ライフサイエンスコーパス: active

1 to generate the structures that are surface active.

2 in the season when the cork cambium becomes active.

3 f tumor where the therapy was designed to be active.

4 s, but not all intraplate faults are equally active.

5 macropinosome is the location where Rab8a is active.

6 on that otherwise would become spontaneously active.

7 conditions, while mTORC1 signaling remained active.

8 e small calcium-binding protein Cdc31p to be active.

9 The extracellular, active 180 amino acid Nogo-A region, named Nogo-A-Delta2

10 of 4.3 years posttransplantation) with late active ABMR and features of CP activation, such as capil

11 SseK3 and NleB2 were not active against either substrate.

12 ansfer (PCET) steps along a pathway of redox active amino acids (Y122beta <--> [W48beta?] <--> Y356be

13 omic groups were found to be less physically active and consume more fats, salt, and processed food t

14 The venlafaxine-exposed larvae were less active and covered shorter distance in a light and dark

15 ilter regeneration is significantly more CCN active and hygroscopic; average kappa values range from

16 Active and inactive arrays on the same chromosome produc

17 pseudohexamers containing mixtures of ATPase active and inactive subunits at defined positions in the

18 probe the solution structure and dynamics of active and inactive TNFalpha using NMR spectroscopy.

19 oductive transition, suggesting that is most active and key for Bailinggu development.

20 nd remaining obstacles to the development of active and passive HIV-1 vaccines.

21 ncogene activation, mTORC1 is constitutively active and resistant to serum and amino acid starvation.

22 These cubanes are redox-active, and calculations reveal that the Co ions behave

23 The Os system is most active, and liberates more than 120 equiv NH3 per Os cen

24 Like many visually active animals, including humans, flies generate both sm

25 cell termination strategies: (1) transiently active anti-CD123 messenger RNA-electroporated CART (RNA

26 n 24 h after the index date, therapy with an active antibiotic for at least 2 days when blood culture

27 Diverse organisms secrete redox-active antibiotics, which can be used as extracellular e

28 to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any difference

29 e decreased since the introduction of highly active antiretroviral therapy (HAART) in 1996.

30 N binding partner, forming transcriptionally active AP-1.

31 heses for those reactions that are currently active areas of investigation.

32 K28 is structurally stable and biologically active as a disulfide-bonded heterodimer, whereas it for

33 kb that contains DNAse hypersensitive sites active at a restricted time window during retinal develo

34 Phasor analysis revealed that Cdc42 is active at all Golgi cisternae and that this activity is

35 c condensation products (TEACOPs), which are active at low picomolar levels.

36 ng at high doses, 6-MHO/GA mixtures were not active at the levels emitted by human skin.

37 irming that SGN-CD19B is pharmacodynamically active at well-tolerated doses.

38 easurements suggested that electrochemically active bacteria Pseudomonas and Acinetobacter transferre

39 ing pathways, as well as increased total and active beta-catenin.

40 electrical signaling to direct blood flow to active brain regions.

41 stained it can boost connectivity between co-active brain regions.

42 iver is frequently affected in patients with active brucellosis.

43 The HS oligosaccharide is functionally active, can restore protein binding, and allows activati

44 ages over previously identified peripherally active cannabinoid compounds, and could have clinical ap

45 t nanoparticle-decorated nanotubes as highly active catalysts for the reduction of 2,4,6-trinitrotolu

46 eased filamentous actin staining, indicating active cell movement.

47 non-coding transcripts, and RNAs present at active centromeres are necessary for kinetochore assembl

48 , which can be further processed to the most active chemerin form, providing a molecular link between

49 ents barely survive >6 months even following active chemotherapy interventions.

50 ifference in uptake of screening between the active choice and control groups (P = .88).

51 lated DNA binding protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse n

52 Female-biased genes already in an active chromatin state in male liver generally showed ea

53 yields (61-98 %) and mostly >90 % optically active cis-aziridines.

54 ear mechanics and energy distribution in the active cochlea.

55 Active community-based surveillance allows for a better

56 Active compared to sham tDCS led to increased performanc

57 r pazopanib has been demonstrated to be more active compared with other soft tissue sarcomas.

58 terials in which multiple optoelectronically active components are arranged in productive ways.

59 18months and can be used as a carrier of an active compound or as a filler in bioplastics.

60 The enzyme activation rates by two most active compounds at 100 muM ( 150% and 130%) were compar

61 ing methods with regard to classification of active compounds for cancers.

62 ion products (containing the above-mentioned active compounds) in a greenhouse study plant material w

63 ound in consistently inactive and frequently active compounds, indicating that the structural context

64 al moieties of numerous natural biologically active compounds.

