ライフサイエンスコーパス: active metabolite

1 as the site of covalent modification by the active metabolite.

2 enhance the conversion of clopidogrel to its active metabolite.

3 ation of flutamide and hydroxyflutamide, its active metabolite.

4 azen-1-yl)imidazole-4-carboximide] MTIC, its active metabolite.

5 ndex, and PK by plasma levels of prasugrel's active metabolite.

6 cleavage for the release of the biologically active metabolite.

7 d in biotransformation of clopidogrel to its active metabolite.

8 ene (CYP2D6), oxidizes tamoxifen to its most active metabolites.

9 te a response to endogenously produced redox-active metabolites.

10 thotrexate, and pemetrexed to produce highly active metabolites.

11 production of toxins and other biologically active metabolites.

12 alysis to determine the presence of possible active metabolites.

13 ct possible parent compounds that might have active metabolites.

14 ting that this could be attributed to highly active metabolites.

15 er to deplete bioactive retinoids or to form active metabolites.

16 oxide metabolites produced by FMOs are often active metabolites.

17 amount of drug available for conversion into active metabolites.

18 Higher levels of the active metabolite 1 alpha,25-dihydroxyvitamin D (1 alpha

19 25(OH)D(3) and its active metabolite 1,25(OH)(2)D(3), both enhance corneal

20 vity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3.

21 on of 25-hydroxyvitamin D(3) (25D(3)) to its active metabolite 1,25D(3).

22 TP is first converted to a pharmacologically active metabolite 1-methyl-4-phenylpyridinum (MPP+).

23 Midazolam has a clinically active metabolite, 1-hydroxymidazolam.

24 hages are abundant sources of PGD(2) and its active metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15-d-PGJ

25 -hydroxyestrone (2OHE1), to the biologically active metabolite, 16alpha-hydroxyestrone (16alphaOHE1),

26 2) and 4.15 hours, respectively; whereas the active metabolite 17-aminogeldanamycin had a t(1/2) of 7

27 -hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1alpha,25-dihydroxyvitamin D(3) (1,25

28 aptohept-4-enoic acid moiety to generate the active metabolite 2, which is an extraordinarily potent

29 thus establishing the stereochemistry of the active metabolite 2.

30 larval molting and metamorphosis through its active metabolite 20-hydroxyecdysone (20E).

31 Systemically administered EDHB and its active metabolite 3,4-dihydroxybenzoic acid accumulated

32 Systemically administered EDHB and its active metabolite 3,4-dihydroxybenzoic acid accumulated

33 Hepatic self-induction of the active metabolite 4-hydroxycyclophosphamide occurs after

34 Low concentrations of tamoxifen or its active metabolite 4-hydroxytamoxifen (OHT) induce estrog

35 In addition, we show that the active metabolite 4-OH-tamoxifen can be used to pharmaco

36 ioconverting cyclophosphamide (CPA) into the active metabolites 4-hydroxyCPA/aldophosphamide (AP).

37 tumor retention of cyclophosphamide and its active metabolite, 4-hydroxycyclophosphamide.

38 We show that TAM and its active metabolite, 4-hydroxytamoxifen (OHT), can activel

39 Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxi

40 tate (NNN-5'-OAc), a stable precursor of the active metabolite 5'-hydroxy(+/-)-N'-nitrosonornicotine

41 Folic acid and its active metabolite, 5-methyltetrahydrofolate, increase en

42 inhibition in yields of the physiologically active metabolite 5alpha-dihydrotestosterone (DHT) in HG

43 nts, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) ca

44 drolysis of the glucuronide conjugate of the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)

45 This prodrug and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-3

46 omide was dosed to a targeted blood level of active metabolite, A77 1726, of 50 microg/ml to 100 micr

47 drug class would enhance liver levels of the active metabolite adefovir diphosphate (ADV-DP) and/or d

48 High peak concentrations of active metabolites after IV EMP may provide an advantage

49 inol and retinal dehydrogenases produces the active metabolite all-trans-retinoic acid.

50 t convert vitamin A to its main biologically active metabolite, all-trans RA.

