ライフサイエンスコーパス: activation domain

1 activities that augment the functions of the activation domain.

2 a microsatellite-associated transcriptional activation domain.

3 effect does not require its transcriptional activation domain.

4 lexes with HIF-2alpha through the C-terminal activation domain.

5 ctivation by p53, through binding to the p53 activation domain.

6 hydrophobic leucines, functions as a strong activation domain.

7 ng of the locus from a silent to a conserved activation domain.

8 in the presence or absence of the C-terminal activation domain.

9 -kappaB subunit endowed with a transcription activation domain.

10 acts as a cell-type-specific transcriptional activation domain.

11 but not a mutant lacking the transcriptional activation domain.

12 d GABPbeta, which contains the transcription activation domain.

13 BD, leading to substantial compaction of the activation domain.

14 rin, dependent on the Meis2d transcriptional activation domain.

15 t SIM in KLF4 functions as a transcriptional activation domain.

16 as a deadenylase but lacks a transcriptional activation domain.

17 e promoter activation by contacting the MotA activation domain.

18 ired for PC2 binding and contains the PLAGL2 activation domain.

19 NA binding domain with 76 amino acids in the activation domain.

20 nal coactivators to the more potent SREBP-1a activation domain.

21 fundamental for transactivation by the IE62 activation domain.

22 y, and is independent of the transcriptional activation domain.

23 oA-I's central loop, which overlaps the LCAT activation domain.

24 nsus HCF-1 binding site on PRC and the NRF-2 activation domain.

25 transcriptional activation by the Rta acidic activation domain.

26 s effect is dependent on the presence of the activation domain.

27 nserved region 3 (CR3) - the transcriptional activation domain.

28 ylation at a site within the transcriptional activation domain.

29 ntified the C-terminal region of BSX1A as an activation domain.

30 ing of its calcium release-activated calcium activation domain.

31 or silenced by Gal80 when fused to the Gal4 activation domain.

32 through direct interaction with an E-protein activation domain.

33 on Mediator for the ATF6alpha transcription activation domain.

34 ytic attack upon mutation of residues in the activation domain.

35 NRF-2beta, which contains the transcription activation domain.

36 ions to the human estrogen receptor and VP16 activation domain.

37 ese LC sequences function as transcriptional activation domains.

38 s encoding its DNA-binding and transcription-activation domains.

39 iption factor containing two transcriptional activation domains.

40 ular lipid composition of immunoisolated TCR activation domains.

41 ignal transduction between the catalytic and activation domains.

42 ins share two highly conserved transcription activation domains.

43 of diversification in cis depends on the E2A activation domains.

44 inding domains and divergent transcriptional activation domains.

45 ains both the regulatory and transcriptional activation domains.

46 , has separable cyclin box and transcription activation domains.

47 atory protein Gal4 DNA binding and AP-2alpha activation domains.

48 we show that, unlike the HEB E-protein, the activation domain 1 (AD1) of E2A has specifically reduce

49 s a conserved amino-terminal RING domain, an activation domain 1 (AD1), and an acidic carboxyl-termin

50 als that LMP1, through its carboxyl-terminal activation domain 1 (LMP1-CTAR1), activates both STAT3 a

51 tif interaction with an F-box-like region in activation domain 1 of TIF2.

52 basic domain enhances, whereas a mutation in activation domains 1-2 and deletion of the proline-rich

53 We also found that activation domains 1-2 and the proline-rich domain are r

54 tion of a novel E-protein activation domain (activation domain 3 [AD3]) with the TAF homology (TAFH)

55 cation occurs at four lysines within the Rta activation domain (426, 446, 517, and 530) and that sumo

56 es an acidic nine-amino-acid transcriptional activation domain (9aaTAD) and a loss-of-function mutati

57 vity requires direct interaction with an ATR activation domain (AAD)-containing partner.

