ライフサイエンスコーパス: acute kidney injury

1 jections of glycerol (rhabdomyolysis-induced acute kidney injury).

2 nal ischemia/reperfusion is a major cause of acute kidney injury.

3 and can be complicated by the development of acute kidney injury.

4 ry outcomes were end-stage renal disease and acute kidney injury.

5 initiation of renal replacement therapy for acute kidney injury.

6 I was not associated with the development of acute kidney injury.

7 t and attenuate the risk of contrast-induced acute kidney injury.

8 sodium, were associated with development of acute kidney injury.

9 ferences in the rates of contrast-associated acute kidney injury.

10 .2) mg/dL and more than 20% had stage 2 or 3 acute kidney injury.

11 Forty-three percent of patients developed acute kidney injury.

12 or for the prevention of contrast-associated acute kidney injury.

13 ath and complications associated with severe acute kidney injury.

14 k of cardiogenic shock, severe bleeding, and acute kidney injury.

15 tional outcomes of children suffering septic acute kidney injury.

16 voke adaptive responses that protect against acute kidney injury.

17 Safety was assessed by the rate of acute kidney injury.

18 idney disease following hospitalization with acute kidney injury.

19 rior allowing more accurate qualification of acute kidney injury.

20 ctive strategy available to prevent or treat acute kidney injury.

21 , which is a key response in the recovery of acute kidney injury.

22 d with genetic susceptibility to in-hospital acute kidney injury.

23 urve had an area under the curve of 0.73 for acute kidney injury.

24 was associated with lower mortality and less acute kidney injury.

25 myocardial infarction, ischemic stroke, and acute kidney injury.

26 tes a strong trend toward the development of acute kidney injury.

27 95% CI, 1.06-1.24; p < 0.001) of more severe acute kidney injury.

28 8%] patients) were the most common causes of acute kidney injury.

29 d non-hospital settings who met criteria for acute kidney injury.

30 urve for plasma angiopoietin-2 levels versus acute kidney injury.

31 hrotoxic drugs are the most common causes of acute kidney injury.

32 logic role in heart ischemia-reperfusion and acute kidney injury.

33 lications, type 4a myocardial infarction, or acute kidney injury.

34 roach for early recognition and treatment of acute kidney injury.

35 and dedifferentiated proximal tubules after acute kidney injury.

36 ther common genetic variants contributing to acute kidney injury.

37 al two genetic loci that are associated with acute kidney injury.

38 injury, 2) pneumonia, and 3) pneumonia with acute kidney injury.

39 events obesity, hepatocellular carcinoma and acute kidney injury.

40 Improving Global Outcomes criteria to define acute kidney injury.

41 could be a potential therapeutic target for acute kidney injury.

42 emia-reperfusion-injury and glycerol-induced acute kidney-injury.

43 rates of procedural complications (5.8%) and acute kidney injury (1.6%) were identical in each group

44 eatening bleeding (8.3% vs. 2.3%; p = 0.03), acute kidney injury (11.1% vs. 4.0%; p = 0.03), and subs

45 .76; 95% CI, 0.62-0.93), lower prevalence of acute kidney injury (16.0% vs 19.2%; p = 0.028; odds rat

46 ex admission and serum creatinine values: 1) acute kidney injury, 2) pneumonia, and 3) pneumonia with

47 001) as well as secondary outcomes of 30-day acute kidney injury (20.8% vs 13.8%, P < .001), 30-day b

48 s also significantly higher in patients with acute kidney injury (28.3% vs 6.1% in the non-acute kidn

49 e 30-day all-cause readmission rates, 30-day acute kidney injury, 30-day blood transfusion, and 1-yea

50 e cardiac injury; 5) The role of exosomes in acute kidney injury; 6) The role of exosomes in sepsis;

51 disability compared with those with no/mild acute kidney injury (64% vs 30%; p < 0.001).

