ライフサイエンスコーパス: activity

1 lation and an increase in in vitro stem cell activity.

2 post-translational regulation of mutant KRAS activity.

3 role for the juxtamembrane region in enzyme activity.

4 S was dependent on eIF4G, but not eIF4E, for activity.

5 duced by TH2 cells, IL-4, and IL-13 and HDAC activity.

6 n cofactor-free kinases with photoswitchable activity.

7 contributes significantly to its biological activity.

8 l being monitored for safety and anti-tumour activity.

9 rons and muscle where they modulate cellular activity.

10 sites, as does the stimulation of ATM kinase activity.

11 emaking compared with Cav1.2 during aSM-like activity.

12 to and suppressing PGC1alpha transcriptional activity.

13 e (S719) that accounts for 40% of basal NHE3 activity.

14 (CBV) as a proxy of drug effects on neuronal activity.

15 tripeptide S-2302, demonstrating proteolytic activity.

16 he level of transcripts, proteins and enzyme activity.

17 8) and that this interaction stimulates ACA8 activity.

18 ormation on the regulation of RNA polymerase activity.

19 the HSA binding capacity and retained enzyme activity.

20 ors and are necessary and sufficient for PRE activity.

21 othelium, the major control site in physical activity.

22 AR2CSA-based vaccine may require multivalent activity.

23 most likely responsible for their biological activity.

24 e of which is impaired lysosomal proteolytic activity.

25 rmal brain functions and to prevent abnormal activity.

26 the 10th transmembrane domain show very poor activity.

27 gion surrounding the Eya1 locus for enhancer activity.

28 maintenance and function by regulating eNOS activity.

29 nding to the Parp9 macrodomains increases E3 activity.

30 viral DNA mutators and have broad antiviral activity.

31 ppression, with dampened baseline microglial activity.

32 t affect short-term release or antibacterial activity.

33 es and reduced superoxide dismutase 2 (SOD2) activity.

34 superior selectivity, potency, and antitumor activity.

35 e chromatin, independently of PTEN enzymatic activity.

36 in part due to elevated acetylcholinesterase activity.

37 l position system data, to quantify physical activity.

38 he effect of excitotoxicity on neuronal PKD1 activity.

39 tor (CPG) during drug-induced locomotor-like activity.

40 ase and ADP-ribosylation factor (ARF) GTPase activity.

41 e regulatory factors in modulating Fshb gene activity.

42 identified by a transient increase in HR and activity.

43 namics are essential for controlling protein activity.

44 SCs induced ZEB1 expression, attenuating LIF activities.

45 the two alleles confer different regulatory activities.

46 lins that can neutralize ILY, MsgA, and NanA activities.

47 VTA) dopamine depletion had attenuated delta activity (1-4 Hz) in the medial frontal cortex (MFC) dur

48 echanism by which a brain region adjusts its activity according to the influence it receives from oth

49 lso observed broader fluctuations of DRN(DA) activity across sleep-wake cycles with highest activity

50 e is associated with an increased antibiotic activity against bacterial strains possessing high level

51 ying conditions along with the anti-swarming activity against Citrobacter rodentium.

52 and the reduction in differential functional activity against the sensitive and Pgp overexpressing re

53 The low activity allele of the maternal polymorphism, 5HTTLPR, i

54 rroborated by showing that MEFs lacking AMPK activity also failed to up-regulate IFN-beta and TNF-alp

55 l studied for over a decade, the DNA-binding activities and the biological functions of these protein

56 te isomerase-like domain associated with DSD activity and a novel C-terminal hydroxyphenylpyruvate di

57 ed only by reducing eIF4E expression or mTOR activity and also blocking MNK1 phosphorylation of eIF4E

58 Synaptic transmission controls brain activity and behaviors, including food intake.

59 ino acid tagging (BONCAT) - for studying the activity and biogeochemical influence of marine viruses.

