ライフサイエンスコーパス: activity-dependent

1 ss I HDACs and nuclear actin was found to be activity dependent.

2 regeneration are not static and are largely activity dependent.

3 promoters, particularly promoter I, which is activity-dependent.

4 6-silenced hippocampal synapses and found an activity dependent accumulation of synaptic endosome-lik

5 dynamically in maturity by the competitive, activity-dependent actions of sensory fibers.

6 g of myelinated fibers and suggest that this activity-dependent alteration of myelination is importan

7 ic accessory protein required for efficient, activity-dependent AMPAR endocytosis.

8 in cultured neurons that C1ql3 expression is activity dependent and supports excitatory synapse densi

9 for determining the role of ZAP-70 catalytic activity-dependent and -independent signals in developin

10 Activity-dependent and BDNF-dependent neuroplasticity wi

11 cing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternativ

12 PR/Cas9 genome editing to separate catalytic activity-dependent and independent functions of Mll3 (Km

13 e spinal motor circuits is dependent on both activity-dependent and independent mechanisms during pos

14 Shh mediates activity-dependent and injury-induced hippocampal neurog

15 Long-term potentiation (LTP) is an activity-dependent and persistent increase in synaptic t

16 This trafficking into selected spines is activity-dependent and results in exocytosis of syt-IV-c

17 Therefore, activity-dependent anterograde capture is a major determ

18 Together, our results reveal that activity-dependent APA provides an important layer of ge

19 of neurovascular coupling (NVC) implies that activity-dependent axonal glutamate release at synapses

20 neurotrophic factor (BDNF) sequence reduces activity-dependent BDNF release and is associated with p

21 The results identify an essential role for activity-dependent BDNF release in the rapid antidepress

22 Here we tested the hypothesis that activity-dependent BDNF release within the mPFC is neces

23 dulators of cognitive behavior that regulate activity-dependent BDNF secretion and/or potentiate TrkB

24 find that increased OB ACh leads to dynamic, activity-dependent bi-directional modulation of glomerul

25 Activity-dependent bidirectional modifications of excita

26 derstand the effect of early brain injury on activity-dependent brain development and cortical plasti

27 ecular similarities to calcineurin-regulated activity-dependent bulk endocytosis in neurons, which re

28 ts independently of futsch/MAP-1B to abolish activity-dependent, but not constitutive, capture.

29 ndoB2 or the CPG2-EndoB2 interaction impairs activity-dependent, but not constitutive, internalizatio

30 Activity-dependent Ca(2+) signalling is well established

31 ined by multiple signaling events, including activity dependent calcium transients.

32 in DMV neurons, which led to a reduction in activity-dependent calcium influx via Cav channels.

33 mon molecular pathways that are regulated by activity-dependent changes in neurons.

34 omo1 proteins as central mediators in neural activity-dependent changes in SV distribution among SV p

35 SIGNIFICANCE STATEMENT: Activity-dependent changes in synaptic strength constitu

36 Objective: To examine whether neuronal activity-dependent changes of gene expression are dysreg

37 The effect of activity-dependent changes of gene expression in schizop

38 hat were associated with a blunted effect of activity-dependent changes of gene expression in schizop

39 to further our understanding on the role of activity-dependent changes of gene expression in the eti

40 can accommodate the function of synapses to activity-dependent changes.

41 activities to study the processes underlying activity-dependent circuit changes.

42 atiotemporal patterns are critical for early activity-dependent circuit elaboration and refinement in

43 es this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synapti

44 ite association is critical specifically for activity-dependent CME of synaptic glutamate receptors.

45 al conditions, receptors and G proteins form activity-dependent complexes that last for around one se

46 lopmentally hardwired and olfactory receptor activity-dependent components that establish and maintai

47 lignment in the SC that incorporate distinct activity-dependent components.

48 Taken together, the activity-dependent control of Ca(2+) signals by A-type c

49 wth to uncover fresh molecular insights into activity-dependent control of the adult nervous system's

50 nd output neuron classes exhibit distinctive activity-dependent critical period dendritic remodeling.

