ライフサイエンスコーパス: activation mechanism

1 cidates common and specific features of this activation mechanism.

2 kinase A (PKA) is a well-characterized CREB activation mechanism.

3 are discussed in the context of the receptor activation mechanism.

4 an and tissue development through an unknown activation mechanism.

5 us to propose a novel model for the receptor activation mechanism.

6 provides a conceptual framework for the TCR activation mechanism.

7 lps to shed light on PKCalpha regulation and activation mechanism.

8 ngth BAK has hampered full dissection of its activation mechanism.

9 motor and consistent with a cargo-dependent activation mechanism.

10 for future studies on dissection of the RdRp activation mechanism.

11 domain of the toxin might be involved in the activation mechanism.

12 tures we propose the individual steps of the activation mechanism.

13 t the molecular level to understand the gene activation mechanism.

14 cooperate with talin to support the integrin activation mechanism.

15 ting a regulatory role for fragment 1 in the activation mechanism.

16 evaluated their participation in this SSH1L activation mechanism.

17 as at the aer promoter, suggesting a common activation mechanism.

18 r is required as part of the transcriptional activation mechanism.

19 from epithelia through a local endocytic JNK-activation mechanism.

20 d to a graded system by the pathway-specific activation mechanism.

21 n of LFA-1 with ICAM-1 through an outside-in activation mechanism.

22 errupt distinct sequential steps of the ATF6 activation mechanism.

23 iated with heme displacement, as part of the activation mechanism.

24 pockets that shed new light on the G-protein activation mechanism.

25 ore detailed hypotheses of the full receptor activation mechanism.

26 ey would shed light on LpoB function and its activation mechanism.

27 DUOX1 or the homolog NOX2, depending on the activation mechanism.

28 n its composition, functional importance and activation mechanism.

29 s may share a common ligand binding mode and activation mechanism.

30 s followed by mutagenic analysis to test the activation mechanism.

31 r recently established reduction-coupled oxo activation mechanism.

32 uctural change plays a secondary role in the activation mechanism.

33 fungus were important steps in the caspase-1 activation mechanism.

34 DFT studies support a ligand-assisted water activation mechanism.

35 ied rapidly, while conserving the allosteric activation mechanism.

36 xchange GDP for GTP, similar to small GTPase activation mechanisms.

37 either telomere recombination or telomerase activation mechanisms.

38 ly related and may share common assembly and activation mechanisms.

39 ries of target genes via threshold-dependent activation mechanisms.

40 distinct atomic motions that confer distinct activation mechanisms.

41 ional, posttranscriptional, or translational activation mechanisms.

42 the specificity of ligand-binding and likely activation mechanisms.

43 se in methane hydroxylation-through dioxygen activation mechanisms.

44 vation of Aurora-B and describe two distinct activation mechanisms.

45 n parameters for the C-CN activation and C-H activation mechanisms.

46 in features of kinases that impact on their activation mechanisms.

47 and the main core provides insights into its activation mechanisms.

48 s, along with a variety of specificities and activation mechanisms.

49 In mammals, a shared activation mechanism allows for coordinate regulation of

50 Blm10, have provided insights to proteasome activation mechanisms, although the biological functions

51 structures offer important insights into the activation mechanism and allosteric modulation of muscar

52 ClpP1P2 activity, its unusual activation mechanism and ClpC1 ATPase represent attracti

53 Resolving the activation mechanism and dimerization state of these rec

54 Furin shows a complex activation mechanism and exists in at least four defined

55 e results present a new view of the platelet activation mechanism and reveal principal mechanistic fe

56 The activation mechanism and roles of each accessory protein

57 The data reveal the activation mechanism and show that overall splicing effi

58 Here we studied the activation mechanism and subcellular compartment in whic

59 switch between these stages in the NF-kappaB activation mechanism and the phosphorylation status of t

60 our data give important insight in the LRRK2 activation mechanism and, most importantly, explain the

61 y of TRPV3 is separable from all other known activation mechanisms and implicate a specific region in

62 y of TRPV3 is separable from all other known activation mechanisms and implicate a specific region in

63 nding the upstream pathway may delineate Rac activation mechanisms and its role in maintaining vascul

64 osite to that in classical potassium channel activation mechanisms and open a passage lateral to the

65 rm channel orthologues that employ different activation mechanisms and serve different functions.

