ライフサイエンスコーパス: activation signal

1 ing leaky transcription in the absence of an activation signal.

2 nd not due to the absence of a 2B4-dependent activation signal.

3 culate Ags is dependent on the nature of the activation signal.

4 cell IFN-gamma production depending upon the activation signal.

5 ed to be involved in the propagation of this activation signal.

6 presentation pathways and the delivery of an activation signal.

7 ransmembrane region that is required for the activation signal.

8 ential for transmission of a transcriptional activation signal.

9 e capacity of aspirin itself to provide this activation signal.

10 nctions in the transduction of the spermatid activation signal.

11 GABA blocked calcium influx, which is a key activation signal.

12 -beta1 binds Hck that further transduces the activation signal.

13 function to terminate the PLA2-mediated NOX2 activation signal.

14 ression on Tregs in the absence of any other activation signal.

15 imuli, the cell type and the duration of the activation signal.

16 l 12-myristate 13-acetate/ionomycin-mediated activation signals.

17 mately respond to innate and acquired immune activation signals.

18 common adaptor protein, MyD88, to transduce activation signals.

19 , and showing marked up-regulation following activation signals.

20 hat iron regulation is usually controlled by activation signals.

21 e, respectively, negative or positive T-cell activation signals.

22 s a potential mediator of membrane-dependent activation signals.

23 ve virus infection after the T cells receive activation signals.

24 they were capable of efficiently delivering activation signals.

25 Vav1 by SHP-1, which blocks actin-dependent activation signals.

26 ultaneously interfere with B7-to-CD28 T cell activation signals.

27 indicates that Fas may also induce cellular activation signals.

28 ent of immature DCs that can fully mature on activation signals.

29 s Bcl-2 expression in B cells in response to activation signals.

30 ty of latently infected cells to lytic cycle activation signals.

31 f a protein tyrosine phosphatase that blocks activation signals.

32 s, to regulate susceptibility to lytic cycle activation signals.

33 TRAIL gene induction by both Tax and T-cell activation signals.

34 -specific genes, and responded to macrophage activation signals.

35 the HIV-1 LTR by both protein kinase C and A activation signals.

36 pes of immune responses by blocking cellular activation signals.

37 ral killer cells but a transient abortion of activation signals.

38 entation in combination with the appropriate activation signals.

39 tically involved in the regulation of T cell activation signals.

40 ructs, suggesting that Tpl-2 may induce NFAT activation signals.

41 inhibitory receptors from those that provide activation signals.

42 lly involved in the regulation of lymphocyte activation signals.

43 mmatory phenotype results from multicellular activation signals.

44 ed in different cell lineages in response to activation signals.

45 perm activation in response to male protease activation signals.

46 ntenance/progression, but not initiation, of activation signals.

47 c microclusters and their ability to trigger activation signals.

48 irectly on T cells by attenuating TCR-driven activation signals.

49 tein BRG1 was programmed by both lineage and activation signals.

50 d hormone receptors rapidly transduce kinase activation signals.

51 (ES) cells and in human cells in response to activation signals.

52 tiate gene transcription induced by distinct activation signals.

53 atory mechanisms may exist downstream of the activation signals.

54 ocytes, their integrins became responsive to activation signals.

55 tivity, potentially by controlling NF-kappaB activation signaling.

56 er uPAR aggregation is capable of initiating activation signaling.

57 lity function by restoring normal Rho GTPase activation signaling.

58 alternative channels must participate in egg activation signaling.

59 Our data demonstrate that full T cell activation (signal 1 plus 2) in the presence of rapamyci

60 ith tolerance pathways after the blockade of activation signal 1 (CD4 monoclonal antibody [mAb]) or s

61 CD4 mAb-induced blockage of activation signal 1 or CTLA4Ig-mediated blockage of cost

62 By targeting T cell activation signals 1 and 2 with the novel combination of

63 By stimulating DCs with two distinct activation signals, a previously unrecognized phenotype

64 and transformed an ATRA signal into program activation signals; a signal integration module that con

65 We stimulated human macrophages with diverse activation signals, acquiring a data set of 299 macropha

66 the TM heterodimer separates to transduce an activation signal across the membrane.

