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1 se, during which Wnt and Hippo signaling are activated.
2 cerevisiae, the exposure to mating pheromone activates a prototypic mitogen-activated protein kinase
4 2+) overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling
11 ion is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceed
12 Combined treatment with DHA and Physcion activates AMP-activated protein kinase, leading to syner
16 on." Here, we show that these areas are also activated and reactivated for haptic object exploration
17 rks and repression marks are associated with activated and repressed gene expression, respectively.
19 g only a low-power ( 3.5 mW) laser source to activate, and without the need for external power supply
20 anoic acid (13b) decreased proliferation and activated apoptosis in MDA-MB-231 breast cancer cells in
21 se is a master growth regulator that becomes activated at the lysosome in response to nutrient cues.
22 tify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models.
23 ewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having substitutions a
24 redistribution to the gut, increases of the activated B cells and circulating tissue-like memory B c
26 cell recordings revealed that the isoflurane-activated background potassium current observed in corti
30 olic heterogeneity is a distinct property of activated beige/brite adipocytes that might be under epi
37 activation of the exchange protein directly activated by cAMP (Epac) provokes inhibition of the phos
38 protein directly activated by cAMP) directly activated by cAMP Epac pathways in the effects of ANP on
39 and cAMP/PKA/Epac (exchange protein directly activated by cAMP) directly activated by cAMP Epac pathw
40 Here, using designer receptors exclusively activated by designer drugs (DREADDs) to selectively act
41 jection (AMR) and have been postulated to be activated by donor-specific anti-HLA antibodies triggeri
43 egenerative P2Y2 nucleotide receptor (P2Y2R) activated by extracellular ATP and UTP molecules release
44 taneous sensory neurons that are selectively activated by high-threshold mechanical stimulation (HTMR
47 medial tegmental nucleus (RMTg) regions were activated by peripheral stimulation and LHb lesions reve
49 MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anom
51 a(2+) entry (SOCE) is a Ca(2+)-entry process activated by the depletion of intracellular stores and h
53 R1545Q, FV(DeltaIIa)) that cannot be cleaved/activated by thrombin or FXa also enhanced TFPI-mediated
56 ompact conformation in which its open Ca(2+)-activated C-lobe and closed N-lobe cooperate to recogniz
58 ogously expressed NaV1.2 channels exposed to activated CaMKII had enhanced persistent current and dep
59 stress protein acting as a Phase II enzyme, activating cancer pro-drugs and stabilizing p53 and p73a
60 ed organic carbon (DOC) adsorbed to granular activated carbon in a drinking water production plant, w
61 biomass char), engineered carbons (biochar, activated carbon), and related materials like graphene a
62 igher affinity for PFOA compared to powdered activated carbon, along with comparable capacity and kin
64 ng of nucleophilic groups on Wnt proteins to activated carboxylic acid (COOH) or glutaraldehyde (COH)
65 ed intestinal macrophages from a classically activated (CD11b(+), CCR7(+), F4/80(-)) to an alternativ
66 b(+), CCR7(+), F4/80(-)) to an alternatively activated (CD11b(+), CCR7(-), F4/80(+)) phenotype, reduc
73 nth postoperative assessment with both leads activated, compared with the preoperative baseline mean
74 MUS81 nucleolytic activity is required to activate compensatory DNA synthesis during mitosis and t
77 ctivation in acinar cells, and CTSD directly activated CTSB but not trypsinogen in vitro During pancr
79 ory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that a
80 of contributing to a larger range of mechano-activated currents in duck trigeminal ganglia than in mo
81 s suggest alteration in subthreshold voltage-activated currents might be the mechanism underlying def
83 that triplet exciton lifetimes of thermally activated delayed-fluorescence-emitter molecules can be
84 otassium (K(+) ) currents such as the slowly activating delayed rectifier current (IKs ) and the smal
85 demonstrated beneficial effects of autophagy-activating digitalislike compounds (DLCs) on redifferent
88 pper kinase (LZK) as cooperating with DLK to activate downstream signaling and cell death in RGCs, in
90 mulation (KES) nerve block to preferentially activate efferent pathways while blocking afferent pathw
91 We conclude that AFM pulling can be used to activate EGL-mediated NO production and that the heparan
93 vated protein kinase (AMPK), a major decorin-activated energy sensor kinase, prevented decorin-evoked
97 parietal, and posterior temporal cortices is activated even under subliminal perceptual conditions.
