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1 der include: unifying implementation science activities through a single organizational structure, li
2 network models that self-generate irregular activity through a balance of excitation and inhibition.
3 t expression of Mef2c by de-repressing MEF2C activity through a Calmodulin-CamKII-histone deacetylase
6 hat the IKK regulator NLRC5 shapes NF-kappaB activity through a feedforward loop of NLRC5 ubiquitinat
8 t cytokinin signaling specifies meristematic activity through a graded distribution that influences t
9 ensing by directly inhibiting cGAS enzymatic activity through a mechanism involving both cGAS binding
10 wn to be involved in the coordination of BER activity through a mechanism regulated by the sirtuin 1
11 ese effects indicate that the propagation of activity through a multi-stage network regulates the wir
14 the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus af
15 adults, and that LRF confers its repressive activity through a NuRD repressor complex independent of
16 functions of MMP12, including antimicrobial activity through a peptide within its C-terminal domain
17 oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for o
18 al 5A (NS5A) protein, which impaired p38MAPK activity through a polyproline motif-dependent interacti
19 ind and cooperatively regulate TBX3 promoter activity through a Smad-binding element at -67 base pair
20 suggesting that LINC complexes support RhoA activity through a transcription-independent mechanism.
21 Tight control of psoriatic arthritis disease activity through a treat-to-target approach significantl
22 R signaling, and, finally, modulation of ATR activity through a variety of post-translational modific
25 ates thermomorphogenesis by suppressing PIF4 activity, through a reduction in PIF4 protein level.
27 tion include regulation of potassium channel activity through abscisic acid signaling, transporter ac
28 cetylation at Lys-183 by p300 potentiates PR activity through accelerated binding of its direct targe
29 an oral drug stimulating the parasympathetic activity through acetylcholinesterase inhibition, in exp
31 he endocannabinoid system modulates dopamine activity through activation of cannabinoid type 1 recept
32 diomyocytes, STIM1 acts by tuning Akt kinase activity through activation of mTOR complex 2, which fur
33 tor (GEF), Epac, known to down-regulate RhoA activity through activation of Rap1 GTPase activity incr
35 d and periphery, adenosine inhibits neuronal activity through activation of the adenosine A1 receptor
36 tested the hypothesis that HNE inhibits LKB1 activity through adduct formation on a specific reactive
38 MCF7-BK-TR cells due to stimulation of MnSOD activity through agonistic effects at mitochondrial ERbe
39 s a multifaceted process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously u
40 s a multifaceted process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously u
42 ly, pharmacologic modulation of beta-catenin activity through alpha-catenin is a potentially attracti
43 control Smad2 and Smad3 transcription factor activities through alternate Activin type 2 receptors.
44 Ca(2+) regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca(2+)-
45 e that LAP1 and LULL1 regulate Torsin ATPase activity through an active site complementation mechanis
47 ain and triggers activation of its E3 ligase activity through an autocatalytic mechanism that amplifi
48 findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism.
49 ADAM10 negatively regulates its constitutive activity through an ER retention motif but is dispensabl
51 arious stresses, the Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unc
52 emonstrating that RTEF-1 stimulates promoter activity through an insulin response element and also me
54 oreover, we find that Abl exerts its diverse activities through at least two different mechanisms: (1
55 dritic MORs in POMC neurons inhibit neuronal activity through at least two effectors with distinct le
56 metastatic melanoma patients show anti-tumor activity through B-cell depletion by anti-CD20 antibody.
59 KII, have been demonstrated to regulate CREB activity through both positive and negative phosphorylat
61 roposed that internal Ca(2+) increases TrpV4 activity through Ca(2+)-CaM binding to a C-terminal Ca(2
64 We propose that rapid alteration of PTEN activity through changes in its phosphorylation status c
66 ons are required to achieve full therapeutic activity through clearance of IgG-opsonized virions and
67 s for multidimensional control of functional activities through combinations of orthogonal, drug-tuna
68 t to prevent inappropriate levels of spiking activity through compensatory adjustments in the strengt
71 m channels helps fine-tune long-term channel activity through conformational changes at the selectivi
73 activity was proposed to link to production activity through connecting fibre tracts, forming the le
74 ion for the regulation of specific enzymatic activities through controlling the conformations of two
78 hip connecting adhesion signaling to YAP/TAZ activity through cytoskeleton dynamics remains poorly un
79 Rho family of GTPases on HSC and progenitor activity through cytoskeleton-mediated signaling pathway
80 sis in behaving rats, monitoring respiratory activity through diaphragm electromyogram, which allowed
81 ymes, and quite often affect their catalytic activity through different mechanisms such as reduced ac