66 the novel types of ubiquitin-mediated signal-activation mechanism, and previously unexpected synergis

67 injury in mice, perhaps via a GPCR-mediated activation mechanism, and suggest that inhibition of Pan

68 physiological role of HdeB in bacteria, its activation mechanism, and the structural requirements fo

69 We examined functional status, activation mechanisms, and biologic role of the mTORC1 s

70 activation of TRPV3 is separable from other activation mechanisms, and depends on 2 cytoplasmic resi

71 ough most integrins contain beta1, canonical activation mechanisms are based on studies of the platel

72 verge to modulate TPC activity, and proposed activation mechanisms are controversial.

73 r findings reveal that G-protein-binding and activation mechanisms are fundamentally different betwee

74 Our results demonstrate that FlgR activation mechanisms are unusual among characterized Nt

75 Apoptotic caspase activation mechanisms are well defined, yet inactivation

76 Structural comparisons reveal a quaternary activation mechanism arising from rigid-body movements b

77 chemical analysis of this enzyme reveals its activation mechanism as well as structural features impo

78 e existence of multiple ligand dependent RyR activation mechanisms associated with distinct conformat

79 nd the P site tRNA and illuminate the GTPase activation mechanism at previously unresolved detail.

80 mplexes) from chromatin can explain the Mot1 activation mechanism at some promoters.

81 buted to lipid cofactor-dependent allosteric activation mechanisms at membranes.

82 An activation mechanism based on encapsulated ultrasmall ga

83 A unique fluorogen activation mechanism based on two spectroscopic changes,

84 l agonists are useful tools for studying the activation mechanism because they produce full channel a

85 ono-5HT-DTPA-Gd) or protein-binding in their activation mechanism (bis-o-dianisidine-DTPA-Gd).

86 t through a physical clustering-based kinase activation mechanism but instead promoted spindle associ

87 search article, we suggested an MCM helicase activation mechanism, but were limited in discussing the

88 point of convergence of distinct complement activation mechanisms, but its involvement in periodonti

89 2+) responses, indicating a highly efficient activation mechanism by local ATP.

90 We provide the first insight into the activation mechanism by mutations in the linker between

91 However, the precise activation mechanism by which catalytic IKK subunits gai

92 ngs are consistent with an allosteric kinase activation mechanism by which RIN1 binding promotes a mo

93 ata demonstrate a redundancy of TRPC channel activation mechanisms by widely different agonists.

94 ted GCK mutations share a strikingly similar activation mechanism, characterized by a population shif

95 oter OFF times, consistent with a multi-step activation mechanism consisting of 10 or more inactive s

96 t mGluR1 upregulation as a novel feedforward activation mechanism contributing to 5-HT(2A)R-mediated

97 ing elevated CO2 The majority of known SLAC1 activation mechanisms depend on abscisic acid (ABA) sign

98 s in this region than GABA, suggesting their activation mechanisms differ.

99 nsmitting the signal employing a unique GPCR activation mechanism, distinct from other multi-domain G

100 ents are perturbed, different charge carrier activation mechanisms dominate the transport properties

101 receptors differs completely from thrombin's activation mechanism due to biased signaling via either

102 hrough the maintenance of telomeres, but the activation mechanism during carcinogenesis remains uncle

103 phagy, which is initiated by a distinct Atg1 activation mechanism during starvation.

104 Currently, understanding about NF-kappaB activation mechanism emphasizes IkappaB-tethered complex

105 Cells lacking this activation mechanism fail to proliferate after hyperosmo

106 beling experiments revealed a novel gamma-CH activation mechanism for AD of alcohols.

