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1 se, during which Wnt and Hippo signaling are activated.
2 e-dimensional DNA contour before cleavage is activated.
7 ion is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceed
9 , populations of tactile nerve fibers become activated and convey information about the shape, size,
13 on." Here, we show that these areas are also activated and reactivated for haptic object exploration
14 rks and repression marks are associated with activated and repressed gene expression, respectively.
15 anoic acid (13b) decreased proliferation and activated apoptosis in MDA-MB-231 breast cancer cells in
16 whereas p110alpha is only minimally basally activated ( approximately 2-fold) when associated with m
17 se is a master growth regulator that becomes activated at the lysosome in response to nutrient cues.
20 ewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having substitutions a
21 BP) and EP300 are recurrently mutated in the activated B cell-like and germinal center (GC) B cell-li
22 y normalized post-ART, with the frequency of activated B cells (CD86(+)CD40(+)) reduced compared with
23 redistribution to the gut, increases of the activated B cells and circulating tissue-like memory B c
25 cell recordings revealed that the isoflurane-activated background potassium current observed in corti
28 olic heterogeneity is a distinct property of activated beige/brite adipocytes that might be under epi
39 activation of the exchange protein directly activated by cAMP (Epac) provokes inhibition of the phos
40 protein directly activated by cAMP) directly activated by cAMP Epac pathways in the effects of ANP on
41 and cAMP/PKA/Epac (exchange protein directly activated by cAMP) directly activated by cAMP Epac pathw
42 the excitatory nature of neural projections activated by cisplatin in rats and reveal the necessity
44 Here, using designer receptors exclusively activated by designer drugs (DREADDs) to selectively act
45 ology DREADD (designer receptors exclusively activated by designer drugs) is widely used for remote m
46 jection (AMR) and have been postulated to be activated by donor-specific anti-HLA antibodies triggeri
47 SCG) neurons expressed adrenergic receptors (activated by epinephrine) and the glucocorticoid recepto
48 ngle-cell resolution, allowing neurons to be activated by exceptionally mild heating, thus preventing
50 egenerative P2Y2 nucleotide receptor (P2Y2R) activated by extracellular ATP and UTP molecules release
51 An inactive chloride-ligated complex can be activated by halide abstraction with sodium salts, with
52 taneous sensory neurons that are selectively activated by high-threshold mechanical stimulation (HTMR
54 ntrary to the established paradigm, TRPV4 is activated by increased cell volume irrespective of the m
56 ivated by pyrantel (Kb 126 nM), and L-nAChRs activated by levamisole (Kb 0.96 microM) and bephenium.
58 n contrast, wildtype RyR1 was closed and not activated by luminal Ca(2+) at low cytosolic Ca(2+) leve
59 titive antagonist and distinguished M-nAChRs activated by morantel (Kb 13.9 nM), P-nAChRs activated b
60 y identifying the stress response strategies activated by Nrf2, we also highlight endogenous coping r
62 medial tegmental nucleus (RMTg) regions were activated by peripheral stimulation and LHb lesions reve
63 activated by morantel (Kb 13.9 nM), P-nAChRs activated by pyrantel (Kb 126 nM), and L-nAChRs activate
67 MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anom
70 a(2+) entry (SOCE) is a Ca(2+)-entry process activated by the depletion of intracellular stores and h
71 and functional responses distinct from those activated by the endogenous cytokines IL-2, IL-4, and IF
73 the zinc exporter CzcD, whose expression is activated by the novel TetR-family transcriptional zinc-
76 R1545Q, FV(DeltaIIa)) that cannot be cleaved/activated by thrombin or FXa also enhanced TFPI-mediated
79 the hair follicle melanocyte precursors are activated by UV light has not been extensively studied.
81 uires a unique protease, caspase-1, which is activated by various protein platforms called inflammaso
83 ompact conformation in which its open Ca(2+)-activated C-lobe and closed N-lobe cooperate to recogniz
84 in terms of the nature of the C-H bond being activated (C(sp(2))-H or C(sp(3))-H), the nature of the
85 mitochondrial calcium uniporter is a Ca(2+)-activated Ca(2+) channel complex mediating mitochondrial
87 ogously expressed NaV1.2 channels exposed to activated CaMKII had enhanced persistent current and dep
88 anscriptional patterns exhibited evidence of activated canonical Wnt signaling in both types of adeno
89 ed organic carbon (DOC) adsorbed to granular activated carbon in a drinking water production plant, w
90 biomass char), engineered carbons (biochar, activated carbon), and related materials like graphene a
91 igher affinity for PFOA compared to powdered activated carbon, along with comparable capacity and kin
93 ng of nucleophilic groups on Wnt proteins to activated carboxylic acid (COOH) or glutaraldehyde (COH)
94 ac fibroblasts using Tcf21 (MerCreMer) or in activated cardiac fibroblasts using periostin (Postn) (M
95 ed intestinal macrophages from a classically activated (CD11b(+), CCR7(+), F4/80(-)) to an alternativ
96 b(+), CCR7(+), F4/80(-)) to an alternatively activated (CD11b(+), CCR7(-), F4/80(+)) phenotype, reduc
99 also inhibit HIV replication, especially in activated CD4(+) T cells that are the preferred target c
102 also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian ce
103 ride current by opening the olfactory Ca(2+)-activated chloride channel to amplify the response.