52 r 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient

53 ) availability was limited, particularly for acute kidney injury (8 countries [7%]) and nondialysis C

54 e; tackle major risk factors for CKD; reduce acute kidney injury-a special risk factor for CKD; enhan

55 When acute kidney injury accompanies pneumonia, postdischarge

56 Assessment of acute kidney injury according to the plasma creatinine l

57 orter ICU length of stay, lower incidence of acute kidney injury, acute respiratory distress syndrome

58 Acute kidney injury, acute respiratory failure, and new-

59 r associated with hyperchloremic acidosis or acute kidney injury after controlling for total fluids,

60 cuses on the risk factors for posttransplant acute kidney injury after liver and heart transplantatio

61 RIPC significantly reduced the incidence of acute kidney injury (AKI) [odds ratio (OR) = 0.79; P = 0

62 Acute kidney injury (AKI) affects 3% of all hospitalized

63 To examine the development of acute kidney injury (AKI) after burn injury as an indepe

64 urin inhibitors, data on the consequences of acute kidney injury (AKI) after cardiac transplantation

65 octreotide preconditioning could also reduce acute kidney injury (AKI) after HIR is unknown.

66 Acute kidney injury (AKI) after percutaneous coronary in

67 dequately powered studies comparing rates of acute kidney injury (AKI) among patients receiving vanco

68 ociated with combination regimens, including acute kidney injury (AKI) and Clostridium difficile infe

69 mice 24 hours before IRI markedly attenuated acute kidney injury (AKI) and decreased plasma TNF.

70 It is unclear how septic shock causes acute kidney injury (AKI) and whether this is associated

71 f renal replacement therapy (RRT) for severe acute kidney injury (AKI) but without life-threatening i

72 /tazobactam may be associated with increased acute kidney injury (AKI) compared to vancomycin without

73 m sodium is associated with a higher risk of acute kidney injury (AKI) compared with vancomycin plus

74 , we analyzed outcomes of donor kidneys with acute kidney injury (AKI) in a large UK cohort.

75 Acute kidney injury (AKI) in children is associated with

76 eria for the diagnosis and classification of acute kidney injury (AKI) in patients with chronic liver

77 abigatran is associated with a lower risk of acute kidney injury (AKI) in patients with nonvalvular a

78 fferentiation between prerenal and intrinsic acute kidney injury (AKI) in the nontransplant populatio

79 Acute kidney injury (AKI) is a common cause of hospital-

80 Acute kidney injury (AKI) is a global public health conc

81 Acute kidney injury (AKI) is a growing global health con

82 Single-center studies suggest that neonatal acute kidney injury (AKI) is associated with poor outcom

83 RATIONALE: Acute kidney injury (AKI) is common during high-risk per

84 Acute kidney injury (AKI) is defined by changes in serum

85 Postinterventional acute kidney injury (AKI) occurred in four kidney transp

86 Acute kidney injury (AKI) remains a common complication

87 Acute kidney injury (AKI) remains a major clinical event

88 Acute kidney injury (AKI) remains challenging for clinic

89 RATIONALE: Little is known about how acute kidney injury (AKI) resolves, and whether patterns

90 Early detection of acute kidney injury (AKI), a common condition with a hig

91 Ischaemic acute kidney injury (AKI), an inflammatory disease proce

92 Septic shock is a common cause of acute kidney injury (AKI), and fluid resuscitation is a

93 FR), doubling of the serum creatinine level, acute kidney injury (AKI), and kidney failure.

94 px axis is associated with disease severity, acute kidney injury (AKI), and outcome.

95 Purpose To compare the rates of acute kidney injury (AKI), emergent dialysis, and short-

96 transferase, alanine aminotransferase (ALT), acute kidney injury (AKI), model for end stage liver dis

97 Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular

98 Statins affect several mechanisms underlying acute kidney injury (AKI).

99 h femoral access (FA), mitigates the risk of acute kidney injury (AKI).

100 Patients with acute kidney injury also had higher mean serum chloride

101 e heart failure, renal failure, hypotension, acute kidney injury, altered gas exchange, or emergency

102 For acute kidney injury analysis, we excluded patients achie

103 lity analysis and 8,085 were included in the acute kidney injury analysis.

104 otein 7 results in patients with and without acute kidney injury and across nonrenal Sequential Organ

105 Acute kidney injury and acute respiratory failure each o

106 al acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes afte

107 There was a significant interaction between acute kidney injury and chronic kidney disease on cumula

108 We examined the differential effect of acute kidney injury and chronic kidney disease on the as

109 International acute kidney injury and CKD guidelines were reportedly a

110 r shock, we examined the association between acute kidney injury and daily mental status using multin

111 apy modified the association between stage 3 acute kidney injury and daily peak serum creatinine and

112 ly ill adults, but it may be associated with acute kidney injury and death.