65 ilent, H3K9me2 domains are transcriptionally active, contain modifications associated with euchromati

66 onal excitation, suggesting a new avenue for active control over molecular function.

67 The results suggest that experiences of active control over threat engage the striatum and promo

68 or to and following tRNS to either IFC or an active control region (area V5/MT).

69 Active coping was associated with better QOL (B = 3.50;

70 inducing clinical remission in patients with active Crohn's disease.

71 at these earliest-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate

72 econciling these observations is engendering active debate about the physical state, spatial distribu

73 ed that a new experience increased firing of active dentate granule neurons rapidly and robustly.

74 We purified trace-active derivatives of kynurenine and identified two nove

75 exposures were ascertained by self-report or active detection and confirmed by prescriptions, clinic

76 During active disease, the CC-slab lesion area was larger than

77 bursitis in more than half of patients with active disease.

78 re effective at delivering a therapeutically active dose of KAFAK to bovine cartilage explants, suppr

79 ours without the use of physical barriers or active drift-correction algorithms.

80 vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infectio

81 centrations, the contribution of exosomes to active drug efflux increased with drug concentration and

82 ieves higher intracellular concentrations of active drug.

83 an target cells convert to pharmacologically active drug.

84 duces a photochemical reaction prompting the active-drug's release, which effectively controls mGlu5

85 Nanostructured ceria becomes profoundly more active due to its enhanced surface area to volume ratio,

86 s, we show that the SIP signaling pathway is active during infection and contributes significantly to

87 , located in midline frontal cortex, becomes active during the early stage of learning a novel vocabu

88 rdiomyocytes provides a functional 3D map of active ECC couplons (on average, 17,000 per myocyte).

89 in an elevation of the cellular fraction of active eEF-2K.

90 ace realized by loading it with controllable active elements.

91 Wild-type cells are required for the active elimination of mutant cells from the tissue, whil

92 eveloped to predict the genomic locations of active enhancers based on histone modifications, but the

93 Gs at PTPN6/PHB2, ANKRD11, and TNRC18 map to active enhancers in kidney cortex.

94 hmCA) and it accumulates in regions flanking active enhancers.

95 n and subsequent generation of catalytically active enzyme.

96 as a promising source of novel carbohydrate active enzymes (CAZymes) that modify plant cell wall pol

97 trate efforts to design and engineer stable, active enzymes without laborious high-throughput activit

98 e ages of 11 and 40 years with dysphagia and active esophageal eosinophilia were randomized to receiv

99 of KI mice, demonstrating that constitutive active FAK signaling downstream of the Pro32Pro33 integr

100 -1-yl)pyridines], which have produced 16 SCO-active [Fe(II)(bpp(X,Y))2](Z)2 complexes (Z = BF4 or in

101 we additionally find that size reduction in active fish species is dramatically larger than for more

102 iarylalkenes as aggregation-induced emission-active fluorogens (AIEgens) are sporadically explored by

103 1000-supported bimetallic-oxide clusters are active for propane ODH after thermal activation under O2

104 The currently known mechanisms for active forgetting include neurogenesis-based forgetting,

105 e Mediator-induced repression to generate an active form of the PIC.

106 f bivalent histone modifications toward more active forms and induced KSHV reactivation in naturally

107 icant decrease of the phosphorylated, likely active, forms of FoxM1.

108 Targeting of a constitutively active FoxM1 construct or the activation domain of FoxM1

109 inocoumarin (C47) and two derivatives in the active fractions.

110 ive compliance of the cochlear partition and active frequency tuning of the basilar membrane are enha

111 Blazars are active galactic nuclei, which are powerful sources of ra

112 mber of primary cilia(+) LPCs, and increased active gamma-glutamyltranspeptidase enzyme secretion.

113 nal elongation) to the coding sequence of an active gene, ADH1, independently of mRNA-capping activit

114 ant 6mA is associated with transcriptionally active genes in early-diverging fungal lineages.

115 Furthermore, these studies suggest the active genotoxins (colibactins) are unsaturated imines t

116 tion of GA19, the immediate precursor of the active gibberellin, GA1, by UV-B in this zone, which is

117 sitized, and 284 were randomized (146 to the active group and 138 to the placebo group).

118 f both variants with known inactive GDP- and active GTP-bound RAB11B mutants, we modeled the variants

119 oes a conversion from inactive homodimers to active heterodimers with retinoid X receptor alpha (RXRa

120 retches attenuate the potential of stem cell active homeobox genes to acquire oncogenic properties.

121 these genes is mediated by transcriptionally active HSF1.