107 Our data reveal a unique activation mechanism for GABA(B) receptor that involves

108 Data were analyzed by using the established activation mechanism for glycine receptors and our measu

109 We characterize a novel activation mechanism for glycogen synthase kinase-3 (GSK

110 ll wall integrity pathways, we show that the activation mechanism for Hog1 during ER stress is distin

111 of the results, we propose a new inside-out activation mechanism for integrin alpha(IIb)beta(3) and

112 latory and core factors may provide a common activation mechanism for mRNA 3' processing, splicing, a

113 Together our data provide an assembly and activation mechanism for NorR.

114 The model combines an activation mechanism for precursor conversion to monomer

115 In this study, a CaM-independent activation mechanism for smMLCK by mechanical release of

116 Our study reveals an activation mechanism for SNARE complex assembly, and unc

117 gether, these findings suggest a cooperative activation mechanism for the ATR checkpoint kinase by To

118 Here we propose an activation mechanism for the beta(2)-adrenergic receptor

119 zation by single-channel analysis of a novel activation mechanism for the glycine receptor.

120 The activation mechanism for the IL-36 pathway is proposed t

121 Collectively, this work suggests a biphasic activation mechanism for the Nlrc4 inflammasome in which

122 e critical role and a common phosphorylation/activation mechanism for the PPPSP motifs in LRP6 and su

123 The present work suggests the activation mechanism for the wild-type CRAC channel is l

124 However, the activation mechanism for these Diaphanous-related formin

125 We propose a novel activation mechanism for TRPC1 SOCs in VSMCs, in which s

126 Altogether, we present a DAG-mediated activation mechanism for TRPC4/5 channels tightly regula

127 We further propose a calcium-dependent activation mechanism for Vasohibin proteins.

128 moter and the AhR receptor, implicating drug activation mechanisms for ABCB6 similar to those found i

129 tivation comparable with previously reported activation mechanisms for EGFR and HER4.

130 s Review, we provide an in-depth analysis of activation mechanisms for kinases in cancer, highlight r

131 The significance of the 'flip' activation mechanism goes beyond understanding the behav

132 iketoesters that proceeds by means of a dual activation mechanism has been developed.

133 also activates gene expression, although an activation mechanism has not been reported.

134 ecent years, and a coherent picture of their activation mechanisms has begun to emerge.

135 y high cost and complex syntheses, and their activation mechanisms have not been well-understood.

136 studies on direct and indirect Fur-mediated activation mechanisms have revealed novel global regulat

137 psin-II conformation obtained by the natural activation mechanism; i.e., illumination of the prebound

138 This activation mechanism illustrates a new paradigm for viri

139 , and PHIP can be used for understanding the activation mechanism in metal-free catalytic systems in

140 1 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-phospho-Se

141 rovides a compelling and unifying allosteric activation mechanism in STKR1 kinases that reconciles a

142 d Tyr(705) phosphorylation-independent STAT3 activation mechanism in the modulation of insulin signal

143 We present evidence of a sequential activation mechanism in the STIM1 cytosolic domains wher

144 Raman spectroscopy and by studies of the INH activation mechanism in vitro.

145 These results suggest an Hsp90 activation mechanism in which cross-monomer contacts med

146 inhibitory C terminus of Swi4, suggesting an activation mechanism in which Mpk1 substitutes for Swi6

147 l domain of AccR is monomeric, we propose an activation mechanism in which phosphorylation of Asp(60)

148 uring autoactivation, the data support a cis-activation mechanism in which the activating protease bi

149 FXIIa may activate fXI through a trans-activation mechanism in which the protease binds to 1 su

150 a movement that is generally associated with activation mechanisms in class A GPCRs.

151 potheses for experiments and also understand activation mechanisms in GPCRs.

152 vated at membrane microdomains with distinct activation mechanisms in response to different physiolog

153 ts provide insights into the distribution of activation mechanisms in this family of proteins.