51 ein binding that modulate calcium signaling, activity-dependent critical period development, and the

52 expressed in primate neocortex and restricts activity-dependent dendritic growth in human neurons.

53 Importantly, activity-dependent dendritogenesis in both neuron classe

54 projections to Dbx1 preBotC neurons undergo activity-dependent depression and we identify a refracto

55 ENT Activation of NMDARs is critical for the activity-dependent development and maintenance of highly

56 ster of pregnancy, a "precritical period" of activity-dependent development characterized by the onse

57 lated myoclonic twitches is thought to drive activity-dependent development in spinal cord and brain.

58 opportunity for sensorimotor integration and activity-dependent development of topography within the

59 ming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hy

60 terneurons in schizophrenia and predicts the activity-dependent down-regulation of parvalbumin and GA

61 activity of parvalbumin interneurons and an activity-dependent down-regulation of parvalbumin expres

62 ty, as determined by using the mitochondrial activity-dependent dye Mitotracker CM-H2TMRosa, is highe

63 r links to a well-studied form of endogenous activity-dependent ectopic axon outgrowth in the same ne

64 Activity-dependent endocannabinoid release may modulate

65 Our findings suggest that activity-dependent exocytosis of Cathepsin B from lysoso

66 +/PSD95+ puncta on PV+ neurons predicted the activity-dependent expression levels of parvalbumin and

67 re it is expressed at very low levels, in an activity-dependent fashion.

68 excitatory-inhibitory balance shifting in an activity-dependent fashion.

69 olved in reinstating specific content, in an activity-dependent fashion.SIGNIFICANCE STATEMENT Upsett

70 promote actomyosin ring assembly and a motor activity-dependent form that supports ring contraction.

71 lts do not support a role for deacylation in activity-dependent Galphas internalization.

72 hibitory interneurons that in turn rely upon activity-dependent gene expression for morphological dev

73 f genomic DNA mediate the rapid induction of activity-dependent gene expression in neurons.

74 g-lasting changes in neural circuits through activity-dependent gene expression.

75 induced significantly more expression of the activity-dependent gene Fos in both D1 and D2 dopamine r

76 By orchestrating distinct activity-dependent gene programs in different neuronal p

77 stigated the molecular mechanisms regulating activity-dependent gene transcription upon activation of

78 tion promotes coupling of Cav1.2 channels to activity-dependent gene transcription.

79 While activity-dependent gene-responsiveness showed little dep

80 Glutamate-receptor signaling initiates the activity-dependent generation of Nrxn-CTF, which accumul

81 signals induce preferential transcription of activity-dependent genes containing promoters with proxi

82 the roles and mechanisms of inactivation of activity-dependent genes have remained poorly understood

83 re NuRD subunit Chd4 impairs inactivation of activity-dependent genes when neurons undergo dendrite p

84 ts the histone variant H2A.z at promoters of activity-dependent genes, thereby triggering their inact

85 We used activity-dependent genetic labeling to characterize neur

86 spect of neuronal energy metabolism in which activity-dependent glutamate release enhances oligodendr

87 Our results suggest that activity-dependent homeostatic mechanisms are better sui

88 this study, we assessed long-term changes in activity-dependent immediate early genes c-Fos and Arc/A

89 ound that CR cell density is sustained by an activity-dependent importation of olfactory CR cells, wh

90 ur cell-conditioned media as well as an iNOS activity-dependent increase in EGFR activity in tumour c

91 reagent latrunculin-B (Lat-B) abolished the activity-dependent increase in spEPSC amplitude in both

92 al layer 1 lacking principal neurons with an activity-dependent increase of extracellular potassium.

93 MCU knockdown did not perturb activity-dependent increases in presynaptic free calcium

94 neuronal activity; however, the mechanism of activity-dependent instruction remains unclear.

95 This study examined activity-dependent interactions between the developing c

96 ents is constitutive endocytosis rather than activity-dependent internalization.