122 promoters are shown to be transcriptionally active in 293T (embryonic kidney), Vero (African-green m

123 ve injury, and show that the same pathway is active in human stem cell-derived RGCs.

124 methylation targeted to candidate enhancers active in liver cells, enriched for the binding sites of

125 r, targets BCR signaling and is particularly active in lymphomas with mutations altering the BCR subu

126 Our data suggest that nivolumab is active in relapsed/refractory PCNSL and PTL and support

127 Surprisingly, what signaling pathways are active in the basal state and the functional relevance o

128 ase of the cell cycle, but both pathways are active in the S and G2 phases.

129 rning based classification of protein kinase active/inactive conformations, taking into account more

130 25D plasma levels in patients with IBD with active inflammation.

131 in PET/CT that is retained by metabolically active inflammatory cells in granulomas, but lacks speci

132 ormation of benzalkonium chlorides (BACs)-an active ingredient of many disinfectants-to benzyldimethy

133 sed to deduce not only a compound's possible active ingredients but also its therapeutic, pharmacolog

134 show that different PKMs, the constitutively active isoforms of PKCs generated by calpain cleavage, i

135 This study is the first to identify active isoprene degraders in estuarine and marine enviro

136 atients with SPMS (35%) than RRMS (23%), but active lesions were found in all patients, including tho

137 tabolically inert feathers and metabolically active liver.

138 The detection of active macrophage-tropic virus expression, and probably

139 cell identity and function requires not only active maintaining of the expression of genes involved i

140 receptors (MOR) of 22 healthy recreationally active males using positron emission tomography (PET) an

141 omprising samples from poultry outbreaks and active market surveillance collected from January 2012 t

142 of the cytoskeleton and designing biomimetic active materials.

143 only recently been demonstrated by combining active media with patterned metallic structures.

144 superparamagnetic microbead suspended in an active medium.

145 Active methylene compounds react with in situ generated

146 nts using thermally driven nanoparticles and active microrheology using micron-scale ellipsoidal magn

147 ced by a single double-strand break requires active microtubule function.

148 Our findings strongly support an active model of chaperonin-mediated protein folding, whe

149 During cell adhesion, an active multistage process naturally leads to pattern tra

150 KEY POINTS: A tonically active, muscarinic cholinergic inhibition of rostral rap

151 Participants were randomised to active (n=12) versus sham (n=13) DBS for 16 weeks.

152 Many biologically and pharmaceutically active natural products contain chlorine and thus, an un

153 Active NL genes with higher RNA polymerase II (Pol II) r

154 The constitutively active Nlrp3(A350V) mutation abolished the protective ef

155 a cell transform its packaged genome into an active one.

156 llected data from 14 countries (where it has active operations) to understand the extent of stock-out

157 odulated from 6 dB to 21 dB, demonstrating active, optoelectronic modulation of the laser frequency

158 ts to estimate virtual-room size with either active or passive sounds while measuring their brain act

159 The primary outcome was detection of active or past placental malarial infection by histopath

160 In mammalian cells, active or primed enhancers are commonly marked by monome

161 abrupt shifts to increased dominance by more active organisms.

162 sites relative to Co(3+) and by the shift of active oxygen 2p states.

163 We consider an active particle performing a blind cruise search for non

164 rgy is a crucial property that distinguishes active particles from Brownian particles.

165 anes, thus promoting cell internalization by active pathways, attachment of cargo molecules to CPPs i

166 The most active peptide was completely symmetrical, rich in Arg a

167 method for achieving high concentrations of active pharmaceutical ingredients (API) per nano-liposom

168 y, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and ot

169 cycle, reduce the intensity of the following active phase by stabilizing the atmosphere.

170 omoters enhance the performance of catalytic active phases by increasing rates, stability, and/or sel

171 Electrochemically active polymers are widely used in (opto)electronic appl

172 sis, which was rescued by the constitutively active PPP1R1A.

173 raries of TAs have been used to discover the active principles of the TA polymers that interact with

174 Inflammation resolution is an active process that functions to restore tissue homeosta

175 tion.SIGNIFICANCE STATEMENT Perception is an active process, especially sensitive to attentional stat

176 ging biomarkers associated with cognition in active professional fighters.

177 Iron complexes bound by redox-active pyridine dialdimine (PDAI) ligands catalyze the c

178 provides new support for the presence of an active pyruvate dehydrogenase in this stage.

179 uch adhesive interactions enhanced levels of active Rac in adherent and fusing myoblasts, as well as

180 ctions as a platform for the presentation of active Rags for mTORC1 recruitment, and might suggest an

181 to high expression of ERAS, a constitutively active RAS protein normally expressed only in embryonic

182 mount of p110alpha-p85 heterodimers bound to active receptors, augmenting PI3K signaling and oncogeni

183 higher temperatures, behaviors indicative of active recruitment to the nucleolus.