154 amines were consistent with an electrophilic activation mechanism; in contrast, the DAC functioned as

155 A handful of unique toehold activation mechanisms, including toehold-exchange, assoc

156 Indeed, important TGF-beta activation mechanisms involve several of the TGF-beta bi

157 Upon DNA damage, an activation mechanism involving autophosphorylation has b

158 FADD, and procaspase-8 and unveil a two-step activation mechanism involving both dimerization and pro

159 No analogous small molecule-induced enzyme activation mechanism involving dissociation and re-assoc

160 tudies suggest a 'cooperative small-molecule activation' mechanism involving spontaneous arene reduct

161 We have previously shown that the activation mechanism is an acylation event directed by a

162 l ortholog of human TopBP1, and the Mec1/ATR activation mechanism is conserved from yeast to humans.

163 ement dlk-1 mutants, suggesting that the DLK activation mechanism is conserved.

164 The activation mechanism is consistent with fatty acid induc

165 diated gene expression and that this initial activation mechanism is different from and independent o

166 Understanding the C-C bond activation mechanism is essential for developing the sel

167 In-depth knowledge of the pCRP activation mechanism is essential to develop therapeutic

168 The DLK activation mechanism is ideally suited for rapid and spa

169 e seen in CRP, suggesting that a common cAMP activation mechanism is present.

170 These studies demonstrate that the dioxygen activation mechanism is preserved in all T201 variants;

171 nervous system, but the understanding of p75 activation mechanism is still incomplete.

172 tion; thus, a virus-specific transcriptional activation mechanism is used.

173 tures of the regulatory domain show that its activation mechanism is very similar to that of NtrC1.

174 Although the Rho-regulated activation mechanism is well characterized, little is kn

175 nding is a key step in the receptor-mediated activation mechanism leading to root nodule development

176 s to emit NIR fluorescence through a turn-ON activation mechanism makes them promising candidate prob

177 the combined data reveal the ligand-induced activation mechanism of a new family of DNA-binding prot

178 results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a mole

179 heir associated calculated conductances) the activation mechanism of AM2.

180 Here we investigated the activation mechanism of botulinum neurotoxin type E upon

181 Nevertheless, the activation mechanism of caspase-8 remains unclear.

182 tructures reveal important insights into the activation mechanism of CB1 and provide a molecular basi

183 The activation mechanism of class B G-protein-coupled recept

184 insights about the allosteric modulation and activation mechanism of class C GPCRs.

185 y mutations engineered to disrupt the Ca(2+)-activation mechanism of CPK34 (CPK34-YFP-E465A,E500A), p

186 s, we provide a detailed view of a multistep activation mechanism of FAK initiated by phosphatidylino

187 cence resonance energy transfer to probe the activation mechanism of full-length mammalian group II m

188 Our results provide insight into the activation mechanism of glutamate receptors and the comp

189 ndings highlight an evolutionarily conserved activation mechanism of GPHRs and will further promote t

190 eir mode of inhibition and shed light on the activation mechanism of I-domain-containing integrins.

191 , indicating a signaling-mediated functional activation mechanism of iNOS.

192 Abs have been invaluable in deciphering the activation mechanism of integrins, but similar reagents

193 ovide a concrete basis for understanding the activation mechanism of mechanosensitive channels by asy

194 and computational analyses reveal a two-step activation mechanism of MLL family proteins.

195 approach harnesses the native targeting and activation mechanism of myosin VI, allowing direct infer

196 Our studies have revealed an activation mechanism of Nedd4 E3 ubiquitin ligases and e

197 nslocation through the C2 domain might be an activation mechanism of Nedd4 in vivo.

198 protein dynamics underlies the DNA-dependent activation mechanism of PARP-1.

199 This is paralleled by a different activation mechanism of PKD1 and PKD2 during oxidative s

200 To fully understand the activation mechanism of PlcR, we took a closer look at t

201 Beyond revealing an upstream activation mechanism of PTEN, our data introduce the con

202 d within its binding pocket can occur in the activation mechanism of rhodopsin.