58 Mediator occupancy, whereas removal of both activation domains abolishes it.

59 ted through interaction of a novel E-protein activation domain (activation domain 3 [AD3]) with the T

60 expression of ATF3 bereft of the C-terminal activation domain acts as a dominant negative factor, in

61 through its Ca(2+) release-activated Ca(2+) activation domain, acutely inhibits gating, and causes l

62 osphorylation or deletion of a 14-amino-acid activation domain (AD) located on the linker connecting

63 nal activator containing a C-terminal acidic activation domain (AD) of 34 amino acids.

64 tending previous studies that the N-terminal activation domain (AD) of ETV5 interacts with Mediator s

65 evious studies have shown that Lys-28 in the activation domain (AD) of Tat is essential for HIV-1 tra

66 (AS) to map and characterize a 41-amino acid activation domain (AD) within the Rap1 C terminus.

67 transcription via a C-terminal transcription activation domain (AD).

68 otein through masking of its transcriptional activation domain (AD).

69 n N-terminal p10 regions and C-terminal Cdk5 activation domains (AD).

70 In contrast, the N-terminal activation domain, AD1, is required for a newly describe

71 They contain at least two activation domains, AD1 and AD2.

72 Transcriptional activation domains (ADs) are generally thought to be int

73 e, do intrinsically disordered transcription activation domains (ADs) use sequence-specific motifs, o

74 155) bind the amino-terminal transcriptional activation domain AF-1, which has not been targeted for

75 The Gcn4 N-terminal activation domain also cross-links to the Mediator subun

76 ins, including a DNA-binding/transcriptional activation domain and a large extracellular domain.

77 PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP,

78 a chimeric protein of Eve1 fused to the Gal4 activation domain and gene-knockdown approaches, we inve

79 hain, but Arg-320 is well defined within the activation domain and is not accessible to proteolysis i

80 t depends on the integrity of its N-terminal activation domain and stems from the high affinity inter

81 tated the association of Nox1 with the NoxA1 activation domain and was necessary for NADPH oxidase co

82 at selected ZF-TFs function with alternative activation domains and in multiple cell lines.

83 ten binding sites in the ASCIZ transcription activation domain, and high DYNLL1 levels inhibit the tr

84 a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 predisposes mice to

85 nserved coactivator complexes, transcription activation domains, and the cooperation of these factors

86 Further, the IE62 activation domain appears to selectively interact with a

87 tions of hybrid activators with Gal4 or VP16 activation domains are diminished in class D mutants as

88 ght-induced degradation, and transcriptional activation domains are located at the N-terminal 150-ami

89 In this study, we show that both activation domains are required for optimal E2A-dependen

90 tional domains, i.e., the cyclin box and the activation domain, are necessary for the overall enhance

91 intracellular amino acid position in the GS activation domain as the engineered constitutively activ

92 uncations reveals a critical transcriptional activation domain at aa 31 to 185 and a nuclear localiza

93 inc fingers at the C-terminus and a putative activation domain at the N-terminus.

94 teraction results in the dissociation of the activation domain-ATPase complex via an allosteric proce

95 fic monoclonal antibody 225.28S and a T-cell activation domain based on combinations of CD28, 4-1BB,

96 Jab1 (Jun activation domain binding protein 1), integrated into CO

97 inhibitor, the COP9 signalosome subunit jun activation-domain binding protein 1 (Jab1), leading to i

98 Jun activation domain-binding protein 1 (JAB1) is a multifun

99 We now report that the nuclear Jun activation domain-binding protein 1 (Jab1) may transduce

100 Jun activation domain-binding protein 1 (JAB1) regulates ubi

101 the Adr1 regulatory domain inhibits an Adr1 activation domain but not a heterologous activation doma

102 h typical TALEs, iTALEs lack a transcription activation domain but retain nuclear localization motifs

103 egative form of Egr-1, which lacks the trans activation domain but retains the DNA-binding domain, in

104 P-1 proteins contain defined transcriptional activation domains, but BATF and the closely related BAT

105 y, the recruitment of multiple transcription activation domains by a single sgRNA, modified to contai

106 Overexpression of the CRAC activation domain (CAD) of STIM1 resulted in a decrease

107 tify a minimal, highly conserved 107-aa CRAC activation domain (CAD) of STIM1 that binds directly to

108 We find that the central activation domain (cAD) of the yeast activator Gcn4 func

109 mains, the transmembrane region and the CRAC activation domain (CAD), and can promote the association

110 ng of Orai1 to STIM1 and to the soluble CRAC activation domain (CAD).

