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1  proliferative responses (referred to as an "activated state").
2  DA release (change in BPND from baseline to activated state).
3 andom walk in both the basal and the agonist-activated state.
4  increase in GCLC expression kept HSCs in an activated state.
5 tion, and may cause the channel to be in the activated state.
6 tacts leading to stabilization of the GTPase activated state.
7 izing the voltage sensor of domain II in its activated state.
8 cific conformations were unable to reach the activated state.
9  stellate cells (HSC) from a quiescent to an activated state.
10  of activation markers, suggestive of a semi-activated state.
11 nteraction when the AChR is in the closed or activated state.
12 ons sample conformations consistent with the activated state.
13 ed antithrombin that locks the serpin in the activated state.
14 e voltage sensor from the deactivated to the activated state.
15  the retention of the entering ligand in the activated state.
16 SC2 phosphorylation and maintains TSC2 in an activated state.
17 present the heterotrimer core of SNF1 in its activated state.
18 play a role in its transcriptionally poised, activated state.
19 en that triggers the reaction, and are in an activated state.
20  suggested that AEA raised the energy of the activated state.
21 the conformational transition of S1P1 to its activated state.
22 pffer cells; only Fzb was expressed in their activated state.
23 is expressed in the nuclear localization and activated state.
24 and VI are only observed in complex with the activated state.
25 id microglia; the latter is indicative of an activated state.
26  the inhibitory segment of TnI in the Ca(2+)-activated state.
27  Immune cells cycle between a resting and an activated state.
28 nteractions within the binding site into the activated state.
29 ose that the open form of SecA represents an activated state.
30 nts with sickle cell disease (SCD) are in an activated state.
31 ilibrium between reactants and a high-energy activated state.
32  alpha1PI Pittsburgh, even in the nonheparin-activated state.
33 esponse regulator from a phosphorelay in its activated state.
34 shes the uniformity of the transcriptionally activated state.
35 sition to the pore domain in the resting and activated state.
36 rms by ligand binding returns the TSHR to an activated state.
37 nent C1s is present in dog joint fluid in an activated state.
38  available for maintaining WM contents in an activated state.
39 mational freedom for the tetrapyrrole in the activated state.
40 t it selectively binds the latter in a fully activated state.
41 t when nearly all of the substrate is in the activated state.
42 them to form new intramolecular bonds in the activated state.
43 c kinase domain (IRKD) without affecting the activated state.
44  TRAP primarily when it is in the tryptophan-activated state.
45  low level expressed in the interferon-gamma-activated state.
46 tasaccharide so as to lock the serpin in the activated state.
47 ity was increased, implying promotion of the activated state.
48 nd selectively recruited G proteins in their activated state.
49 uced conversion toward a mature inflammasome-activated state.
50 esponsive genes from a repressed state to an activated state.
51           These motions are moderated in the activated state.
52 rotein to progress from the basal toward the activated state.
53  stabilizing the voltage sensor domain in an activated state.
54 osslinking of these two residues favored the activated state.
55 ce that stabilizes the channel in a pre-open activated state.
56 he resting state and others only in the GABA-activated state.
57 egment moves outward to its intermediate and activated states.
58 ein structure in both dark-adapted and light-activated states.
59  alpha1I228C, alpha1Q229C and alpha1L232C in activated states.
60 lls than in naive CD8 T cells at resting and activated states.
61 d in CD4+ T lymphocytes, both in resting and activated states.
62 r memory or naive cells in their resting and activated states.
63 gment spans the membrane in both resting and activated states.
64 ponses was present during both quiescent and activated states.
65  of human vinculin in its inactive and talin-activated states.
66 te the transit of stem cells from dormant to activated states.
67 ibilities to these proteinases in native and activated states.
68 uce neuromodulator-independent transition to activated states.
69 allosteric activation and suggested multiple activated states.
70 an allosteric equilibrium between native and activated states.
71 tforms assembling ULK1 and Beclin 1 in their activated states.
72 h these proteases in unactivated and heparin-activated states.
73 al networks, called the "desynchronized" or "activated" state.
74  during quiescent states and during aroused (activated) states.
75 low turnover (quiescent) and rapid turnover (activated) states.
76 r either 0 ms (closed state), 1.5 and 10 ms (activated states), 1 s (fast desensitized state), or > o
77 nt exometabolomic profiles in both naive and activated states; 2) approximately 30% of detected metab
78 increased in the resting (37%; P < 0.05) and activated state (26%; P < 0.005) in type 1 diabetic comp
79 with overexpression have the receptor in the activated state, a substantially greater proportion than
80 the Arf family GTPases, in which a partially activated state, achievable from a receptor-mediated act
81 have distinct conformations in the basal and activated states, acting as switch regions.