203 haq coupled GPCRs, resembling the well-known activation mechanism of RhoGEFs activated by Galpha12/13

204 The activation mechanism of Rtt109-Vps75 provides a valuable

205 and structural data that reveal an exquisite activation mechanism of SAMHD1 via combined action of bo

206 Despite intense study, the pH-dependent activation mechanism of the AM2 channel has to date not

207 ent of a tryptophan residue important in the activation mechanism of the class A receptors.

208 The activation mechanism of the classical transient receptor

209 cular dynamics (MD) simulations to probe the activation mechanism of the kinase domain of Fibroblast

210 esults provide fundamental insights into the activation mechanism of the KOR and suggest that "functi

211 the characteristics, molecular identity and activation mechanism of the shear stress-sensitive curre

212 ure has brought invaluable insights into the activation mechanism of this essential methyltransferase

213 Our findings provide insight into the activation mechanism of this highly expanded family of p

214 These results indicate that the activation mechanism of TRPA1 may involve N-terminal con

215 These findings identify a new activation mechanism of TRPC1-based SOCs in VSMCs, and a

216 findings of the present study identify a new activation mechanism of TRPC1-based SOCs in VSMCs, and a

217 The activation mechanism of TRPP2 is unknown, which signific

218 In contrast to the classical proteolytic activation mechanism of trypsinogen-like serine proteina

219 ighlight functional similarities between the activation mechanisms of ATM, phosphatidylinositol 3-kin

220 These findings highlight plasticity in the activation mechanisms of closely related Rab GTPases.

221 Thus, our results reveal 2 different activation mechanisms of MAPKs that are involved in dist

222 We investigate activation mechanisms of native TRPC1/C5/C6 channels (te

223 antagonists and prove useful for elucidating activation mechanisms of other receptors.

224 erve as a paradigm for the poorly understood activation mechanisms of protein cysteine residues.

225 Thus, our results reveal two different activation mechanisms of Rap1b as well as novel function

226 Finally, similarities between the oxygen activation mechanisms of the monooxygenases and cytochro

227 mportance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain

228 IM2 inflammasomes, little is known about the activation mechanisms of the NLRP3 inflammasome.

229 distinct molecular entities or two different activation mechanisms of the same channel complex is unk

230 Recent studies have begun to reveal the activation mechanisms of these checkpoint kinases.

231 t is important to elucidate both binding and activation mechanisms of this peptide.

232 asoconstriction or stenosis, are the primary activation mechanisms of vWF, and unfold the multimeric

233 Rather an allosteric or 'parallel activation' mechanism of energy consuming and producing

234 of receptors that display a wide variety of activation mechanisms, often involving ligand-dependent

235 igands on the cluster), in contrast with the activation mechanism on conventional gold nanocatalysts.

236 al studies have provided insight into the NO activation mechanism, precise molecular-level details ha

237 n p110delta (N334K, E525K, E1021K) mimic the activation mechanisms previously discovered for oncogeni

238 Establishment of an aGPCR activation mechanism provides a rational platform for th

239 l, and computational approaches, we find the activation mechanism reconfigures atomic interactions be

240 tructural studies of GPCRs, details of their activation mechanism remain unclear.

241 merization, but extracellular regulation and activation mechanisms remain unclear.

242 nscriptional activity; however, the receptor activation mechanism remains poorly understood.

243 E253Q-DNA complexes support a transcription activation mechanism requiring the expulsion of Tyr-152

244 tional protein domains and protein co-factor activation mechanism requisite for the complexity of blo

245 ment by modulating a lineage-specific P-TEFb activation mechanism, revealing potential strategies tow

246 wn about their physiological function(s) and activation mechanism(s).