60 ost vital roles: the coupling between neural activity and blood flow.

61 RNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly under

62 neurons via diverse effects on NADPH oxidase activity and dendritic spine morphology.

63 modest effects on GTP binding and on GTPase activity and did not perturb stability of the MCM-MeaB c

64 Msh3 overexpression led to high expansion activity and elevated levels of MutSbeta complex, indica

65 le invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic

66 at CircPVT1 might selectively modulate let-7 activity and hence expression of let-7-regulated mRNAs.

67 can both deconvolve the stages of polymerase activity and identify significant changes in activity be

68 ounds with moderate to potent antitubercular activity and improved physicochemical properties.

69 d S81 phosphorylation markedly suppresses AR activity and initiation of this positive feedback loop.

70 monophosphate (cGMP) analog on KATP channel activity and insulin secretion point to participation of

71 anslation, and thus suppressed mTORC2 kinase activity and invasion in colon tumor cells.

72 d indirectly through the combination of time-activity and meteorological data sets.

73 in saturable high-affinity nitrate transport activity and nitrate selectivity.

74 inhibitor, has shown preclinical antitumour activity and objective responses in patients with epithe

75 ing direct measurements of sympathetic nerve activity and pharmacological manipulation of blood press

76 blood-stage and gametocytocidal antimalarial activity and proteasome inhibition.

77 ssue exhibited significantly lower metabolic activity and release of pro-inflammatory cytokines than

78 m as a quantitative screen to assess peptide activity and selectivity by precisely controlling exposu

79 amining the effect of E6APC820A on wild-type activity and single-turnover pulse-chase kinetics.

80 Peripheral blood ADAM17 activity and soluble CD163 levels were elevated in strok

81 Their activity and structural underpinnings provide insights i

82 ggesting a direct link between reduced CD11b activity and the chronically increased inflammatory stat

83 vation of AMPK was shown to downregulate PXR activity and, consistent with that, potentiate the respo

84 ated that rs9920291 shows allelic regulatory activity, and CRISPR/Cas9 targeting of human chondrocyte

85 ts of fatigue, depressive symptoms, physical activity, and psychomotor speed.

86 The environmental impacts of these activities are generally accepted as necessary for the p

87 How these different activities are mediated is not known.

88 h dual therapeutic and transmission-blocking activity are desired as high-value partners for combinat

89 inally, interval timing and striatal ramping activity are disrupted when the medial frontal cortex is

90 Our data indicate that SOCE and KATP channel activity are regulated by STIM1.

91 The primary mediators of this activity are the SMAD proteins, particularly SMAD3.

92 FES, notably a 4-fold decrease in blood-pool activity as compared with (18)F-FES.

93 Respiration is a rhythmic activity as well as one that requires responsiveness to

94 AR1 binding behaviors related to its editing activity, as well as the antagonizing effect of RBP bind

95 in vivo FLT3 inhibition by plasma inhibitory activity assay and indicated improved overall survival a

96 Importantly, through in vitro binding and activity assays, we showed that CML36 interacts directly

97 est is defined as the termination of cardiac activity associated with loss of consciousness, of spont

98 is highly thermostable, reaching its highest activity at 65 degrees C and that Tfu-FNO is likely to a

99 e harsh environment and capable of metabolic activity at in situ temperatures, possessing a suite of

100 Activity at synapses triggers insertion of GLUT4 into th

101 diated through the suppression of c-Fos/AP-1 activity at transcriptional and post transcriptional lev

102 ril disarray, whereas inhibiting Calcineurin activity attenuated FoxO-mediated murf1 expression and p

103 activity and identify significant changes in activity between experiments.

