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1 , Lys-565 and Lys-663, coordinate ATP in the active site.
2 ansition-metal ion (Fe(2+) or Ni(2+)) in the active site.
3 ion with two aspartate carboxy groups at the active site.
4 and perturbing/inactivating the phosphatase active site.
5 substrates and products enter and leave the active site.
6 arge motions by four loops that surround the active site.
7 the distal end of the motor domain with the active site.
8 s the channeling of two nickel ions into the active site.
9 residues of the precursor peptide within the active site.
10 that effectively disassemble the adenylation active site.
11 of Pol mu with a ribonucleotide bound at the active site.
12 actions using two divalent metal ions in the active site.
13 olar and radical transformations in the same active site.
14 CS on Lys-395, which is localized in the CS active site.
15 trance of the substrate UDP-glucose into the active site.
16 "pre-bound" molecular oxygen adjacent to the active site.
17 alculations) to improve the structure of the active site.
18 the cross-linked Tyr residue present at the active site.
19 flexible loop (residues 70-81) covering the active site.
20 n-line pockets for substrate binding and the active site.
21 often mediated by substitutions outside the active site.
22 rs ATP binding and the core structure of the active site.
23 catalytic domain with a Zn(2+) bound at its active site.
24 ng a distinct non-primed binding mode to the active site.
25 lective of the transition state at the CARM1 active site.
26 nd that they are distinct from the enzymatic active site.
27 ion and substrate-specific adaptation of the active site.
28 n within the enzyme and its reactions at the active site.
29 tward-facing position pointing away from the active site.
30 lows us to model DNA binding in the nuclease active site.
31 nment of a substrate delivery channel to the active site.
32 iary interactions, and molecular kink at the active site.
33 lysis, likely through binding at or near the active site.
34 structure and the catalytic chemistry at its active site.
35 ate binding site distinct from the sialidase active site.
36 ements of PEG and water molecules within the active site.
37 eta-sheet regions in domain B distant to the active site.
38 ries that transfer electrons to and from the active site.
39 shows that it fills three key pockets in the active site.
40 t oxidize sulfite to sulfate at a molybdenum active site.
41 with respect to the substrate in the enzyme active site.
42 and the Pb(IV) product remains bound in the active site.
43 flexibility and accessibility of the enzyme active site.
44 en Candida albicans with GDP and Mg2+ in the active site.
45 IM) barrel structure with a highly conserved active site.
46 e Glc and not by rearrangement of Glc in the active site.
47 causing an electrostatic perturbation at the active site.
48 l-glutamate-gamma-semialdehyde dehydrogenase active sites.
49 mbination with CH3CO radicals on adjacent Pd active sites.
50 hindered by their constrained pocket-shaped active sites.
51 onstraints in pockets of enzymes stabilizing active sites.
52 inserted along its backbone chain working as active sites.
53 can provide abundant unsaturated defects as active sites.
54 knowledge of the location and nature of the active sites.
55 ibutions have enabled the rational design of active sites.
56 her enzymes having constrained pocket-shaped active sites.
57 efficacy of this trigger in other PLP-enzyme active sites.
58 reaction kinetics by providing more exposed active sites.
59 tRNA(Cys) between SepRS and SepCysS distant active sites.
60 vation time increases the population of such active sites.
61 as the precursors to the methane-converting active sites.
62 tion of l-Arg resulted in compression of the active site, a conformational change of the carboxylate
63 by shortening the distance between Pd and Ni active sites, achieved through shape transformation from
65 The results identify crucial roles for the active site amino acid trio in determining OleTJE cataly
66 n-bond-interactions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger con
67 on product GlcA, revealed a location for the active site among beta-propeller enzymes cited on the po
68 of the heptaketide mimetic deep into the PT active site and anchor one end of this linear array to p
69 acity, the Pro-->2-Hyp conversion alters the active site and enhances significantly deacetylase activ
71 e for modeling this reaction inside the SpnF active site and inferring the catalytic architecture of
72 res with the deacetylation reaction the same active site and one catalytic residue, and utilizes mole
73 , the heme 7-propionate is positioned in the active site and provides additional restraints on substr
74 ume ratio, favorable orientation of antibody active sites and approaching the source of the electric
75 omium species (i.e., low coordinated) as the active sites and attribute a fundamental role to externa
76 catalysts to probe the relationship between active sites and catalytic activity for the electroreduc
77 found to improve electronic coupling between active sites and current collecting substrates without t
78 strate specificity in enzymes with identical active sites and guide the future design of organophosph
81 th evolutionary conservation and distance to active site, and anticorrelated with contact number.
