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2 ificant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay using chor
3 entrations in vitro, have aggregate-clearing activity in a cellular model of Huntington's disease, an
5 these abilities are associated with enhanced activity in a core network of neural regions, including
6 xidatively modified DNA base OG to guide BER activity in a gene promoter and impact cellular phenotyp
7 bind to the same nonheme site and confer HCO activity in a heme-nonheme biosynthetic model in myoglob
8 In the present study, we measured temocillin activity in a large collection (n = 333) of P. aeruginos
9 e production and alter hypothalamic neuronal activity in a manner that depends on FA type and cellula
10 so found that TRIM6 enhances EBOV polymerase activity in a minigenome assay and TRIM6 knockout cells
11 olymorphism, rs577676, which alters enhancer activity in a mouse atrial cell line and in embryonic ze
12 To address this question, we recorded neural activity in a prefrontal sensorimotor area while monkeys
13 alogues and determination of their antiviral activity in a single-cycle and a multicycle infection as
14 has been associated with increased amygdala activity in a stress paradigm, and being brought up in a
15 n 15-LOXs 1 and 2, induced TF expression and activity in a time-dependent manner in the human monocyt
16 omains SD2 and SD3 modulated IFN binding and activity in accordance with the relative attenuation of
18 nyl groups, thiol groups and metal chelation activities in addition to phenolic, total flavonoid and
19 mbrane fluctuations are affected by cellular activity in adherent cells, their spatial regulation and
20 pediatric seizure onset with ongoing seizure activity in adulthood, (2) intellectual disability of an
22 in which recently approved drugs with known activity in AITL are paired with induction regimens with
23 We show that the effects of post-Columbian activities in Amazonia are likely to have played a large
24 asket cell types can powerfully regulate the activity in amygdala networks predominantly via their pe
25 TRA2-3 also was found to have chaperone-like activity in an insulin aggregation assay, which we propo
27 hances mitochondrial biogenesis and synaptic activity in APP mice; and that SS31 may confer protectiv
28 cturonase (PG) gene, ADPG2, and increases PG activity in Arabidopsis leaves, which in turn reduces le
30 gered an anticipatory widespread increase of activity in attentional, sensory and executive regions,
31 modified TFS were then used to evoke neural activity in auditory neurons of the inferior colliculus
32 ability to partly compensate for loss of Btk activity in B cell differentiation, although the underly
33 We spatiotemporally perturbed electrical activity in beta-cells of channelrhodopsin2-expressing i
34 s to play an accessory role in modulating Mp activity in BlaJ mice in a gender, age and muscle-depend
36 PtZn iNPs exhibited ca. 10 times higher mass activity in both acidic and basic solution toward the me
38 d value is represented in patterns of neural activity in both medial and lateral parts of the orbitof
39 , with no overt signs of toxicity and potent activity in both murine xenograft and patient-derived br
41 4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not c
45 ompounds 3 and 4 have shown low cytotoxicity activity in cell line A-431 and low green staining in ce
47 ibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accountin
48 t association between PEx risk and influenza activity in children and adults and with RSV activity in
50 creased aerosol loading due to anthropogenic activities in China substantially increases column cloud
51 e data on the spatial distribution of retail activities in cities makes it possible to build models f
53 e progression, brain growth, NAGLU enzymatic activity in CSF, and specific anti-NAGLU immune response
54 ormality was corrected by restoring ADAMTS13 activity in cTTP serum, which prevented VWF multimer acc
55 nd relapse, and found that either increasing activity in D1-MSNs or decreasing activity in D2-MSNs au
56 increasing activity in D1-MSNs or decreasing activity in D2-MSNs augmented cue-induced reinstatement.