104 otal community and maintained high metabolic activity but also had the highest proportion in transiti

105 ysosomal Cu exporter, or a regulator of Ctr1 activity, but its functional and evolutionary relationsh

106 KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation.

107 ection through this dNTP triphosphohydrolase activity by reducing the cellular dNTP pool to a level t

108 Inhibition of LDH activity by small hairpin ribonucleic acid or expression

109 exerts a feedback control on T-type channel activity, by modulating the channel availability, a mech

110 to serotonin receptors and its antiepileptic activity can be mimicked by drugs acting on serotonin si

111 Increased Rac1 activity caused by OGD/ischemia contributes to neuronal

112 ly lead to disease when their abundances and activities change due to alterations in the environment

113 Here, we investigated how motor cortical activity changed in the presence of an object independen

114 H1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglut

115 rrestin 2 recruitment, no ligand-independent activity could be measured.

116 indicators of happiness, food, and physical activity culture from geolocated Twitter data to examine

117 For compounds with in vivo target activity data (e.g. animal toxicity testing results), th

118 Knee extensor muscle activity decreased slightly during exoskeleton-assisted

119 The forcing activity demarcates coherent phase space regions where t

120 By inducing activity-dependent plasticity in the visual cortex of ad

121 Using a novel activity-dependent technology called CANE developed in o

122 ity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell death.

123 MMP activity differed between HIV-1-infected and -uninfected

124 ce between inhibitory and excitatory spiking activity directly.

125 Islets deficient in GATA6 activity display decreased insulin content and impaired

126 es and how they changed as a function of the activity distribution were assessed and compared with th

127 nnaire = 18 (95% CI, 7-30), and St. George's Activity Domain = 12 (95% CI, 2-21).

128 de the first dynamic view of corticostriatal activity during bond formation, revealing how social int

129 Joint morphogenesis requires mechanical activity during development.

130 nces examined display p53-dependent enhancer activity during the DNA damage response.

131 ogenic biocathode, and/or maintain microbial activity during voltage interruptions.

132 tivity across sleep-wake cycles with highest activity during wakefulness.

133 in thermodynamics and to engage in research activities early in their scientific career.

134 as shown clear evidence of disease-modifying activity, even if some patients treated with interferon

135 tically accelerates the proteolytic cleavage activity, even in the absence of forces or denaturants.

136 The NanoLuc activity faithfully monitored the transcriptional regula

137 demonstrate enhanced natural community APase activity following iron amendment within the low zinc an

138 tor target to develop RNA aptamers with dual activity for effectively blocking both AMPA and kainate

139 ecific and approximately 6 times higher mass activity for the oxygen reduction reaction than Pt/C, an

140 Full separation of GVL activity from GVHD has yet to be achieved.

141 or is routinely done by measuring electrical activity from single neurons in experimental sessions.

142 in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellul

143 Mutants with reduced enzymatic activity had slower replication in mammalian neuronal ce

144 oles in immune function, while abnormal JAK1 activity has been linked to immunological and neoplastic

145 The Snail-repressive activity, here monitored on genes with a pivotal functio

146 In this Review, we summarize the biochemical activities, host cell interaction partners, and physiolo

147 peripheral blood mononuclear cell (PBMC) ADA activity, improved lymphocyte numbers, and normal prolif

148 erneuron are known to shape diverse rhythmic activities in the cortex, but how they interact to orche

149 -48 significantly inhibited topoisomerase II activity in a concentration-dependent manner.

150 so found that TRIM6 enhances EBOV polymerase activity in a minigenome assay and TRIM6 knockout cells

151 To address this question, we recorded neural activity in a prefrontal sensorimotor area while monkeys

152 hances mitochondrial biogenesis and synaptic activity in APP mice; and that SS31 may confer protectiv

153 ibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accountin

154 Inhibition of KCC2 activity in clonal MIN6 beta-cells increases basal and g

155 Recordings of phrenic nerve activity in female Sprague Dawley rats (3-4 months) reve

156 eletion of AC9 decreases Hsp20-associated AC activity in heart.