105 that the frequency of CXCR5(+)PD-1(+)ICOS(+)-activated circulating Tfh cells is increased both in chi
107 nth postoperative assessment with both leads activated, compared with the preoperative baseline mean
111 ctivation in acinar cells, and CTSD directly activated CTSB but not trypsinogen in vitro During pancr
112 ory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that a
113 of contributing to a larger range of mechano-activated currents in duck trigeminal ganglia than in mo
114 s suggest alteration in subthreshold voltage-activated currents might be the mechanism underlying def
115 on phenotype with generation of mechanically activated currents that inactivate more slowly than wild
116 These results suggest that those who possess activated cytokine responses beyond the current treatmen
117 that triplet exciton lifetimes of thermally activated delayed-fluorescence-emitter molecules can be
119 cell-penetrating polymers that undergo acid-activated endosomal escape in living cells.Hydrogen bond
120 vated protein kinase (AMPK), a major decorin-activated energy sensor kinase, prevented decorin-evoked
122 parietal, and posterior temporal cortices is activated even under subliminal perceptual conditions.
124 hether the O- to C-state transition in fully activated fibers of fast skeletal muscle of the rabbit o
127 ned whether there are any areas additionally activated for dual-task performance, and compared the ne
129 and p115RhoGEF augmented interaction between activated Galpha13 and R7-RGS heterotrimers, indicating
132 at a highly selective TLR7 agonist, GS-9620, activated HIV from peripheral blood mononuclear cells is
136 de chemokinesis and chemotaxis of previously activated human T cells to CXCL11, but not CXCL10 or CXC
139 tion of different cancers, and JNK is highly activated in basal-like triple-negative breast cancer (T
140 We report here a mechanism by which they are activated in cancer cells, involving release of the I(-)
141 Considering that Notch signaling is commonly activated in cancer, tankyrase inhibitors may have thera
143 nockouts, indicating that the endocardium is activated in multiple cases where sinus venosus angiogen
144 ity of two key MMPs known to be secreted and activated in neuroinflammation, MMP2 and MMP9, in brains
145 s a vital role in cell cycle progression, is activated in numerous human malignancies, and is linked
146 the central nervous system (CNS) that become activated in pathological conditions and determine the f
147 We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acid
148 ration and proximal or distal geometry, were activated in solution by ultrasound-generated elongation
150 f Sema3a, Sema3d, and Sema3e, is ectopically activated in the developing palatal mesenchyme in Osr2(-
151 +) T cells, as well as murine CD4(+) T cells activated in the presence of rapamycin, a pharmacologic
153 genes, pathways, and cell behaviors to those activated in wound healing and identifies a repertoire o
156 crose diet also exhibited elevated levels of activated JNK as well as enhanced p70S6K1 autoinhibitory
157 The large-conductance, calcium- and voltage-activated K(+)(BK) channel consists of the pore-forming
158 by transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7), which is associated w
159 ed the biological and functional role of p21-activated kinase 4 (PAK4) and its potential as a new tar
164 amplified and dispersed stimuli by releasing activated kinases from receptors lacking intrinsic catal
166 administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassettes to n
168 ession, and serum sCD163 levels (a marker of activated macrophages) are greater in individuals with t
169 tone of the adipose tissue and expansion of activated macrophages, both of which occurred prior to c
170 production, and activation of alternatively activated macrophages, contributed by deregulation of th
174 e "exhausted," virus-specific B cells, i.e., activated memory cells and tissue-like memory B cells.
175 inflammatory cytokine interleukin-1beta from activated microglia, consistent with K(+) loss being nee
178 o releasing bradykinin from HK, Kal directly activated monocytes to produce proinflammatory cytokines
180 fective treatment protocol was identified as activated MSC co-administered with antibiotic therapy.
