ライフサイエンスコーパス: active form

1 we suggest might be related to its membrane-active form.

2 uantities and in a biologically relevant and active form.

3 d mature into a nitric oxide (NO)-responsive active form.

4 n population of inactive conformation to the active form.

5 regulating the quantities of the drug in its active form.

6 ransforms the proenzyme into a catalytically active form.

7 e from ABI5, thereby maintaining ABI5 in its active form.

8 uring maturation of sGC to its NO-responsive active form.

9 ng assay and of the crystal structure in its active form.

10 onformational change as it compacts into its active form.

11 TP in the catalytically inactive than in the active form.

12 -dependent cleavage of pro-IL-1beta into the active form.

13 osome-localized GPCRs are even present in an active form.

14 not the monomeric state, is the functionally active form.

15 irmed by Ptx, to shift integrin-beta1 to its active form.

16 nverts a monomeric PAK1 into a catalytically active form.

17 ibit kinase function by interacting with the active form.

18 esting it has difficulty in switching to the active form.

19 ed fatty acids (PUFAs) into their long-chain active form.

20 folate pathway that hinder conversion to its active form.

21 ed', non-transcribed rDNA chromatin into its active form.

22 ergoes proteolytic activation to generate an active form.

23 e to the switch from the inactive to a fully active form.

24 ynthetic Abeta into a potent in vivo seeding-active form.

25 fficient reserves of their transcriptionally-active forms.

26 e subsequently converted to the biologically active forms.

27 erence or viral transduction of constitutive active forms.

28 -1beta and pro-IL-18 into their biologically active forms.

29 TI triphosphates (NRTI-TP), the biologically active forms, act as chain terminators of viral DNA synt

30 -(thio)triphosphate (GTPgammaS)-loaded ARF6 (active form) added to permeabilized sperm induces acroso

31 We examined processing of the nuclear active form and identified a motif around S87-S90 with h

32 f bivalent histone modifications toward more active forms and induced KSHV reactivation in naturally

33 transcribe different gene subsets, and whose active forms are contained in supramolecular complexes k

34 of [4]:[Cu(2)(+)] at (s)(s)pH 7.9, where the active forms are Cu(II):4:((-)OCH(3)).

35 Here we report that the active forms are the trivalent arsenic-containing specie

36 h accumulation into the lower molecular mass active form as characterized by FPLC.

37 n changes when the enzyme transitions to the active form, as induced either by its cofactor tissue fa

38 patible electrodes could hold bacteria in an active form at the anode allowing chemical oxidation of

39 as well by converting gemcitabine to a less active form, both leading to its increased intracellular

40 usly expressed VcrA was reconstituted to its active form by addition of hydroxocobalamin/adenosylcoba

41 Da pro-IL-1beta is processed into the 17-kDa active form by caspase-1-activating inflammasomes.

42 inactive IL-1beta precursor is processed to active form by inflammasomes, multi-protein complexes ac

43 RNAs and undergo conversion to catalytically active forms, by the same polymerization chemistry used

44 Accordingly, molecular imaging of the MMP-12 active form can inform of the pathogenic process in aneu

45 signaling pathway, by expression of the XBP1-active form, compromised GCB DLBCL tumor growth in a mou

46 f the protein bound to DNA suggests that the active form could be either a dimer or tetramer.

47 o convert the AhR into its transcriptionally active form, deciphering the AhR:ARNT dimerization mode

48 tion that prevents conversion of EDN3 to its active form (Edn3(ls)).

49 isomerization to a structure similar to its active form, exposing a large hydrophobic surface that f

50 in (Ptx) was used to decrease integrin-beta1 active form expression.

51 hain zymogen and a two-chain proteolytically active form, generated by matriptase-dependent activatio

52 t concentration of DE-117 and its hydrolyzed active form (hDE-117) was maintained in the aqueous humo

53 wall and, if required, conversion to another active form; (ii) multiple drugs within a treatment comb

54 ates and the conditioned media in a dimeric, active form in both compartments.

55 t in the cytoplasm with stabilization of the active form in the nucleus.

