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1 ely facilitates interaction with the agonist-activated form of a G-protein-coupled receptor (R*) and
2 ing CDX activity by ectopic expression of an activated form of a Xenopus Cdx gene (XcadVP16) in the h
6 ng antibodies recognizing the phosphorylated/activated form of AKT kinases, we observed elevated phos
7 nsgenic mice expressing a membrane-targeted, activated form of Akt under control of the 2',3'-cyclic
8 anti-apoptotic molecules and found that the activated form of Akt was suppressed in the E1A transfec
10 characterized by combined overexpression of activated forms of AKT and neuroblastoma Ras viral oncog
12 ells ectopically expressing a constitutively activated form of Akt3 or endogenously expressing mutant
13 the TGF-beta signaling pathway by expressing activated forms of ALK-1 and ALK-5, type I receptors for
17 precursor cells, we conditionally express an activated form of an FGF receptor or delete the FGF rece
18 compound failed to significantly suppress an activated form of another RTK, the Drosophila epidermal
19 Moreover, the co-expression of Cat-1 and an activated form of Arf6 in fibroblasts was sufficient to
20 phila Arfaptin protein directly binds to the activated forms of Arf6 and Rac1 GTPases, and mutants in
21 of furrow progression, can be mimicked by an activated form of armadillo and blocked by a dominant ne
22 Studies in Drosophila have revealed that an activated form of Armadillo, the effector of Wnt signall
28 sponse, characterized by the accumulation of activated forms of ATM and Chk2 as well as nuclear foci
30 In converse, conditional expression of an activated form of beta-Catenin leads to expansion of Nkx
32 encoding either a stabilized, constitutively activated form of beta-catenin or a dominant negative fo
34 gene transfer to force the expression of an activated form of beta-catenin that should constitutivel
35 mportance, we have targeted expression of an activated form of beta-catenin to the urothelium of tran
38 etroviral transduction of the constitutively activated forms of both GTPases into primary murine macr
39 d in mice through the combined expression of activated forms of both KRas and Akt in glial progenitor
40 (RCAS)/TVA system to transfer genes encoding activated forms of BRAF, KRas, Akt and Cre to nestin-exp
41 ion has attracted considerable interest, and activated forms of BRAF, such as BRAF(V600E), have becom
43 to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a membe
47 o the cytoplasm and the nucleus, whereas the activated forms of calpain-7 and -10 are found only in t
48 tion, whereas expression of a constitutively activated form of CaMKII mimicked the effects of morphin
49 mmunohistochemical analysis reveals that the activated form of caspase-3 and a caspase cleavage produ
50 nogenic soft agar assay and detection of the activated form of caspase-3 and cleavage of poly(ADP-rib
54 genesis of C431 resulted in a constitutively activated form of CBS that could not be further activate
55 Cat-1 from NIH3T3 fibroblasts expressing an activated form of Cdc42 (Cdc42 F28L), or from the human
56 sed an assay in yeast where expression of an activated form of Cdc42, a Rho-type guanosine triphospha
58 Da protein that formed a stable complex with activated forms of Cdc42 and thereby showed characterist
60 We demonstrate that CRL4(CDT2) targets the activated form of CHK1 for destruction in the nucleoplas
61 ocalization of the phosphorylated, therefore activated, form of cJun, a JNK target in dorsal root gan
63 nesis and lipolysis, forced expression of an activated form of CREBH protein in the liver significant
66 uorescein, fluorescein and resorufin with an activated form of cyclic trimetaphosphate to give interm
67 clease-coupled DNA methylation assay with an activated form of Dnmt1 engineered to lack the replicati
69 three-dimensional structures of the apo and activated forms of DtxR show conformational changes in t
70 ratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that
71 tudies, the effects of a novel conditionally activated form of EGF-R, v-ErbB:ER, on the morphological
73 somal maturation assay and observed that the activated form of EhRab35 significantly increased the ra
74 ther contexts, and MsEphrin colocalizes with activated forms of endogenous Src in the leading process
75 xide synthase (r(part) = 0.46, P = 0.02), an activated form of endothelial nitric oxide synthase.