184 g, defined as the tight relationship between activated neurons and hemodynamic responses, is a fundam
185 tudies demonstrated CXCR4 and CXCR2 can both activated NF-kappaB and STAT3 signaling, while NF-kappaB
189 ased on our prior studies with the bile acid-activated nuclear hormone receptor farnesoid X receptor
190 air cells is the expression of a low-voltage-activated outward rectifying K(+) current, IK,L , whose
193 f 2.39% with short prothrombin time (PT) and activated partial thromboplastin time (APTT) of 14.2 and
194 n patients with impaired liver function, and activated partial thromboplastin time confounding may in
195 At 24 hours, STAT3 occurred in four of seven activated pathways associated with pro-oncogenic genes a
197 ied and selectively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatom
199 tein ligand 1 (PD-L1)-mediated inhibition of activated PD-1(+) T lymphocytes plays a major role in tu
201 fold increase in the rate constant for actin-activated phosphate release, the biochemical step in myo
205 The tube surface is resistant to adhesion of activated platelets unlike planar control titania and sm
206 emarkably, all these inflammatory actions by activated platelets were abrogated by lack of CD40 on in
207 tical model of a small conductance Ca(2)(+) -activated potassium (SK) channel was developed and incor
210 ompanied by consistent reductions in voltage-activated potassium currents near the action potential t
211 Immune cell-infiltration is controlled by activated PPARgamma/RXRalpha that inhibits expression/se
212 ng a variety of cancer cell lines as well as activated primary T cells, that cytosolic malate dehydro
213 would advance understanding of how thermally activated processes contribute to the denaturation of ad
215 of reactive oxygen species (ROS) and mitogen-activated protein (MAP) kinase phosphorylation, but exhi
217 study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as a beta1-integrin inhi
218 preceded by increased phosphorylation of AMP activated protein kinase (Ampk) at tyrosine 172 and of u
219 s larvae, the master metabolic regulator AMP-activated protein kinase (AMPK) plays a critical role in
220 Mechanistically, inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activat
221 ta-cell electrical activity by promoting AMP-activated protein kinase (AMPK)-dependent trafficking of
222 ing pheromone activates a prototypic mitogen-activated protein kinase (MAPK) cascade and triggers a d
224 ical" upregulation of the downstream mitogen-activated protein kinase (MAPK) pathway in cancer cells.
226 MAPK pathway results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphor
227 on of the phospho-5' adenosine monophosphate-activated protein kinase and phospho-AKT serine/threonin
228 eptide (CGRP) stimulated CLR endocytosis and activated protein kinase C (PKC) in the cytosol and extr
232 modes of injury converge on p38alpha mitogen-activated protein kinase within the fibroblast to progra
233 reatment with DHA and Physcion activates AMP-activated protein kinase, leading to synergistic inhibit
235 e BRAF inhibitor vemurafenib and the mitogen-activated protein kinase/extracellular signal-regulated
236 ive stress, early phosphorylation of mitogen-activated protein kinases and Akt, and upregulation of p
237 ory effects of BCL6 on both MEK-ERK (mitogen-activated protein/extracellular signal-regulated kinase
238 r 4 in human podocytes, and between protease-activated receptor 1 and protease-activated receptor 4 i
241 depended upon interactions between protease-activated receptor 3 and protease-activated receptor 4 i
242 n protease-activated receptor 3 and protease-activated receptor 4 in human podocytes, and between pro
244 as the expression of peroxisome proliferator-activated receptor alpha target genes was suppressed.
245 protein (UCP)-1 and peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha as wel
246 gh the regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha expression.
247 ilure to undergo the peroxisome proliferator-activated receptor signaling-dependent switch from glyco
249 activating protein 2) and F2rl2 (proteinase-activated receptor-3), 2 genes that were also silenced a
250 tive agonist for the peroxisome proliferator-activated receptor-delta (PPAR-delta), which is implicat
252 PCRs, such as the ADP receptors and protease-activated receptors, can also potentiate CLEC-2 signalin
256 tial for the survival and differentiation of activated satellite cells into the myogenic lineage.
259 ermophila, protozoa that are utilized during activated sludge treatment ((R)-FL is 30x more toxic tha
263 drothermal method, were deposited onto epoxy-activated standard glass slides, followed by immobilizat
264 ain-infiltrating CD8(+) T cells represent an activated subset of those found in the periphery, having
265 CO2 in the presence of DBU, is dehydrated by activated sulfonium reagents to generate the correspondi
267 portant to control HSV, and proliferation of activated T cells requires increased metabolism of gluta
268 pneumotropica ( Pp)-reactive immune response activated T cells to produce receptor activator of nucle
270 ired the presence of the antigen-specific or activated T cells whereas exposure to innate stimuli suc
273 r clinical activity has been correlated with activated T-cell recognition of neoantigens, which are t
274 Overall, EVL and VASP selectively mediate activated T-cell trafficking by promoting the diapedesis
278 l regulator of T cell differentiation and is activated through proteolytic cleavage in response to li
279 e to its significant homology with the force-activated titin kinase, smMLCK is suspected to be also r
280 Our results indicate that KATP channels are activated to a greater extent in perfused hearts when th
281 to linear form by flow, and is subsequently activated to bind GPIbalpha in a tension-dependent manne
284 Herein, we report that (S)P(MeAN) can be activated to generate O(MeAN) and perform the oxidation
286 tor that is negatively regulated by Akt, was activated, translocated to the nucleus, and induced the
292 ry previously determined that mast cells are activated via a non-FcepsilonRI mediated response follow
293 argeted by the Art1 alpha-arrestin, which is activated via the TORC1 kinase complex upon arginine upt
294 t this to indicate that stabilization of the activated voltage sensor limits the return of hERG chann
295 E1R/R4E KCNQ1, a mutant with constitutively activated voltage sensors, F56Bpa and F57Bpa KCNE1 were
296 pecifically, early measurements of thermally activated vortex motion (creep) in iron-based supercondu
297 e system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharid
298 nner chamber produced ET-1 when T cells were activated with antigen or anti-CD3 antibody in the outer
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