ライフサイエンスコーパス: activation

1 ed maternal mRNAs and impedes zygotic genome activation.

2 pAg sensing that ultimately leads to T cell activation.

3 old (P < 0.05), which was dependent on MMP-1 activation.

4 k mechanism that amplifies the TRPM2 channel activation.

5 super-enhancer, resulting in high-level gene activation.

6 tensile force yields physiological integrin activation.

7 PF-positive T. denticola strain restored the activation.

8 ted with suppression of LPS-induced enhancer activation.

9 ntified a NF-kappaB site as critical in this activation.

10 med that the effects depended on cholinergic activation.

11 teral destruction associated with macrophage activation.

12 , and neurite outgrowth, as well as for RhoA activation.

13 in oxygen levels might initiate Type I cell activation.

14 ved and appears to be essential for receptor activation.

15 ergo large-scale conformational changes upon activation.

16 rs the ability of ICAP1 to suppress integrin activation.

17 ss, but blocking fission did not affect AMPK activation.

18 n and suppression of AKT, S6, ERK, and STAT3 activation.

19 ovel mechanism of TFIID recruitment and gene activation.

20 ge, astrogliosis, and conspicuous microglial activation.

21 on NLRP3, but not AIM2 or NLRC4 inflammasome activation.

22 topoiesis to monocyte changes and macrophage activation.

23 ivity of compound I with respect to C-H bond activation.

24 UNC-45A results in increased levels of NMII activation.

25 D88/p100 signaling as a regulator for B-cell activation.

26 ng proteins play an essential role in ICAM-4 activation.

27 tes macrophage IL-6 production through STAT3 activation.

28 an instability leading to unbounded cortical activation.

29 otype, likely reflecting decreased basal p53 activation.

30 ose residues, decreased the extent of B cell activation.

31 ostimulatory pathways are involved in T cell activation.

32 eoclastogenesis by down regulating NF-kappaB activation.

33 ess lymphadenopathy and T helper cell type 2 activation.

34 programs that are a hallmark of immune cell activation.

35 s cell death and tumor regression due to p53 activation.

36 RNAs (miRs) delivered by microvesicles to MC activation.

37 rian development after queen loss and immune activation after pathogen exposure).

38 sthma severity by transiently increasing MMP activation, airway smooth muscle growth, and airway resp

39 atics pathway analysis demonstrated that IgE activation aligned with processes such as oxidative phos

40 ss induces transient energy stress, and AMPK activation allows cells to manage this energy stress for

41 els in aging lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an

42 es the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models.

43 Treg functions result in uncontrolled immune activation and autoimmunity.

44 ally dimorphic in both basal and LPS-induced activation and contribute to the sexually dimorphic effe

45 ation fork stabilization, S-phase checkpoint activation and establishment of sister chromatid cohesio

46 Since complement activation and genetic variants in inhibitory complement

47 e key platelet functions after their initial activation and identifies a novel mechanism for controll

48 hus, TRAF3 plays a negative role in platelet activation and in thrombus formation in vivo.

49 kallikrein, subsequently accelerates contact activation and is responsible for the full procoagulant

50 Vascular endothelium activation and lymphocyte attraction, together with dend

51 e an impaired ability to regulate complement activation and may benefit more from complement-inhibiti

52 Type I IFN-mediated neutrophil activation and NET formation may contribute to inflammat

53 , it remains unclear how LAP shapes both the activation and outcome of the immune response at the mol

54 kine that potently promotes endothelial cell activation and pathological angiogenesis in our previous

55 of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory

56 -related proteins led to increased caspase 3 activation and reduced Bcl-2 expression, rendering them

57 a central player in epigenetics and in gene activation and repression.

58 They perform activation and repressive functions in the regulation of

59 ic carbene (NHC) chemistry, a novel C-N bond activation and ring-opening process is described for the

60 In the past several years, inflammasome activation and subsequent signal transduction have emerg

61 ation, reduced IL-2 production, and enhanced activation and survival.