67 ceptor necessary for the transduction of the activation signal across the sperm plasma membrane.

68 Whether the activation signal, after transmission through multiple d

69 These data support a model in which PARP-1 activation signals AIF release from mitochondria, result

70 of the GPIb complex, in addition to sending activation signals, also initiates a negative feedback l

71 est that Chk2 oligomerization regulates Chk2 activation, signal amplification, and transduction in DN

72 omains is critical in the propagation of the activation signal and for PKR dimerization.

73 BE by itself was not a conventional upstream activation signal and instead behaved like a repressor.

74 fection consistently resulted in an improved activation signal and was essential for detectable funct

75 ine genes that use STAT5 in their macrophage activation signaling and contributes approximately 50% o

76 ells increase CD95 expression in response to activation signals and become susceptible to CD95-induce

77 phorylation prevents essential Crk-dependent activation signals and blocks F-actin network formation,

78 diverse immune responses in RC, depending on activation signals and cytokines present.

79 ailure is largely attributed to insufficient activation signals and dominant inhibitory stimuli for t

80 we explored the relationship between T cell activation signals and early events in the life cycle of

81 or IL-2 mRNA stabilization induced by T-cell activation signals and for JNK-induced stabilization in

82 nding provides a direct link between NK-cell activation signals and KIR expression required for acqui

83 lymphocytes which integrates diverse Ca(2+) activation signals and may be broadly operative in sever

84 hat BRG1 interprets both differentiation and activation signals and plays a causal role in gene regul

85 C-I-specific inhibitory receptors both block activation signals and trigger signals to phosphorylate

86 ma membrane was a requisite component of egg activation signaling, and not simply a Ca(2+) source for

87 CTLA-4 (CD152) negatively regulates T cell activation signaling, and the cytoplasmic domain of CTLA

88 orted defects, did not mature in response to activation signals, and failed to express CD8alpha and i

89 icity of natural killer cells as well as the activation, signaling, and cytokine production of T cell

90 utophagy and increased PRR-induced caspase-1 activation, signaling, and cytokine secretion.

91 investigated the role of the C tail in Tie2 activation, signaling, and function both in vitro and in

92 were associated with immune response, glial activation, signaling, and gene expression, whereas down

93 indicate that EGFR contributes to RET kinase activation, signaling, and growth stimulation and may th

94 ersinia outer proteins (Yops), that modulate activation, signaling, and survival of immune cells.

95 s the receptor to the center of the IS where activation signals are accumulating and provides a docki

96 However, the step at which activation signals are blocked by SHP-1 is not known.

97 macrophage quiescence and activation, strong activation signals are modulated via negative regulation

98 The activation signals are partially inhibited by using a ne

99 egulation, and potential mechanisms by which activation signals are propagated from integrin cytoplas

100 stitutively expressed, and specific cellular activation signals are required for both the up-regulati

101 Activation signals are transduced between the cytosolic

102 provide insight into the mechanisms by which activation signals are transduced to allow the induction

103 Some of the most potent activation signals are triggered by innate immune molecu

104 lated in a distinct manner by different cell activation signals at the ligand-binding stage.

105 is not capable of initiating a transmembrane activation signal because it is a glycosylphosphatidylin

106 unstimulated RA cells that requires cellular activation signals beyond that provided by IL-2 alone fo

107 omously to establish a graded, prespore gene activation signal but autonomously to localize prespore

108 ding to integrin beta tails provides one key activation signal, but additional factors are likely to

109 n to the integrin beta tail provides one key activation signal, but recent data indicate that the kin

110 A macrophage activation signal by IFN-gamma/LPS led to a global slowd

111 of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors.