111 Recently, we defined a minimal CRAC activation domain (CAD; residues 342-448) that binds dir

112 coiled-coil 1, CC1; coiled-coil 2, CC2; CRAC activation domain, CAD) to this process are not well und

113 The VP16 activation domain can recruit various transcriptional co

114 that replacement of key residues within the activation domain causes these zymogens to spontaneously

115 resulted in the absence of the essential MYB activation domain coding region.

116 for the first time, direct evidence that TCR activation domains comprise a distinct molecular lipid c

117 chanism of IE62 transactivation is an acidic activation domain comprising the N-terminal 86 amino aci

118 interacts directly with the transcriptional activation domain (conserved region 3 [CR3]) of adenovir

119 RS-4 interacts with both the transcriptional activation domain (conserved region 3) and the N-termina

120 mutated USF or SREBP lacking the N-terminal activation domain could inhibit the transactivation of t

121 observed that AL2 lacking its transcription activation domain could reverse TGS in reproductive plan

122 gh the action of a conserved transcriptional activation domain, CR3.

123 The individual Gcn4 activation domains cross-link to three common targets, G

124 or, namely, human HDAC3 with the deacetylase activation domain (DAD) from the human SMRT co-repressor

125 p53 bound to the SMRT deacetylase activation domain (DAD), which mediates HDAC3 binding an

126 quires stable binding to a nucleosomal site; activation domain-dependent recruitment of co-factors in

127 riptional activators in that it contains two activation domains, designated AD1 and AD2, which are re

128 s provides increased regulatory control over activation domain dominance.

129 indicating a crucial role for the N-terminal activation domain during acetate metabolism.

130 both constitutive and wild-type VirG-tandem activation domain effectors.

131 in human cells by tethering transcriptional activation domains either directly to a nuclease-null Ca

132 However, deletion of a 14 amino acid activation domain encompassing S742 and S747 inhibits ch

133 the receptor binding domain (RBD) and the F activation domain (FAD).

134 tein, lacking the C-terminal transcriptional activation domain (Fli-1(DeltaCTA)).

135 nding domain of CREB-binding protein and the activation domain from the p160 transcriptional co-activ

136 hypersensitive site required transcriptional activation domains from TFE3 and PU.1, respectively.

137 ng transcriptional activator based on tandem activation domains from the Drosophila fushi tarazu and

138 Therefore, the E protein activation domains function redundantly in promoting B c

139 the I2 and R regions contain portions of the activation domain, functionally linking DNA binding and

140 s of an EWSR1-derived strong transcriptional activation domain fused, in-frame, to the DNA-binding do

141 , we also found that while a transcriptional activation domain fusion, CebpFlagWdr68, functionally su

142 fusing zinc finger peptides to repression or activation domains, genes can be selectively switched of

143 ariants, is part of the second transcription activation domain in Gis1 and is essential for both the

144 or modeling of the solution structure of the activation domain in the absence and presence of ERRgamm

145 transcriptional activator, and identified an activation domain in the C terminus.

146 from a preferential inactivation of the AF2 activation domain in the GR LBD of Dex-bound, but not DA

147 binds to the relatively uncharacterized tau2 activation domain in the hinge region of GR.

148 the primordium and a stable Wnt/beta-catenin activation domain in the leading region of the primordiu

149 e distinct functionalities for the E protein activation domains in B lymphocytes and macrophages.

150 identified potent classical transcriptional activation domains in the C termini of several tail modu

151 Targets of the tandem Gcn4 acidic activation domains in transcription preinitiation comple

152 Last, Cyc8-Tup1 can interact with activation domains in vivo.

153 we reveal unique features of the interferon activation domain, including a set of beta-sheets and lo

154 ich contain a DNA-binding domain but lack an activation domain) interact with YAP (which lacks a DNA-

155 essed nuclear factor PTIP (pax transcription activation domain interacting protein).