51 vitamin A to enzymes for metabolism into an active metabolite, all-trans retinoic acid (atRA), where

52 Vitamin A and its active metabolite, all-trans retinoic acid (RA), regulat

53 ur results showed that the production of the active metabolite (AM) from 2-oxoclopidogrel by human li

54 formation of a glutathionyl conjugate of the active metabolite (AM) of clopidogrel and the covalent m

55 cement of an anti-METH scFv for METH and its active metabolite amphetamine (AMP), through the introdu

56 ed biotransformation of clopidogrel into its active metabolite and decreased efficacy of clopidogrel

57 Generation of clopidogrel active metabolite and inhibition of platelet function we

58 n by comparison of its induction between the active metabolite and its parent compound (B[a]PDE versu

59 nverted in rat or mouse plasma solely to two active metabolites and had significantly enhanced oral b

60 lleles showed excessive levels of thiopurine active metabolites and toxicity.

61 oxifen, 4-OH tamoxifen (a major biologically active metabolite), and 17beta-estradiol in native myocy

62 CYP)1A2, which converts clopidogrel into its active metabolite, and prior studies suggest greater inh

63 tion, decreases plasma levels of clopidogrel active metabolite, and retards and diminishes its effect

64 s with long-term adjuvant therapy, examining active metabolites, and considering chemoprevention all

65 ities recently entering the marketplace have active metabolites, and many more are (or have been) in

66 Plasma levels of ticagrelor and its active metabolite AR-C124910XX were determined.

67 zymes responsible for the formation of these active metabolites are unknown.

68 hine lowers the plasma levels of clopidogrel active metabolite as well as its effects on platelets.

69 s were drawn for thrombelastograpy (TEG) and active metabolite assay.

70 uted uracil analogue is converted to several active metabolites but the mechanism of cytotoxicity has

71 duced the area under the curve levels of its active metabolite by 34% (p = 0.001).

72 Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for

73 te that PPD is selectively hydrolyzed to the active metabolite by hiCE.

74 n attenuate metabolism of clopidogrel to its active metabolite by inhibiting various hepatic CYP450 e

75 l and prasugrel require biotransformation to active metabolites by cytochrome P450 (CYP) enzymes.

76 eudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin bio

77 tions as low as 2.6 muM) four distinct redox-active metabolites called phenazines.

78 lts show that modulating extracellular redox-active metabolites can influence the fitness of a biofil

79 Ceftaroline fosamil, the prodrug form of the active metabolite ceftaroline, is a new broad-spectrum p

80 The active metabolite, ceftaroline, demonstrates in vitro ac

81 sayed for concentrations of imatinib and its active metabolite, CGP74588.

82 At steady-state, clopidogrel active metabolite (clopidogrel(AM)) pharmacokinetics var

83 genesis in in vitro studies and implies that active metabolites contribute to its in vivo pharmacolog

84 ous to the relationship of proguanil and its active metabolite cycloguanil.

85 has a longer half-life and exposure than its active metabolite decitabine.

86 The area under the curve for clopidogrel active metabolite decreased significantly with esomepraz

87 ucoma drugs tested only metipranolol and its active metabolite, desacetylmetipranolol, blunted the SN

88 mplex interactions between testosterone, its active metabolite DHT, and androgen receptors.

89 9 alleles have significantly lower levels of active metabolite, diminished platelet inhibition, and h

90 inistration resulted in the formation of the active metabolite, diminution of tumor vasculature, and

91 technique that can detect hundreds of redox-active metabolites down to the level of femtograms on co

92 supplementation on the formation of flavour active metabolites during wine fermentation, we evaluate

93 n situ monitoring of the production of redox-active metabolites (e.g., pyocyanin) during the course o

94 urs, and peak plasma concentrations of these active metabolites exceeded 10 micromol/L after IV EMP d

95 umor activity of ICT2588 was superior to its active metabolite, exhibiting reduced toxicity, improved

96 PARADOX demonstrated lower clopidogrel active metabolite exposure and PD effects of clopidogrel

97 Prasugrel was associated with greater active metabolite exposure and PD effects than clopidogr

98 mary endpoint) and mean MPA was similar, but active metabolite exposure was lowered by 38%.