112 LFA-1 engagement leads to altered Rho GTPase activation signaling by downregulating RhoA and Rac1, wh

113 phosphatases plays a critical role in T cell activation signaling by regulating the tyrosine phosphor

114 endent role for FcgammaRs in transduction of activation signals by bacterial products.

115 oter was evaluated for sensitivity to T-cell activation signals by using a promoter reporter plasmid.

116 Thus B cell activation signals can biochemically modify proximal ele

117 tor (TCR) ligation initiates tyrosine kinase activation, signaling complex assembly, and immune synap

118 y lipid rafts exclusion prevent formation of activation signaling complexes.

119 We hypothesized that LMP1-mediated activation signals cooperate with and/or amplify events

120 suppression by regulatory T cells or strong activation signals could overcome such regulation.

121 The activation signal delivered by hOKT3gamma1(Ala-Ala) was

122 ocytes, thereby lowering the strength of the activation signal delivered.

123 s only up-regulated in response to mast cell activation signals delivered through the FcepsilonRI or

124 s have primarily been considered in terms of activation signals delivered through the TCR and the co-

125 requires a series of discrete selection and activation signals delivered to maturing progenitors in

126 cts with TRAF6 or IkappaB kinase (IKK) in an activation signal-dependent fashion.

127 from other receptors, NK cells receive early activation signals directly through LFA-1.

128 Thus, P2X7R activation signals distinct, novel membrane blebbing eve

129 val factor for oligodendrocytes and receptor activation signals downstream to the phosphatidylinosito

130 Expanding our understanding of activation signals driving CNS migration of distinct B c

131 ancers and genes, thereby resisting the gene activation signals during embryonic stem cell differenti

132 explains how KIR can efficiently block early activation signals during NK-target cell contacts.

133 rced overexpression of Lnk demonstrated that activation signals emanating from both forms of FLT3 are

134 Its activation signaling enhances cell survival.

135 uPAR aggregation triggers activation signaling even though this glycolipid-anchore

136 Human NKG2D transduces activation signals exclusively via an associated DAP10 a

137 usly show that the conformational allosteric activation signal extends to the EGF1 domain in the ligh

138 a GPI-anchored MMP13 with a functional furin activation signal fails to promote cell growth in a thre

139 in secretion during hypoglycemia provides an activation signal for alpha-cells to release glucagon.

140 case domain binds HCV RNA and transduces the activation signal for IRF3 by its caspase recruiting dom

141 cting with the PH domain acts as an upstream activation signal for Tec kinases, resulting in Tec kina

142 We see that the strengths of the activation signals for each T helper cell subset, which

143 However, the contribution of LFA-1 to activation signals for NK cell cytotoxicity, besides its

144 uxes in BMECs, suggesting that generation of activation signals for the BBB is critically dependant o

145 mplicating the dermis as the primary site of activation/signaling for IL-10 upregulation in cutaneous

146 i requires a priming signal from TLRs and an activation signal from purinergic receptors or pore-form

147 the most upstream protease that receives the activation signal from the Fas-receptor to initiate the

148 responsible for transmission of the receptor activation signal from the membrane to cytosolic targets

149 The activation signal from tyrosine kinase receptors, such a

150 They transmit activation signals from a diverse repertoire of platelet

151 and is responsible for transducing receptor activation signals from the cytoplasm to the nucleus, wh

152 the functional plasticity needed to transmit activation signals from the retinal-binding pocket to th

153 to IpaD's C-terminal helix and likely affect activation signal generation or transmission.

154 interdependent relationship between receptor activation, signal generation and endocytosis.

155 the KIR family, including some that deliver activation signals, have unknown ligand specificity and

156 mutant sperm activate prematurely without an activation signal in males, and mutant males are sterile

157 of T-cell receptor stimulation or a primary activation signal in the presence of CD28 stimulation to

158 t a model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes fun

159 o determine whether uPAR clustering mediates activation signaling in human polymorphonuclear neutroph

160 We conclude that uPAR aggregation initiates activation signaling in polymorphonuclear neutrophils th

161 trating genotoxic stress-initiated NF-kappaB activation signaling in the colon tissue and whole anima

162 n in adults indicating a lack of appropriate activation signaling in the local environment.