82 sion of the energy and relaxation toward the activated state after Fe(2+)-His bond breaking.
83 of the TKD-EGFR resides in the cytosol in an activated state, although surface-localized subsets of t
84 n SSc, epidermal cells are in a persistently activated state and are able to promote dermal fibrosis.
85 n of c-Src with the beta3 tail occurs in its activated state and at a site that overlaps with PPII bi
86 cling under conditions similar to the stress-activated state and indicate a clathrin/dephosphin-media
87 s, Lyn is constitutively bound to GPVI in an activated state and platelets lacking Lyn exhibit defect
88 ity to progress from a naive to functionally activated state and rapidly mediate autoimmune IDDM deve
89 and IXa in the native as well as the heparin-activated state and support a new model of allosteric ac
90 he Nox4 DH domain exists in an intrinsically activated state and that electron transfer from NADPH to
91 e GDP-bound inactive state and the GTP-bound activated state and their activation is predominantly me
92 tants copurified with Ste7 and Fus3 in their activated state and their activation required Ste20.
93 e the energetic cost of attaining the GTPase-activated state and thereby decrease the stringency of d
94 s required to propel the B cell into a fully activated state and thus a normal humoral immune respons
95 ormational equilibrium between inhibited and activated states and that electrostatic interactions inv
96 scherichia coli ribosome, the SRP-SR in the 'activated' state and the translocon.
97 ansition between the final closed (partially activated) state and the open state.
98 oth mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-termi
99 onformation for HER2 that resembles a ligand-activated state, and show HER2 poised to interact with o
100 s upon GTP binding, forming tetramers in the activated state, and stimulates the GTPase activity in a
101 e but is released from the core in the fully activated state, and the bulk of allosteric activation h
102 val indiscriminately, at either a resting or activated state, and to cooperate with CD40L, further su
103  inactive {[Fe4S4]2+ Nip2+ Nid2+} state, the activated state appears to be 2-electrons more reduced,
104                         Transitions to these activated states are likely to play a crucial role in fo
105  ubiquitination in both the basal and ligand-activated states as well as delayed the processing of li
106 crystal structures of troponin in the Ca(2+)-activated state at 3.0 angstroms resolution and in the C
107 nhibited state at negative potentials to its activated state at positive potentials.
108 s capable of representing both repressed and activated states at the same time and in the same nucleu
109 was activated only by assembled E2, and this activated state beget high responsiveness to those effec
110 h the transition from the unactivated to the activated state being induced by the templated NTP bindi
111                                           In activated states, beta2M286C formed disulfide bonds with
112 Spider Roll binds to full-length PAK1 in its activated state but does not bind PAK1 when it forms an
113 y associating with closed-resting and closed-activated states but a low affinity interaction with the
114 ptured the voltage sensor module (VSM) in an activated state, but structure of the deactivated voltag
115  dendritic cells (FDCs) exist in resting and activated states, but are activated in germinal centers,
116      Leukocytes are thus maintained in a non-activated state by appropriate receptor clustering or re
117              Subsequently, they maintain the activated state by autocrine production of proinflammato
118 I were examined in the dark and in the light-activated state by fluorescent probes and cysteine cross
119 tion R1441H traps Roc in a more persistently activated state by increasing its affinity for GTP and,
120 number of different stimuli to a chronically activated state by signaling through both purinergic and
121  dynamically converts these complexes to an "activated" state by phosphorylation events, primarily me
122                HIV viremia induces an immune activated state; by comparison, HCV infection induces im
123 ate of the active site FeMo-cofactor into an activated state capable of reducing dinitrogen remains e
124 phages revealed markers characteristic of an activated state (CD80, CD86, Ly-6C/G), whereas macrophag
125               In this complex, TnpA is in an activated state competent for DNA cleavage and strand tr
126  and subsequently switches the oxidase to an activated state dependent upon PtdIns(3)P and SH3 domain
127                                    Partially activated states do not exist at the scale of the cell,
128 ss exercise, converts satellite cells to the activated state due to accelerated Wnt signaling.
129                              In such a phase-activated state, electrostatic interactions from these 8
130 s of GPCRs that are thought to be in a fully activated state, except that the cytoplasmic end of tran
131  unactivated state or the +2 DNA base in the activated state facilitates translocation via a ratchet
132      The structure of troponin in the Ca(2+)-activated state features a nearly twofold symmetrical as
133 u(2+) mediates the formation of a monomeric, activated state followed by the formation of a discrete
134 on, but CD19 expression maintained Btk in an activated state following BCR engagement.