100 hether the O- to C-state transition in fully activated fibers of fast skeletal muscle of the rabbit o
108 eminiscent of the native enzyme: the complex activates H2 under mild conditions, and catalyses C-H hy
109 strate that MUC13 functionally interacts and activates HER2 at p1248 in PDAC cells, leading to stimul
110 ne genes in the memory T cells are marked by activating histone modifications even in the resting sta
111 at a highly selective TLR7 agonist, GS-9620, activated HIV from peripheral blood mononuclear cells is
113 de chemokinesis and chemotaxis of previously activated human T cells to CXCL11, but not CXCL10 or CXC
115 tion of different cancers, and JNK is highly activated in basal-like triple-negative breast cancer (T
116 We report here a mechanism by which they are activated in cancer cells, involving release of the I(-)
117 Considering that Notch signaling is commonly activated in cancer, tankyrase inhibitors may have thera
119 ity of two key MMPs known to be secreted and activated in neuroinflammation, MMP2 and MMP9, in brains
120 the central nervous system (CNS) that become activated in pathological conditions and determine the f
121 We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acid
122 ration and proximal or distal geometry, were activated in solution by ultrasound-generated elongation
124 +) T cells, as well as murine CD4(+) T cells activated in the presence of rapamycin, a pharmacologic
126 otein (IFI)16, bind dsDNA and form caspase-1-activating inflammasomes that are important in immunity
132 The large-conductance, calcium- and voltage-activated K(+)(BK) channel consists of the pore-forming
133 by transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7), which is associated w
134 ed the biological and functional role of p21-activated kinase 4 (PAK4) and its potential as a new tar
138 und that knockdown of Akt1 and the NF-kappaB-activating kinase IKKbeta cooperatively downregulated hi
141 ts imply that exosomes from uninfected cells activate latent HIV-1 in infected cells and that true tr
142 degradation and demonstrate the potential to activate latent plasticity as a novel therapeutic strate
143 factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed as a modif
145 administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassettes to n
147 ession, and serum sCD163 levels (a marker of activated macrophages) are greater in individuals with t
148 tone of the adipose tissue and expansion of activated macrophages, both of which occurred prior to c
153 o releasing bradykinin from HK, Kal directly activated monocytes to produce proinflammatory cytokines
155 tophagy, providing critical amino acids that activate mTOR and enable the metabolic transition of act
156 ution, and phase stability to simultaneously activate multiple micromechanisms that resist crack prop
158 cells in the tumor microenvironment and the activating mutations appear to sensitize the tumors to W
160 component of the signaling network by which activating mutations in the FGF receptor inhibit bone gr
162 rt through NF-kappaB-mediated signaling that activates neural stem cells to reconstitute the olfactor
164 re, we find that acute stress preferentially activates neuronal subpopulations that express the neuro
165 g, defined as the tight relationship between activated neurons and hemodynamic responses, is a fundam
167 emonstrated peptide-dependent binding of the activating NK cell receptor KIR2DS1, providing new insig
168 IL-15 exacerbates the severity of sepsis by activating NK cells and facilitating IFN-gamma productio
171 ased on our prior studies with the bile acid-activated nuclear hormone receptor farnesoid X receptor
172 Moreover, we show that light can be used to activate oncogene expression in selected tissues and sin
175 d by designer drugs (DREADDs) to selectively activate or inhibit ArcN NPY neurons expressing agouti-r
176 -dependent and -independent contributions by activating or inhibiting neurogenic activity with veratr
177 air cells is the expression of a low-voltage-activated outward rectifying K(+) current, IK,L , whose
179 Collectively, we conclude that nucleotides activate P2Y6 receptors to suppress GC growth through a
181 f 2.39% with short prothrombin time (PT) and activated partial thromboplastin time (APTT) of 14.2 and
182 n patients with impaired liver function, and activated partial thromboplastin time confounding may in
183 At 24 hours, STAT3 occurred in four of seven activated pathways associated with pro-oncogenic genes a
185 ied and selectively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatom
189 emarkably, all these inflammatory actions by activated platelets were abrogated by lack of CD40 on in
192 ompanied by consistent reductions in voltage-activated potassium currents near the action potential t
193 absence of a surface, FXII-R353A and FXII-T activate prekallikrein and cleave the tripeptide S-2302,
195 study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as a beta1-integrin inhi
196 preceded by increased phosphorylation of AMP activated protein kinase (Ampk) at tyrosine 172 and of u
197 Mechanistically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activat
198 ta-cell electrical activity by promoting AMP-activated protein kinase (AMPK)-dependent trafficking of
199 ing pheromone activates a prototypic mitogen-activated protein kinase (MAPK) cascade and triggers a d
202 MAPK pathway results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphor
203 on of the phospho-5' adenosine monophosphate-activated protein kinase and phospho-AKT serine/threonin
204 eptide (CGRP) stimulated CLR endocytosis and activated protein kinase C (PKC) in the cytosol and extr
206 modes of injury converge on p38alpha mitogen-activated protein kinase within the fibroblast to progra
207 reatment with DHA and Physcion activates AMP-activated protein kinase, leading to synergistic inhibit
209 ive stress, early phosphorylation of mitogen-activated protein kinases and Akt, and upregulation of p
210 ory effects of BCL6 on both MEK-ERK (mitogen-activated protein/extracellular signal-regulated kinase
212 apping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteinase-activated re
213 )/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoietin 4 (ANGPT4
214 e to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positive regu
217 at phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in inv
218 r 4 in human podocytes, and between protease-activated receptor 1 and protease-activated receptor 4 i
220 depended upon interactions between protease-activated receptor 3 and protease-activated receptor 4 i
221 n protease-activated receptor 3 and protease-activated receptor 4 in human podocytes, and between pro
223 ilure to undergo the peroxisome proliferator-activated receptor signaling-dependent switch from glyco
224 activating protein 2) and F2rl2 (proteinase-activated receptor-3), 2 genes that were also silenced a
225 tive agonist for the peroxisome proliferator-activated receptor-delta (PPAR-delta), which is implicat
228 p3 axis promotes cardiac healing after MI by activating reparative Ly6C(low) Mos/Mps, indicating that
231 tial for the survival and differentiation of activated satellite cells into the myogenic lineage.
233 ivation, Rst2 is first recruited to upstream-activating sequence 1 (UAS1), then it subsequently binds
235 ermophila, protozoa that are utilized during activated sludge treatment ((R)-FL is 30x more toxic tha
238 that targeting a lncRNA to transcriptionally activate SMN2 can be combined with SMN2 splicing modific
241 esults indicate that GRIKs phosphorylate and activate SnRK1 and other members of the SnRK3 family, an
242 drothermal method, were deposited onto epoxy-activated standard glass slides, followed by immobilizat
243 unsuspected, non-cell-autonomous program to activate STAT3 signalling in hepatocytes through IL-6 pr
244 minal complement complex on other complement-activating structures such as monosodium urate crystals
245 CO2 in the presence of DBU, is dehydrated by activated sulfonium reagents to generate the correspondi
250 r clinical activity has been correlated with activated T-cell recognition of neoantigens, which are t
252 oid (Bcd) provides positional information to activate target genes at different positions along the a
253 uring human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), wh
254 other parvoviruses, HBoV1 infection did not activate the apoptotic or necroptotic cell death pathway
255 oliferative leukemia virus (MPL), abnormally activate the cytokine receptor/JAK2 pathway and their do
256 rol allow it to interact with the beta2AR to activate the Gbetagamma-Akt-eNOS-sGC pathway to induce M
258 nscripts of Alu transposable elements, which activate the NLRP3 inflammasome and additional downstrea
262 rvation, or caloric restriction, is known to activate the transcription factor EB (TFEB), a master re
263 ion of HBx negatively affects its ability to activate the transcription of downstream genes and promo
270 receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of b
271 e a strong innate antiviral response through activating the ER stress pathway during viral infection.
272 relay station in the parasympathetic pathway activating the iris sphincter and ciliary muscle to medi
273 n, and permeability of inflammatory cells by activating the mammalian target of rapamycin (mTOR) path
275 as a gate to prevent innocuous stimuli from activating the nociceptive and pruritic transmission pat
276 on of the molecules approaching the surface, activating the O-H bonds and inducing deprotonation.
278 ation in epithelial cells by synergistically activating the two EBV immediate early promoters (Zp and
281 e to its significant homology with the force-activated titin kinase, smMLCK is suspected to be also r
283 to linear form by flow, and is subsequently activated to bind GPIbalpha in a tension-dependent manne
286 ipocytes with the adipogenic cocktail, which activates transcription factors (TFs) glucocorticoid rec
288 er during the oocyte-to-embryo transition by activating transcription, altering protein-coding sequen
292 ry previously determined that mast cells are activated via a non-FcepsilonRI mediated response follow
293 argeted by the Art1 alpha-arrestin, which is activated via the TORC1 kinase complex upon arginine upt
294 t this to indicate that stabilization of the activated voltage sensor limits the return of hERG chann
295 E1R/R4E KCNQ1, a mutant with constitutively activated voltage sensors, F56Bpa and F57Bpa KCNE1 were
296 pecifically, early measurements of thermally activated vortex motion (creep) in iron-based supercondu
297 e system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharid
298 nner chamber produced ET-1 when T cells were activated with antigen or anti-CD3 antibody in the outer
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