163 ream of both hermaphrodite- and male-derived activation signals in a spermatid signaling pathway that

164 nal FDG brain images and result in increased activation signals in a three-dimensional [15O]water fun

165 cells to fibronectin by modulating cellular activation signals in a unique fashion.

166 NF receptor superfamily member that provides activation signals in antigen-presenting cells such as B

167 ATc.alpha mRNA is strictly dependent on cell activation signals in both T and mast cell lines.

168 that Tax interaction with Chk2 generates two activation signals in Chk2, oligomerization and autophos

169 r-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for the

170 ceptor-2 (CLEC-2), elicits powerful platelet activation signals in conjunction with Src family kinase

171 anti-HLA Abs have the capacity to transduce activation signals in endothelial cells that may promote

172 ct means by which inhibitory signals obviate activation signals in immune cells are not totally eluci

173 ent of LFA-1 alone is sufficient to initiate activation signals in NK cells.

174 hich cytokine receptors transduce telomerase activation signals in T cells.

175 , which are unable to respond to alternative activation signals in vitro.

176 Therefore the quality of early target T cell activation signals, in particular engagement of CD28, re

177 blockade of DC maturation in response to all activation signals, including CD40L, monocyte-conditione

178 IB is an inhibitory receptor that terminates activation signals initiated by antigen cross-linking of

179 In response to cell activation signals, integrins switch from a low to a hig

180 In summary, Rho activation signals interaction of IP3R with TRPC1 at the

181 n complex, which transmits collagen-specific activation signals into the cell interior through the ac

182 eptor tyrosine-based activation motif, sends activation signals into the cell.

183 uired for cell surface integrins to transmit activation signals into the cell.

184 In this way a single activation signal is insufficient for complete activatio

185 velopment, inhibits spermiogenesis until the activation signal is received.

186 -kappaB in the cytoplasm until the NF-kappaB activation signal is received.

187 SPE-8 is released from the membrane when the activation signal is transduced into the spermatid.

188 oactivator complexes and the way the steroid activation signal is transduced remain elusive.

189 The activation signal is transduced through SPE-8, SPE-12, S

190 lls to respond to TLR4 and CD40 survival and activation signals is further attenuated compared with s

191 DAP12-associated receptors can give activation signals leading to cytokine production; howev

192 In the present study, T cell activation signals leading to mitochondrial hyperpolariz

193 mon adaptor molecule, MyD88, for transducing activation signals leading to proinflammatory mediator e

194 hese cells are also able to sense endogenous activation signals liberated by injured tissues even in

195 signals into acetylcholine-mediated muscular activation signals may be obtained, applicable for bridg

196 ions, and that pathogen-associated secondary activation signals may facilitate the full differentiati

197 These dual activation signals may represent a system for selectivel

198 In the thymus, maturing lymphocytes receive activation signals mediated by the T-cell antigen recept

199 Depending on the activation signal, microglia/macrophages (MPhi) can beha

200 d by prostaglandin E(2) regulation of T-cell activation signaling molecule P59fyn.

201 46(hc197) mutation bypasses the need for the activation signal; mutant sperm activate prematurely wit

202 o responsible for initiating and transducing activation signals necessary for B cell proliferation an

203 In response to T cell activation signaling, NFATc1 bound to two of the novel r

204 ggesting a key process in resistance protein activation/signaling occurs in this subcellular compartm

205 The activation signal of KIR2DL4 was sensitive to inhibition

206 Summation of discrete and rhythmic activation signals of the pattern generators was suffici

207 It has been shown that its ligation inhibits activation signals on cells of both myeloid and lymphoid

208 ly viable and were responsive to consecutive activation signals on subsequent removal of LTA.