97 t expression but not the result of a blunted activity-dependent intracellular Ca(2+) increase followi

98 Finally, we describe a novel form of activity-dependent intrinsic plasticity that persistentl

99 pant in a circuit or whether this process is activity dependent is not known, especially as spike-dep

100 s, identified by 2-photon Ca(2+) imaging and activity-dependent labeling to recruit the relevant neur

101 piny neuron axons using immunocytochemistry, activity-dependent labeling, and electrophysiology have

102 We find differences in activity-dependent lateral inhibition between mitral and

103 gaged in exocytosis, a result confirmed with activity-dependent loading of the endocytic probe FM1-43

104 The mechanisms of activity-dependent local regulation of AMPAR expression,

105 suggest a novel mechanistic link between an activity-dependent long non-coding RNA and epilepsy.

106 dentified a crucial role for this pathway in activity-dependent long-term depression (LTD) at hippoca

107 ial role for canonical JAK-STAT signaling in activity-dependent LTD at TA-CA1 synapses and provide va

108 induction (P < 0.05) in an mTOR- and InsP3R- activity dependent manner.

109 lysosomes traffic to dendritic spines in an activity-dependent manner and can be recruited to indivi

110 at a subset of SV proteins is degraded in an activity-dependent manner and that key steps in this deg

111 tracellular adenosine level fluctuates in an activity-dependent manner and with sleep-wake cycle, mod

112 ealed that vesicle motion is modulated in an activity-dependent manner apparent as the reduction in o

113 ndings suggest that m(6)A is regulated in an activity-dependent manner in the adult brain, and may fu

114 (NTR) was static, SorCS2 bound to TrkB in an activity-dependent manner to facilitate its translocatio

115 dulating spontaneous neurotransmission in an activity-dependent manner, but not for viability.

116 glial connexin 43 hemichannels, opened in an activity-dependent manner, increases UP state amplitude

117 e release of various neurotransmitters in an activity-dependent manner, thereby influencing the excit

118 erved that vesicle motion is modulated in an activity-dependent manner, with dynamical changes appare

119 molar) increases in cGMP concentration in an activity-dependent manner.

120 synaptic terminals and stabilizes them in an activity-dependent manner.

121 gical properties and release serotonin in an activity-dependent manner.

122 nhibits CFA-induced hyperalgesia in a kinase activity-dependent manner.

123 ppresses the SIAH2 protein level in a kinase activity-dependent manner.

124 rn but not early-born neurons relocate in an activity-dependent manner.

125 it regulated STAT3 phosphorylation in a GEF activity-dependent manner.

126 drites by compartmentalizing functions in an activity-dependent manner.

127 rontal cortex (mPFC) in a transcription- and activity-dependent manner.

128 am and epigenetic landscape in a demethylase-activity-dependent manner.

129 cuits underlying memory and navigation; this activity-dependent maturation occurs sequentially along

130 ation mutant mouse models, suggesting either activity-dependent mechanism is plausible.

131 Currently, the only activity-dependent mechanism known to support such bidir

132 Activity-dependent mechanisms also contribute to wiring

133 o focus on the synapse, where well-described activity-dependent mechanisms are known to play a key ro

134 of topics demonstrates how developmental and activity-dependent mechanisms coordinate inhibition in r

135 axon diameters are dynamic and regulated by activity-dependent mechanisms.

136 synapse maturation involving epigenetic and activity-dependent mechanisms.

137 t with a low dose of the potent and specific activity-dependent mGluR1-negative allosteric modulator

138 ffected microRNA expression levels, with the activity-dependent miR-124 and miR-132 being upregulated

139 Knockdown of MCU resulted in ablation of activity-dependent mitochondrial calcium uptake but had

140 Additionally, activity-dependent mitochondrial positioning by Miro1 re

141 the microtubule transport network to control activity-dependent mitochondrial positioning in neurons.

142 We examine two activity-dependent models, which tune weak network conne

143 porally overlapping activity-independent and activity-dependent modes of myelination are beginning to

144 arations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks,

145 that it is a presynaptic regulator of rapid activity-dependent modifications in synaptic structure.

146 Learning is primarily mediated by activity-dependent modifications of synaptic strength wi

147 ptical electrophysiology techniques to study activity-dependent modulation of ion channels, in a form

148 Activity-dependent modulation of myelination can dynamic

149 Formation and activity-dependent modulation of PSDs is considered as o

150 It is vital for activity-dependent modulation of synaptic transmission a

151 Activity-dependent modulation of vesicle mobility may re

152 cal states during recycling and reveal their activity-dependent modulation.