156 es by NMR spectroscopy reveal that the Oaf1p activation domain interacts with the Gal11p/MED15 KIX do

157 ng domain, and a single metalloid binding or activation domain is located at the interface of the two

158 rylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated tra

159 Surprisingly, however, neither activation domain is required for E2A to rescue B lympho

160 The Tat trans activation domain is required for RON degradation, and t

161 Autoacetylation of lysine-290 within the activation domain is required for stabilizing the intera

162 This suggested that an activation domain is required for stable binding, and co

163 A second domain, the activation domain, is tightly associated with the PAT do

164 broadly, these findings suggest that kinase activation domains may be previously unappreciated sites

165 suggest that the N terminus contains a true activation domain, mediating interactions with TFIID, me

166 mutant ICP4 molecule lacking the C-terminal activation domain (n208) efficiently activates many earl

167 We suggest that the dephosphorylated activation domain normally interacts with CBS1 and/or CB

168 nd TGS reversal required the transcriptional activation domain of AL2.

169 Kctd15 binds specifically to the activation domain of AP-2alpha and efficiently inhibits

170 least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the fun

171 Therefore the recombination-activation domain of Atf1-Pcr1 heterodimer resides exclu

172 HSP70 interacts strongly with the N-terminal activation domain of ATF5, which is expected to be rigid

173 e activity of the N-terminal transcriptional activation domain of Brn-3a is increased following RA tr

174 domain was identified for APH proteins, the activation domain of c-Jun was very important in the obs

175 equence motif present in the transcriptional activation domain of class A-HSFs.

176 in leads to an enhancement of binding by the activation domain of CREB (phosphorylated kinase-inducib

177 region within the N-terminal transcriptional activation domain of E2A-PBX1, termed the PCET motif, wh

178 fingers, in combination with the gain of the activation domain of ENL or of other partner proteins, m

179 constitutively active FoxM1 construct or the activation domain of FoxM1 to the cyclin B1 gene promote

180 constitutively active FoxM1 construct or the activation domain of FoxM1 to the cyclin B1 gene promote

181 We show that Rb binds to the C-terminal activation domain of FoxM1b.

182 F644 and WIZ interact with the transcription activation domain of G9a and GLP, respectively.

183 al structure of a complex between the acidic activation domain of Gal4p and Gal80p.

184 ex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a di

185 that this motif is part of the transcription activation domain of Glis3.

186 However, despite its being the major activation domain of GRs, knowledge of AF1 structure/fun

187 We show that two phiXXphiphi motifs in the activation domain of HBZ mediate binding to a single sur

188 Their I-mfa domains also bind the activation domain of HIV-1 Tat and inhibit Tat- and P-TE

189 ion, and native states in the folding of the activation domain of human procarboxypeptidase A2 (ADA2h

190 Our study identifies the central cleavage/activation domain of IL-33 (amino acids 66-111) as an im

191 CblD, CblC, and the activation domain of methionine synthase share several d

192 important for cobalamin trafficking, and the activation domain of methionine synthase.

193 complexation of KIX with the transcriptional activation domain of mixed-lineage leukemia protein lead

194 ly bind two polypeptide ligands, such as the activation domain of MLL and the kinase-inducible activa

195 t Mxr1 residues 212-225 and mapped the major activation domain of Mxr1 to residues 246-280, and showe

196 erminus (domains III and IV) of ARFs and the activation domain of MYB77.

197 ein interaction domain, binds the C-terminal activation domain of myocardin and enhances myocardin-me

198 Although the activation domain of Noxa1 was not required for Duox fun

199 Binding of the E1B protein to the activation domain of p53 inhibits p53-dependent transcri

200 le positioning of the N-terminal part of the activation domain of PGC-1alpha, favorable for assembly

201 Inhibitory antibodies targeting the activation domain of PR3 could be exploited as highly se

202 Acidic residues in the activation domain of protein C are thought to electrosta

203 Phosphorylation of the activation domain of protein kinase C (PKC) isoforms is

204 ucture of the human RNMT in complex with the activation domain of RAM.