76 gested that evaluation of the phosphorylated/activated form of ErbB-2 might be more precise in defini
77 etastases of uveal melanoma patients express activated forms of ERBB2 (the coreceptor for ERBB3) and
81 Mutant tibiae have increased levels of the activated form of ERK1/2, consistent with the idea that
83 y, FHL2 interacted more efficiently with the activated form of ERK2 than with the dephosphorylated fo
84 partate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase
87 veral multiple myeloma cell lines expressing activated forms of FGFR3, NDGA generally resulted in a d
88 efects are associated with low levels of the activated forms of focal adhesion kinase (FAK) and extra
91 ed receptor kinases (GRKs) phosphorylate the activated form of G protein-coupled receptors leading to
92 stins selectively bind to the phosphorylated activated form of G protein-coupled receptors, thereby b
93 alian cells that these RhoGEFs interact with activated forms of G alpha 12 or G alpha 13 through thei
94 ounced with the mutationally or functionally activated form of Galpha(13) compared to that of wild-ty
101 ounced with the mutationally or functionally activated form of Galpha13 as compared with the wild-typ
104 Conversely, expression of a constitutively activated form of GSK3beta sensitized cancer cells to mT
105 he global gene expression pattern induced by activated forms of H-Ras, RhoA, Rac1 and Cdc42 using cDN
106 e report that expression of a constitutively activated form of HIF2alpha (P405A, P530A, and N851A, na
107 elets selectively lacking the G(beta)(gamma)-activated form of his enzyme (PI3Kgamma), we show that G
108 of inhibitors shows higher affinity for the activated form of Hsp90 compared to our earlier 8-sulfan
112 NSP1 can induce degradation of inactive and activated forms of IAD-containing IRF proteins (IRF3 to
114 We investigated whether mice that express an activated form of IKKbeta in the esophageal epithelia de
115 uced platelet aggregation, expression of the activated form of integrin alphaIIbbeta3, and exposure o
116 ells engineered to express human SERT and an activated form of integrin beta3 exhibited enhanced SERT
117 the structural features associated with the activated form of Itk, we have solved the NMR structure
123 umors that developed in mice that express an activated form of Kras (Kras(LSL-G12D/+);Ptf1a(Cre/+) mi
125 m with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreati
126 2H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pa
127 n the de novo synthesis of GDP-L-fucose, the activated form of L-fucose, which is a component of glyc
128 tact, TCR microclusters are colocalized with activated forms of Lck, ZAP-70, and the linker for activ
129 rved following overexpression of Pitx2 or an activated form of Lef1, suggesting an effect on cell pro
131 nonical Wnt signaling stimulated by Wnt1 and activated forms of LRP5 (low density lipoprotein recepto
133 ferentially interact with the phosphorylated/activated form of MAD, and Nup93 acts to recruit the imp
134 defects due to loss of Msk are rescued by an activated form of MAPK or the secreted epidermal growth
137 xpressed dominant-negative or constitutively activated form of MEK5 to inhibit or activate the MEK5-E
138 lls with CP-654577 reduces the levels of the activated form of mitogen-activated protein kinase, incr
139 lpha/beta activity, and the expression of an activated form of MKK6 (an immediate upstream activator
141 edium, is between the intermediate and fully activated forms of MMP-2 induced by membrane type 1-MMP.