56 cally facilitate ZEITLUPE maturation into an active form in vitro and in planta.

57 werful tool for monitoring the levels of MMP active forms in various diseases.

58 rsion of latent TGF-beta to its biologically active form is a major regulatory node controlling its a

59 The proposed transition into the active form is based on a concerted structural rearrange

60 ve conformations, and conversion to the open active form is promoted by binding to PAT-4 (ILK).

61 owth promoter for poultry and swine, and its active form is the trivalent species Rox(III).

62 mine, often mutated to create constitutively active forms, is involved in GEF mediated GDP-release.

63 from these virus particles in enzymatically active form; it is still not clear why it fails to induc

64 the kinase is generated in a constitutively active form, its expression levels are restricted by a v

65 Mcc(ia)), and a soluble, protease-sensitive, active form (Mcc(a)).

66 on complex can be assembled with a minimally active form of 2C that then becomes fully activated by p

67 The front accumulates high levels of the active form of a polarity-determining Rho-family GTPase

68 Overexpression of a myristoylated and active form of A. stephensi and Ae. aegypti Akt in the f

69 mical and cellular levels, by binding to the active form of ABL1(T315I) in a mutation-selective bindi

70 We now report prevalence of an active form of ADAM10 in tumors compared with normal tis

71 -overloaded cells harboring a constitutively active form of Akt showed decreased oxidants levels.

72 Expression of a constitutively active form of AKT1 restored proliferation to tumor cell

73 vered a transposon encoding a constitutively active form of Akt2 (myrAkt2).

74 rs, or forced expression of a constitutively active form of AMPK, results in polarization to an anti-

75 erated transgenic mice expressing a dominant active form of ARL3 (ARL3-Q71L) under a rod-specific pro

76 PK activators, metformin and salicylate (the active form of aspirin).

77 his effect is rescued by an shATF4-resistant active form of ATF4, but not by a mutant that lacks tran

78 kinase M-zeta (PKM-zeta) is a constitutively active form of atypical protein kinase C that is exclusi

79 Also, the crystal structure of the trans-active form of AVCP has been determined to 1.81-A resolu

80 n of acetylated p53 and the conformationally active form of Bax were found to be significantly higher

81 The result of this complementation-an active form of beta-gal-was detected colorimetrically, a

82 ilage, forced expression of a constitutively active form of BMP receptor-Ia (caBmprIa) in CNC lineage

83 type-specific expression of a constitutively active form of BZR1 confirms that the high and low level

84 However, the active form of CAPS bound to PC12 cell membranes or to l

85 alleviated by expression of a constitutively active form of CelR, suggesting that DivK acts upstream

86 rescued by co-expression of a constitutively active form of cofilin, demonstrating that Rnd3-mediated

87 (Cul3KO) cells resulted in a decrease in the active form of Cul3WT.

88 enzyme kinetic analyses in solution that the active form of DAPDC from Bacillus anthracis, Escherichi

89 al packing forces, we propose that the fully active form of E6AP is a trimer, analysis of which revea

90 cient Emu-Myc B cells had high levels of the active form of FOXO1 and elevated RAG1 and RAG2.

91 Fyn kinase mimics, whereas a constitutively active form of Fyn kinase rescues, the effects of NCAM k

92 nerated mice that expressed a constitutively active form of Gli2 in the Osx-lineage cells.

93 Transplant glomerulitis is an active form of glomerular injury associated with subopti

94 There remains considerable debate over the active form of gold under operating conditions of a rece

95 ssion in the IGF-I-ir neurons belongs to the active form of GSK3beta known to exert neuroinflammatory

96 factors via transgenic overexpression of the active form of HB-EGF.

97 mbinant adenovirus encoding a constitutively active form of HIF-1alpha into mouse hind limb muscle wa

98 Further, expression of a constitutive active form of hStim1 plus Orai1, which increases basal

99 Here, we report the structure of the active form of human ORC determined by X-ray crystallogr

100 rt the crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated

101 expressed a degradation-resistant, dominant-active form of IDOL (super IDOL [sIDOL]) in C57Bl/6J mic

102 onic liver-specific expression of a dominant-active form of IDOL in mice.