82 Asp206, which form a pocket adjacent to the active site, and galloyl-containing theaflavins are then
83 cis-BP-N (2)-dG adducts in a DNA polymerase active site, and offer a basis for understanding error-f
84 tic domain of human A3B has a tightly closed active site, and rearrangement of the surrounding loops
91 contain a shared core protein fold but whose active sites are located in entirely different regions,
93 rameworks decorated with uniformly dispersed active sites are prepared by using polyaniline as a grap
95 interface between Hda monomers occludes the active site arginine finger, blocking its access to DnaA
96 tance occurs through an unusual ground state active site arrangement or by thermally sampling conform
97 n inhibitor's amine group with the conserved active-site Asp is essential for activity and likely dic
99 ic zinc, thus increasing the activity at one active site at the cost of preventing substrate from ado
103 e next isolated two anti-muPA nanobodies; an active-site binding nanobody and an allosteric nanobody.
105 descriptor for C-C coupling, identifying two active sites, both of which have an under-coordinated su
106 l dNTPs, due to their low fidelity and loose active site, but are limited by poor processivity and ac
107 e (4)C1 conformation within the GH125 enzyme active site, but the FEL of corresponding O-glycoside su
109 in altering the solvent accessibility of the active site by expanding the active site volume, allowin
110 exclusion and the core H-bond network in the active site by relocating to replace the missing Arg85'
111 he emergence and subsequent evolution of new active sites by improving substrate and transition-state
112 of concept that both sides of DENV protease active site can be exploited to potentially achieve spec
113 ons in the hetero-tetramer interface and the active sites can abolish Pseudomonas aeruginosa growth i
114 driven by the complementarity of the enzyme active site cleft and the conformation of the substrate.
115 e nature of Nun interactions inside the RNAP active site cleft suggests that RNAP clamp opening is re
116 the structural bases for allosteric site-to-active site communication and for beta-lactam mimicry of
117 mate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine
118 urprisingly pervasive double-Psi beta-barrel active-site configuration among different nucleic acid p
121 h the enhanced conductivity and the retained active sites contributed to the remarkable electrocataly
124 ic lysine (Lys163) in domain 2 away from the active site core, whereas the two other active site lysi
126 ed across the Herpesviridae; mutation of the active site cysteine results in a loss of enzymatic acti
128 ucleus, and blocking (or oxidation) of GAPDH active site cysteines suppressed GAPDH/Ape1 interaction
130 foliation enables simultaneous modulation of active site density and intrinsic HER activity regardles
131 o-crystal structure analysis revealed a dual active site-directed and allosteric inhibition mode of t
133 he movement of one dynamic domain widens the active site entrance, while another domain acts like a l
136 unreported monodentate interaction with the active site Fe(2+) ion, while the benzonitrile group acc
137 computational, and binding studies elucidate active-site features that explain how orthologs can gene
138 Altering the chemical environment around the active site FeMo-cofactor in the MoFe protein, either by
139 dinitrogen (N2) to two ammonia (NH3) at its active site FeMo-cofactor through a mechanism involving
140 n fitted into the HER volcano plot, the MoS2 active sites follow a trend distinct from conventional m
142 olve the long-standing controversy about the active sites for SCR of NO with NH3 by supported V2O5-WO
143 atomic Fe model catalysts, we elucidated the active site formation process through correlating measur
144 ng approach with a thermodynamic analysis of active site formation to provide a map of methane activa
150 three-dimensional representation of the SLO active site ground state contains a reactive (a) conform
151 domonas reinhardtii, which contains only the active-site "H cluster," and CpI from the fermentative a
153 larities between caspase-6 and other caspase active sites have hampered precise targeting of caspase-
154 exaketide was accommodated within the Pik TE active site; however, intrinsic conformational preferenc
155 r mechanism of cyclization within the enzyme active site; however, there is evidence that conformatio
156 Mo2B4 compensates its smaller density of active sites if compared with highly active bulk MoB2 (w
157 8-269 of securin are located in the separase active site, illuminating the mechanism of inhibition.