142 ction in myogenic processes, we expressed an activated form of mouse calcineurin A in Drosophila and
143 ncogenic stress and that the phosphorylated (activated) form of MSK1 is significantly increased in th
144 rmined by analysis of the phosphorylated and activated forms of mTORC1 signaling proteins in the pref
145 yzed hydroacylation between aldehydes and an activated form of N=N bond was achieved under mild condi
148 MM cells from all the patients expressed the activated forms of NF-kappaB and STAT3 but to a variable
149 marrow of 22 MM patients and checked for the activated forms of NF-kappaB and STAT3 by immunocytochem
155 -inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like
156 l of Notch1 in solid tumors, we expressed an activated form of Notch1 (N1ICD) in the developing mouse
159 :nicd1a transgenic embryos overexpressing an activated form of notch1, nicd1a, displayed increased cp
160 ferent studies of transgenic mice expressing activated forms of Notch1 (Notch1IC) led to conflicting
161 and brain, we injected retroviruses encoding activated forms of Notch1, Notch2, or Notch3 into embryo
162 n this study, we show that the effects of an activated form of Notch2 (N2IC) on the T-cell lineage ar
164 conclude that there is no accumulation of an activated form of O2 before C-H abstraction in the Dbeta
167 een previously demonstrated to represent an "activated" form of p53 in both in vivo and in vitro assa
169 e-introducing expression constructs encoding activated forms of phosphoinositide 3-kinase, Akt, or Ak
170 Subsequent studies demonstrated that an activated form of PI 3-kinase restored Rac GTP loading i
171 , but not HIV infection alone, contained the activated form of PKR, which localized predominantly to
172 dy specific for the tyrosine-phosphorylated, activated form of PLCgamma1, we now show that chronic mo
173 ing SKN-1, the MEDs, PAL-1, and the Wnt/MAPK-activated form of POP-1, are responsible for activating
175 cretion by strains containing a mutationally activated form of prfA, the key regulator of L. monocyto
176 t that hES cells localize a conformationally activated form of proapoptotic BAX to the trans Golgi ne
178 on of 3'-phosphoinositol lipids (PI3Ps), the activated form of Rac, a small GTPase, and F-actin.
181 We investigated whether expression of the activated form of Ras in gastric chief cells of mice lea
186 arily muscle-forming mesoderm, and expressed activated forms of Ras or Notch to induce FC or FCM fate
188 We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course of TORC2
194 This phenotype can be recapitulated using an activated form of RhoA and rescued by inhibiting Rho-kin
195 ns that bind with high affinity to the light-activated form of rhodopsin without requiring phosphoryl
197 solid tumors, we established a conditionally activated form of ROCK II by fusing the kinase domain to
199 luble guanylyl cyclase (sGC) itself, the NO -activated form of sGC, and phosphodiesterase(s) (PDE).
200 re known mutations predicted to result in an activated form of Shp2, whereas six are new mutations.
201 In this study, the biosynthesis of this activated form of sialic acid completely from endogenous
202 antibody specific for the phosphorylated and activated form of Smad1 to examine endogenous patterns o
209 ached high levels in the mother cell; (2) an activated form of Spo0A impaired sporulation when produc
212 -Tyr containing proteins, an antibody to the activated form of Src-family PTKs was used to localize a
213 othelial cell-specific overexpression of the activated form of SREBP2 synergized with hyperlipidemia
214 Stat3 protein levels and the levels of the activated form of Stat3 (pStat3) at P12, P15, P18, and P
216 pression were increased by overexpressing an activated form of Stat3 but decreased by attenuation of
217 , while the introduction of a constitutively activated form of Stat3 into immortalized human breast e
218 ereas the overexpression of a constitutively activated form of STAT3 promoted HSC senescence through
219 correlation between increased levels of the activated form of Stat3, phosphorylated-Stat3, and incre
220 igodendrocytes; (2) the overexpression of an activated form of STAT5 prevents alpha-amino-3-hydroxy-5
221 Transgenic mice expressing a constitutively activated form of STAT5b have been shown previously to c
223 n addition, we demonstrate expression of the activated form of STAT6, a mediator of IL-4 signaling, b
225 fonyl transfer, and nodPQ, which produce the activated form of sulfate, 3'-phosphoadenosine-5'-phosph
226 These enzymes function together to produce activated forms of sulphate, APS and PAPS (3'-phosphoade