83 receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gbetagamma subuni
84 nds have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43
86 ibutes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition o
87 M, suggesting that ATM can modulate DNA-PKcs activity through direct phosphorylation of DNA-PKcs.
90 ty of GPe-STN neurons reliably patterned STN activity through disinhibition and inhibition, respectiv
93 mutant proteins restored full oncogenic Ras activity through diverse mechanisms, which included acqu
94 new insight into how regulation of enhancer activity through DNA methylation can have dramatic conse
96 als, and could also impact peripheral T cell activity through effects of self-peptide.L(d) interactin
97 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
98 s pro-inflammatory NF-kappaB transcriptional activity through effects on the cytosolic NADH:NAD(+) ra
101 ed that selective manipulation of baroreflex activity through electrical carotid sinus stimulation in
103 cyte and macrophage phagocytic and cytotoxic activities through enhanced binding to CD16a under condi
104 we explore potential regulation of physical activity through epigenetic mechanisms, including those
105 served ascending system that gates forebrain activity through fast and powerful synaptic inhibition o
107 t it serves to curb high levels of courtship activity through functioning as an inhibitory neuromodul
112 ing of molecules with potential antimalarial activity through heme-binding mechanism are described.
113 ical role in DNA binding and transcriptional activity through heterodimeric association with several
115 hips demonstrate that this compound achieves activity through hydrophobic and aromatic substituents o
116 ized and screened for their antiinflammatory activities through in vitro and in vivo experiments.
117 nto the intracellular mechanism of sorafenib activity through in situ kinome profiling identified the
118 ial library toward cysteine-mediated protein activities through incorporation of thiol-specific elect
119 ote EADs and underlie the enhanced triggered activity through increased forward mode of Na(+)/Ca(2+)
121 enhance glycogen synthase kinase (GSK)-3beta activity through increased phosphorylation of Tyr-216 in
122 d, enhanced, and selective antiproliferative activity through inducing cell apoptosis confirmed by nu
123 Ci, which positively regulates Hh signaling activity through inhibiting Ci ubiquitination and degrad
124 or of Yes-associated protein (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats
126 , we propose that prolonged induction of AHR activity through inhibition of CYP1 disturbs feedback re
127 own to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function.
129 c inhibitory receptor that modulates NK cell activity through interacting with HLA-A and HLA-B allele
130 ibited Npas2 gene transcription and promoter activity through interaction with Rorgamma to repress Ro
131 aNp63 mRNA, protein expression, and promoter activity through interaction with the transcription fact
133 trogen is indispensable for sustaining human activities through its role in the production of food, a
134 lts show that PGD2 markedly augments disease activity through its ability to enhance the proinflammat
135 hat ChREBP regulates EtOH metabolism and ADH activity through its direct control of sirtuin 1 express
137 This molecule displays trispecific binding activity through its recognition of the CD20 molecule on
140 ay recruit other brain regions and propagate activity through large brain networks, which comprise br
141 es both in vitro and in vivo and exert their activity through locus-specific alterations of histone a
142 lar Mg(2+) concentration can modulate enzyme activity through long-range interactions in the protein,
143 emonstrate their cell type-specific receptor activities through loss of function and gain of function
145 Pin1 proved to be a main regulator of FOXM1 activity through MEK-dependent physical regulation durin
146 ly held that streptolysin S exerts its lytic activity through membrane disruption, its exact mode of
147 ofactor tissue factor (TF), which stimulates activity through membrane-dependent substrate recognitio
151 dy we investigated the role of mitochondrial activity through mild uncoupling during in vitro activat
152 Furthermore, quercetin has anti-obesity activity through mitogen-activated protein kinase and ad
153 e to understand the origins of resting state activity through modeling via a global spiking attractor
154 both muscarinic antagonist and beta2 agonist activities, through modification of the linker motif, to
156 whether these mAbs could influence enzymatic activity through modulation of TG2 susceptibility to oxi
157 oth lacking extracellular domains and kinase activity, through mRNA degradation to promote immunity.