99 s have demonstrated that triphosphate is the active metabolite for both these purine nucleoside analo

100 analog inhibitors, including the clinically active metabolite formed by sofosbuvir, to elucidate key

101 mercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel

102 t even the spontaneous release of NPY (or an active metabolite) from recurrent mossy fibers is suffic

103 18 to be more efficiently converted into its active metabolite, gemcitabine triphosphate (dFdCTP), an

104 ducts proved useful in the identification of active metabolites generated by either in vitro or in vi

105 has been associated with reduced clopidogrel active metabolite generation and higher ex vivo platelet

106 f a PPI with clopidogrel reduces clopidogrel active metabolite generation and subsequent platelet inh

107 The concentrations of clopidogrel active metabolite had no significant difference (P = 0.2

108 h attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to s

109 Preferential hydrolysis of ICT2588 to its active metabolite (ICT2552) was observed in tumor homoge

110 ecent findings have identified lactate as an active metabolite in cell signalling, although its effec

111 ate are made available for the generation of active metabolites in platelets when the NEFA binding ca

112 earthworms possess a class of unique surface-active metabolites in their gut, which we term 'drilodef

113 ells transduced in situ, and accumulation of active metabolites in tumors).

114 The conversion of tamoxifen to active metabolites involves several cytochrome P450 (CYP

115 ion with dithiothreitol, confirming that the active metabolite is linked to a cysteinyl residue of CY

116 Deficiency in vitamin D and its active metabolites is a pathologic feature of chronic ki

117 oped to release the doxorubicin-formaldehyde active metabolite, is tethered via derivatized ethylene

118 elta(9)THC) is metabolized to only one major active metabolite, it has been reported that several maj

119 report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M.

120 (SC-51) is rapidly converted in vivo to the active metabolite L-N6-(1-iminoethyl)lysine (L-NIL).

121 ibed natural substance largazole (1) and its active metabolite largazole thiol (2) is described.

122 cleaved to produce detectable levels of the active metabolites Leu-Dox and Dox.

123 (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a

124 ent data have surfaced demonstrating altered active metabolite levels of clopidogrel in patients harb

125 The most active metabolite M2 had almost no toxicity to CCD-18Co

126 These active metabolites may prolong the parent compound's psy

127 All of these active metabolites may prolong the parent compound's psy

128 ment (thionamides such as carbimazole or its active metabolite methimazole are the drugs of choice).

129 TGN) are currently being considered as major active metabolites, methylthioinosine nucleotides seem t

130 ), which converts 25-hydroxyvitamin D to its active metabolite, might be up regulated in human colon

131 DMF and, more so, its active metabolite, monomethyl fumarate, are known agonis

132 neurons, and behavioral changes due to TLR4 active metabolite, morphine-3-glucuronide (M3G) exposure

133 Although morphine and its active metabolite, morphine-6beta-glucuronide (M6G), eac

134 The serum concentration of the active metabolite N-desethylamiodarone correlates with t

135 omilast and roflumilast; the latter (and its active metabolite N-oxide) is more selective and potent

136 ted but less is known about its biologically active metabolite, N-desmethylclozapine.

137 dies have reported that both nitrate and its active metabolite, nitrite, have therapeutic activity in

138 Since 8 is the likely active metabolite of 1 and a significant number of deriv

139 like cycloguanil, however, 1a (WR99210), the active metabolite of 1, has retained in vitro potency ag

140 The actions of the active metabolite of 1,25-(OH)2D3 (1,25-D) are mediated

141 The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydr

142 lves 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydr

143 used increased selectivity for dGTP over the active metabolite of abacavir (carbovir triphosphate).

144 stance to monodesethylamodiaquine (MDAQ; the active metabolite of AQ) than to CQ, whereas a pfcrt all

145 Benzo[a]pyrene diol epoxide (BPDE), the active metabolite of benzo[a]pyrene present in tobacco s

146 50 to benzo(a)pyrene-diol-epoxide (BPDE), an active metabolite of BP in human bronchial epithelial BE

147 Norbuprenorphine (NBUP) is the primary active metabolite of BUP.

148 Ticagrelor, dipyridamole and the active metabolite of clopidogrel (CAM), an alternative P

149 tein mass corresponds to the addition of the active metabolite of clopidogrel to CYP2B6.