135  that Ror2 expression results in a partially activated state for canonical Wnt signaling through an i
136 ein alpha subunit (GalphaCT) to trap a light activated state for crystallization.
137 odulate a voltage-dependent transition to an activated state from which Cl(-)/H(+) exchange can occur
138                                   In the non-activated state, gfp* is transcribed from the aadA promo
139  by an unstable converter locus which in its activated state gives rise to a high nornicotine, low ni
140 sal activity, revealing that PDE5 in its non-activated state has low intrinsic catalytic activity.
141 ar to lock the protein into a constitutively activated state have been identified.
142 in both unphosphorylated and beryllofluoride-activated states have been determined, revealing a mecha
143 ression when the protein is not in its fully activated state; however, saturating levels of the prote
144  bound toxin traps the voltage sensor in the activated state in a voltage-dependent but concentration
145 state in erythroid progenitors, to the fully activated state in late, erythroid cells.
146                    Platelets circulate in an activated state in patients with inflammatory bowel dise
147 the distal region of SRP-RNA, trapped in the activated state in presence of GDP:AlF4.
148 PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.
149 may be important in maintaining STAT3 in the activated state in the ALK+ TCL cells.
150 -type maternal Rasgrf1 allele maintained its activated state in the next generation independently of
151  To be effective, Treg cells should be in an activated state in the target tissue.
152 ate and a low H(+)/ATP coupling ratio and an activated state in which ATP hydrolysis is tightly coupl
153 by rapidly transiting from its resting to an activated state in which it serves as a receptor for lig
154 e barrel cortex produces well differentiated activated states in rats.
155 e them to maintain depolarized, persistently activated states in the absence of sustained input are p
156 describes many essential features of SWS and activated states in the thalamocortical system as well a
157             The CAF phenotype represents an "activated state" in which cells are primed for cell deat
158       PKD phosphorylation, indicative of the activated state, increased after 2-3 days of treatment o
159 adhesion and spreading in both the basal and activated states, increased F-actin content, and increas
160 te significantly impact sensory coding, with activated states increasing the reliability of responses
161 fines the dimer interface in the resting and activated state, indicates how ligand binding is coupled
162 s Xa and IXa in both unactivated and heparin-activated states, indicating that these residues made cr
163  1-layer 2 interactions also destabilize the activated state induced on HIV-1 by treatment with solub
164 ion cycle is predominantly a monomer and the activated state is a dodecamer.
165 croglia from the normal resting state to the activated state is associated with an increased expressi
166 xit of a stem cell out of quiescence into an activated state is characterized by major metabolic chan
167 ibiting histone deacetylases; however, their activated state is reversed quickly by withdrawal of tri
168 ive-helix bundle protein lambda(6-85), whose activated state is significantly populated during foldin
169           The significance of the long-lived activated state is that SAMHD1 can remain active long af
170  cortical extrasynaptic glutamate during EEG-activated states is counteracted by a decrease during NR
171 that nucleotide release under both basal and activated states is likely an important mechanism for fi
172   Expression of Vav1 Y174F, which mimics its activated state, is a potent inducer of invadopodia form
173                                       In the activated state, La(3+) is displaced by outward movement
174  consistent with these cells remaining in an activated state longer and undergoing more rounds of pro
175  isolated in transcriptionally repressed and activated states maintain their characteristic chromatin
176 tion activity varies between deactivated and activated states marked by the presence and absence of s
177 al to all-trans retinal leading to the fully activated state, metarhodopsin II.
178 ated in this study that, in both resting and activated states, mouse peripheral CD4(+)CD25(+) T regul
179  is believed to parallel the induction of an activated state observed in pancreatic disease such as c
180  and adopts a conformation distinct from the activated state observed in structures of other voltage-
181 minator regions during the transcriptionally activated state of a gene.
182 rolyl isomerization not only to generate the activated state of a protein but also to maintain it for
183              How mesangial cells sustain the activated state of Akt is not clearly understood.
184 e a model explaining how TARPs stabilize the activated state of AMPARs and how the interactions betwe
185 dMyc cascade plays a key role in setting the activated state of AMPs.
186 t (Fab30) that recognizes the phosphopeptide-activated state of beta-arrestin-1.
