ライフサイエンスコーパス: activatable

1 whereas Stx2, Stx2c, Stx2e and Stx1 are not activatable.

2 in the cardiac lymph remained latent but was activatable.

3 ormationally restricted form that is readily activatable.

4 e I domain closed abolished constitutive and activatable adhesion.

5 that was resistant to activation but became activatable after dithiothreitol treatment.

6 molecular imaging with an emphasis on smart, activatable agent technology.

7 ocarcinoma in mice harboring a conditionally activatable allele of oncogenic K-ras.

8 ase 1 that lacks the FeMo-co) to the FeMo-co-activatable alpha2beta2gamma2 form.

9 osteogenesis in vivo, we coadministered catS-activatable and calcification-targeted molecular imaging

10 l at the site of target expression but shows activatable and differential contrast depending on their

11 n; stable in zero extracellular calcium; IP3-activatable; and functional SOCE.

12 Here, we report H2O2-activatable antioxidant prodrug (BRAP) that is capable o

13 has tremendous therapeutic potential as H2O2-activatable antioxidant prodrug for the treatment of I/R

14 4 x 4 droplet bilayer array comprising light-activatable aqueous droplet bio-pixels.

15 We propose that synthetic biological light-activatable arrays, produced with soft materials, might

16 We chemically incorporated a photo-activatable benzophenone moiety into a series of coumari

17 ious than ACh, and shows that ACR-8 can form activatable binding-sites, thus opening doors for elucid

18 h submicron resolution, we developed a force-activatable biosensor named integrative tension sensor (

19 Conversely, inhibitors that do not orient an activatable bond in this manner, such as glutarate and c

20 Tumors with "activatable" but not "inactive" beta3 integrin secrete h

21 sensitivity to ATP inhibition and was fully activatable by adenine nucleotides.

22 erminal kinase activity (Jun kinase) was not activatable by epidermal growth factor in Rsu-1 PC12 cel

23 a1(II) promoter an inert form of Cre that is activatable by exogenous tamoxifen (TM); TM administrati

24 They were activatable by GTP but to a much lesser extent by branch

25 emic delivery and tumor-selective MR imaging activatable by internalization.

26 n of embryonic extracts revealed that BXR is activatable by low-molecular-weight molecules with spect

27 contrast agent was developed that was highly activatable by means of MMP-2-induced conversion.

28 med the jump muscle to be moderately stretch-activatable by replacing its myosin isoform with an embr

29 hese results suggest that PAR2, although not activatable by thrombin, may nonetheless function as a s

30 Unlike PAR1, PAR3, and PAR4, PAR2 is not activatable by thrombin.

31 ules based on BODIPY chromophores (COR-BDPs) activatable by visible-to-NIR (up to 730 nm) light.

32 Phospholamban decreases the number of activatable Ca2+ATPase without affecting substrate affin

33 V-Cre or WAP-Cre in combination with the Cre-activatable CAG-CAT-EGFP construct, we find stronger exp

34 h that overcomes this limitation by using UV-activatable caged phosphopeptides.

35 Light-activatable ("caged") proteins have been used to correla

36 The report of a PKC activatable cAMP response element (CRE) in the bcl-2 pro

37 Thrombin-activatable carboxypeptidase B (CPB), also called thromb

38 ct apoptosis in vivo, a novel cell-permeable activatable caspase substrate, TcapQ647, was synthesized

39 from control cells contained a spontaneously activatable caspase-3 zymogen.

40 Here, we report an activatable cell penetrating peptide (CPP) strategy ulti

41 nce of dendrimeric nanoparticles coated with activatable cell penetrating peptides (ACPPs), labeled w

42 can be imaged in real time with ratiometric activatable cell penetrating peptides (RACPPs).