157 SK channels, contributes to exacerbated MNC activity in HF rats.

158 am1 mediates an OGD-induced increase in Rac1 activity in hippocampal neurons; however, the identity o

159 ntly lower cerebral blood flow and metabolic activity in key brain areas compared with control subjec

160 of p50 and showed decreased transcriptional activity in luciferase reporter assays.

161 ose Pembrolizumab provides durable antitumor activity in metastatic melanoma, including complete resp

162 ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRC

163 We intraoperatively recorded single unit activity in ten patients with PD who performed repetitiv

164 t lung adenocarcinomas increase bone stromal activity in the absence of bone metastasis.

165 ked to the temporal irregularity of neuronal activity in the central nervous system.

166 The L(OH) complex maintains its SOD activity in the presence of (*)OH and Mn(IV)-oxo species

167 s to precisely modulate Wnt/Norrin signaling activity in the retinal endothelium and coordinate the t

168 med increased Cldn14 expression and promoter activity in the TAL of Ksp-cre;Pth1r(fl/fl) mice.

169 TMBPF did not show estrogenic activity in the uterotrophic assay and did not alter pub

170 h results in T-cell activation and antitumor activity in tumor models.

171 that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cel

172 However, ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-in

173 ver, evidence for direct inhibition of MmpL3 activity is also lacking.

174 Key to the chaperone activity is an ATP-induced allosteric regulation of poly

175 ous recovery of ipsilateral diaphragm muscle activity is associated with increased phrenic motoneuron

176 st a mechanism in which MEF2 transcriptional activity is differentially recruited to fine-tune gene e

177 cific expression studies indicate that vpr-1 activity is important in the nervous system, germ line a

178 mutating residues in ABD1, we find that this activity is mediated by a positively charged surface tha

179 Condensin's translocation activity is rapid and highly processive, with individual

180 MUS81 nucleolytic activity is required to activate compensatory DNA synthe

181 strate that Env-specific HLA-B*14-restricted activity is substantially more efficacious than the subd

182 AMPA-BBB model and high in vitro antioxidant activity, its conversion to AChEI 2r could be easily ach

183 ouseholds may experience greater HPA and HPG activity, leading to steeper decreases in cortical thick

184 nsmission delays in mice varied depending on activity levels, and axonal myelination and conduction v

185 dependence of oxygen consumption depends on activity levels, these findings are consistent with the

186 Here we demonstrate that key RQC activities-Ltn1p-dependent ubiquitination and Rqc2p-medi

187 Lower leisure-time physical activity (LTPA) and higher body mass index (BMI) are ind

188 The cabbage extracts exhibited antimicrobial activity mainly on the ninth day after the expiry date a

189 ibited the best extracellular antitubercular activity (MIC50 = 500 nM).

190 (RT) was believed to mediate antineoplastic activity mostly (if not only) as a consequence of cancer

191 Three patients received treatment activities of 5.1-7.5 GBq.

192 ined functional impairment and impairment in activities of daily living (ADL) (defined as severe or m

193 which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac

194 ceptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal sp

195 Optimum ACE-inhibitory and antioxidant activities of proteins separated by RP-HPLC were observe

196 one, enhanced the antiviral and antifibrotic activities of single and dual HBV shRNAs.

197 The photocatalytic activities of the Al-TiO2 samples were investigated by t

198 heir tetrapeptidic backbones, the anticancer activities of these precursors largely match their self-

199 We tested the cis-regulatory activity of 69 TE subfamilies by luciferase reporter ass

200 res of various agents to enhance the overall activity of a cocktail of multiple enzymes and achieve o

201 This indicates that the helicase activity of a UvrD dimer is promoted via direct interact

202 of vivax invasion assays, binding-inhibitory activity of antibodies has been reported to be associate

203 eriments have shown a heterogeneous promoter activity of autoinducer synthase genes, suggesting that

204 o electricity, based on the use of metabolic activity of bacteria.