187 upstream activators: instead of mimicking an activated state of CDC42, EspF(U) mimics an autoinhibito
188                 We show that, by setting the activated state of cerebral endothelium, astroglial Cx43
189                                         This activated state of DCs may be responsible for their incr
190   Wnt-5A/Fz5 signaling may contribute to the activated state of FLS in RA.
191 perimentally resolved structures of the Ca2+-activated state of its isolated C2alpha domain, one dete
192 a membrane in response to ATP and during the activated state of microglia that is associated with ner
193 tant, which conformationally mimics the PDBu-activated state of Munc13-1.
194      Despite extensive studies on the Ca(2+)-activated state of NCS proteins, little is known about t
195  affinity reagent that selectively binds the activated state of PAK1, we used molecular modeling to r
196 dimer provides a scaffold for assembling the activated state of PARP-1 and suggests a mechanism for c
197                                          The activated state of PARP-1 was generated by treatment of
198 1-yl)ethanone (FLB-12)] that antagonizes the activated state of PXR with limited effects on other rel
199 stabilized by approximately 30% in the light-activated state of PYP.
200 acterization of soluble mimics for the light-activated state of rhodopsin have shown that grafting de
201 created based on a recent model of the light-activated state of rhodopsin.
202  approximate structural mimic for this light-activated state of rhodopsin.
203 tions investigated increased the GTP-loaded, activated state of RIT1 in vitro, but they could be clas
204                                          The activated state of such organs appears to trigger host i
205 S3 (a talin peptide that mimics a postulated activated state of talin), nor F-actin alone can activat
206                     The ligation ensures the activated state of the acid for reduction into monoligno
207 ical movement plays a role in regulating the activated state of the AT(1) receptor, and this role may
208 nnabinoid type-2 receptor (CB2R) affects the activated state of the brain endothelium and blood-brain
209  each of these four mutations stabilized the activated state of the channel, thereby producing gain-o
210 g a role for the alphaK/beta15 insert in the activated state of the complex.
211 ing that hydrophobic compounds stabilize the activated state of the enzyme.
212 use AlF4- complexes with GDP to stabilize an activated state of the Galpha subunit, these results sug
213                                          The activated state of the LHR gene induced by TSA and 5-Aza
214 -I changes the character of MEFs to a highly activated state of the MAPK pathway, indicating the crit
215                                          The activated state of the octameric enzyme is characterized
216 mers are formed in the resting state and the activated state of the receptor by different TM interact
217 ner alpha(IIb)CT, thus likely maintaining an activated state of the receptor.
218 l conformation to relax, thereby forming the activated state of the receptor.
219 istidine 205 and 266 residues interact in an activated state of the receptor.
220 e and does not constrain the basal or ligand-activated state of the receptor.
221 ructures, at present, they all represent the activated state of the sensor.
222 r and oxygen is the key factor retaining the activated state of the TiO2 powder for a time period.
223 larization and therefore is conducted in the activated state of the voltage sensor.
224 the open conformation of the channel and the activated state of the voltage sensors, yet decouples th
225 s on the three-dimensional structure for the activated state of this receptor, metarhodopsin II.
226 raction in living cells under the resting or activated state of TRPV1, as well as in presence of stru
227 R SOD1YFP motor neurons, correspondent to an activated state of ULK1 that initiates autophagy.
228  the pore opens at both the intermediate and activated state of voltage sensor activation.
229    GX-936 and related inhibitors bind to the activated state of voltage-sensor domain IV (VSD4), wher
230 basal activity state and glucose-6-phosphate activated state of yeast glycogen synthase-2.
231                        While the resting and activated states of multiple receptors are well characte
232 oid agonists) to determine structures of two activated states of the capsaicin receptor, TRPV1.
233 re important for stabilizing the resting and activated states of the channel, respectively.
234 affect the stability between the resting and activated states of the nAChR.
235 l and solution structures of the resting and activated states of the photosensory core of the bacteri
236 role of specific residues in the resting and activated states of the receptor.
237 le to proteinases in both native and heparin-activated states of the serpin and contributes similarly
238 arget proteinases in both native and heparin-activated states of the serpin.
239 uctural models of resting, intermediate, and activated states of the voltage-sensing domain of the ba
240 capacity to alternate between repressive and activated states of transcription.
241 impact on cAMP observed with the inactive or activated states of wild type Atr1a on function, and not
242  showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face,
243 unphosphorylated (basal) and phosphorylated (activated) states of the kinase.
244 ed repression state to an activator-mediated activated state on a promoter may be mediated in part th
245 iactivated T cells ready to shift to a fully activated state once a CD3-mediated signal has been rece
246  ATPase activities, suggesting a permanently activated state or, alternatively, a complete lack there
247 d only when ErbB-2 is in the phosphorylated (activated) state or coexpressed with EGFR.