62 our knowledge of mRNA-specific translational activation and the function of the PABP-eIF4G complex in

63 d oligomers at neutral pH that are caused by activation and thiol deprotonation of beta-subunit cyste

64 ys and light microscopy, we find that GTPase activation and trans-SNARE complex zippering have opposi

65 nt mechanism in Zn(2+)-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca(2+)]c

66 cytokinin response, mechanism of type-B ARR activation, and basis by which cytokinin regulates diver

67 ntibody-mediated rejection (AMR), complement activation, and graft thrombosis.

68 thereby increasing NEMO expression, NFkappaB activation, and IL6 secretion.

69 signal, which arises largely from microglial activation, and measures of subsequent disease progressi

70 5% for more than 10 weeks without microglial activation, and reduced the levels of cerebellar ATXN2.

71 biased capacity for CD4(+) and CD8(+) T cell activation are asymmetrically distributed in lymph nodes

72 s PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn(2+)-induced T

73 H2AZ regulates transcriptional activation as well as the maintenance of gene silencing,

74 campus inputs to LS showed enhanced neuronal activation (as measured by Fos expression) during contex

75 allergen challenge reduced ILC2 numbers and activation, as well as airway inflammation and IRF4 and

76 y disease resulting from dysregulated immune activation associated with a large local secretion of cy

77 We found that greater hippocampal activation at baseline was associated with increased Abe

78 The calculated activation barrier for the highly exothermic reaction to

79 the alpha1-helix is critical for alphaLbeta2 activation because trimming the Phe by small amino acid

80 hrough the inhibition of MAPKs and NF-kappaB activation but was mediated through the suppression of c

81 folding homeostasis likely contribute to UPR activation, but deletion of the unfolded protein stress-

82 , which is distinct from the effect of STING activation by DMXAA on enhancing proinflammatory respons

83 lated the ability of pTRS1 to antagonize PKR activation by dsRNA.

84 er the desired treatment zone and subsequent activation by laser light 753 nm with a fixed power of 1

85 been exploited to achieve meta-selective C-H activation by using a covalently attached, U-shaped temp

86 GR1 promoter was engineered to enhance trans-activation capacity and optimized for simple screening a

87 Thus FXIa, generated on contact phase activation, cleaves chem163S to generate chem158K, which

88 undertook translatome analysis of CD8 T-cell activation, combining polysome profiling and microarray

89 HD5 ligands, demonstrating that ABHD5 lipase activation could be dissociated from its other functions

90 ypothesized that macrophages and their M1/M2 activation critically involve in the hepatoprotection co

91 zes TRF1 at telomeres after damage in an ATM activation-dependent manner.

92 Myt1l allows newborn neurons to escape Notch activation during normal development.

93 However, in voluntary activation, EMG- and ultrasound-detected activation onse

94 e found to be concerted involving small free activation energies and are all exoenergonic.

95 temperature sensitivity, as measured by the activation energy (Ea , in eV).

96 Calculation of the rate constant (k) and activation energy (Ea) for this hydrolysis reaction are

97 peratures below the bulk solvent Tg, has low activation energy, and is likely due to fast vibrations

98 stic inactivation model parameters, standard activation enthalpy and entropy, are directly related to

99 otein expression in mouse NK cells is a late activation event.

100 The sequence of gene activation/expression and receptor editing of these isot

101 p I metabotropic glutamate receptor (mGluRI) activation, facilitates D1 dopamine receptor (D1R) expre

102 Moreover, activation following trauma exposure reduced the suscept

103 ha) regulates gene transcription through two activation functions (ERalpha-AF1 and ERalpha-AF2).

104 cible T-Cell costimulator (ICOS), lymphocyte activation gene 3 protein (LAG-3), and CD49b, and exert

105 etal protein essential in mediating integrin activation, has been previously shown to be involved in

106 Intensity of prefrontal activation (HbO2 concentration) was not clearly correlat

107 This shows that two different pathways of activation, immunogenic and tolerogenic, induce differen

108 with AMR provides evidence for NK cell CD16a activation in AMR.

109 wed that HNK inhibited Stat3-phosphorylation/activation in an LKB1-dependent manner, preventing its r

110 e cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manners.