150 reduction of 32.4% in plasma exposure to the active metabolite of clopidogrel, as compared with nonca

151 allele had significantly lower levels of the active metabolite of clopidogrel, diminished platelet in

152 Almost 30% of the variability in SN-38 (the active metabolite of CPT-11) AUC is explained by ABCC1 1

153 With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, t

154 man colon cancer cells Hct116 with SN-38 (an active metabolite of CPT-11) resulted in G2 cell cycle a

155 sensor, which emits light in response to the active metabolite of cytosine arabinoside (ara-C, cytara

156 l variability in blood concentrations of the active metabolite of dabigatran etexilate and influence

157 Retinoic acid, an active metabolite of dietary vitamin A, acts as a ligand

158 , we show that 20-hydroxyecdysone (20E), the active metabolite of ecdysone that is induced by environ

159 hosphorylase (PNP) that locally converts the active metabolite of F-araAMP to a highly diffusible sub

160 tions and in complex with norfluoxetine, the active metabolite of fluoxetine (Prozac) and a state-dep

161 ecently demonstrated that FTY-phosphate, the active metabolite of FTY720, acts as a full agonist for

162 We thus examined whether morphine, the active metabolite of heroin, has the ability to inhibit

163 Purpose Palifosfamide is the active metabolite of ifosfamide and does not require pro

164 ure to cytotoxic concentration of SN-38, the active metabolite of irinotecan (0.1 microM) alone and i

165 Their response to oxaliplatin, to SN38, the active metabolite of irinotecan (drugs active in colon c

166 a synergistic activity of 5c with SN-38 (the active metabolite of irinotecan) and 5-fluorouracil on c

167 platin, 5-fluorouracil (5-FU), or SN-38 (the active metabolite of irinotecan) induced Notch-1 intrace

168 asma concentration (Css) of total SN-38 (the active metabolite of irinotecan) was 6.42 +/- 1.10 nmol/

169 d 7-ethyl-10-hydroxycamptothecin (SN-38; the active metabolite of irinotecan), two S-phaseselective a

170 porter that confers resistance to SN-38 (the active metabolite of irinotecan), was readily detected i

171 e to, but reduces the toxicity of, SN38 (the active metabolite of irinotecan).

172 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan, in a number of differen

173 y 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan, in p53-null compared wi

174 how for the first time that SN38, the potent active metabolite of irinotecan, induces c-Jun NH(2)-ter

175 In this study, we chose SN-38, an active metabolite of irinotecan, to characterize DNA dou

176 p-2 for the selective delivery of SN-38, the active metabolite of irinotecan.

177 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan.

178 ates in vitro with sensitivity to SN-38, the active metabolite of irinotecan.

179 mproving the therapeutic index of SN-38, the active metabolite of irinotecan.

180 t that reduces the elimination of SN-38, the active metabolite of irinotecan.

181 o SN38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan.

182 We show that the active metabolite of leflunomide, a drug approved for tr

183 A77 1726 (LEF) is the active metabolite of leflunomide, a recently approved im

184 Brequinar and the active metabolite of leflunomide, A77 1726, have been cl

185 harmacologic concentrations of A77 1726, the active metabolite of leflunomide.

186 The active metabolite of mercaptopurine and thioguanine (TG)

187 s demonstrate that both ethosuximide and the active metabolite of methsuximide, alpha-methyl-alpha-ph

188 asculature than A-61603 (2), ST-1059 (3, the active metabolite of midodrine), and phenylpropanolamine

189 lpropanolamine (PPA) (1) and ST-1059 (2, the active metabolite of midodrine), supporting the hypothes

190 ncentrations of mycophenolic acid (MPA), the active metabolite of MMF, and outcomes in 85 patients wi

191 s of 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of MPTP.

192 Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, an effective

193 d the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropo

194 7,8,9,10-tetrahydro benzo[a]pyrene (BPDE, an active metabolite of PAHs) induced cytotoxicity, mutagen

195 the effects of ASA, acetaminophen (APAF, the active metabolite of phenacetin), caffeine, and other re

196 Prednisolone (the principal active metabolite of prednisone) metabolism was determin

197 TIZ and RM-4848, the active metabolite of RM-5038, were shown to stimulate in

198 4 inhibitor roflumilast N-oxide (RNO) is the active metabolite of roflumilast approved as a treatment

199 This compound is an active metabolite of tamoxifen, a selective estrogen rec

200 optimization, to improve the binding of the active metabolite of the anti-inflammatory drug leflunom

201 cy are comparable or superior to MRE269 (the active metabolite of the clinical compound NS-304) with

202 possible to demonstrate that vedelianin, an active metabolite of the family of prenylated stilbenes

203 Mizoribine monophosphate (MZP) is the active metabolite of the immunosuppressive agent mizorib

204 agents soman and sarin, and of paraoxon, the active metabolite of the insecticide parathion.