153 se sites in small central synapses and their activity-dependent modulation.

154 es from the cortex, which provides a strong, activity-dependent modulatory feedback influence on info

155 However, the activity-dependent molecular mechanisms remain incomplet

156 Inhibiting activity-dependent mRNA translation through mechanistic

157 e to transform neurotransmitter release into activity-dependent myelination.

158 hat the L1CAM mutation selectively decreased activity-dependent Na(+)-currents, altered neuronal exci

159 llus), NL is a well-studied model system for activity-dependent neural plasticity.

160 ownregulation of the alternative splicing of activity-dependent neuron-specific exons, and attenuatio

161 ar dominance plasticity (ODP), a paradigm of activity-dependent neuronal plasticity in the visual cor

162 Activity-dependent neuronal plasticity is a fundamental

163 Identifying the mechanisms of activity-dependent neuronal plasticity is crucial to fin

164 (required for Pc-ODP).SIGNIFICANCE STATEMENT Activity-dependent neuronal plasticity is the cellular b

165 rly play critical roles in the regulation of activity-dependent neuronal transcription, synaptic conn

166 des in cross-modal signaling, by showing how activity-dependent neuropeptide signaling leads to speci

167 e Met allele, which is linked with decreased activity-dependent neuroplasticity.

168 hat this synaptic rearrangement requires the activity-dependent, non-apoptotic Bax/Bak-caspase signal

169 ity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell death.

170 athway, and interfered with viral polymerase activity (dependent on its PB1-binding capability).

171 he expression of the Rag activator Foxo1, an activity dependent on M303 in c-Myb's transactivation do

172 s and gene coexpression analysis to identify activity-dependent or disease-specific changes of the tr

173 uced hippocampal memory deficits through BLA activity-dependent p25 generation.

174 Here we show that activity-dependent palmitoylation of the atypical AMPA r

175 enhancement or a decrease, respectively, of activity-dependent parameters.

176 hat these actions of Tomo1 are regulated via activity-dependent phosphorylation by cyclin-dependent k

177 t the SNARE fusion clamp Complexin undergoes activity-dependent phosphorylation that alters the basic

178 ity, increasing evidence supports a role for activity-dependent, plastic changes in myelin-forming ce

179 ects of intraspinal inflammation and augment activity-dependent plasticity (e.g., rehabilitation) and

180 removal of PNNs opens for plasticity and how activity-dependent plasticity affects neural activity ov

181 ity, suggesting a novel mechanism initiating activity-dependent plasticity and driving the rapid chan

182 adverse effects of inflammation and augment activity-dependent plasticity and restoration of functio

183 accompanying electrophysiological changes to activity-dependent plasticity and we report on novel mec

184 r in both areas at this age, suggesting that activity-dependent plasticity between visual and associa

185 Experimentally induced activity-dependent plasticity by monocular deprivation c

186 Synaptic connections undergo activity-dependent plasticity during development and lea

187 NMDAR signaling using DCS therefore enhanced activity-dependent plasticity in human adults, as demons

188 By inducing activity-dependent plasticity in the visual cortex of ad

189 CaMKII is an ideal candidate for mediating activity-dependent plasticity in touch because it shifts

190 find therapeutic targets for diseases where activity-dependent plasticity is disrupted.

191 nges in movement, it remains unknown whether activity-dependent plasticity is sufficient to produce l

192 Activity-dependent plasticity modulated by reward is tho

193 ther demonstrate that microglia regulate the activity-dependent plasticity of glycinergic synapses by

194 emporal lobe epilepsy, little is known about activity-dependent plasticity of their synaptic connecti

195 response to spaced depolarization, a type of activity-dependent plasticity shown to require both tran

196 mission and are selectively recruited during activity-dependent plasticity to increase synaptic stren

197 role for RIT1 function in the modulation of activity-dependent plasticity, exercise-mediated potenti

198 ease that is necessary for the full range of activity-dependent plasticity, we conclude that it proba

199 us release frequency that takes place during activity-dependent plasticity.