103 ines expressing an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key k

104 a, leading to expression of a constitutively active form of IKKbeta (IKKbetaca) in epithelial cells b

105 The secreted active form of IL-16 has been detected at sites of TH1-m

106 oB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, an

107 ally, N(pro) interacts with a constitutively active form of IRF3 bound to its transcriptional cofacto

108 IRF3, since N(pro) binds to a constitutively active form of IRF3 in the presence of its transcription

109 mediated through increased expression of the active form of its ligand, GAS6, that also served to sta

110 rasG12D mice, which express a constitutively active form of KRAS after Cre recombination.

111 2D)Tg/+ (Mist1-Kras) mice, which express the active form of Kras in chief cells on tamoxifen exposure

112 Expression of the constitutive active form of KRAS in this system led to activation of

113 or lipoamide, we identified the biologically active form of LA, R-LA, to be the physiological substra

114 im-3 interacts with Lck, but not the phospho-active form of Lck.

115 re we show that Tfh cells expressed a highly active form of leukocyte function-associated antigen-1 (

116 n cancer in mice that express a constitutive active form of LXRalpha only in the intestinal epitheliu

117 Our data suggest that the active form of MAP kinase interacts with gamma-tubulin o

118 It was the active form of MAP kinase that was enriched with microtu

119 Labeling of the active form of matriptase in vivo was measured in human

120 A constitutively active form of mDia2 rescues the defect in new CENP-A lo

121 at the MIF homotrimers were the functionally active form of MIF.

122 was suggested that these copolymers are the active form of MinC/MinD.

123 In conclusion, the active form of MMP-12 can be detected by optical imaging

124 This new probe can detect the active form of MMP-12 down to a threshold of 1 fmol.

125 ive counting showed the concentration of the active form of MMP-12 to be around 1 fmol/mul in BALf fr

126 ive MMP-12 inhibitor, RXP470.1 to target the active form of MMP-12.

127 resent study, we further identified that the active form of mTor per se accumulates in tangle-bearing

128 ivity of alpha-tocopherol, the main and most active form of natural vitamin E. alpha-Tocopherol-assoc

129 tion of Brd4 in maintaining the persistently active form of NF-kappaB found in tumors, and they sugge

130 n and ectopic expression of a constitutively active form of NFkappaB-p65 (S536E-NFkappaB-p65) signifi

131 Misexpression of the constitutively active form of Notch, a suppressor of neural induction,

132 rform limited proteolysis that generates the active form of Nrf1.

133 d to a decrease in circulating levels of the active form of osteocalcin, thereby decreasing insulin s

134 Co-electroporation with a constitutively active form of PI3K rescued migration.

135 The expression of this dominantly active form of PI3K results in hyperplasia and invasive

136 Here, we overexpressed an active form of PKMzeta in rat hippocampus, a structure h

137 Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the

138 Overexpression of an active form of Rab5 in strip-mutant neurons suppresses t

139 Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosph

140 Expression of a constitutively active form of RAC1 (RACV12) in mice resulted in the dev

141 Whereas a constitutively active form of Rac1, a molecule implicated in cell motil

142 ntrol the localization of the constitutively active form of RacE require its effector domain, but not

143 The active form of RAD51 is a nucleoprotein filament that as

144 tein SYX-5 colocalizes with a constitutively active form of RAL-1 at the plasma membrane, and MVBs ac

145 The transition from the autoinhibited to the active form of RasGRP1 involves the rearrangement of an

146 emains elevated in proplatelets, whereas the active form of RhoA is substantially downregulated in pr

147 ssion of wild type (WT) and a constitutively active form of RNase L (NDelta385), but not a catalytica

148 se studies set the stage for identifying the active form of S. sanguinis class Ib RNR in an animal mo

149 nsils from control individuals displayed the active form of signal transducer and activator of transc

150 nsgenic mice overexpressing a constitutively active form of Smad1 under K14 promoter) mice exhibited

151 hip to T-cell antigen receptor (TCR) and the active form of Src kinase p56lck (Lck) using single and

152 A constitutively active form of SRF/Mkl1 was not sufficient to induce foc

153 hat the risk allele increased binding to the active form of STAT1.