113 reatments, therapeutic advances to attenuate acute kidney injury and expedite recovery have largely f

114 among infants at high risk for postoperative acute kidney injury and fluid overload.

115 We observed an association between acute kidney injury and four single-nucleotide polymorph

116 The prevalence of septic acute kidney injury and impact on functional status of P

117 indices of urinary GAG fragmentation predict acute kidney injury and in-hospital mortality in patient

118 in postischemic tissue is a potent source of acute kidney injury and is amenable to sugar-specific bl

119 chloremia and acute kidney injury as well as acute kidney injury and mortality.

120 out the associations of obesity with risk of acute kidney injury and post acute kidney injury mortali

121 p inhibitors (PPI) have been associated with acute kidney injury and recent studies suggest that they

122 l ischemia-reperfusion injury (IRI) leads to acute kidney injury and renal fibrosis.

123 Innate immune activation contributes to both acute kidney injury and tissue remodeling that is associ

124 All adult patients with acute kidney injury and treated with regional citrate an

125 filter group and 5 in the control group had acute kidney injury, and 3 patients in the filter group

126 Sepsis, acute kidney injury, and acute respiratory failure were

127 gical conditions, including viral infection, acute kidney injury, and cardiac ischemia/reperfusion.

128 nine value, albuminuria, greater severity of acute kidney injury, and higher serum creatinine value a

129 Crude rates of hyperchloremic acidosis, acute kidney injury, and hospital mortality all increase

130 ven after controlling for the development of acute kidney injury, and its addition to clinical models

131 dural myocardial infarction, major bleeding, acute kidney injury, and new-onset atrial fibrillation w

132 h improved survival, decreased prevalence of acute kidney injury, and shorter duration of vasoactive

133 es included in-hospital mortality, bleeding, acute kidney injury, and stroke.

134 the development of hyperchloremic acidosis, acute kidney injury, and survival among those with highe

135 ns, including cerebral and cardiac ischemia, acute kidney injury, and transplantation.

136 vive a pneumonia hospitalization and develop acute kidney injury are at high risk for major adverse k

137 Because pneumonia and acute kidney injury are in part mediated by inflammation

138 e of marginal kidneys; however, kidneys with acute kidney injury are often declined/discarded.

139 stopathologic changes associated with septic acute kidney injury are poorly understood, in part, beca

140 Epidemiological data for acute kidney injury are scarce, especially in low-income

141 ected to be study drug-related (eltrombopag: acute kidney injury, arterial thrombosis, bone pain, dia

142 trong association between hyperchloremia and acute kidney injury as well as acute kidney injury and m

143 nts included in this cohort, 16.7% developed acute kidney injury, as defined by Kidney Disease Improv

144 t was the development of contrast-associated acute kidney injury, as defined by the Acute Kidney Inju

145 One death in the everolimus group (acute kidney injury associated with diarrhoea), and two

146 An episode of acute kidney injury at 7 months was reversed by reducing

147 day mortality among patients who do not have acute kidney injury at the time of measurement.

148 Surgery was associated with higher rates of acute kidney injury, atrial fibrillation, and transfusio

149 95% CI, 1.1-2.6; OR, 1.8; 95% CI, 1.4-2.4), acute kidney injury (beta coefficient, 5.0; 95% CI, 3.9-

150 Access to diagnosis and dialysis for acute kidney injury can be life-saving, but can be prohi

151 e of the resulted phenotypes are sepsis with acute kidney injury, cardiac surgery, anemia, respirator

152 sms and performed genotype imputation in 760 acute kidney injury cases and 669 controls.