111 Heightened inflammation and immune activation in HIV-1+ infants did not alter IgA responses

112 that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC with exacerbated SFK acti

113 ooperation between p16 inactivation and Kras activation in PDAC development and suggest that NOX4 is

114 in DA neurons exhibited increased locomotor activation in response to acute cocaine administration a

115 Relative to sham tDCS, anodal tDCS increased activation in right Crus I/II during semantic prediction

116 isplay distinctly different kinetics of MAPK activation in the cumulus cells, much increased cumulus

117 als with gambling addiction showed decreased activation in the dorsal striatum compared with healthy

118 ls with substance addiction showed increased activation in the ventral striatum, whereas individuals

119 fect HIV-1 gene expression induced by T cell activation in these rCD4s.

120 us monkey platelets, and cynomolgus platelet activation in vitro These experiments demonstrate that t

121 Activations in the right anterior insula and amygdala we

122 tes with potential critical roles in protein activation, including the histone acetyltransferase p300

123 ate that C3 plays specific roles in platelet activation independent of formation of the terminal comp

124 immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by u

125 Collectively, these data show that ROCK2 activation induces malignancy in ras(Ha)-initiated/promo

126 We propose that radiation-induced STING activation is immunosuppressive due to (monocytic) M-MDS

127 Lexical and conceptual activation is measured by semantic priming.

128 Thus, mTORC1 activation is required for fueling B cells prior to DZ p

129 suggest that controlled but not constitutive activation is required for gonococcal infection in mice.

130 Genital immune activation is suspected to modulate local human immunode

131 ficiency virus (HIV) disease, chronic immune activation leads to T-cell exhaustion.

132 one acetyltransferase p300 acetylated in its activation loop, which could explain self-acetylation as

133 tion, mechanistic target of rapamycin (mTOR) activation, loss of glutamate and potassium buffering ca

134 In human sarcoidosis patients, mTORC1 activation, macrophage proliferation and glycolysis were

135 IV viremia, CD4(+) T-cell counts, and immune activation markers, suggesting their pathogenic involvem

136 rrelation studies have revealed that histone activation marks and repression marks are associated wit

137 C(low) Mos/Mps, indicating that Ep3 receptor activation may be a promising therapeutic target for acu

138 ve study suggests that inhibiting complement activation may heighten immunotherapeutic responses in l

139 cluding proteasome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR) activ

140 by a GPCR-independent mechanism of G protein activation mediated by cytoplasmic factors.

141 ation and neutrophil-associated inflammasome activation might represent interacting pathways in patie

142 araviroc prophylaxis showed increased T-cell activation, naive T-cell skewing, and elevated serum CXC

143 rbation promoted downstream endothelial cell activation, neutrophil accumulation, endothelial cell de

144 Notably, neither H2 activation nor C-H hydride abstraction was observed in t

145 ltimolecular FRET based sensor for detecting activation of a heterotrimeric G-protein by G-protein co

146 paper, we report that CGRP-mAbs prevent the activation of Adelta but not C-type meningeal nociceptor

147 ponectin and nitric oxide are released after activation of adipocyte-expressed beta3 adrenoceptors by

148 BM stroma-derived conditions was a result of activation of alternative signaling pathways mediated by

149 racterized mouse model for DM1 (HSALR mice), activation of AMPK signaling in muscle was impaired unde

150 Activation of AMPK was shown to downregulate PXR activit

151 rasting functional outcomes that may involve activation of an integrin/reactive oxygen axis.

152 Activation of apoptosis signal-regulating kinase 1 (ASK1

153 of a cytosolic Art1-target region coupled to activation of Art1 via TORC1.

154 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the

155 ll aggregation triggers the mechanosensitive activation of beta-catenin in adjacent epidermal cells,

156 In contrast, a slight activation of beta-catenin significantly increased bone

157 ese signals are potential key players in the activation of bulge melanocyte precursors during vitilig

158 We show that ATZ induces activation of c-Jun N-terminal kinase (JNK) and c-Jun an

159 stone H3K27 acetyltransferase CBP to promote activation of C/EBPbeta-primed enhancers of adipogenic g

160 ochondrial membrane potential leading to the activation of Ca(2+)-independent phospholipase A2gamma (

161 Endocannabinoid activation of cannabinoid (CB1) receptors known to inhib

162 s study addresses how IFN-gamma can suppress activation of diabetogenic CD8(+) T cells.