248  stabilization of tropomyosin in the "Ca(2+)-activated state" or "C-state." The last 17 amino acids p
249                                 This delta2 "activated" state overcomes its impediment in ATP hydroly
250                Forcing VLA5 to remain in the activated state permits NETosis but prevents homotypic a
251  closed state (pH 7.5) and in a submaximally activated state (pH 5.0).
252 ent microglial cells in both the resting and activated state produced the protein Ym1, which is a mar
253  presence of alpha(v)beta3 in a functionally activated state provides a unique advantage for circulat
254  neurons gradually increased and, in a fully activated state, reached the same or even higher values
255 r switch mechanism from autoinhibited to the activated state remains unknown for alpha-catenin.
256           On the other hand, formation of an activated state requires copper binding to both NMBD and
257  where shifting the equilibrium to the fully activated state requires total unclasping of the cytopla
258 nism of the M5aFull at the inhibited and the activated states, respectively.
259 VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO
260            In contrast, during behavior-ally activated states, sensory responses are already adapted.
261 ation, quiescent glial cells converted to an activated state showing a decrease in nuclear chromatin
262 d state to background levels, but the TS2/16-activated state still retained approximately 30% of the
263 ain's tissue macrophages and are found in an activated state surrounding beta-amyloid plaques in the
264 ons, LFA-1 must convert from a resting to an activated state that avidly binds its ligands such as in
265 state that catalyzes synthesis slowly and an activated state that catalyzes synthesis rapidly, with t
266  a substrate switches the proteasome into an activated state that persists throughout the degradation
267 ssion of M-CSFR causes microglia to adopt an activated state that results in proliferation, release o
268 s shown to push conventional T cells into an activated state that seems to be proinflammatory.
269 a(2)(+) stimulation converts CaMK-II into an activated state that, in the zebrafish, is detected in t
270 gered, the native peptide transiently visits activated states that are very similar to those sampled
271                         Within the transport-activated state, the channel remains open even though th
272          Our structures show that in the ATP-activated state, the D1 loops are stabilized at the cent
273        During the transition from SWS to the activated state, the input resistance of cortical neuron
274 activates from the intermediate state to the activated state, the VSD-pore coupling has less efficacy
275 onal antibodies were used to achieve uniform activated states, the binding of alpha5beta1 to full-len
276 chanism that could keep infected cells in an activated state, thereby promoting viral replication.
277  to favor the attractive interactions in the activated state through core conformational changes indu
278 , resulting in an apparent reversal of their activated state to a quiescent, nonproliferative state.
279 e mutant synergy site reduced the AG89 (low)-activated state to background levels, but the TS2/16-act
280  studies suggest that vinculin must be in an activated state to bind to alpha-catenin and that this i
281 ormal RAS protein locked in a constitutively activated state to drive malignant transformation and tu
282                      The failure of the AG89-activated state to show mechanical coupling to either th
283 d beta-catenin follicles in both resting and activated states to uncover the discrete set of genes wh
284 olved in the transformation of Ste2p into an activated state upon agonist binding.
285 ors result in their coordinated shift to the activated state upon being released from inhibition by r
286 ed myofibroblasts also revert back to a less-activated state upon injury resolution.
287 inactive state of CB(1) and be broken in the activated state via a chi(1) rotamer switch (F3.36(201)
288 lizes the voltage sensor in domain II in its activated state via a voltage-sensor trapping mechanism.
289 positions of key side chains in resting- and activated-state VS model structures, providing new insig
290 ylcholine activity, which is associated with activated states, was modeled by the reduction in the K+
291                     By modeling of the GPR55 activated state, we compared the GPR55 binding conformat
292  The kinetic constants of these steps of the activated state were similar to those of the unregulated
293 ing distinct native, intermediate, and fully activated states wherein the P14 residue retains an inte
294  glycoprotein alpha(IIb)/beta(3), in a fully activated state, which is critical for thrombus formatio
295 rhodopsins that lead to the formation of the activated state, which is ready to interact with the G p
296 ts with sickle cell disease reveal a basally activated state, which suggests that pathological platel
297 ift in ATM phenotype toward an alternatively activated state, which was accompanied by reduced AT inf
298 n the Nitrosomonas enzyme already is in the "activated" state with only one His ligand and an open di
299 the transition of ECs from a quiescent to an activated state, with higher proliferation rate, upregul
300 s GTPase deficient, remaining in a GTP-bound activated state without cycling.

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