58 ut not absent, P4HA1 protein level and C-P4H activity in dermal fibroblasts compared to age-matched c
59 od is useful for determining the proteolytic activity in different media and its effectiveness depend
60 mporal patterns, which orchestrate signaling activity in different subcellular compartments at differ
61 r, due to volume conduction, FPs may reflect activity in distant neurons superimposed upon that of ne
62 sed to screen potential cumulative endocrine activity in drinking water and to inform prioritization
63 tive computational framework in which neural activity in each brain area depends on a combination of
65 ective phenotypic detection of carbapenemase activity in Enterobacteriaceae In this issue of the Jour
67 hat the absence of Topoisomerase and RNase H activity in Escherichia coli or Saccharomyces cerevisiae
69 amount of daily sedentary time with physical activity in everyone, regardless of age and current heal
71 o age-specific changes in voluntary physical activity in female offspring that are differentially inf
73 Findings support the role of maternal immune activity in fetal neurodevelopment, exacerbated in part
74 ctivation, Pn3a alone displayed no analgesic activity in formalin-, carrageenan- or FCA-induced pain
78 sphorylation positively correlates with AMPK activity in glioma specimens and grades of glioma malign
80 tors can be integrated to influence cellular activity in growing bones and ultimately gross limb morp
83 We also directly monitored SIRT1 and SIRT2 activity in HEK293T cells with an mCherry fusion of EGFP
84 C) inhibition has shown remarkable antitumor activity in hematological malignancies, it has been less
88 am1 mediates an OGD-induced increase in Rac1 activity in hippocampal neurons; however, the identity o
92 overexpression or knockdown influences NALP3 activity in human monocyte and HEK293FT cells when the c
93 y, the assay was used to detect elevated FAP activity in human patients diagnosed with liver cirrhosi
94 d TNFalpha-induced NF-kappaB transcriptional activity in human TNBC cells and suppressed downstream N
97 showed excellent peroxidease-like catalytic activity in hydrogen peroxide-Amplex red (AR) system (AR
99 we report the measurement of MRP1 functional activity in individual cancer cells using scanning elect
100 quantifying apoptosis-induced intracellular activity in individual cells following exposure to tumor
101 ntly lower cerebral blood flow and metabolic activity in key brain areas compared with control subjec
102 was associated with greater infant-specific activity in key parental brain regions, including the or
104 te body maps, revealed by cytochrome-oxidase activity in layer 4 of 8 rodent and 1 lagomorph species.
107 altered metabolic expenditure and locomotor activities in male offspring, and increased number of pr
110 sal of drug resistance and enhanced anti-MCL activity in MCL patient samples and patient-derived xeno
113 ose Pembrolizumab provides durable antitumor activity in metastatic melanoma, including complete resp
115 (Dgcr8), thus removing RPE miRNA regulatory activity in mice by disrupting two independent and essen
118 In addition, we highlighted a novel DNMT3B activity in modulating the self-regulatory circuit of se
121 sms and the effects of SPDEF on beta-catenin activity in mouse models of colorectal cancer (CRC), CRC
122 ase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect that could
127 e thought to reflect profound disruptions of activity in neuronal circuits that mediate awareness and
128 a Ca(2+)-dependent process to regulate miRNA activity in neurons in response to the induction of long
130 melanized strains of both species, while the activity in non-melanized cells remained stable or decre
133 ulate folate metabolism, however folate/DHFR activity in oligodendrocyte development has not been ful
138 on associated with decreased transcriptional activity in patient kidney cells and impaired binding of
139 termine changes in noncardiomyocyte cellular activity in patients with end-stage HF after left ventri
140 it of enhanced social recovery on structured activity in patients with first-episode psychosis who re
141 on of interleukin 22 associated with disease activity in patients with IBD; there was an inverse asso
144 an acceptable safety profile and antitumour activity in patients with progressive or treatment-resis
145 ile and evidence of single-agent antimyeloma activity in patients with relapsed/refractory MM, predom
147 However, pembrolizumab showed encouraging activity in patients with undifferentiated pleomorphic s
150 ear rate, indicating a role for Vps34 kinase activity in platelet activation, independent from its ro
152 ins that, remarkably, integrates several key activities in polysaccharide biosynthesis into a single
156 ce testing might not accurately predict NRTI activity in protease inhibitor-based second-line ART.
157 ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRC
159 l role for Set1A catalytic methyltransferase activity in regulating ESC differentiation but not self-
160 Histone modifiers regulate proper cellular activities in response to various environmental stress b
165 pression of several markers for regenerative activity in sensory neurons, including phospho-STAT3 and
166 ndent of catalysis, and that its biochemical activity in septum formation can be provided by PBP 3.
170 rotene and lutein and changes in antioxidant activities in six edible greens during simulating gastro
172 68Q), mimicking acetylation, decreased MnSOD activity in SNc dopaminergic neurons, whereas mutagenesi
174 IIa provided a final complex with FVIIa-like activity in solution, while exhibiting a two to three or
176 which is associated with increased hemolytic activity in ST3081 and may contribute to increased virul
179 ools for characterizing electrophysiological activity in subcortical structures in the human brain.
181 We intraoperatively recorded single unit activity in ten patients with PD who performed repetitiv
184 erneuron are known to shape diverse rhythmic activities in the cortex, but how they interact to orche
186 thioureas displayed significantly different activities in the Morita-Baylis-Hillman reaction of meth
188 xhibits two types of gamma rhythm: broadband activity in the 30-90 Hz range and a narrowband oscillat
194 ), are characterised by irregular electrical activity in the atria, generally associated with erratic
195 nnels could explain arrhythmic SAN pacemaker activity in the atrial-specific Na(+) /Ca(2+) exchange (
196 oximately 100 ms) response peak with reduced activity in the auditory cortex ipsilateral to the leadi
197 Since previous studies observed that gamma activity in the auditory cortex is correlated with tinni
198 has previously been shown to increase local activity in the beta band [14] and to modulate long-rang
202 iation method that uses a protease with high activity in the cold, purified from a psychrophilic micr
203 ent texture, biogeochemistry, and biological activity in the Columbia River HZ, the grain size distri
205 linked to abnormally correlated and coherent activity in the cortex and subthalamic nucleus (STN).