247 However, a fundamental activation mechanism shared by all protein kinases is ph

248 is compensated for by alternative signaling activation mechanisms, Src family kinase (SFK) signaling

249 using mutant of TorsinA is defective in this activation mechanism, suggesting a loss-of-function mech

250 This activation mechanism suggests an intriguing functional r

251 nce of a previously unrecognized ion-channel activation mechanism that couples extracellular thioredo

252 The oligomeric state and activation mechanism that enable p75(NTR) to mediate the

253 , and provides an integrative picture of the activation mechanism that explains the seemingly contrad

254 s that the Arp2/3 complex participates in an activation mechanism that includes additional diffuse co

255 em and, for the first time, reveal an oxygen activation mechanism that involves carbanion intermediat

256 Our study provides evidence of an activation mechanism that involves the extracellular reg

257 activity of ARAF, this study reveals an ARAF activation mechanism that is different from that of CRAF

258 e transcription elongation factor b (P-TEFb) activation mechanism that is known to drive adult megaka

259 This implies a nonproteolytic activation mechanism that is reminiscent of, yet distinc

260 as a novel protein kinase Cdelta (PKCdelta) activation mechanism that modifies PKCdelta-dependent ph

261 186 CII owes its potent activity to activation mechanisms that are dependent on both the sig

262 osure is a critical component of the channel activation mechanism, the differences in domain opening

263 Consistent with the two-step activation mechanism, the mechanism-based pan-E1 inhibit

264 gical functions, their substrates, different activation mechanisms, the signal transduction pathways

265 go, followed by studies of IgE receptors and activation mechanisms, this review provides a historic p

266 LOV) by exploiting its natural spring-loaded activation mechanism through rational insertion of the l

267 ) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff e

268 mmandeers a cellular dynein-dependent mTORC1 activation mechanism to maintain stress-resistant mTORC1

269 rylation to be an essential layer of the Akt activation mechanism to regulate its physiological funct

270 m the canonical trypsin-like serine protease activation mechanism to show that isolated peptides corr

271 We have fitted activation mechanisms to single-channel activity elicite

272 AF dimerization is part of the physiological activation mechanism, together with phosphorylation, and

273 An examination of the aryl halide activation mechanism using radical probes was undertaken

274 e cysteine oxidation mechanism and that this activation mechanism variably involves DUOX1 and NOX2.

275 s, it does not use the previously identified activation mechanism via covalent cysteine modification.

276 Four possible modes of dual activation mechanism via hydrogen bonds were considered.

277 Evaluation of the phenoxide activation mechanism was complicated by the concurrent a

278 This activation mechanism was dependent on TLR2, but not on T

279 The activation mechanism was determined by NMR analysis.

280 A direct activation mechanism was explicitly demonstrated using a

281 The importance of this activation mechanism was made evident, as dysregulation

282 idate the role of the 3-O-sulfo group in the activation mechanism, we compared the effects of deletin

283 To elucidate the IL-36 activation mechanism, we considered all possible binding

284 To investigate this activation mechanism, we determined x-ray structures of

285 e the model's assumption of an autocatalytic activation mechanism, we imaged cells expressing markers

286 In efforts to understand this activation mechanism, we recently identified an acidic c

287 Leveraging both activation mechanisms, we engineer a fully noncooperativ

288 Three sequential steps in the activation mechanism were identified.

289 therefore suggest a novel enzyme inhibition/activation mechanism where a disulfide loop inhibits Pla

290 mputed six-membered carboxylate-assisted C-H activation mechanism where the deprotonating carboxylate

291 These results support an activation mechanism where the role of the dsRNA is to b

292 Our data suggest an activation mechanism where, upon extracellular ligand bi

293 DISC, we have delineated a crucial two-step activation mechanism whereby activated death receptor co

294 Our results support an activation mechanism whereby collagen induces lateral as

295 We present a novel co-activation mechanism whereby CRP is placed at a non-opti

296 ide mechanistic insight and supported a dual activation mechanism, whereby ternary adducts form in th

297 acts with CaM will help in understanding the activation mechanism, which may provide insights for new

298 eceptor have provided a detailed view of its activation mechanism, which we review here.

299 We propose a multiscale activation mechanism with a complex energy landscape, wh

300 that betaarrs have a conserved structure and activation mechanism, with plasticity of their structura