43 Using an activatable cell-penetrating peptide engineered to detec

44 be selectively delivered to tumors using an activatable cell-penetrating peptide targeting matrix me

45 get, proteolytic enzyme MMP-2, the probe, an activatable cell-penetrating peptide, Ceeee[Ahx]PLGLAGrr

46 We recently developed activatable cell-penetrating peptides (ACPPs) that targe

47 hod to visualize tumors during surgery using activatable cell-penetrating peptides (ACPPs), in which

48 nds (i.e., EGFR-specific GE11 peptide), acid-activatable cell-penetrating peptides (i.e., TH peptide)

49 We report a family of novel ratiometric activatable cell-penetrating peptides, which contain Cy5

50 ation can be localized to tumors by targeted activatable cell-penetrating peptides.

51 such as the modified Volvox carteri ChR1 red-activatable channelrhodopsin ("ReaChR," lambdamax = 527

52 Here we show that a recently described red activatable channelrhodopsin (ReaChR) permits control of

53 We engineered a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with

54 eratinocytes by use of wild-type and steroid-activatable constructs.

55 h magnetic resonance (MR) imaging and use of activatable contrast agents.

56 ation change, and durable target capture via activatable covalent cross-linking.

57 and its subsequent inactivation by thrombin-activatable CPB (generating OPN-L) occurs locally within

58 Our data suggest that thrombin-activatable CPB plays a central homeostatic role in RA b

59 This activatable CPP conjugate platform could find applicatio

60 We call these fusions activatable CPPs (ACPPs) because cleavage of the linker

61 and in mature rods and cones by a tamoxifen-activatable Cre.

62 ations ranging from the development of light-activatable cysteine-containing peptides to the developm

63 conjugate with activatable fluorescence and activatable cytotoxicity.

64 bstitution of Tyr(B16) by an isosteric photo-activatable derivative (para-azido-phenylalanine) enable

65 Previously, we generated a "hyper-activatable" derivative of HPC (FLIN-Q3) with an increas

66 Light-activatable drugs offer the promise of controlled releas

67 rene biosynthesis, is shown to inhibit flash-activatable electron transfer in photosynthetic membrane

68 intermediate complexity harboring weak, but activatable, electrophiles are matched with the protein(

69 espiratory burst oxidase is a multicomponent activatable enzyme comprising one of the major phagocyte

70 iquitous, amiloride-sensitive, growth factor-activatable exchanger whose role has been implicated in

71 by targeted integration of a Cre recombinase-activatable expression cassette driven by the cytomegalo

72 r (TFPI) and reduction in levels of thrombin activatable fibrinolysis inhibitor (TAFI) and fibrinogen

73 Circulating thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminoge

74 ediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby he

75 Thrombin-activatable fibrinolysis inhibitor (TAFI) is an importan

76 Thrombin-activatable fibrinolysis inhibitor (TAFI) is the precurs

77 ced fibrinolysis secondary to lower thrombin activatable fibrinolysis inhibitor (TAFI) production.

78 te the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated

79 s observed on depletion of PAI-1 or thrombin activatable fibrinolysis inhibitor (TAFI).

80 n in complex with TM also activates thrombin-activatable fibrinolysis inhibitor (TAFI).

81 thrombomodulin (TM), protein C, and thrombin-activatable fibrinolysis inhibitor (TAFI).

82 of a clot through the activation of thrombin activatable fibrinolysis inhibitor (TAFI).

83 Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxyp

84 I)-deficient plasma by an activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-dependent mec

85 veloped as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).

86 or carboxypeptidase B and activated thrombin-activatable fibrinolysis inhibitor (TAFIa).

87 in degradation product D-dimer, and thrombin-activatable fibrinolysis inhibitor by ELISA in 118 monoz

88 lasminogen activator inhibitor-1 or thrombin-activatable fibrinolysis inhibitor display modest phenot

89 % heritability, and that of zymogen thrombin-activatable fibrinolysis inhibitor showed a very strong

90 asminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor succumb to yersiniosi

91 fibronectin binding protein A, and thrombin-activatable fibrinolysis inhibitor were examined directl

92 peptidase-R, procarboxypeptidase-B, thrombin-activatable fibrinolysis inhibitor), a proenzyme that is

93 asmin-antiplasmin complex, D-dimer, thrombin activatable fibrinolysis inhibitor, and lipoprotein(a) f

94 ce deficient in alpha2-antiplasmin, thrombin-activatable fibrinolysis inhibitor, or fibronectin, indi

95 rboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-termin

96 g a natural antifibrinolytic agent, thrombin-activatable fibrinolysis inhibitor.