205 The transcriptional activation domain of RelB, but not RelA, directly intera

206 of zebrafish SLIP1 bound to the translation-activation domain of SLBP and identified the determinant

207 of KLF3 plus the MADS box and transcription activation domain of SRF are implicated in this synergy.

208 The SH2 dimerization and activation domain of STAT3 is frequently mutated in pati

209 se (EGR)-binding domain of NAB2 fused to the activation domain of STAT6.

210 ly converting an inhibitory aptamer into the activation domain of the activator, we also introduced a

211 In this study, we show that AF1, an ID activation domain of the glucocorticoid receptor (GR), a

212 A peptide that mimics a putative activation domain of the Nox1 activator subunit NOXA1 (N

213 BD) of transcription coactivator CBP and the activation domain of the p160 steroid receptor coactivat

214 lanine (pBpa) throughout the transcriptional activation domain of the prototypical eukaryotic transcr

215 ivin binds to the N-terminal transcriptional activation domain of the STAT3 dimer and represses STAT3

216 ata demonstrate a mechanism through which ID activation domain of the steroid receptors and other sim

217 Most notably, we find that the activation domain of the Wee1 kinase is also required fo

218 CPR3-7 preferentially bound to the so-called activation domain of the zymogen and changed the conform

219 assembly in which Mediator was bound to the activation domain of viral protein 16 (VP16).

220 nner dependent mostly on the presence of the activation domain of VP16.

221 We map the transcriptional activation domain of ZLD to a central region characteriz

222 the synergy we have observed depends on the activation domains of both proteins and that mutated USF

223 ligand-independent and the ligand-dependent activation domains of estrogen receptor alpha.

224 y was utilized, in which the DNA binding and activation domains of Gal4 and VP16, respectively, were

225 Thus, the context-specific function of the activation domains of NFAT can be potentiated by DNA-dir

226 ses the possibility that the function of the activation domains of NFATp is dimer-specific.

227 Our finding that deletion of the activation domains of S. cerevisiae Med2 and Med3, as we

228 is transcriptionally activated by tethering activation domains of several transcription factors that

229 y masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by ac

230 Furthermore, we show that the 'activation domain' of Cdc20 associates with the Apc6 and

231 t, peptides derived from the phosphoacceptor activation domain on ATF2 (peptides 4 and 5) were recogn

232 dr1 activation domain but not a heterologous activation domain or artificially recruited Mediator, co

233 was inhibited either by deletion of the VP16 activation domain or by chemical inhibition of RNA polym

234 Mutants in the transcriptional activation domain or DNA-binding domain of N-ATF6 alpha

235 PGC-1alpha activation domain (PGC-1alpha(2-220)) is intrinsically d

236 H and R helices mediate CLH-3b regulation by activation domain phosphorylation.

237 nding of the phosphorylated kinase-inducible activation domain (pKID) of CREB, and intrinsically diso

238 ation domain of MLL and the kinase-inducible activation domain (pKID) of CREB, using distinct interac

239 on, that the phosphorylated kinase inducible activation domain (pKID) of the transcription factor CRE

240 ual activation domain strains, well-designed activation domain pools are screened in an array format

241 rowth signaling by mutation of the Shc/FRS-2 activation domain prohibited Erk activation and eliminat

242 y ablate PAX interacting (with transcription-activation domain) protein 1 (PTIP), a key component of

243 he NFATp monomer, even in the absence of its activation domains, recruits bZIP proteins to canonical

244 bservations indicate that Hsf1, via its dual activation domains, recruits holo-Mediator to HSP promot

245 Interestingly, we discovered that both the activation domain (residues 1-59) and the proline-rich d

246 rylation sites or C-terminal transcriptional activation domain, restores positive selection in SRF nu

247 ted form of CBF2 lacking its transcriptional activation domain resulted in a cold-stimulated increase

248 argets Q167 and Q189 within the constitutive activation domain, resulting in cleavage of IRF7.