153 functional, potentially reversible, form of acute kidney injury characterized by rapid (<2 wk) and p

154 Survival and post acute kidney injury chronic dialysis dependency were ass

155 p (adjusted odds ratio, 1.06 [1.03-1.09] for acute kidney injury+/chronic kidney disease+; 1.09 [1.05

156 ospital mortality were identified: 5.9 L for acute kidney injury+/chronic kidney disease+; 3.8 L for

157 hronic kidney disease+; 1.05 [1.03-1.08] for acute kidney injury+/chronic kidney disease-; and 1.07 [

158 y injury-/chronic kidney disease+; 4.3 L for acute kidney injury+/chronic kidney disease-; and 1.5 L

159 hronic kidney disease+; 1.09 [1.05-1.13] for acute kidney injury-/chronic kidney disease+; 1.05 [1.03

160 y injury+/chronic kidney disease+; 3.8 L for acute kidney injury-/chronic kidney disease+; 4.3 L for

161 ic kidney disease-; and 1.07 [1.02-1.11] for acute kidney injury-/chronic kidney disease-).

162 jury+/chronic kidney disease-; and 1.5 L for acute kidney injury-/chronic kidney disease-.

163 associated with hospital mortality based on acute kidney injury/chronic kidney disease status, under

164 [95% CI] 1.04-1.08; p < 0.001), and in each acute kidney injury/chronic kidney disease subgroup (adj

165 continues to pose a risk of contrast-induced acute kidney injury (CI-AKI) for a subgroup of patients

166 e preventive strategies for contrast-induced acute kidney injury (CIAKI) is a matter of debate.

167 asure of readmission for the same infection, acute kidney injury, Clostridium difficile infection, or

168 ly higher in patients with septic shock with acute kidney injury compared with patients with septic s

169 d by inflammation, we hypothesized that when acute kidney injury complicates pneumonia, major adverse

170 Severe acute kidney injury conferred an increased risk of death

171 ury analysis, we excluded patients achieving acute kidney injury criteria in the first 2 days of ICU

172 nal six events each occurred in two (3%) for acute kidney injury, decreased lymphocyte count, fatigue

173 Exposures: Acute kidney injury defined as a postoperative serum cre

174 Acute kidney injury defined as an increase of 0.3 mg/dL

175 m2 and who had survived hospitalization with acute kidney injury (defined by a serum creatinine incre

176 A total of 4683 patients were evaluated; acute kidney injury developed in 1261 patients (26.9%; 9

177 nce interval [CI], 25.6 to 28.2), and severe acute kidney injury developed in 543 patients (11.6%; 95

178 More than twice as many patients with severe acute kidney injury died or developed new moderate disab

179 ratio [HR]: 20.6; P = 0.01), development of acute kidney injury during hospitalization (HR: 23.2; P

180 Also in human oxalate crystal-related acute kidney injury, dying tubular cells stain positive

181 nd 1-year survival rates associated with the acute kidney injury episodes were similar across body ma

182 The primary endpoint was moderate-severe acute kidney injury (equivalent to Kidney Disease Improv

183 control group experienced significantly more acute kidney injury events (14 vs 4, respectively; P = .

184 Among critically ill patients with acute kidney injury, exposure to positive fluid balance,

185 , electrolyte abnormalities, bradycardia, or acute kidney injury/failure).

186 ith reduced hospital mortality and with less acute kidney injury from days 3-7 after ICU admission.

187 ischarge were most common in the pneumonia + acute kidney injury group (51% died and 62% reached majo

188 cute kidney injury (28.3% vs 6.1% in the non-acute kidney injury group [p < 0.001]).

189 s without acute kidney injury, patients with acute kidney injury had a higher prevalence of diabetes

190 cteristics of children and young adults with acute kidney injury have been described in single-center

191 emonstrated a strong trend toward developing acute kidney injury (hazard ratio, 1.39; 95% CI, 0.99-1.

192 ing for the aforementioned confounders, both acute kidney injury (hazard ratio, 3.73; 95% CI, 2.39-5.

193 y disease, failed ventilator liberation, and acute kidney injury +/- hemodialysis requirement.

194 kidney disease after a hospitalization with acute kidney injury; however, no risk-prediction tools h

195 7; 95% confidence interval [CI], 1.24-1.73), acute kidney injury (HR, 1.23; 95% CI, 1.05-1.44), >4 El

196 al disease (HR, 2.40; 95% CI, 0.76-7.58) and acute kidney injury (HR, 1.30; 95% CI, 1.00-1.69).

197 ructokinase in the pathogenesis of ischaemic acute kidney injury (iAKI).