97 tly between groups after inhibiting thrombin-activatable fibrinolysis inhibitor.

98 dase-R, pro-carboxypeptidase-B, and thrombin-activatable fibrinolysis inhibitor.

99 hesis of a folate-doxorubicin conjugate with activatable fluorescence and activatable cytotoxicity.

100 imultaneous injections with Prosense-680, an activatable fluorescence sensor reporting on cathepsin a

101 To provide the capability of activatable fluorescence signaling, we conjugated a fluo

102 esolution intravital microscopy with a photo-activatable fluorescent albumin marker to simultaneously

103 escence molecular tomography and a cathepsin-activatable fluorochrome to image autophagy in the heart

104 We demonstrate that enzyme-activatable fluorochromes can be detected with high posi

105 This FITC is conjugated in end-terminal of activatable fluorogenic peptide (ActFP).

106 eptide substrate GHPGGPQGKC-NH2 linked to an activatable fluorogenic polymer.

107 A dual-activatable, fluorogenic probe was developed to sense es

108 A current example of an activatable fluorophore is one that is normally self-que

109 neutravidin-biotin binding with an attached activatable fluorophore) could be useful in tumor-specif

110 oading cells with a cell-permeable and photo-activatable fluorophore, NPE-HCCC2/AM (acetoxymethyl est

111 innovative structural design translates into activatable fluorophores with excellent photochemical an

112 ate this issue further, we have expressed an activatable form of hepsin, and have generated a set of

113 und SgrAI (i.e., HMWS) are the activated, or activatable, forms of the enzyme.

114 tein that binds specifically to the paraquat activatable fpr promoter region as the E1 subunit of the

115 agnetic resonance imaging of MPO with an MPO-activatable Gd-chelate revealed a spatially defined T1-w

116 oded by the Ifi 202 gene from the interferon-activatable gene 200 cluster.

117 We also examined the role of Stx2d-activatable genes and the large hemolysin-encoding plasm

118 1, was reported, which complements the photo-activatable GFP by providing a red super-resolution colo

119 Caspase Activatable-GFP (CA-GFP) can be activated both in vitro

120 caspase proteolytic activity, called caspase-activatable green fluorescent protein (CA-GFP).

121 ry culture HUC, identification of HER1 as an activatable HB-EGF receptor on HUC surfaces, stimulation

122 framework of a genetically encodable, light-activatable heterodimerizer system, the actin-remodellin

123 The interferon-activatable Ifi200 gene cluster is located on mouse Chro

124 Our efforts have focused on developing activatable imaging probes to measure specific enzyme ac

125 ational design and screening of targeted and activatable imaging reporter agents to sense fundamental

126 In conjunction with the cysteine protease-activatable imaging reporter Prosense VM110 (VisEn Medic

127 reat microscopic tumors selectively using an activatable immunoconjugate.

128 nt manner through activation of the thrombin activatable inhibitor of fibrinolysis, and in a thrombin

129 d granzymes-A/K), with properties of rapidly activatable innatelike T cells.

130 tion pathway in cells expressing a prototype activatable integrin, platelet alphaIIbbeta3.

131 to model this event, we crossed conditional activatable K-ras(G12D/WT) mice with the prostate condit

132 se mice and was characterized by using a Cre-activatable lacZ reporter mouse strain (R26R).