209 the alphaF helix shifts and/or propagate the activation signal once the covalent bond with H105 has b

210 These data indicate that interference with activation signals one and two may provide synergy essen

211 These studies suggest that inhibiting activation, signaling, or both by PDGFRalpha has the pot

212 pl-2 contributes to the transduction of NFAT activation signals originating in the T cell receptor.

213 ram through an oxidative stress-involved JNK activation signaling pathway.

214 trigger a 'nuclear-to-cytoplasmic' NF-kappaB activation signaling pathway; however, the early nuclear

215 -2 in MM cells act upstream in the NF-kappaB activation-signaling pathway and the potential use of NF

216 sity of an intact cAMP-PDE4-PKA-LIMK-cofilin activation-signaling pathway for sleep deprivation-induc

217 targeted by miR-155 were enriched in NK cell activation signaling pathways.

218 ss-talk between innate immunity and integrin activation signaling pathways.

219 inhibitor (sodium orthovanadate) and T-cell activation signals (phorbol 12-myristate 13-acetate plus

220 se TRP proteins respond to a multiplicity of activation signals--promiscuity of gating that could ena

221 competition between the compartments for the activation signaling protein SpoIIR.

222 s identify fibrinogen as a primary astrocyte activation signal, provide evidence that deposition of i

223 ool apparently unperturbed by the incomplete activation signals provided by the peptide.

224 due to a failure to transmit transcriptional activation signals provided either from the MyoD or the

225 tides to platelets eliciting strong platelet activation, signaling, reactive oxygen species generatio

226 e production, and phenotype depending on the activation signals received by the T cells.

227 lpha) mRNA is transformed into a translation activation signal, recruiting Argonaute (AGO) and fragil

228 T lymphocyte activation signals regulate the expression and transacti

229 scription factor knockouts, we show that the activation signal(s) that lead to homeostatic B cell pro

230 uired for amplification of the initial FLICE activation signal, showed that pro-ICE expression signif

231 hils is not only cell type specific but also activation signal specific.

232 Thus, NK cell activation signaling specifically induces transcriptiona

233 ted specifically in T lymphocytes, following activation signals, suggesting a role in cellular immuni

234 generation, we identified a new inflammasome activation signal that originates from defects in autoph

235 inding to the neutrophil surface triggers an activation signal that regulates the adhesive activity o

236 the neutrophil surface triggers a transient activation signal that requires extracellular calcium an

237 (T and B cells) causing autoimmunity require activation signals that are normally provided by the inn

238 ent primary cell model to determine cellular activation signals that induce renewed expression of lat

239 rom NK cell lysis, the NK cell also received activation signals that induced mobilization of intracel

240 , dimers, and oligomers may control cellular activation signals that influence the adhesive propertie

241 s, little is known about the chemotactic and activation signals that influence this response.

242 downregulate natural killer cell and T-cell activation signals that lead to cytotoxic activity.

243 model based on a half-center oscillator with activation signals that produce either rhythmic or discr

244 In this study, we attempt to characterize activation signals that transform quiescent keratinocyte

245 Thus, BCR-derived activation signals that up-regulate D-type cyclin and Cd

246 In contrast, right hippocampal activation signaled the presence of objects in familiar

247 a subject operated "off-switch" which, upon activation, signaled the computer to record the subject'

248 In response to T cell activation signals, the half-life of interleukin-2 (IL-2

249 7-2 regulate T cell activation by delivering activation signals through CD28 and inhibitory signals t

250 3 domain and that this interaction initiates activation signals through GPVI.

251 telomerase activity in vitro in response to activation signals through the B cell antigen receptor i

252 trate that, in addition to the decreased Ras activation, signaling through phosphatidylinositol-3 kin

253 h its polypeptide core) and a maturation and activation signal (through its carbohydrate moieties).

254 Smo transmits its activation signal to a microtubule-associated Hedgehog s

255 gand gene that prevent it from delivering an activation signal to antigen-presenting cells via CD40.