205 ound to gemcitabine diphosphate (GemdP), the active metabolite of the mechanism-based chemotherapeuti

206 1-Methyl-4-phenylpyridinium (MPP(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,

207 oxide homeostasis and suggest that it is an active metabolite of the organic nitrates that can be us

208 in-2-yl)phenyl)-3-(pyridin-4-yl)urea (2), an active metabolite of the potent PI3 kinase inhibitor PKI

209 Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is

210 Benzo(a)pyrene diol epoxide (BPDE), an active metabolite of the tobacco carcinogen benzo(a)pyre

211 1 (1 microM) prior to exposure to SN-38, the active metabolite of the topoisomerase I inhibitor, CPT-

212 roteins for all-trans-retinoic acid (RA), an active metabolite of vitamin A (retinol), and have been

213 Retinoic acid (RA) is the active metabolite of vitamin A and whether it directly r

214 a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differenti

215 herein that all-trans-retinoic acid (RA), an active metabolite of vitamin A that is known to induce m

216 Retinoic acid (RA), an essential active metabolite of vitamin A, controls numerous physio

217 All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcripti

218 tem (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from

219 Retinoic acid (RA), the main biologically active metabolite of vitamin A, is known to promote gut

220 effect of all-trans retinoic acid (ATRA), an active metabolite of vitamin A, on the neuropathology an

221 Retinoic acid (RA), an active metabolite of vitamin A, plays a critical role in

222 All-trans-retinoic acid (atRA), the major active metabolite of vitamin A, plays a role in many bio

223 Retinoic acid, an active metabolite of vitamin A, plays essential signalin

224 Here we report that ATRA, an active metabolite of vitamin A, restores mechanical quie

225 For example, the active metabolite of vitamin A, retinoic acid (RA), has

226 The active metabolite of vitamin A, retinoic acid (RA), is a

227 All-trans-retinoic acid (atRA) is the active metabolite of vitamin A.

228 All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. atRA is also used as a d

229 The active metabolite of vitamin D (1,25-dihydroxyvitamin D(

230 droxyvitamin D(3)(1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D(3), mediates anti-prolife

231 ihydroxyvitamin D(3) [1, 25(OH)(2)D(3)], the active metabolite of vitamin D(3), on angiogenesis by us

232 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(

233 study, we hypothesized that the biologically active metabolite of vitamin D, 1,25(OH)2D3, inhibits hu

234 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(

235 The active metabolite of vitamin D, 1alpha,25-dihydroxyvitam

236 Since the discovery of the active metabolite of vitamin D, i.e., 1alpha,25-dihydrox

237 rmone (VDH; 1,25-dihydroxyvitamin D(3)), the active metabolite of vitamin D, is the major Ca(2+)-regu

238 amin D3 (1alpha,25(OH)2D3), the biologically active metabolite of vitamin D3 To further investigate t

239 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, inhibits the proliferat

240 vivo without releasing toxic amounts of the active metabolites of 1 into circulation.

241 iously we demonstrated that the biologically active metabolites of 17beta-oestradiol, 2-hydroxyoestra

242 op1cc in biochemical assays, we propose that active metabolites of 4NQO trap Top1cc by forming DNA ad

243 We now report the synthesis of suspected active metabolites of BcF, specifically the trans-3,4-di

244 We speculate that the active metabolites of clopidogrel and CS-747 form disulf

245 A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM and endoxifen, is by

246 etramethyl tetralin (1,2-DATT), the putative active metabolites of the neurotoxic aromatic hydrocarbo

247 provide comparable systemic exposure to the active metabolites of the prior, stable tetrabenazine re

248 ing compounds for the synthesis of the other active metabolites of these PAHs thought to be involved

249 The capacity for quantification of active metabolites of vitamin D (VitD) is highly valuabl

250 ts produce an enormous array of biologically active metabolites, often with stereochemical variations

251 the peak plasma concentration of clopidogrel active metabolite (omeprazole > esomeprazole > lansopraz

252 Plasma concentrations of CI-1040 and its active metabolite, PD 0184264, increased in a less than

253 We examined PD and active metabolite pharmacokinetics (PKs) with prasugrel

254 ug PDM) and as a monoamine releaser (via the active metabolite PM).