163 terning or neuronal differentiation by their activation of different type I BMP receptors and distinc

164 asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter.

165 High expression and activation of EGFR and/or ErbB2 were recently demonstrat

166 Cytokine activation of endothelial cells (EC) upregulates VCAM-1

167 l functions for chromatin-remodelling in the activation of EPDCs during cardiovascular development an

168 on are impaired in M-ILK-deficient mice, and activation of epithelial NF-kappaB and PI3K signaling pa

169 Activation of GABAergic neurons in the rostromedial tegm

170 Mitotic activation of Gwl requires both cyclin-dependent kinase

171 Activation of hepatic stellate cells (HSCs) in response

172 sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg)

173 Posterior ectodermal activation of Hox is initiated in the late larva prior t

174 -mediated intercellular communication in the activation of HSC for liver fibrosis in HCV infection.IM

175 vide important mechanistic insights into the activation of IL-36gamma and highlight that cathepsin S-

176 amma and highlight that cathepsin S-mediated activation of IL-36gamma may be important in the develop

177 ntribution of lncRNAs in the development and activation of immune cells and their roles in immune-rel

178 cytoskeleton signalling pathways as well as activation of inflammatory pathways.

179 or immortalized human hepatocytes (IHH) and activation of its downstream signaling molecules.

180 PH involves an early compartment-independent activation of lung macrophages toward a conserved hypoxi

181 kinases in the BCR signaling pathway inhibit activation of lytic viral expression but do not inhibit

182 onserved role of this kinase in the epigenic activation of MOR in neurons.

183 Lalpha endonuclease, PCNA- and DNA-dependent activation of MutLalpha ATPase, and MutLalpha function i

184 raction with PCNA, as well as PCNA-dependent activation of MutLalpha endonuclease, PCNA- and DNA-depe

185 In both conditions, the activation of myofibroblast-like pancreatic stellate cel

186 ha-(1,3)-Glucan-educated" DCs stimulated the activation of naive T cells and polarized a subset of th

187 lished computational saliency model with the activation of neurons in the primate superior colliculus

188 Such activation of neutrophils under conditions mimicking inf

189 e T. denticola and the purified PF triggered activation of NF-kappaB through TLR2, as determined usin

190 ogether, our study demonstrates CXCR2-driven activation of NLRP3 inflammasome in macrophages and indi

191 Activation of Nlrp3 leads to synthesis of proinflammator

192 impairs macrophage priming by inhibiting the activation of non-canonical IkappaB kinase varepsilon an

193 Accordingly, constitutive activation of Notch1 prevents SC depletion despite Pten

194 reover, artesunate attenuated the HS-induced activation of nuclear factor kappa B and reduced the exp

195 oinduced ligation reactions, i.e., the light activation of o-methylbenzaldehydes, leading to the form

196 ) shed new light on how the skin handles the activation of oncogenic pathways in the stem cell compar

197 FN-gamma, TNF-alpha, IL-1beta and RANTES and activation of p38/Stat pathways in T-cells exposed to ex

198 ptional profiling of cDKO HSPCs revealed the activation of p53 and interferon (IFN) pathways, which e

199 Here, we have shown that blocking the activation of PERK using GSK2656157 prevents the loss of

200 he PM was achieved either by agonist-induced activation of phospholipase C beta or with a rapamycin-i

201 e the active site conformations in the AppA (activation of photopigment and puc expression) BLUF doma

202 evealed a convergence of pathways indicating activation of PKA.

203 y causing involuntary fatigue through remote activation of prey muscles [4].