205 Copper is required for the activity of cytochrome c oxidase (COX), the terminal ele

206 ce interval [CI], -175 to -43), London Chest Activity of Daily Living Questionnaire = 18 (95% CI, 7-3

207 The mechanism involved enhanced activity of defence related enzymes, i.e. chitinase, bet

208 and WNT/beta-catenin, inhibited the biologic activity of domain 4.

209 ies and synaptic regulation that control the activity of dopamine neurons.

210 Because the GTPase activity of each of these proteins depends on interactio

211 and is responsible for the full procoagulant activity of FXII.

212 Persistent activity of hippocampal and amygdala neurons was stimulu

213 ion with PTPdelta, but IL1RAPL1 mediates the activity of IL-1beta on dendrite morphology.

214 h, affected the accumulation and tolerogenic activity of MDSCs in tumors, and inhibited the expressio

215 The biological activity of methylone and its metabolites was then compa

216 n of ankyrin isoforms relies on differential activity of positive and negative regulators of alternat

217 bulb (MOB), inhibitory circuits regulate the activity of principal cells precisely to drive olfactory

218 Calcium orchestrates the activity of several kinases and phosphatases, which inte

219 BCNT), is essential for the histone exchange activity of SWR, whereas an acidic region at the N-termi

220 The activity of the "drug-free macromolecular therapeutics"

221 odes, whilst simultaneously recording muscle activity of the affected limbs.

222 ibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1)

223 ction reaction than Pt/C, and twice the mass activity of the hollow nanoframe.

224 In addition to the robust autophagy activity of the Kalpha2-helix peptide, the present study

225 Here, we quantify the extent to which the activity of the supermassive black hole at the center of

226 ic region of the cell; it also regulates the activity of these receptors.

227 T allele variation at rs604723 increased the activity of this fragment by promoting serum response tr

228 cytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic cells durin

229 ced in the clinic and have shown significant activity, particularly against tumors driven by the estr

230 calcium transients, and that changes in the activity patterns coincide with the course of nucleogene

231 a common educational and quality improvement activity performed in cardiac catheterization laboratori

232 he positive feedback, shape the temporal ERK activity profile but are dispensable for oscillations.

233 sting that Y10 phosphorylation-mediated LDHA activity promotes cancer cell invasion and anoikis resis

234 eresis over the entire temperature and water activity range considered here.

235 frequency invariant for their physiological activity range.

236 nalysis and modelling of human brain voltage activity recorded simultaneously across microscopic and

237 tion determination, a PET-specific structure-activity relationship (SAR) effort, and specific binding

238 Initial structure-activity relationship studies have resulted in compounds

239 This study expands the structure-activity relationships on our original series by present

240 in situ production of HO(*) using structure-activity relationships.

241 he immobilized catalyst exhibits much higher activity relative to 4-acetamido-TEMPO, an electronicall

242 iculum (ER) and similar to other Hsp70s, its activity relies on nucleotide- and substrate-controllabl

243 the specific ion channels essential to these activities remain to be identified.

244 impact of dentate mossy cells on hippocampal activity remained uncertain despite a long history of in

245 w they interact to orchestrate specific band activity remains largely unknown.

246 apy studies to evaluate safety and antiviral activity should be conducted prior to proceeding to comb

247 Although monthly supplementary immunization activities (SIAs) continued, the targeting of settlement

248 ith pulsed focused ultrasound-induced bubble activity significantly increases the plasma abundance of

249 When RADX is inactivated, excessive RAD51 activity slows replication elongation and causes double-

250 To identify neural activity specifically associated with contextual retriev

251 s of IYO and prevents its prodifferentiation activity, supporting the conclusion that RIMA-dependent

252 importantly, blocking reverse transcriptase activity suppressed the expression of interferon genes i

253 The anti-V2 MAbs displayed stronger activity than other anti-gp120 MAbs in screening against

254 ls and diavoli beans, had higher antioxidant activity than those with pale testa, and a positive corr

255 exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester strain

256 orometric method to measure carboxypeptidase activities that cleave the proline-phenylalanine dipepti

257 The contribution of various enzyme activities that collectively lead to the formation of An

258 udies implicated variations in gut microbial activities that mapped onto tacrine-induced transaminiti

259 We have developed mathematic models of brain activity that allow for accurate prediction of regional

260 cts could be explained by patterns of neural activity that do not represent neural tuning to numerosi

261 on between FTO RNA binding and demethylation activity that influences several mRNA processing events.