200 tential new mechanisms for the initiation of activity-dependent plasticity.

201 different sorbate concentrations, a sorbate-activity-dependent polyparameter linear free-energy rela

202 Here we found that activity-dependent potentiation of presynaptic voltage-g

203 tter, has long been presumed to mediate this activity-dependent process, but glutamatergic transmissi

204 These findings reveal that activity-dependent processes are central bona fide compo

205 eak, FLARE should be useful for the study of activity-dependent processes in neurons and other cells

206 T: Synaptic refinement and strengthening are activity-dependent processes that establish orderly arra

207 Synaptic refinement and strengthening are activity-dependent processes that establish orderly arra

208 Although these patterns can be adjusted by activity-dependent processes, they were found to be cons

209 ress-compromised rats, suggesting a role for activity-dependent protein synthesis in the therapeutic

210 e show that expression of many stress and/or activity-dependent proteins is highly induced while some

211 Application of this method, activity-dependent proximity ligation (ADPL), to serine

212 Activity-dependent pruning also occurs at embryonic Dros

213 ostpubertal monkeys and positively predicted activity-dependent PV levels, suggesting a greater stren

214 We conclude that an activity-dependent quantal size increase contributes to

215 put is linear but shows enhanced gain due to activity-dependent recruitment of NMDA receptors.

216 A similar activity-dependent reduction in synaptic strength also o

217 This analysis highlights the utility of activity-dependent regulation in achieving homeostasis a

218 KCC2 undergoes activity-dependent regulation in both physiological and

219 This activity-dependent regulation is unique among histone-mo

220 Activity-dependent regulation of intrinsic excitability

221 show that, in mixed neuron glia co-cultures, activity-dependent regulation of metabolic gene expressi

222 al studies and from human neuroimaging, that activity-dependent regulation of myelin may play a role

223 that downregulation of active transporters (activity-dependent regulation) is a simple and biologica

224 6Met allele, which blocks the processing and activity-dependent release of BDNF.

225 or for vesicle fusion, a crucial step in the activity-dependent release of neurotransmitter.

226 crotubules required for axonal transport and activity-dependent remodeling of presynaptic terminals.

227 The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance betwe

228 Here we show that BRAG1 is required for the activity-dependent removal of AMPA receptors in rat hipp

229 that the Rab35/ESCRT pathway facilitates the activity-dependent removal of specific proteins from SV

230 tract fibres and spinal motoneurones undergo activity-dependent reorganization.

231 tract fibres and spinal motoneurones undergo activity-dependent reorganization.

232 es and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptid

233 e synaptic plasticity through the release of activity-dependent retrograde signals.

234 bafilomycin A1, respectively, inhibited the activity-dependent retrograde trafficking of BoNT/A-Hc.

235 Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensi

236 of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), th

237 results support the hypothesis that reduced activity-dependent secretion of BDNF impairs the benefit

238 As a consequence, the activity-dependent secretion of BDNF in the vitreous is

239 egregation, indicating a critical period for activity-dependent shaping of patterns of innervation.

240 onal conductance, thus demonstrating spiking activity-dependent short-term plasticity of electrical s

241 we speculate that CDKL5 deficiency disrupts activity-dependent signaling and the consequent synapse

242 ervous system, this work has investigated an activity-dependent signaling mechanism in the peripheral

243 he hypotheses that dysregulation of neuronal-activity-dependent signaling plays a significant part in

244 sively slower speeds, but the impact of this activity-dependent slowing (ADS) is unknown.

245 C fibers display activity-dependent slowing (ADS), whereby repetitive sti

246 reasing sympathetic outflow and by measuring activity-dependent slowing at 2 Hz stimulation.

247 vel feedback signal that is critical for the activity-dependent stabilization of presynaptic terminal

248 itic spine density and impaired responses to activity-dependent stimulation.

249 dendritic spine morphology, and responses to activity-dependent stimulations.

250 tem governing map alignment depending on the activity-dependent strategy utilized.

251 A larger propensity for activity-dependent strengthening at muscle afferent syna

252 ong-term potentiation (LTP), a long-lasting, activity-dependent strengthening of synaptic transmissio

253 d function for dynamic MTs in enabling rapid activity-dependent structural plasticity.