256 tein kinase Calpha isozyme and transmits the activation signal to CREB via the Raf/MEK/extracellular

257 gG3-Rae-1beta), thereby targeting an NK cell activation signal to HER2+ breast tumor cells.

258 ace of infected cells may serve a role as an activation signal to other cells of the immune system.

259 bditis elegans are stimulated by an external activation signal to reorganize their membranes and cyto

260 ti-CD3 mAb, hOKT3gamma1(Ala-Ala) delivers an activation signal to T cells that is quantitatively and

261 n factors interact directly in delivering an activation signal to the basic transcription machinery.

262 liver a biologically relevant, Lck-dependent activation signal to thymocytes in the absence of the TC

263 subsets depending on the environment and the activation signal to which they are submitted.

264 nal envelope glycoproteins failed to provide activation signals to autologous dendritic cells (DCs).

265 studies demonstrated that pDCs could provide activation signals to autoreactive B cells via a cell-to

266 the germinal center reaction provides unique activation signals to B cells that allow for continued,

267 complete environment of Ag presentation and activation signals to become fully functional in this mo

268 elevant Ag, bone marrow-derived DC delivered activation signals to CD4(+) T cells isolated from the D

269 ells mediates the specific modulation of TCR activation signals to facilitate their survival and diff

270 dition to BTN3A1, BTN3A2 and BTN3A3 transmit activation signals to human gammadelta T cells in respon

271 nstrate that Ly-49D is capable of delivering activation signals to Jurkat T cells even in the absence

272 t to show the potential of PIR-A3 to deliver activation signals to macrophages and establish its depe

273 unknown whether PIR-A receptors can deliver activation signals to macrophages, and if so, through wh

274 eptor signaling that synergizes with primary activation signals to maximally activate platelets and r

275 requires synergistic interaction of multiple activation signals to overcome the quiescent state.

276 that DC undergoing apoptosis deliver unusual activation signals to T cells during Ag presentation, si

277 let-derived membrane vesicles to communicate activation signals to the B-cell compartment.

278 c-Fos and JunD and transmit protein kinase C activation signals to the HIV LTR.

279 and CD3epsilondelta subunits, which transmit activation signals to the T cell, inside the TCR-pMHC-CD

280 tion, a direct role for Mediator in relaying activation signals to this machinery.

281 3 activity is required, in the absence of an activation signal, to repress transcription of particula

282 ller' DCs, deliver death signals, instead of activation signals, to T cells after antigen-specific in

283 ibility of the immunoreceptor tyrosine-based activation signal transduction pathway.

284 he last few years our understanding of their activation, signal transduction and gene regulation has

285 During T-cell activation, signal transduction through the phosphoinosi

286 olecular trafficking and clearance, receptor activation, signal transduction, and endocytosis.

287 pholipase A2 (PLA2) proteins affect cellular activation, signal transduction, and possibly innate imm

288 ne or lipid phosphatases, which modulate the activation signals transmitted by receptors linked to th

289 inase, succeeds in blocking proximal NK cell activation signals upon binding HLA class I on target ce

290 to receive appropriate T-cell receptor (TCR) activation signals upon cognate antigen recognition ("st

291 tacts with p15/ARPC5; 2) propagation of WASp activation signals via contacts with p19/ARPC2; and 3) d

292 elet responses to collagen, which transduces activation signals via the GPVI/FcR gamma-chain complex.

293 r localization of c-Abl, triggered by T-cell activation signals, was essential for its activity in re

294 In order to assess possible oncogene activation signals, we produced an experimental transloc

295 human NK cells, 2B4/CD48 interaction induces activation signals, whereas in murine NK cells it sends

296 hocytes with a combination of these cellular activation signals, which are sufficient to lead to G1 c

297 Modulating target T cell activation signals with provision of CD28, IL-2, or high

298 cified towards an anterior neural fate by an activation signal, with its subsequent regionalization a

299 potentially due to the lack of TLR-mediated activation signals within the tumor microenvironment.

300 nce lymphocytes rendered anergic by a single activation signal would be nonpermissive for productive