184 f implementing the AlN/GaN DA as a promising active region design for high efficiency mid- and deep-U

185 are either in the clinic or currently under active research and clinical development, with particula

186 pathological conditions and there have been active research efforts to develop high-throughput platf

187 not separate alpha-retinol derivatives from active retinol.This study aimed to accurately characteri

188 ned with computational modeling reveals that active Rho-kinase diffuses to growing other immature neu

189 , the signal appears to play a versatile and active role in adaptive sensorimotor prioritization.SIGN

190 chanosensory mechanism in VSMCs and plays an active role in both the arteriolar myogenic response and

191 6) , but the porins do not appear to play an active role in phospholipid transport.

192 ng persons with a chronic illness to take an active role in the management of their condition is a co

193 Our simulations further demonstrate how active scale selection controls mirror-symmetry breaking

194 plers, splitters, polarization rotators, and active section with phase shifters-are included in a sin

195 score of 70 to 84 and either GMFCS level 2, active seizures, or hearing with amplification.

196 However, developing active, selective and stable electrocatalysts is challen

197 ur results establish brain capillaries as an active sensory web that converts changes in external K(+

198 Overexpression of constitutively active SHP2 reduced the responsiveness of fibroblasts to

199 as a generic platform to target other redox-active side chains for native conjugation.

200 ed incorporates a monolayer of near-infrared active silica-coated gold nanostars (GNS) decorated by s

201 P90, exclusively nuclear, and constitutively active similarly as previously reported for v567es.

202 evaluated for in vitro binding to the enzyme active site and for inhibition constants.

203 , the heme 7-propionate is positioned in the active site and provides additional restraints on substr

204 tance occurs through an unusual ground state active site arrangement or by thermally sampling conform

205 in altering the solvent accessibility of the active site by expanding the active site volume, allowin

206 exclusion and the core H-bond network in the active site by relocating to replace the missing Arg85'

207 Free-energy simulations elucidate the active site conformations in the AppA (activation of pho

208 ic lysine (Lys163) in domain 2 away from the active site core, whereas the two other active site lysi

209 unreported monodentate interaction with the active site Fe(2+) ion, while the benzonitrile group acc

210 auIII is not accessible to the corresponding active site for SOAT2 located on the luminal side.

211 7) were located in the TIM barrel around the active site in domain A, and two residues (I476 and V482

212 ith a second (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests that nucleot

213 n by either nutrient starvation or use of an active site inhibitor reduces Skp2 levels and stabilizes

214 the active site core, whereas the two other active site lysines from the two other domains are not a

215 we report a dominant mutation in the ATPase active site of human CLPX, p.Gly298Asp, that results in

216 e highly conserved -GH- residues in the CGHC active site of PDI, we created PDI variants with a slowe

217 ation of GSH and a base-off cobalamin in the active site of this enzyme.

218 This structure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoi

219 The lack of an appropriately positioned active site residue as a catalytic base leads us to prop

220 n this manuscript, we have focused on OleTJE active site residues Phe(79), His(85), and Arg(245) to i

221 A complex hydrogen bond network of four active site residues, which was installed in the late st

222 e concluded that BeauIII binds to a putative active site responsible for SOAT1 that is located on the

223 y, while these substitutions modulate PON1's active site shape, volume, and loop flexibility, their l

224 ational differences in loops adjacent to the active site that include the extended loop prior to the

225 sibility of the active site by expanding the active site volume, allowing additional water molecules

226 ring of the cofactor transiently enters the active site where it displaces the pterin ring of the TH

227 amidohydrolase superfamily revealed a novel active site with a bound unknown ligand.

228 Although located distant to the active site, the C2 domain greatly enhances catalytic tu

229 a3 and L3 regions, which flank the di-Zn(II) active site, were selectively (19) F-labeled using 3-bro

230 s of the protein scaffold that surrounds the active site, yet the exact nature of catalytically relev

231 that effectively disassemble the adenylation active site.

232 catalytic domain with a Zn(2+) bound at its active site.

233 lective of the transition state at the CARM1 active site.

234 ate binding site distinct from the sialidase active site.

235 ements of PEG and water molecules within the active site.

236 eta-sheet regions in domain B distant to the active site.

237 with respect to the substrate in the enzyme active site.

238 r mechanism of cyclization within the enzyme active site; however, there is evidence that conformatio

239 d in release (step 4) of cyt c from the HCCS active site; thus, we term these "release mutants."