154 nsgenic mice that expressed a constitutively active form of STAT3 in the corneal epithelium had abnor

155 Furthermore, expression of a constitutively active form of STAT3 leads to marked increases in HCV re

156 ption 3 inhibitor NSC74859; a constitutively active form of STAT3 was expressed in colon and lung can

157 cellular transformation by a constitutively active form of STAT3, whereas tumor-derived mutants L71P

158 we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) with mice in which a mu

159 The structure of the mature, active form of TbCatB has so far not provided sufficient

160 ulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo

161 ells lacking YaeL accumulate a truncated yet active form of TcpP termed TcpP*.

162 on of TDP-43 homodimers, the physiologically active form of TDP-43, may be a promising therapeutic st

163 While transport of the active form of TH (T3) across the blood-brain barrier is

164 T8 was necessary for polarized influx of the active form of TH across the BBB.

165 re viable and express a stable but minimally active form of the AADC protein.

166 ) oxidized [Rua (III) Rub (IV) O](5+) as the active form of the assembly.

167 lly, we describe a method to purify a highly active form of the Bam complex that should facilitate th

168 nhanced in lines expressing a constitutively active form of the BR signaling component BZR1, further

169 Third, DFT calculations revealed that the active form of the catalyst has two active exo anionic l

170 alyst precludes the dinuclear species as the active form of the catalyst.

171 one of these proteins was identified as the active form of the catalytic domain of MMP-12.

172 We propose that the most active form of the cytokinetic RhoGEF involves complex f

173 for pregnant women might better reflect the active form of the drug, although these are technically

174 -opts the guanosine triphosphate (GTP)-bound active form of the endosomal Rab5 small GTPase via direc

175 The active form of the enzyme on the Holliday junction conta

176 t TGF-beta1 that leads to the release of the active form of the growth factor from the extracellular

177 etermine whether expressing a constitutively active form of the GTPase Rheb (caRheb) in adult neurons

178 P(c) from human astrocytes by increasing the active form of the metalloprotease ADAM10.

179 latory regions of the B-domain to produce an active form of the molecule.

180 and show that introducing the constitutively active form of the mTORC1 regulator, Rheb, into HD mouse

181 of its instability: the concentration of the active form of the mutant is 3-fold lower than WT.

182 report the atomic-resolution structure of an active form of the OCP consisting of the N-terminal doma

183 mly associated with a mutant, constitutively active form of the oncogene Kras.

184 enhanced expression of the transcriptionally active form of the p65 (acetylated on lysine 310) subuni

185 e Mediator-induced repression to generate an active form of the PIC.

186 dy termed U33 that selectively inhibited the active form of the protease urokinase plasminogen activa

187 e free ferrous deoxy-NGB, which is the redox active form of the protein in contrast to oxy-NGB.

188 ay be truncated to generate a constitutively active form of the receptor called EGFRvIII.

189 thereby shifting the equilibrium toward the active form of the receptor to trigger defense signaling

190 state, which is thought to correspond to the active form of the receptor, we have identified further

191 these proteins to GPCRs usually requires the active form of the receptors plus their phosphorylation

192 of phosphorylated OmpR, i.e. the presumably active form of the regulator.

193 oped a mouse model in which a constitutively active form of the serine/threonine kinase BRAF was expr

194 unoassay that cannot distinguish between the active form of the toxin, which poses a threat to life,

195 the monomer is the genuine, physiologically active form of the toxin.

196 inducing the expression of a constitutively active form of the upstream activator IkappaB kinase bet

197 lial-specific expression of a constitutively active form of the WNK1 substrate protein kinase OSR1 (o

198 We present evidence that the active form of these molecules is the initially released

199 phaS does not result from a particularly ROS-active form of these peptides, but rather from either a

200 Thiamin pyrophosphate (ThDP), the active form of thiamin (vitamin B1), is believed to be a

201 y that SAMHD1 tetramers are the biologically active form of this dNTPase and provide new insights int

202 t skin mast cells and fibroblasts secrete an active form of this enzyme.