249 ants by directly tethering the minimal STIM1 activation domain (S) to Orai1 (Orai1-SS channels), indi

250 at truncation of either its N- or C-terminal activation domain significantly reduces Mediator occupan

251 Mutation of the Raf-1 activation domain (SS338/9AA) not only prevents Raf-1/AS

252 (SPA) system in which, instead of individual activation domain strains, well-designed activation doma

253 pment in mice expressing p53 transcriptional activation domain (TAD) mutants.

254 Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase E

255 of CBP/p300, and second, the transcriptional activation domain (TAD) of RelA binds to the TAZ1 domain

256 lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated Notch1 function

257 ion by tethering an autonomous transcription activation domain (TAD) to an intended gene promoter at

258 trans-activation, including an acidic trans-activation domain (TAD), a serine-rich tract (SRT), and

259 s a potent N-terminal acidic transcriptional activation domain (TAD).

260 rans-activation mediated by the acidic trans-activation domain (TAD).

261 pha (the p73 isoform that contains the trans-activation domain) target gene and activates the express

262 e work presented here, we show that the IE62 activation domain targets the human Mediator complex via

263 The EDLL motif represents a potent plant activation domain that can be used as a tool to confer t

264 cally, we determined that KLF16 possesses an activation domain that couples to histone acetyltransfer

265 cts with CycD2 through a discreet N-terminal activation domain that is essential for the cardiogenic

266 gest that the Vpx amino terminus contains an activation domain that serves as the binding site for a

267 1 channels by increasing the number of STIM1 activation domains that are directly tethered to ORAI1 c

268 ve separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-

269 In addition to a previously identified activation domain, this region contains a previously unc

270 ruiting multiple copies of a transcriptional activation domain to a nuclease-deficient CRISPR/Cas9 pr

271 Mutation of one proline residue in the activation domain to an alanine (P59A) yields a protein

272 direct dCas9 fused to a VP64 transcriptional activation domain to increase expression of endogenous h

273 Fusing the Tat activation domain to some splicing factors, particularly

274 Fusion of a TCF C-terminal activation domain to SRF.V194E effectively restores ERK-

275 ivity could be used to recruit transcription activation domains to specific promoters.

276 The contribution of the two Gcn4 activation domains to transcription was gene specific an

277 ctive Cpf1 nuclease fused to transcriptional activation domains to tune the expression of endogenous

278 h lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric tran

279 haracterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR

280 pha independent of the HIF-2alpha C-terminal activation domain via enzyme/substrate interactions, p30

281 n be largely substituted by the heterologous activation domain VP16.

282 This activation domain was also not identical to a previously

283 Although no activation domain was identified for APH proteins, the a

284 the MS2 coat protein linked to transcription activation domains, was reported to induce otherwise sil

285 Moreover, by using dCas9 linked to an activation domain, we can either enhance or suppress tar

286 esides near the center of the protein's LCAT activation domain, we determined whether its oxidation b

287 pervariability maps to important binding and activation domains, we hypothesized that vCXCL-1s differ

288 effect of mutations in the C-terminal trans-activation domain were characterized.

289 Interestingly, TCR activation domains were also enriched in plasmenyl phosp

290 oxA2 induces Arx through its transcriptional activation domain whereas Nkx2.2, induced by Shh, abolis

291 is mediated by a cytosolic C-terminal trans-activation domain, which carries a conserved Thr (T460)

292 ed by phosphorylation of a carboxy-terminus "activation domain," which disrupts its interaction with

293 ctivator-binding domains that bind each Gcn4 activation domain with micromolar affinity.

294 s of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain

295 In keeping with the presence of an activation domain within Nkx6, we also report that Nkx6

296 sence of two repression domains and a single activation domain within this transcription factor.

297 Activation domains within coactivators are likely an imp

298 Classical activation domains within DNA-bound eukaryotic transcrip

299 We have identified distinct DNA-binding and activation domains within the critical transcription fac

300 ex of T cells engineered to express powerful activation domains without the associated safety concern