262 atalyst for HER in this series, with initial activity that is slightly worse compared to the pristine

263 porewaters corresponding to peak industrial activity that occurred 5 to 10 years earlier.

264 thylene has a combination of selectivity and activity that surpasses that of commercial homogeneous c

265 the absence of sodium-dependent Pi transport activity, the PiT1-PiT2 heterodimerization was still reg

266 es and shown to have promising antimicrobial activity, the structure of the conformationally flexible

267 (9)-tetrahydrocannabinol depressed GABA cell activity, therefore downstream dopamine cells will be di

268 EBI2 signaling activated Pin1 isomerase activity through a cascade that was sensitive to ERK inh

269 domain kinase (LIMK), which regulates actin activity through phosphorylation of cofilin, an actin-de

270 gnancy illustrates the need to control Notch activity tightly.

271 ecruitment of Akap450-mediated MT nucleation activity to the NE.

272 ranscript elongation and restriction of gene activity to the promoter-proximal approximately 25 kb is

273 msey et al. (2017) demonstrate that neuronal activity triggers lysosomal fusion with the plasma membr

274 analysis revealed an increase in luciferase activity under HG, which was reduced after mutation of t

275 T-based kinase sensors for monitoring kinase activity under two-photon fluorescence lifetime imaging

276 ts to investigate how left-hemispheric brain activity varies during the formation of phrase structure

277 physiological processes, including neuronal activity, vascular tone, inflammation, and energy metabo

278 (99m)Tc activity was also used to calculate the amount of dye wi

279 ith Fic acting as a deAMPylation enzyme, its activity was both time- and concentration-dependent.

280 Participants' activity was categorized as <1000, 1000 to 2000, or >200

281 ed restriction of multiple viruses, and this activity was dependent on both its RING E3 ligase and AD

282 prisingly, the rseA mutant strain where RpoE activity was elevated expressed very little pertussis to

283 king compared to baseline, while knee flexor activity was elevated in some participants.

284 ITPR2 promoter activity was measured in Huh7 and HepG2 cells.

285 Telomerase enzymatic activity was not directly affected by BRD4 inhibition.

286 Rather, a higher transporter activity was observed, which possibly acted as a compens

287 The pathological brain activity was recorded intra-operatively via implanted DB

288 d use of a computer or telephone during each activity was recorded.

289 s while recording single unit and population activity, we demonstrate that PNN removal alters the bal

290 Importantly, evoked neural activities were modeled by Bayesian inference, which had

291 HPA axis genetic variation and activity were important predictors of cognition across t

292 ents, total phenolic content and antioxidant activity were investigated in artichokes, green beans, b

293 C) exhibited high oxygen reduction reaction activity with an onset potential of 0.92 V, and a half-w

294 r passive sounds while measuring their brain activity with fMRI.

295 nctional assay, 1b displayed full antagonist activity with IC50 = 6 +/- 2 muM.

296 xplored the mechanism of any plaque DOTATATE activity with immunohistochemistry in resected specimens

297 pared biosensor has 7 folds higher catalytic activity with lower oxidation potential towards CC than

298 ticulum calcium trasport ATPase (SERCA) pump activity with thapsigargin prolonged NMDAR-DeltaCa(2+) r

299 the benefits of the enhanced host catabolic activity with the risk of being eliminated by the cell's

300 tions by activating or inhibiting neurogenic activity with veratridine and tetrodotoxin, respectively