203 valent of alpha-tocopherol known as the most active form of this lipophilic vitamin.

204 Px44-TRAIL formed a trimer, the biologically active form of TRAIL.

205 ed by bleomycin or an adenovirus encoding an active form of transforming growth factor (TGF)-beta.

206 Levels of the cleaved active form of TSLP were increased in nasal polyps from

207 The active form of U7 snRNP contains the HLB component FLASH

208 A soluble, active form of UGM from Mycobacterium tuberculosis (MtUG

209 Generally, the active form of vanadium remains elusive, although studie

210 produce significant quantities of a soluble active form of VEGF-A(165)-HBD will enable further studi

211 oxidized to retinoic acid, the biologically active form of vitamin A that acts as a transcription fa

212 yridoxal 5'-phosphate (PLP; the biologically active form of vitamin B-6), and vitamin B-12 and breast

213 f inflammasomes and the observation that the active form of vitamin B6 (pyridoxal phosphate, P5P) mod

214 s of pyridoxal 5'-phosphate (PLP), the major active form of vitamin B6 .

215 ependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse c

216 in production of pyridoxal 5'-phosphate (the active form of Vitamin B6), which we validate experiment

217 Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in hu

218 The active form of vitamin D (calcitriol) restored the SLE M

219 The active form of vitamin D [1,25(OH)2D] regulates B cells

220 vitamin D3 [1,25(OH)2D3] is the biologically active form of vitamin D and is immunoregulatory.

221 1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(

222 In contrast, the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25

223 The ability of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25

224 In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calc

225 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25

226 s response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3

227 CYP24A1, which initiates degradation of the active form of vitamin D, ameliorates skeletal abnormali

228 nappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities.

229 of vitamin D emerges, 1alpha,25(OH)2D3, the active form of vitamin D, has been applied in anti-cance

230 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has been documented in vitro.

231 ihydroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promisi

232 Vitamin D3, the active form of vitamin D, may counteract intracellular c

233 ied outcomes and 1,25-dihydoxyvitamin D, the active form of vitamin D, the study was underpowered to

234 ing the antitumor effects of calcitriol, the active form of vitamin D.

235 High doses of the active form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,2

236 Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differen

237 xyvitamin D3 [1,25(OH)2D3], the biologically active form of vitamin D3, is a pleiotropic hormone that

238 demonstrate that calcitriol, the hormonally active form of vitamin D3, is an excellent candidate for

239 The active form of VWF bound to vimentin, and the purified A

240 ing this finding, gene therapy to deliver an active form of XBP1 provided neuroprotection and reduced

241 sues from mice that express a constitutively active form of YAP (YAP(S127A)) and analyzed gene expres

242 rsely, forced expression of a constitutively active form of Yap in the adult heart stimulates cardiac

243 nic mice that overexpressed a constitutively active form of YAP in the dental epithelium.

244 ymogen proteolytically processes itself into active forms of 48, 37, and 33 kDa via sequential trunca

245 Moreover, expression of constitutively active forms of Akt1 and Akt2 restores the anchorage-ind

246 Here we investigated the active forms of ATP and found that the action of MgATP(2

247 This latter phenotype is rescued by active forms of beta-catenin at central and caudal but n

248 tation bzr1-1D, which causes accumulation of active forms of BZR1 [12].

249 the vacA m1 allele or with more biologically active forms of cagA with longer 3' variable regions.

250 Both full-length and constitutively active forms of CREB3L1 (CREB3L1CA) induce the expressio

251 s associated with membranes of metabolically active forms of Ct throughout development.

252 t electron transfer to produce the substrate-active forms of each.