228 the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the a
229 misexpressing dominant-negative and dominant-activated forms of Tbx5 in the chick wing we provide evi
230 C-893 selectively killed cells expressing an activated form of the anabolic oncogene Ras in vitro and
231 difier screen in the Drosophila eye using an activated form of the catalytic subunit to identify new
232 gulated by the polarized distribution of the activated form of the Cdc42 protein, rather than by the
233 Transgenic mice expressing a constitutively activated form of the cellular homologue Akt2 specifical
234 ate that albicin specifically recognizes the activated form of the complex, allowing more efficient i
235 neered to inducibly express a constitutively activated form of the cyclic AMP-dependent protein kinas
236 Conversely, expressing a constitutively activated form of the Drosophila JAK kinase (hop(Tum-l))
238 is required to stabilize the lifetime of the activated form of the enzyme against reoxidation of Fe(H
239 ss spectrometry data show that the TIH-bound activated form of the enzyme closely resembles the inhib
240 )(III) couple), the kinetic stability of the activated form of the enzyme has been greatly diminished
242 hat while the thermodynamic stability of the activated form of the enzyme is unchanged (characterized
246 ) to the Golgi complex is initiated when the activated form of the GTPase Sar1p recruits the Sec23p-S
247 ted cells is rescued by the expression of an activated form of the immediate upstream p38-activating
248 d levels of expression of fibronectin and an activated form of the integrin alphavbeta3, which coordi
249 Here, we describe a mouse line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1),
250 ctive form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin, determined
251 ne to enforce expression of a constitutively activated form of the Notch 4 receptor, we show that sig
252 wo known clock components [Lfng mRNA and the activated form of the Notch receptor (cleaved Notch intr
253 g the number of polar cells by expressing an activated form of the Notch receptor increases the numbe
254 confirmed by misexpressing a constitutively activated form of the Notch receptor, Notch(IC), in tran
255 ory progenitors, we transiently expressed an activated form of the Notch1 receptor (NICD) using a com
258 dose-dependent manner by coexpression of an activated form of the nuclear kinase Sik/BRK that hyperp
260 inant antibody (scFvSCE5), which targets the activated form of the platelet-integrin glycoprotein IIb
261 s a crucial factor for stabilizing the light activated form of the protein, and have been used to pro
265 he intracellular domain of Notch, a dominant activated form of the receptor, is sufficient to prevent
267 steady-state level of the phosphorylated or activated form of the response regulator CheY dictates t
270 ted with high levels of immunoreactivity for activated forms of the BDNF receptor TrkB and beta1-inte
271 We also show that senescent cells contain activated forms of the DNA damage checkpoint kinases CHK
272 IB point mutations also disrupt signaling by activated forms of the kinase cascade scaffold protein S
274 tromal tumors (GISTs) express constitutively activated forms of the KIT receptor tyrosine kinase prot
275 ption factor lhx1a, and forced expression of activated forms of the lhx1a gene product rescued nephri
279 Cell type- or region-specific expression of activated forms of the oncoproteins Harvey-Ras and AKT i
281 asses of FLT3 mutations cause constitutively activated forms of the receptor that are found in signif
285 Arrestins selectively bind to phosphorylated activated forms of their cognate G protein-coupled recep
286 bstrates and by detection of proteolytically activated forms of these caspases by Western immunoblott
287 unt of PKMzeta protein and the amount of the activated form of this kinase, phospho-PKMzeta (p-PKMzet
291 L-cmk decreased the nuclear content of SKI-1-activated forms of transcription factors SREBP-1, SREBP-
292 isplay substantially increased levels of the activated form of transforming growth factor beta, a pot
293 GF treatment results in the translocation of activated forms of TrkA to lipid rafts, and this localiz
295 Furthermore, selective expression of an activated form of UNC-43 in ADF neurons is sufficient to
297 sformed by IL-27R contain elevated levels of activated forms of various signaling proteins, including
299 nic mice that overexpressed a constitutively activated form of YAP (YAP(S127A)), and measured protein
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