133 pi 2.1 gene and is also distinct from the GH-activatable latent cytoplasmic transcription factors STA

134 The concentrations of active and acid-activatable latent plus active TGF-beta in the aorta wer

135 w that the concentration of active plus acid-activatable latent TGF-beta1 [(a+l) TGF-beta therefore i

136 The Ler-activatable LEE3:lacZ fusions extended to what would be

137 f the assay allowed the determination of the activatable levels of TAFI in human and other animal pla

138 matin isolated from HeLa cells using binding activatable localization microscopy (BALM).

139 n anti-alphaIIbbeta3 mAb fused to a thrombin-activatable, low-molecular-weight pro-uPA (PLT/uPA-T).

140 To address this need, an activatable magnetic resonance (MR) probe that is respon

141 delivery have taken inspiration from natural activatable materials like zymogens, membrane proteins,

142 man filamin A acts as an autoinhibited force-activatable mechanosensor.

143 we demonstrate that alpha-catenin is a force-activatable mechanotransducer at cell-cell junctions by

144 gy based on systemic administration of tumor-activatable minicircles that use the pan-tumor-specific

145 Purpose To test whether MPO-Gd, an activatable molecular magnetic resonance (MR) imaging ag

146 tivity of MRI has limited the development of activatable molecular MR contrast agents.

147 hina et al. intravitreally deliver the light-activatable molecule acrylamide-azobenzene-quaternary am

148 ethods for targeting the expression of light-activatable molecules to specific cell types, under gene

149 rofiles, suggest potential of the iRGD-based activatable monolithic peptide probe as a promising imag

150 her conjugation, the dye/quencher-conjugated activatable monolithic peptide probe visualized tumor re

151 sing light-directed DNA synthesis with photo-activatable monomers, can currently achieve densities on

152 performed after intravenous injection of the activatable MPO sensor (bis-5-hydroxytryptamide-diethyle

153 These activatable MR contrast agents can potentially be used a

154 We report here that a functional, enzyme-activatable MRI agent can accurately track the oxidative

155 eport the development of "opto-MOR," a light-activatable mu opioid receptor (MOR) chimera that can be

156 neral strategy to produce pH-tunable, highly activatable multicolored fluorescent nanoparticles using

157 The Ifi202 gene is part of the interferon-activatable murine gene 200 cluster on chromosome 1.

158 Here we used a somatically activatable mutant Kras-driven model of mouse lung cance

159 energy transfer (FRET) using the Gbetagamma activatable mutant, PLCbeta2/delta1(C193S).

160 has been recent growth in the development of activatable near-infrared (NIR) fluorescent probes for m

161 optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) probe can

162 proteolytic activity visualized by protease-activatable near-infrared fluorescence probes.

163 mouse model of ovarian carcinoma with enzyme-activatable near-infrared probes sensitive to tumoral pr

164 Thus, we have developed an activatable NIR optical probe that "switches on" only in

165 This property can be harnessed to create an activatable NIR probe.

166 ns (n = 7) after administration of an enzyme-activatable NIR probe.

167 Use of this novel protease-activatable NIRF agent for optical imaging in vivo demon

168 human coronary arteries in real time with an activatable NIRF agent.

169 received an injection of a cysteine protease-activatable NIRF imaging agent (Prosense750; excitation/

170 other markers and represents a shift toward activatable nuclear medicine agents.

171 -mediated activation of a pyrophosphorolysis-activatable oligonucleotide (P*) followed by extension o

172 itional p53-null allele and a loxP-stop-loxP activatable oncogenic K-Ras allele.

173 By using an activatable Otx1-glutocorticoid receptor fusion protein

174 U-cytoplasts, which have activatable oxidase, killed opsonized B. burgdorferi wit

175 ntrol, demonstrating the first aptamer-based activatable PA probe for advanced molecular imaging in l

176 ion sequence, DEVD, and a flanking optically activatable pair comprising a far-red quencher, QSY 21,

177 In order to create stable, activatable particles, a complex between copper and doxo

178 Thus, a "hyper-activatable" PC molecule such as FLIN-Q3 may represent a

179 n vitro evolution strategy to generate light-activatable peptide ligands to targets of choice.