206 t return and present risk modulated with the activity in the cuneus; while present return and past ri
208 did not show estrogen-agonist or antagonist activity in the estrogen receptor-transactivation assay.
213 rated novel ML290 analogues and tested their activity in the HEK293-RXFP1 cAMP assay and the human he
214 tual fear memory requires coordinated neural activity in the hippocampus, medial prefrontal cortex (m
215 Here we used MEAs to record neuronal spiking activity in the human middle temporal gyrus (MTG), a cor
217 Moreover, the nickel OMCs offer exceptional activity in the hydrogenation of bulky molecules ( appro
219 to determine the contributions of nsp14 ExoN activity in the induction of and resistance to the innat
220 sensitivity and a marked increase of channel activity in the intact cell irrespective of the identity
221 ression phase, men with BPD exhibited higher activity in the lateral orbitofrontal and dorsolateral p
222 that these incremental differences in neural activity in the maternal brain reflect the building of p
223 ng link between motion perception and neural activity in the middle temporal (MT) area of the macaque
225 Altogether, these results indicate that AMPK activity in the NAc core is critical for the cue-induced
226 serum significantly reduced the ecto-AMPase activity in the nociceptive lamina in the brainstem.
227 tected the existence of CD73 and ecto-AMPase activity in the nociceptive lamina of the trigeminal sub
230 a novel mechanism whereby lipid phosphatase activity in the nucleus can regulate mammalian target of
232 trated marked though distinct anti-silencing activity in the pluripotent state and during PSC-differe
233 approximate the distribution of patterns of activity in the population, matching the correlations be
235 ons of Drs2p can greatly increase its ATPase activity in the presence of PI4P and demonstrate that re
236 These results suggest that texture-sensitive activity in the primary somatosensory cortex and superio
238 stigate these mechanisms, we recorded neural activity in the rat hippocampus and prefrontal cortex, s
242 s to precisely modulate Wnt/Norrin signaling activity in the retinal endothelium and coordinate the t
243 s outcomes (ie, successful and unsuccessful) activity in the right habenula decreased in CD in the ab
245 first time; MoB2 and beta-MoB show excellent activity in the same range as the recently reported alph
246 We demonstrate that the amplitude of beta activity in the subthalamic nucleus increases in proport
247 regation of function would predict that when activity in the superior colliculus is suppressed by rev
248 sent return and past risk modulated with the activity in the superior temporal gyrus and the angular
257 t visual latency of the LFP preceded spiking activity in the visual epoch, whereas spiking activity p
259 16:4(n-3)-GPR120 axis led to enhanced cPLA2 activity in these splenic macrophages and secretion of t
265 a significant correlation between high EGFR activity in tumour cells and macrophage-tumour cell prox
267 (S)-FPMPA amidate prodrug, exerts anti-HIV-1 activity in TZM-bl and peripheral blood mononuclear cell
268 odels, and perform simulations of electrical activity in various cell types, which show that BKCa-CaV
273 e lead compounds, 6 and 12, exhibited strong activity in vitro against a wide panel of M. abscessus i
274 s analyzed were found to possess antioxidant activity in vitro and a wide range of phenolic and organ
275 that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cel
276 re-based design and focused on antibacterial activity in vitro and in vivo, culminating in the discov
278 .V742G variant showed reduced ubiquitination activity in vitro and white blood cells from affected in
279 t disrupt the base triples reduce telomerase activity in vitro NMR studies also reveal that the pseud
280 ations lead to modulation of their chaperone activity in vitro, the in vivo functions of alphaB-cryst
282 lico refinement and screening for biological activity in vitro, we identified 21 hit compounds which
286 )F-FASu as a specific gauge for system xC(-) activity in vivo and its potential for breast cancer ima
290 efore accumulates within HSCs to promote Tet activity in vivo, limiting HSC frequency and suppressing
296 UMOylation is tightly controlled by neuronal activity, in which synapse to nucleus signalling, mediat
297 s the reference standard, a test for NK cell activity in whole blood samples identified patients with
298 o the RNR beta subunit and the RNR catalytic activity in yeast mutants depleted of individual compone
299 sess tactile defensiveness and barrel cortex activity in young and adult Fmr1 knock-out mice, the mou
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