159 lles and fibers, demonstrating that the heme active site in both morphologies is accessible to small
160 enesis implicate several residues around the active site in catalysis and substrate binding, and supp
161 7) were located in the TIM barrel around the active site in domain A, and two residues (I476 and V482
162 ith a second (-)3TC-TP molecule bound to the active site in the absence of PPi, suggests that nucleot
164 iary contacts among the regions close to the active site in the first step of unfolding, i.e., the N-
166 ce is due to the activity enhancement of the active sites in MoS2 by the intercalated protons, which
167 sformed into a more active 1T' phase as true active sites in photocatalytic HERs, resulting in a "cat
168 1D carbon structure and the embedded FeNx C active sites in the carbon framework manifest in superio
169 rative interactions between CO2 and multiple active sites in the preorganized anion are the driving f
171 -22, Thr-182, and Thr-240) were close to the active site, indicating their possible role in phosphory
172 n by either nutrient starvation or use of an active site inhibitor reduces Skp2 levels and stabilizes
173 troduced to generate highly effective FeNx C active sites into the carbon framework and to induce a h
179 ects either that H/D exchange at hydrogenase active sites is rapid compared to the rate of recombinat
181 tal binding can prevent ROS release from the active site, lessen damage to the protein, and produce h
182 lease fold and formed a homohexamer with the active sites located at the interfaces between RICE1 sub
183 t that conformational equilibrium of the A3B active site loops, skewed toward being closed, controls
185 the active site core, whereas the two other active site lysines from the two other domains are not a
186 protease of the complement system: in silico active site mapping for hot spot identification to guide
187 Our results classify this process as an active-site "maturation", which is highly atypical in be
188 nctional theory geometry optimizations of an active site model reveal that the intermediate is an ary
190 set of 434 A-domain sequences, showing that active-site-motif-based algorithms outperform whole-doma
192 chanisms for the emergence of completely new active sites must therefore either plausibly exist or at
194 of a new screening paradigm that utilizes an active site mutant D134A (D3.32) 5-HT2C receptor to iden
195 accharomyces cerevisiae using DNA polymerase active-site mutants as a "sensitized mutator background.
197 f the MOF to contain a high concentration of active sites necessary for the isomerization reaction.
199 r ATP stoichiometrically with substrate, the active site nucleotide species in Dop is ADP and inorgan
200 at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocyt
204 with the conservation of amino acids in the active site of BAM2, suggested that it might be catalyti
207 ion activity, while similar mutations in the active site of FPPase failed to significantly promote fo
208 ecule inhibitor that covalently binds in the active site of GSTO1-1 can be used to ameliorate the inf
209 we report a dominant mutation in the ATPase active site of human CLPX, p.Gly298Asp, that results in
210 Here, we report a synthetic model of the active site of lactate racemase, which features a pyridi
211 porated at 12 different positions within the active site of N-acetylneuraminic acid lyase (NAL), and
212 Z degrees , an intermediate form of the Cu4S active site of nitrous oxide reductase (N2OR) that is ob
213 esterol) hydroperoxides docked well into the active site of Ohr from Xylella fastidiosa and were effi
214 inolin-2(1H)-one does not bind to the kinase active site of over 380 human kinases including Akt.
215 e of a small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes
216 e highly conserved -GH- residues in the CGHC active site of PDI, we created PDI variants with a slowe
217 ve investigated the nature of the molybdenum active site of the arsenite oxidase from the Alphaproteo
218 AO to occur, they must first be bound in the active site of the enzyme in their phenolate anion form.
219 an replacing Cys276 by an Ala residue in the active site of the enzyme, as encountered in (Cys276-->A
220 ngineered a weak-binding ligand covering the active site of the protease without addressing the S1' p
225 n Pro hydroxylation activity which occurs in active sites of polysaccharide deacetylases (PDAs) from
227 ly tuning the spatial environment around the active sites of synthetic catalysts is a difficult chall
228 the proper Ni/Cu ratio and a large number of active sites on the surface of hierarchical structures.