180 compare the efficiency of other fluorescent activatable phospholipase probes as suitable molecular i

181 A two-photon-activatable photoacid generator, based on a bis[(diaryla

182 A visible-light activatable photoacid has been studied, which upon irrad

183 monstrate these concepts of "tumor-targeted, activatable photoimmunotherapy" in a mouse model of peri

184 Quantitative, unquenched activatable photosensitizers (QUaPS) hold potential for

185 One method is to use activatable photosensitizers that can both induce cell d

186 l in rat hippocampal neurons created a light-activatable PIRK switch for suppressing neuronal firing.

187 plex revealed a significant increase of cAMP-activatable PKA activity that was associated with a sign

188 s by DE52 chromatography suggests that total activatable PKC levels are lower in infected erythrocyte

189 indicated critical roles for streptokinase, activatable plasminogen, and fibrinogen.

190 f coagulation required the presence of fully activatable platelets and was not ascribable to platelet

191 y (PDT), we designed a smart plasma membrane-activatable polymeric nanodrug by conjugating the photos

192 Herein we report that much of the LPS-activatable pool of MAPK in primary mouse peritoneal mac

193 l of the signal recorded in lesions was from activatable probe administration.

194 ch could be evaluated by using a Cy5.5-based activatable probe and GFP.

195 the design, synthesis, and evaluation of an activatable probe that shows great promise for enabling

196 at all tumors were visible with the protease-activatable probe, even when they were not readily appar

197 nded genetic-code technology to insert photo-activatable probes at key sites in L1 and alphaCT.

198 Let me get my nanoruler: Activatable probes based on radionuclide and quantum dot

199 The utility of SPNs for designing smart activatable probes for real-time in vivo imaging is also

200 a lack of strategies to design selective and activatable probes for targets.

201 lular biomarkers, if and only if there exist activatable probes that appropriately respond to the bio

202 k of previously uncharacterized targeted and activatable probes that are excited by a nuclear decay-d

203 c probes is dependent on the availability of activatable probes that respond rapidly and selectively

204 Such activatable probes with near-infrared (NIR) emission wou

205 Several targeting moieties, including enzyme-activatable probes, antibodies, peptides, and lectins, h

206 PA imaging, especially in the area of enzyme-activatable probes.

207 Our studies show that thrombin-activatable proCPB, in addition to its role in fibrinoly

208 it and the cytotoxic doxorubicin, a targeted activatable prodrug is obtained that becomes activated (

209 hese problems, we prepared the far-red light-activatable prodrug of PTX by conjugating photosensitize

210 vivo efficacy of the novel low-energy-light-activatable prodrug using the photo-unclick chemistry.

211 anhydrides) showed the most promise as acid-activatable prodrugs under mildly acidic conditions foun

212 emonstrated its application to visible light-activatable prodrugs.

213 in the putative TetD binding site of a TetD-activatable promoter and a mutation in the protein's N-t

214 rmation of a specific nucleosome array at an activatable promoter, and describe present information o

215 ymerase from UP-containing promoters to SoxS-activatable promoters.

216 f proPC2 maturation and in the production of activatable proPC2 from CHO cells.

217 inducible genes, such as double-stranded RNA-activatable protein kinase and inducible nitric oxide sy

218 The recent development of synthetic photo-activatable proteins designed using the light-oxygen-vol

219 Genetically encoded, light-activatable proteins provide the means to probe biochemi

220 Using these progenitors and a conditionally activatable PU.1 protein, we show that PU.1 can negative

221 ting, phosphorylated Raf-1, representing the activatable Raf-1 pool, is the Raf-1 subpopulation targe

222 to their cell and organelle permeability and activatable reactivity, could be considered for the deve

223 l component that is best studied using light-activatable reagents.