254 mation, maintenance of dendritic spines, and activity-dependent structural plasticity.

255 on of ApoER2 and is associated with impaired activity-dependent structural remodeling of spines and d

256 f SNARE-binding Tomosyn1 (Tomo1) proteins as activity-dependent substrates that regulate dynamics of

257 These results suggest that activity-dependent SUMOylation of FOXP1 may be an import

258 ally, model RT neurons are predisposed to an activity-dependent switch from GABA-mediated inhibition

259 however, the cellular mechanisms underlying activity-dependent synaptic and behavioral responses to

260 Spontaneous firing of cartwheel cells led to activity-dependent synaptic depression of individual car

261 Enhanced spontaneous release is required for activity-dependent synaptic growth.

262 FMRP-null PNs lose activity-dependent synaptic modulation, with impairments

263 is may occur via PAFR-mediated modulation of activity-dependent synaptic physiology downstream of mic

264 ural and electrophysiological changes during activity-dependent synaptic plasticity at the Drosophila

265 ociative synaptic learning rule that governs activity-dependent synaptic plasticity in the mouse pref

266 Activity-dependent synaptic plasticity plays a critical

267 ian potentiation, these results suggest that activity-dependent synaptic plasticity underlies the for

268 By modifying rules that govern activity-dependent synaptic plasticity, addictive drugs

269 tion of Arc, a gene known to be critical for activity-dependent synaptic plasticity.

270 hriveled (Shv) regulates synaptic growth and activity-dependent synaptic remodeling at the Drosophila

271 Activity-dependent synaptic remodeling occurs during ear

272 ate that mature OSN axons undergo continuous activity-dependent synaptic remodelling that persists in

273 ance of LTP and LTD plays a critical role in activity-dependent synaptic stabilization and eliminatio

274 the phase separation to occur and for proper activity-dependent SynGAP dispersions from the PSD.

275 that the precise regulation of CaMKv through activity-dependent synthesis and post-translational phos

276 , we propose the coexistence of two distinct activity-dependent systems of bidirectional synaptic pla

277 ding suggest the coexistence of two distinct activity-dependent systems of bidirectional synaptic pla

278 Using a novel activity-dependent technology called CANE developed in o

279 Because the endogenous release of opioids is activity dependent, this modulation of synaptic plastici

280 kinesin-4 KIF21B as a molecular regulator of activity-dependent trafficking and microtubule dynamicit

281 ine an epigenetic mechanism that inactivates activity-dependent transcription and regulates dendrite

282 Here, we demonstrate that the activity-dependent transcription factor, Myocyte enhance

283 anscription, but only silencing required the activity-dependent transcription factors MEF2A/D.

284 x in CRE/TATA-containing promoters to engage activity-dependent transcription in neurons.

285 adult mice, FLARE also gave light- and motor-activity-dependent transcription in the cortex.

286 Activity-dependent transcription influences neuronal con

287 Rodent-based studies show that activity-dependent transcriptional programs mediate myri

288 We compared activity-dependent transcriptional responses in developi

289 Activity-dependent transcriptional responses shape corti

290 ing technology enables robust measurement of activity-dependent transcriptional signatures, cell-iden

291 ly, we show that a system that utilizes both activity-dependent transporter downregulation and regula

292 Activity-dependent transporter regulation creates a trad

293 cribe a long-duration ( approximately 60 s), activity-dependent, TTX- and ouabain-sensitive, hyperpol

294 Based on experimental evidence of activity-dependent tuning of connectivity, we examined p

295 Recently, activity-dependent ubiquitination of the GluA1 subunit h

296 G2019S-induced mtDNA damage is LRRK2 kinase activity dependent, uncovering a novel pathological role

297 This includes the coordinated activity-dependent upregulation of major astrocytic comp

298 s the molecular rhythms via time-of-day- and activity-dependent upregulation of transcription from E-

299 ic-machinery components that are specific to activity-dependent versus constitutive glutamate recepto

300 emporal properties of the release sites were activity dependent with a reduction in reuse frequency a