204 address this knowledge gap, we asked whether activation of PZ(Vgat) neurons could attenuate or block

205 The autophagy protein Beclin1 regulates activation of Rab5 and endosomal-mediated degradation of

206 increases receptor tyrosine kinase-dependent activation of RAS more potently in colorectal cancer tha

207 At the input level, the activation of rod/cone and suprachiasmatic nuclei (SCN)

208 al morphogenesis through preventing aberrant activation of Sema3 signaling.

209 Formation of PGCCs was associated with activation of senescence, while budding of daughter cell

210 LCbeta-PKCalpha pathway, possibly regulating activation of SFKs, which are crucial for initiation of

211 of fibroblast growth factor 21 (FGF21), and activation of signaling pathways in adipose tissue.

212 ression, but not changes in Ca(2+) -mediated activation of SK channels, contributes to exacerbated MN

213 n, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional outcomes

214 BP2, an adapter protein that is required for activation of SRC tyrosine kinase and simultaneously coo

215 34A reduces expression of PPP1R11 to prevent activation of STAT3 and inhibit the EMT and metastasis.

216 CXCL12 treatment also produced rapid activation of STAT3, NFkappaB, and MAPK signaling in HMV

217 IFN-gamma-primed MCs guide activation of T cells by Staphylococcus aureus superanti

218 We also found that rmIFN induces the activation of T, B, and NK cells and exhibits antiviral,

219 Activation of the adamantanyl thioglycoside in the donor

220 Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3

221 ws binding of complement factor 1q (C1q) and activation of the classical complement pathway.

222 Bacterial sepsis triggers robust activation of the complement system with subsequent gene

223 Activation of the delta-opioid receptor (DOR) produces s

224 By contrast, activation of the Eomes target genes Foxa2 and Lhx1 is a

225 utations were also associated with augmented activation of the ERK pathway in vitro and in hearts in

226 In parallel, activation of the exchange protein directly activated by

227 GnT-III expression regulates the levels and activation of the heavily glycosylated Notch receptor in

228 liferation rates of cell lines with aberrant activation of the Hedgehog signaling pathway.

229 cognitive flexibility.SIGNIFICANCE STATEMENT Activation of the human default mode network (DMN) can b

230 echanism for NALP7 protein stabilization and activation of the inflammasome by Toll-like receptor (TL

231 In living glands, activation of the initiator caspase dronc triggers corti

232 sient inhibition of DA neurons attributed to activation of the LHb.

233 Moreover, these data identify activation of the MAP kinase pathway in microglia as a c

234 4 (DLL4) in endothelial cells, we find that activation of the MAPK/ERK pathway mirrors the rapid and

235 T4 into the axonal plasma membrane driven by activation of the metabolic sensor AMP kinase.

236 These deleterious effects culminated in the activation of the mitochondrial apoptosis pathway.

237 is role of midkine was linked to a paracrine activation of the mTOR pathway in lymphatic endothelial

238 nation and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathway.

239 scle-restricted expression that promotes the activation of the myogenic program, and is therefore ter

240 The activation of the N-methyl D-aspartate receptor (NMDAR)

241 chlea can mediate local autoinflammation via activation of the NLRP3 inflammasome.

242 In utero, electroporation demonstrates that activation of the Nrp2 gene in MCs is sufficient to inst

243 sensitive ICAM-1 downstream signaling toward activation of the PI3K, and recruitment of F-actin and o

244 ses at higher frequencies because of reduced activation of the rapid delayed-rectifier current IKr.

245 radigm of atrial ECC that is based on tandem activation of the RyRs by cytosolic and luminal Ca(2+) t

246 negative regulation of muscle mass via their activation of the Smad2/3 signaling axis, we used local

247 In activation of the transforming growth factor-beta1 precu

248 model of perfused microvessels to show that activation of the transmembrane receptor NOTCH1 directly

249 ically greatly reduced, while the downstream activation of the ventral-subparaventricular zone (vSPVZ

250 Prolonged activation of these synapses leads to initial depression

251 The localized activation of Toll a few cell diameters from wound edges

252 ers from wound edges is reminiscent of local activation of Toll in early embryonic ventral hypoderm,

253 cells (GLKD) of Drosophila ovaries leads to activation of transposons.