231 the formation of a deep, solvent-accessible, active-site pocket, which may allow recognition of speci
233 ne-rich domain partially occludes the enzyme active site, preventing unfettered substrate access.
235 terase families according to their catalytic active site, protein oligomerization, and substrate spec
236 motif, conserved in 1-Cys Prxs, precedes the active site PxxxTxxCp signature and might contribute to
237 corroborate kinetically predicted trends in active site reactivity and to reveal unexpected features
238 reochemistry through accumulation of several active site rearrangements that lead to a decreased nucl
240 The lack of an appropriately positioned active site residue as a catalytic base leads us to prop
241 and structure-guided mutagenesis of putative active site residues identified Asn(24) and Asp(39) as b
243 g of AhAI revealed tighter interactions with active site residues of T. castaneum alpha-amylase compa
244 n this manuscript, we have focused on OleTJE active site residues Phe(79), His(85), and Arg(245) to i
245 A complex hydrogen bond network of four active site residues, which was installed in the late st
249 e concluded that BeauIII binds to a putative active site responsible for SOAT1 that is located on the
250 y, while these substitutions modulate PON1's active site shape, volume, and loop flexibility, their l
251 ively charged residues, and a portion of the active site shows structural similarity to the GTP-bindi
253 ools for the characterization of enzyme- and active site-specific GST activity in mammalian model sys
254 y for omega-hydroxylation is orchestrated by active-site sterics, partially mediated by an unusual he
255 -residue zebrafish P450 17A1 mutant, and the active site still resembled the structure in the other p
256 profound differences between these enzymes' active site structure, beta-lactam specificity and metal
257 the R2H2.CglI complex has only one nuclease active site sufficient to cut one DNA strand suggesting
258 ational differences in loops adjacent to the active site that include the extended loop prior to the
261 -10a, and 10b were binding within the MMP-13 active site, the Zn(2+) chelating unit was replaced with
262 r than sterically blocking 40S translational active sites, the associated assembly factors Tsr1, Enp1
264 by the structure or electronic properties of active sites, the enhanced oxidation resistance originat
265 ons stabilize H-bonds in the vicinity of the active site, thereby masking subtle dynamic features tha
267 at mediate protein palmitoylation, including active site thioester-linked palmitoyl intermediates.
269 entatic state imposed by the protein on the active site through relative orientation of the two moly
270 deactivation process consists of the loss of active sites through the agglomeration and possible dewe
271 t the BoNT/A metalloprotease zinc-containing active site, thus impeding its proteolysis of the endoge
272 optimization of chemical positioning in the active site, thus yielding a approximately 3 order magni
273 d in release (step 4) of cyt c from the HCCS active site; thus, we term these "release mutants."
274 zyme may prearrange the substrate within the active site to accelerate the [4+2] cycloaddition and im
278 covalent flavinylation by preorganizing the active site to stabilize the quinone-methide intermediat
279 a dynamic allosteric pathway connecting the active site to the main allosteric site that remains in
282 ism, binding of the primary substrate in the active-site triggers the release of the solvent-derived
284 ytic BamB subunit of this complex harbors an active site tungsten-bis-pyranopterin cofactor with the
285 , together with partial rearrangement of the active site upon activation, explains the lack of inhibi
286 sibility of the active site by expanding the active site volume, allowing additional water molecules
288 a3 and L3 regions, which flank the di-Zn(II) active site, were selectively (19) F-labeled using 3-bro
289 owed a rearrangement of the substrate in the active-site, when compared to the structure of the binar
290 ring of the cofactor transiently enters the active site where it displaces the pterin ring of the TH
291 rs after the molecule is formed, or that the active sites where D2 oxidation and proton reduction occ
292 omoted production of free OH radicals (on Ni active sites) which facilitate the oxidative removal of
293 the number of low-coordinated catalytically active sites, which dramatically lowers the overpotentia
294 s complement hydrophobic residues around the active site, while the third residue projects away from
296 lytically essential monovalent cation at its active site, yet another parallel with B12 enzymes, and
297 s of the protein scaffold that surrounds the active site, yet the exact nature of catalytically relev
298 n of the acidic ring nitrogen with the CA II active site zinc, as well as two hydrogen bonds between
300 of CSN5 inhibitors, which interact with the active-site zinc ion of CSN5 through an unprecedented bi
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