158 as a preferred location of repeated hominin activity through multiple changes in climate and local e
159 it level requires representation of neuronal activity through multiple recording sites and at high sa
166 documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is kno
167 that JP-8g may execute its anti-inflammatory activity through nitric oxide synthase signaling pathway
168 matory cytokine that exhibits chemokine-like activities through non-cognate interactions with the che
170 ally to Hmox1 induction and mitochondrial HO activity through Nrf2 transcriptional and Akt kinase act
174 ene but exhibit reduced p53 tumor suppressor activity through overexpression of the negative regulato
175 l protrusions and that H2O2 inhibits cofilin activity through oxidation of cysteines 139 (C139) and 1
176 nd sertraline, directly suppress TIDA neuron activity through parallel effects, independent of 5-HT t
177 increasing dihydrosphingosine activates Mef2 activity through PDK1 in mammalian neuronal cell line su
178 ence on CaM, but also limited maximal enzyme activity through persistence of LAVP-mediated autoinhibi
179 urinergic P2Y receptors, and modulates Duox1 activity through phospholipase C (PLC) and intracellular
180 rotein Kinase A (PKA) modulates Hh signaling activity through phosphorylating the transcription facto
181 e cAMP-PKA pathway negatively regulates AMPK activity through phosphorylation at Ser-485/497 on the a
183 domain kinase (LIMK), which regulates actin activity through phosphorylation of cofilin, an actin-de
184 t DYRK1A stimulates GLI transcription factor activity through phosphorylation of general nuclear loca
185 factor receptor (EGFR) modulates invadopodia activity through phosphorylation of the actin regulatory
187 contrary to most bacteria that regulate ICDH activity through phosphorylation, Mtb is capable of regu
188 ynthetic scalability and excellent catalytic activity through physical-transformation into 3D structu
190 eal a mechanism of downregulation of RhoGDI2 activity through PKC-mediated phosphorylation of Ser31.
191 F-23 promoter and stimulated FGF-23 promoter activity through PLCgamma/calcineurin/NFAT and MAPK path
192 h extracts presented significant antioxidant activity through positive interactions with the lipid bi
196 urthermore, we show that Ypk1 regulates Pkc1 activity through proper localization of Rom2 at the plas
199 high solubility, and retention of biological activity through purification and storage steps are requ
203 ing controls complex functions such as motor activity through regulation of cell firing and heterolog
204 limits LPS-induced NF-kappaB transcriptional activity through regulation of intracellular redox state
206 G-T risk haplotype decreased transcriptional activity through rs7278468, which lies in a consensus bi
207 cells restore the majority of these reduced activities through selection of specific genomic mutatio
209 cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, in
210 ieved by the induction of its expression and activity through shifting from cytoplasm to the nucleus.
211 as an inactive input should suppress network activity through shunting; this prediction was supported
212 ron-alpha (IFN-alpha) exhibits its antiviral activity through signal transducer and activator of tran
213 dence suggests that UPF3A acquired repressor activity through simple impairment of a critical domain,
214 , plays a critical role in regulation of Vav activity through stabilization of the Dbl homology domai
215 ate that inhibition of WAVE2-mediated Arp2/3 activity through stable shRNA knockdown of Arp3 dramatic
217 in their lmFG, we found that disrupting lmFG activity through stimulation, and later surgical resecti
219 side studies that attempted to dissect these activities through structural and biochemical characteri
220 zation requires SUMOylated TOP2A CTD binding activity through SUMO-interaction motifs and the phospho
222 ptide substrates for the detection of BoNT/E activity through systematic and comprehensive approaches
225 harmacological inhibition of viral E3 ligase activity through targeting SOCS box motifs is a putative
226 that carnosine may exert its neuroprotective activities through the histidine/histamine pathway.
227 t, antibodies also exhibit effector-mediated activities through the interaction of the Fc glycan and
228 uring the study of evolution of PaO and RCCR activities through the olive fruits maturation in two va
230 of RelA but also its inflammatory suppressor activities through the regulation of the interleukin-4 s
231 ial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-
232 ulosis, vitamin A supplementation, and other activities, through the work of widely deployed communit
234 cholinergic neurons is to inhibit EEG delta activity through the activation of cerebral cortex, rath
235 nt antioxidants and displayed cytoprotective activity through the activation of nuclear factor erythr
236 of tremor episodes drives tremulous network activity through the basal ganglia or the cerebello-thal
238 localization, dimerization, and antipoxviral activity through the characterization of BAF phosphomime
239 sion studies suggest that Bmh regulates Adr1 activity through the coactivators Mediator and Swi/Snf.