198 Acute kidney injury II or III rate was 3.3%.

199 ma creatinine level alone failed to identify acute kidney injury in 67.2% of the patients with low ur

200 s that showed the strongest association with acute kidney injury in a replication patient population

201 The use of plasma NGAL to diagnose acute kidney injury in AHF cannot be recommended at this

202 ride reduces the risk of contrast-associated acute kidney injury in critically ill patients.

203 paediatric and adult patients with confirmed acute kidney injury in hospital and non-hospital setting

204 roduction of cell-free plasma hemoglobin and acute kidney injury in infants and children undergoing c

205 Dehydration was the most frequent cause of acute kidney injury in LLMICs (526 [46%] of 1153 vs 518

206 Cast nephropathy is the main cause of acute kidney injury in multiple myeloma and persistent r

207 unctional and potentially reversible form of acute kidney injury in patients with advanced cirrhosis,

208 To assess the prevalence of acute kidney injury in patients with subarachnoid hemorr

209 may reduce the incidence of contrast-induced acute kidney injury in selected patients.

210 id a systematic review to assess outcomes of acute kidney injury in sub-Saharan Africa and identify b

211 Acute kidney injury in sub-Saharan Africa is severe, wit

212 Seven patients (5%) developed acute kidney injury in the sitagliptin-basal group and s

213 tially under-representing the true burden of acute kidney injury in these areas.

214 Acute kidney injury increases the risk of acute respirat

215 Acute kidney injury-induced neutrophil dysfunction is re

216 , plasma from patients with septic shock and acute kidney injury inhibited neutrophilic-differentiate

217 RATIONALE: Acute kidney injury is a common and severe complication

218 Acute kidney injury is a common complication in critical

219 Acute kidney injury is a heterogeneous group of conditio

220 Acute kidney injury is a risk factor for delirium and co

221 To examine whether acute kidney injury is associated with delirium and coma

222 Acute kidney injury is associated with high mortality, e

223 Acute kidney injury is associated with major adverse kid

224 Acute kidney injury is common and is associated with poo

225 Acute kidney injury is concerning because it is associat

226 Insight into the pathophysiology of acute kidney injury is gleaned from the temporal change

227 Acute kidney injury is highly frequent after cardiac tra

228 nd development of hyperchloremic acidosis or acute kidney injury is less clear, and further research

229 chloride for preventing contrast-associated acute kidney injury is marginal, if any.

230 The incidence of contrast-induced acute kidney injury is strongly related to the amount of

231 ized trial, we assigned patients with severe acute kidney injury (Kidney Disease: Improving Global Ou

232 Resistin by itself was able to induce acute kidney injury-like neutrophil dysfunction in vitro

233 RATIONALE: Acute kidney injury may contribute to distant organ dysf

234 Animal models of septic acute kidney injury may help define such changes.

235 netic loci associated with increased risk of acute kidney injury may reveal novel pathways for therap

236 changes found in modern experimental septic acute kidney injury models.

237 ty with risk of acute kidney injury and post acute kidney injury mortality.

238 erload, hepatic and coagulation dysfunction, acute kidney injury, mortality, and plasma cytokines in

239 grade 4 hyperkalemia (n=1 [6%]), and grade 2 acute kidney injury (n=1 [6%]) in the NSCLC cohort.

240 AKI was defined using Acute Kidney Injury Network (AKIN) criteria.

241 ied as no AKI, or AKI stage 1-3 according to Acute Kidney Injury Network (AKIN) criteria.

242 risk/injury/failure/loss/end stage (RIFLE), acute kidney injury network (AKIN), or kidney disease: i

243 ry outcome was AKI, defined according to the Acute Kidney Injury Network criteria as an absolute incr

244 ft failure was defined as AKI stages 1 to 3 (Acute Kidney Injury Network criteria), exclusion criteri

245 ne concentration within 48 hours of surgery (Acute Kidney Injury Network criteria).

246 iated acute kidney injury, as defined by the Acute Kidney Injury Network criteria, 72 hours after con

247 (Acute Kidney Injury Neutrophil Gelatinase-Associated Lip

248 Acute kidney injury occurred in 94584 patients (7%).

249 ale gender were found to be risk factors for acute kidney injury (odds ratio, 1.02 and 3.78, respecti

250 xception of a higher rate of adjusted 30-day acute kidney injury (odds ratio, 1.22; 95% CI, 1.10-1.36

251 ts with septic shock (with or without severe acute kidney injury) on neutrophilic-differentiated NB4

252 ciated with hospital mortality regardless of acute kidney injury or chronic kidney disease presence.

