification, as well as to identify actionable targets for informing molecularly guided ther

268 and its signaling pathway may serve as novel actionable targets for PEL management.

269 patient management decisions and may provide actionable targets for quality improvement.

270 receptor CXCR4 represent the most promising actionable targets for this strategy.

271 Actionable targets found in a single MB biopsy were seld

272 combinatorial biomarkers of response and co-actionable targets in cancer.

273 The discovery of actionable targets is crucial for targeted therapies and

274 l conditions for which the identification of actionable targets is urgently needed.

275 Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; how

276 Whether actionable targets such as tyrosine kinases are also sim

277 ctivation), revealed novel pharmacologically actionable targets, and confirmed the expectation of sig

278 bona fide cancer drivers and therapeutically actionable targets, requires functional testing.

279 terms of DNA variants, genes, pathways, and actionable targets.

280 rations that include previously undiscovered actionable targets.

281 avonoids and to provide valid, specific, and actionable tea consumption information to consumers.

282 ere diagnostics providing more immediate and actionable test results are needed to improve patient ou

283 physicians are often unaware of potentially actionable test results returning after discharge.

284 revalence and characteristics of potentially actionable test results returning after hospital dischar

285 subset of genomic alterations is clinically actionable, the majority of somatic events remain classi

286 The results have directly actionable therapeutic implications.

287 serving as both a trackable biomarker and an actionable therapeutic target for breast cancer.

288 inical trials, DOT1L could be an immediately actionable therapeutic target for the treatment of this

289 the HuR-IDH1 regulatory axis as a critical, actionable therapeutic target in pancreatic cancer.

290 rofiling to guide prognosis and selection of actionable therapeutic targets.

291 vival in glioma patients and may provide an "actionable" therapeutic target in cancer.

292 a driver of prostate cancer in vivo and an "actionable" therapeutic target.

293 utation testing and the increasing number of actionable therapeutics, we expect the methods for analy

294 tal diagnostic setting is possible within an actionable time frame and can provide precise delineatio

295 ultiple myeloma patients within a clinically actionable time frame, has shown high predictive accurac

296 mediator of immune suppression that might be actionable using pharmacological avenues.

297 te that a significant fraction of clinically actionable variants have low VAFs, often due to low tumo

298 We also discovered 32 potentially clinically actionable variants in 18 genes unrelated to the referra

299 ociations, potential disease mechanisms, and actionable variants.

300 Collecting reliable and actionable water quality information in low-resource set