253 CB2 stimulation in monocytes down-regulated active forms of integrins, lymphocyte function-associate

254 than mutants null for VacA or producing more active forms of it, providing the first evidence of a po

255 Cre (KPC) mice (which express constitutively active forms of KRAS), and C57/B6 mice.

256 We previously identified two active forms of matrix metalloproteinases (MMPs), MMP-8

257 Overexpression of active forms of MYRF is sufficient to accelerate synapti

258 Furthermore, constitutively active forms of RAC1, CDC42 and RHOA activated the NOD1

259 alters the balance between the inactive and active forms of RasGRP1.

260 In addition, active forms of RNA polymerase-II also colocalized in th

261 n perform a variety of different passive and active forms of synaptic integration on their inputs.

262 evels of PLP and PM phosphate (PMP), the two active forms of the AGT coenzyme, are found.

263 s subsequently converted to the biologically active forms of the cofactor.

264 The ligands preferentially engage the active forms of the integrins and trigger signaling casc

265 n phosphorylated/inactive and phosphorylated/active forms of the kinase.

266 sensory signaling and inflammation, yet the active forms of the nucleotide are unknown.

267 alyst furnish the product and regenerate the active forms of the photocatalyst and base.

268 n by limiting accumulation of phosphorylated active forms of the stress kinase JNK.

269 elicobacter pylori virulence gene, cagA, and active forms of the vacuolating cytotoxin gene, vacA, ar

270 hydroxyvitamin D3 (1,25D3), the biologically active forms of vitamin A and vitamin D, respectively, i

271 FKBP65 PPIase activity reduced the dimeric (active) form of LH2 but did not affect the binding of mo

272 icant decrease of the phosphorylated, likely active, forms of FoxM1.

273 metabolizing enzymes, was immobilized in its active form on graphene oxide (GO) for enhanced electroc

274 of ascorbate, were quickly reduced to their active form, oxaliplatin, when co-incubated with a macro

275 to the ectodomain-deleted and constitutively active form p95HER2.

276 e the transformation of plasminogen into its active form (plasmin), which degrades fibrin and extrace

277 uPA cleaves the zymogen plasminogen into the active form (plasmin), which then degrades the fibrin cl

278 tfB readily binds to C. albicans cells in an active form, producing glucans locally that provide enha

279 G-protein-coupled receptor, switches to its active form (R( *)) in response to absorbing a single ph

280 By controlling the reaction conditions, the active form responsible for 4-aminophenol (4-AP) oxidase

281 unproven biochemically and the biologically active form(s) of Rb remains unknown.

282 Knowledge of tenofovir concentration and its active form, tenofovir diphosphate, at the putative vagi

283 mers, or trimers have been reported, but the active form that binds and activates the MIF receptor (C

284 nds RNA with high affinity in a functionally active form that is capable of immediately unwinding RNA

285 Mss51 was enriched in a translationally active form that maintains full Cox1 synthesis even if C

286 ison of the structure of AVP with that of an active form, the AVP-pVIc complex, reveals why AVP is in

287 ex that remains more abundant is usually the active form, the miRNA, while steady-state levels of the

288 thylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs lig

289 in free Ca2+, resulting in a constitutively active form under physiological Ca2+-concentration, show

290 r to be involved in the stabilization of the active form upon phosphorylation and is not essential in

291 ve prodrugs are typically converted to their active forms using short-wavelength irradiation, which d

292 en the allosterically inhibited form and the active form, we predict a discrete sequence of domain mo

293 onversion of the inactive form of Rho to the active form, we show mathematically that this active reg

294 these transcriptionally inactive AR-Vs into active forms, we identified the two separate elements th

295 by directed evolution, reconstitute into an active form when driven together by an intercellular PPI

296 apable of activating known prodrugs to their active form, which suggests a possible treatment route f

297 ent to convert the inactive holoenzyme to an active form, while hydrolysis per se is required for nuc

298 Structural comparisons of the active form with the crystal structures of available sub

299 idate the conformation of the peptide in its active form within silica sheets by interface-specific v

300 ive unspliced form [XBP1(U)] and the spliced active form [XBP1(S)], is a key UPR component mediating