224 stasis-related genes, including the thrombin-activatable receptor PAR-1 (protease-activated receptor-

225 T cells possess Mn(+2)-activatable receptors for ATX, which are localized at th

226 approximately 60% or the fraction of Ca(2+)-activatable regulatory units was reduced to approximatel

227 rapy (effector elements) and a drug function-activatable reporter element.

228 endogenous SM22alpha locus combined with Cre-activatable reporter genes that were integrated into the

229 ed fluorogenic MMP substrates can be used as activatable reporter probes to sense MMP activity in int

230 nd in intact erythrocytes when using a light-activatable reporter.

231 Using QCM-D crystals modified with a photo-activatable RGD peptide, the time point of presentation

232 Herein we describe a quantitative redox-activatable sensor (qRAS) for the real-time monitoring o

233 have used a small-molecule, gadolinium-based activatable sensor for magnetic resonance imaging of MPO

234 that alpha-catenin is a reversible, stretch-activatable sensor that mechanically links cadherin comp

235 Activatable singlet oxygen generation agents provide inc

236 maging microcatheters combined with protease-activatable smart probes results in a beacon effect that

237 asms after the intravenous administration of activatable "smart" probes that increase in NIR fluoresc

238 eplication, it is termed nutritional shiftup-activatable stable DNA replication, nSDR.

239 Transitions to this putative Ca(2+)-activatable state may thus provide a mechanism for contr

240 s, may be a natural property of the relaxed, activatable state of alpha7.

241 cle AChR macroscopic currents in the resting/activatable state with approximately 100-fold higher pot

242 shold that maintains the muscle in a stretch-activatable state.

243 ptors with a greater stability of the bound, activatable state.

244 may also be relaxing from this state to the activatable state.

245 one of the two binding sites in the resting activatable state.

246 and stabilizes separase in an inhibited yet activatable state.

247 Bivalency signifies repressed but activatable states of gene expression and can be resolve

248 arries two functional alleles for the potent activatable Stx2 variant toxin, Stx2d, for the presence

249 es between the activatable Stx2d and the non-activatable Stx2c.

250 the only amino acid differences between the activatable Stx2d and the non-activatable Stx2c.

251 E. coli strains that produce the activatable Stx2d are more virulent in a streptomycin (s

252 endothelial NO synthase, which serve as PKA-activatable substrates, inhibits the tube formation, whe

253 se VEGF receptors, but these were not active/activatable suggesting that inherent differences between

254 rticle sizes, switchable surface charges and activatable surface ligands, will be introduced.

255 An activatable system has been developed that enables tumor

256 me catabolism) as well as establishing tumor-activatable systems for cancer imaging and drug delivery

257 However, the utilization of light-activatable systems is hampered by the lack of suitable

258 Here, we developed an activatable T1 magnetic resonance (MR) imaging contrast

259 Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar a

260 noise ratio and superior photostability with activatable therapeutic effects.

261 arent association between the level of Stx2d-activatable toxin produced by an STEC strain and the sev

262 ding the range of activities of this rapidly activatable transcription factor.

263 efficiently quenched by it being bound to an activatable trigger group through a novel self-immolativ

264 Second, we varied the number of Ca(2+)-activatable troponin complexes at maximal Ca(2+) using m

265 A frontier area in the development of activatable (turn-on) fluorescence-based probes is that

266 rough the use of cell-penetrable, bioanalyte-activatable, turn-on probes is dependent on the presence

267 ndent on the expression of particular ligand-activatable, tyrosine-containing STAT docking sites in r

268 n vitro cross-linking experiments with photo-activatable unnatural amino acids, we show that full-len

269 This suggests that Hsp27, which is otherwise activatable upon heat shock, remains inactive in the R6/

270 H21 strain B2F1, an isolate that produces an activatable variant of Stx2 (Stx2d) and is lethal to mic

271 ght-induced sensitivity characteristic of an activatable visual phototransduction cascade.

272 hea, but isolates containing stx2c or stx(2d-activatable) were recovered more often from patients who

273 Here, we describe a broad-band light activatable white-opsin for generating significant photo