255 logic profile and its ability to deliver two active metabolites, potentially simplifying HCV treatmen

256 cessed by dendritic cells and T cells to the active metabolite, providing a mechanism for the local r

257 the high functional versatility of the redox-active metabolite pyocyanin and the susceptibility of ar

258 (1) Plasma levels of R348's active metabolite R333 sustained high for 8 hr or more,

259 Blood levels of R348 and of its active metabolite R333 were measured.

260 R788, a prodrug of active metabolite R406, has been shown to be an inhibito

261 The V(max) for production of the active metabolites ranged from 10.8 to 27.7 pmol/min/mg

262 tration to mice and Wistar rats generated an active metabolite recovered from the rodent's brains.

263 sphamide and irinotecan (CPT-11), into their active metabolites, respectively.

264 ssential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for

265 is known about the role of vitamin A and its active metabolite, retinoic acid (RA) in host defenses a

266 retinol (vitamin A) to its transcriptionally active metabolite, retinoic acid (RA).

267 ral levels of the prodrug irinotecan and its active metabolite SN-38 compared with free irinotecan.

268 ed PEG conjugates of the irinotecan (CPT-11) active metabolite SN-38 via a phenyl ether that release

269 UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38.

270 endent on redox properties and generation of active metabolites such as quinone methides.

271 Its active metabolite, T-705-ribose-5'-triphosphate (T-705-R

272 ntrations of tenofovir, emtricitabine, their active metabolites (tenofovir diphosphate [TFVdp] and em

273 Leflunomide and its active metabolite teriflunomide inhibited protein aggreg

274 umatic fluorescent drug leflunomide into its active metabolite teriflunomide through isoxazole ring o

275 Because of a wide inter-patient range of active metabolite terminal half-life (>300%), monitoring

276 lized in rats, but MDC is the only centrally active metabolite that could contribute to overall effec

277 50 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y(1)(2) a

278 l molecules would benefit the study of redox-active metabolites that are produced by microbial biofil

279 h agents undergo intracellular processing to active metabolites that disrupt RNA and DNA metabolism.

280 Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platele

281 s that PAHs are transformed enzymatically to active metabolites that react with DNA to form adducts t

282 lism leads to the generation of biologically active metabolites that regulate cell growth and prolife

283 oA modulating the generation of biologically active metabolites that regulate mitochondrial bioenerge

284 d that vitamin A, retinol, functions through active metabolites: the visual chromophore 11-cis-retina

285 an inactive prodrug; it is converted to its active metabolite through the cytochrome P450 (CYP3A4) p

286 eportedly reduce clopidogrel's metabolism to active metabolite, thus attenuating its inhibition of pl

287 Concentration of the primary active metabolite, TLK236, increased proportionate to ez

288 TAF is formulated to deliver the active metabolite to target cells more efficiently than

289 is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than

290 vir impairs the conversion of 25(OH)D to the active metabolite, utilization of 25(OH)D may have been

291 Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two waste water tr

292 ationship suggested the presence of a common active metabolite which may preclude this series of comp

293 ch has been focused on the identification of active metabolites, which are crucial for selenium chemo

294 both the parent compound ranolazine and its active metabolites, which have shown potent blocking eff

295 ic, antagonistic; (iv) drugs converted to an active metabolite with a similar mode of action.

296 pedunculata studied is a potential source of active metabolites with a positive effect on human healt

297 resuscitation to promote renal excretion of active metabolite, withholding the doses and timely mana

298 ical models by enhancing accumulation of its active metabolite within the tumor microenvironment.

299 their abilities to convert amifostine to its active metabolite WR-1065, amifostine may not only prote

300 the absence or presence of amifostine or its active metabolite WR-1065.