240 n-bond-interactions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger con

241 at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocyt

242 We mutated distinguishing active-site residues to generate enzymes that had a comm

243 We also show that an active-site tryptophan, Trp-321, participates in off-pat

244 sphatase (DFPase) have essentially identical active sites and tertiary structures.

245 contain a shared core protein fold but whose active sites are located in entirely different regions,

246 embrane interaction, toward which the kinase active sites are oriented.

247 ons in the hetero-tetramer interface and the active sites can abolish Pseudomonas aeruginosa growth i

248 The redesign of enzyme active sites to alter their function or specificity is a

249 To identify active sites, we first predict the CO binding at a large

250 onstraints in pockets of enzymes stabilizing active sites.

251 Complete active space self-consistent field (CASSCF) and multiref

252 trodes with kinetic selectivity toward redox active species and help guide synthetic approaches for t

253 This new material is related to the active species of industrial supported MoO3/SiO2 olefin

254 characterized by a periodic inversion of the active spin during the real-time acquisition.

255 ined mixture of rigid microtubules (MTs) and active springs that have arms that cross-link neighborin

256 g network linked to tight spatial control of active Src and FAK levels, and so crucially regulates th

257 ated form) were identical and similar to the active state of receiver domains of bacterial response r

258 adopts an open, a closed, or a catalytically active state.

259 transition of NF-kappaB from its inactive to active state.

260 parison of this structure with inactive- and active-state structures of the beta2AR reveals the mecha

261 meability of the films and electrochemically active surface area of electrodes becoming accessible to

262 n in a previously CRE-free region, including active surveillance for CRE carriers and enhanced isolat

263 infection, detected through population-based active surveillance for influenza in Bangladesh, to asse

264 The most common serious adverse event in the active surveillance group was myocardial infarction (thr

265 Compared with active surveillance, mean sexual dysfunction scores wors

266 Utilization of active surveillance.

267 ted photodynamic therapy and 207 patients to active surveillance.

268 fixed power of 150 mW/cm for 22 min 15 s) or active surveillance.

269 otein TPX2 shifts the equilibrium towards an active T-loop conformation whereas addition of the inhib

270 enzyme, providing a first glimpse of what an active TAM receptor kinase may look like and suggesting

271 IV-infected or uninfected and with latent or active TB (aTB), were screened using M.tuberculosis-spec

272 ceptible individuals that had recovered from active TB.

273 ith recent STEMI exhibited increased LV wall active tension when normalized by SBP.

274 ative or semi-quantitative analysis of aroma-active terpenes in liquid food matrices.

275 onism (AGN 197727), AGN 197727 was much less active than AGN 211377, but pronounced anti-inflammatory

276 the newly formed ring are considerably more active than their axial diastereomers, lending strong su

277 be caught by alkylation of the isomerization active thiol.

278 attaining the identities of the biologically active titanium species and how these interact with the

279 Results highlighted that KuQs are highly active toward the analyzed cell lines and almost nontoxi

280 ysis following nuclear RNA-seq of neutrophil active transcriptomes reveals a significant upregulation

281 ines than CFC tissue, but surprisingly, more active transforming growth factor beta.

282 lysis revealed that MOFs are internalized by active transport and that inhibiting the caveolae-mediat

283 ting diffusion, binding/unbinding rates, and active transport velocities using FRAP data that capture

284 ome the paradigm for this class of secondary active transporters.

285 w-risk prostate cancer who require or choose active treatment, low-dose rate brachytherapy (LDR) alon

286 ic bidirectional transcription signatures at active TSSs in GRO/PRO-seq data, and provides accurate T

287 eople at the highest risk for progressing to active tuberculosis (TB) and have various sensitivities

288 y 336) and determined risk of progression to active tuberculosis disease over the subsequent 6-24 mon

289 There is no biomarker for diagnosing active tuberculosis in patients with human immunodeficie

290 anoelectromechanical platform to demonstrate active tuning.

291 Redox-active tyrosines (Ys) play essential roles in enzymes in

292 and comparable to the activity of the single active units.

293 t risk factor of atherosclerosis, due to its active uptake by monocytes/macrophages.

294 ane synthesis was also observed as a sign of active viral replication.

295 s could similarly remove those cells through active virus replication and resulting cytopathicity.

296 During the active volcanic eruption periods (1901-1935 and 1963-199

297 moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera.

298 ivation and might also allow CPK28 to remain active when Ca(2+) levels are low.

299 malignancy, most tumors display hallmarks of active Wnt signaling but lack activating Wnt-pathway mut

300 yaws was taken to be non-inferior to that of active yaws if the lower limit of the two-sided 95% CI f