253 al Classification of Diseases-9 code 584.xx (acute kidney injury) or 486.xx (pneumonia) between Octob

254 toneal injections of folic acid (nephrotoxic acute kidney injury) or by IM injections of glycerol (rh

255 %) were marked by acute respiratory failure, acute kidney injury, or sepsis.

256 fter a hospitalization for either pneumonia, acute kidney injury, or the combination of both.

257 and coagulation (p < 0.0001) dysfunction and acute kidney injury (p < 0.0001).

258 ty was associated with worsening severity of acute kidney injury (P<0.001 by log-rank test).

259 5 of the 4140 patients (2.5%) without severe acute kidney injury (P<0.001).

260 rcentage points in the rate of postoperative acute kidney injury (P=0.005).

261 he control group, developed contrast-induced acute kidney injury (P=0.028).

262 Compared to patients without acute kidney injury, patients with acute kidney injury h

263 and 88 700 (95% CI, 80 400-97 000) cases of acute kidney injury per year.

264 te kidney injury was defined as stage 2 or 3 acute kidney injury (plasma creatinine level >/=2 times

265 Acute kidney injury rates vary greatly among physicians,

266 We aimed to assess regional differences in acute kidney injury recognition, management, and outcome

267 g/dL; glomerular filtration rate <15 mL/min; acute kidney injury requiring dialysis; and renal transp

268 One treatment-related AE (acute kidney injury) resulted in treatment discontinuati

269 toperative complications with a preoperative acute kidney injury risk index of class III or higher (i

270 ransaminase, international normalized ratio, acute kidney injury, septic shock, hepatic encephalopath

271 surgery and also resulted in lower rates of acute kidney injury, severe bleeding, and new-onset atri

272 Experimental acute kidney injury significantly inhibited neutrophil m

273 5% CI, 1.9%-25.1%) or included age, sex, and acute kidney injury stage alone (integrated discriminati

274 Acute kidney injury staging and markers of intravascular

275 plasma from patients with septic shock plus acute kidney injury still showed elevated resistin level

276 fusion injury (IRI) is an important cause of acute kidney injury that can lead to end-stage renal fai

277 crucial role in the pathogenesis of ischemic acute kidney injury through regulating tubular cell apop

278 alidate predictive models for progression of acute kidney injury to advanced chronic kidney disease.

279 atients without significant risk factors for acute kidney injury undergoing elective colectomy to a m

280 n 60 of the 543 patients (11.0%) with severe acute kidney injury versus 105 of the 4140 patients (2.5

281 ession model showed the hazard ratio (HR) of acute kidney injury was 2.212 (95% CI: 1.334-3.667), sep

282 Acute kidney injury was a predictor of mortality only in

283 Among 466 patients, stage 2 acute kidney injury was a risk factor for delirium (odds

284 Contrast-associated acute kidney injury was a secondary end point.

285 Severe acute kidney injury was associated with increased use of

286 Acute kidney injury was associated with markers of volum

287 Acute kidney injury was characterized daily using the di

288 Severe acute kidney injury was defined as stage 2 or 3 acute ki

289 Acute kidney injury was defined using KDIGO criteria and

290 Acute kidney injury was defined using Kidney Disease/Imp

291 Murine acute kidney injury was induced by intraperitoneal injec

292 Acute kidney injury was more common with rosuvastatin.

293 The frequency of contrast-associated acute kidney injury was similar in both groups: 52 patie

294 nvolving critically ill patients with severe acute kidney injury, we found no significant difference

295 thic hemolytic anemia, thrombocytopenia, and acute kidney injury were found in a group of 3 patients

296 to event analyses, patients with pneumonia + acute kidney injury were most likely to die or reach maj

297 I, 0.56 to 0.95; P=0.02), but admissions for acute kidney injury were not (101.9 and 86.0 admissions

298 In 743 patients without acute kidney injury, where ICU discharge renal function

299 Obesity is a risk factor for acute kidney injury, which is associated with increased

300 of mortality, clinical ischemic stroke, and acute kidney injury within 30 days after surgery; deliri