240 ores results in synergistic cardioprotective activity through the combination of both molecular pathw
242 regulator that recruits histone modification activity through the CtBP repressor complex exclusively
243 onstrate that increasing cellular proteasome activity through the direct delivery of purified proteas
244 cepts in electrocatalysis is to optimise the activity through the direct engineering of the propertie
245 We measured mutation impact on the enzyme activity through the estimation of amoxicillin minimum i
246 ively cool the body during extreme prolonged activity through the evapotranspiration of water on the
247 obe neurons or the inhibition of presynaptic activity through the expression of dominant negative dyn
248 chia coli class I RNRs, dATP inhibits enzyme activity through the formation of inactive alpha6 and al
250 cellular mechanism regulating mitochondrial activity through the function of the inner membrane dyna
251 mor-related neuronal activity) drove network activity through the GPi, which effectively influenced t
253 ote both long-lasting and glucose-responsive activity through the incorporation of an aliphatic domai
254 presses mammalian target of rapamycin (mTOR) activity through the induction of an mTOR inhibitor, DDI
255 hanism(s) by which HNK exerts its anti-tumor activity through the inhibition of c-Met-Ras-HO-1 axis;
256 /Akt pathways control cell survival and mTOR activity through the inhibitory post-translational phosp
257 information in the form of border modulated activity through the integration of additional sensory m
258 is dependent on regulation of BAMBI promoter activity through the interaction with NF-kappaBp50 and H
259 episodes (assessed using EMG) drove network activity through the internal globus pallidus (GPi), ext
260 tion of normal patterns of prefrontal cortex activity through the loss of cAMP regulation of metabotr
261 ly confirmed that these agents trigger their activity through the mitochondria-dependent apoptosis.
262 recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol
263 regulate the aromatase gene transcriptional activity through the recruitment of nuclear receptor cor
264 ation leads to inhibition of IKKalpha kinase activity through the recruitment of PP2A, allowing ASC t
265 usion, PGE2 increases both TF expression and activity through the regulation of the EP1/SIRT1 pathway
266 (azocasein) was used to quantify the enzyme activity through the release of a chromogenic product th
268 sponse to redox events by regulating protein activity through the reversible formation of disulfide b
269 ation occurred independent of ubiquitination activity through the RING-between-RING domain, providing
270 ce a coordinated change in Na(+),K(+)-ATPase activity through the signaling of protein kinases such a
271 agation of ascending sensory-evoked afferent activity through the thalamus en route to the cortex.
274 ed the role of sumoylation in regulating TDG activity through the use of TDG mutants defective for su
275 and Sp3 were potent inducers of the promoter activity, through the binding of several GC-rich boxes.
276 ruit additional ligand proteins with diverse activities through their dimerization domain, the chromo
277 ungal functional composition and soil enzyme activities through their direct effect on dissolved orga
278 rent extraction methods affected antioxidant activities through their effect on biologically active c
279 eceptors (D2R) are major regulators of motor activity through their signaling on striatal projection
280 e receptors (KARs) regulate synaptic network activity through their slow channel kinetics, most promi
281 opposite effects on the brown adipose tissue activity through thermoregulatory nuclei such as the dor
282 nsory stimuli trigger cascades of electrical activity through these circuits, causing specific featur
286 cleavage and offer potential ways to inhibit activity through this receptor, which may dampen autoimm
287 Notably, we found that E93 controls enhancer activity through three different modalities, including p
289 ynthetic ligands of TSPO do not regulate PTP activity through TSPO, 3) outer mitochondrial membrane r
290 ell as their relationship to changes in drug activity through two algorithms: e-Driver and e-Drug.
291 t least in some cell types, Sin3b limits Myc activity through two complementary activities: Mxd-depen
292 ements arise from disturbed striatal resting activity through two different population dynamics.
293 ator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or m
294 tivation of GPER/GPR30 further inhibits PMCA activity through tyrosine phosphorylation of the pump.
295 action to achieve delicate control of oxygen activity through uniformly creating oxygen vacancies wit
296 omodimers to promote greater transcriptional activity through utilization of IRF3:IRF7 heterodimers.
297 relationships are correlated with enzymatic activity through variable pressure kinetic studies of el
299 dings support that netrin-1 exerts oncogenic activity through YAP signaling, providing a mechanism co
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