254 th phosphoantigen-dependent and -independent activation of Vgamma9Vdelta2 T cells and, importantly, s

255 several pathways implicated in E-T coupling, activation of voltage-gated L-type Ca(2+) channels (LTCC

256 Gata4, Nkx2.5 and Baf60c (MTGNB) along with activation of Wnt and JAK/STAT signaling.

257 of 41 men were enrolled between the trial's activation on August 9, 2011, and closure on August 1, 2

258 t membrane perturbations to prothrombotic TF activation on myeloid cells.

259 ary activation, EMG- and ultrasound-detected activation onsets may not correspond.

260 gions in the Notch1 extracellular domain for activation or inhibition.

261 distinct temporal patterns of translational activation or repression.

262 aced within the channel's cleft early during activation, or that conformational changes in KCNQ1 alte

263 ssion but do not inhibit several other lytic activation pathways.

264 hierarchy, indicating that it reflects gene activation per se.

265 Cre) mice resulted in spontaneous lymphocyte activation, primarily due to numerical and functional de

266 1R2 and TAS1R3, which is consistent with the activation process observed biophysically on the metabot

267 k-out bone marrow-derived macrophages, NLRP3 activation promoted excess cytosolic extrusion of mitoch

268 Fibroblast activation protein (FAP) is overexpressed by fibroblastl

269 Importantly, IFN-gamma exposure during activation reduced the cytotoxicity of human-origin type

270 Astroglial and microglial activation, reduced neuronal density, perivascular CD3-p

271 experiments further reveal that vCA1 GLP-1R activation reduces food intake and inhibits impulsive op

272 However, the mTOR activation remained unchanged.

273 therefore defines a novel mechanism of MAPK activation requiring binding of an activator and also sh

274 Genes associated with neutrophil activation, ROS production, intracellular antioxidation,

275 gs offer functional evidence that complement activation serves as a critical immunomodulator in lung

276 with variations in N allocation and Rubisco activation state further influencing photosynthetic rate

277 intrinsically disordered independent of the activation state of caspase-6; however, its complete rem

278 matic time course is sigmoidal, signaling an activation step, prior to turnover.

279 Immune cell activation stimulates neuronal circuits that regulate in

280 hies are caused by altered levels of pathway activation, the signaling changes in developing tissues

281 ization and lowering of the cytosolic Ca(2+) activation threshold.

282 enetic loss of Gcn2 intensified hepatic PERK activation to asparaginase, yet surprisingly, mRNA level

283 amma for Akt-dependent signaling during TLR4 activation to limit the production of the proinflammator

284 onists required pannexin-1 and P2X7 receptor activation to stimulate IL-1beta release.

285 els of serum tryptase, a marker of mast-cell activation, to a greater extent than did placebo (decrea

286 in the endoplasmic reticulum prevents their activation under basal conditions.

287 ers are active for propane ODH after thermal activation under O2 to open a cobalt coordination site a

288 o polarized MPhis that mediate stellate cell activation via TGF-beta.

289 the advancements in Pd-catalyzed C(sp(3))-H activation via various redox manifolds, including Pd(0)/

290 same effect of macrophage infiltrate on EGFR activation was also seen in a colorectal cancer xenograf

291 cases of GIST, we observed that Braf(V600E) activation was sufficient to drive ICC hyperplasia but n

292 ion in LSC and that LIC with exacerbated SFK activation was uniquely found within the JAM-C-expressin

293 Samples with NOTCH pathway activation were also clinically distinct and were associ

294 iated with the switchblade model of integrin activation, where the development of tensile force yield

295 low protocol has been developed for bond C-H activation which promotes the alpha-cyanation of seconda

296 Lipin-2 regulates MAPK activation, which mediates synthesis of pro-IL-1beta dur

297 2 causes reduced pigmentation through mTORC1 activation, which results in hyperactivation of glycogen

298 roinflammatory gene expression and NF-kappaB activation while enhancing HIF-1alpha levels and the exp

299 lation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447

300 Our results establish potent Sirt6 activation with small molecules and provide a structural