ライフサイエンスコーパス: acute-phase protein

1 hepatic cells with the characteristics of an acute phase protein.

2 EIU), which suggests that PEDF is a negative acute-phase protein.

3 ed by hepatocytes with characteristics of an acute-phase protein.

4 regulated by proinflammatory cytokines as an acute-phase protein.

5 physiological regulator of angptl4, another acute-phase protein.

6 egulation of inflammation and immunity by an acute-phase protein.

7 In liver, they regulate the secretion of acute phase proteins.

8 n-6 is also responsible for the synthesis of acute phase proteins.

9 nd type II (haptoglobin, alpha1-antitrypsin) acute phase proteins.

10 that this effect may limit the synthesis of acute phase proteins.

11 rs, proinflammatory cytokine production, and acute phase proteins.

12 d no significant effect on concentrations of acute phase proteins.

13 and induction of a characteristic pattern of acute phase proteins.

14 IGF-I/ BP-3 had no effect on type II acute phase proteins.

15 ctor alpha, followed by a decrease in type I acute phase proteins.

16 The complex had no effect on type II acute phase proteins.

17 amination were each associated with elevated acute phase proteins.

18 3 had no effect on interleukin 6 and type II acute phase proteins.

19 e production of IL-6 and the upregulation of acute phase proteins.

20 presence of numerous activated microglia and acute phase proteins.

21 any increase in proinflammatory cytokines or acute phase proteins.

22 ecules and chemokines, oxidative markers and acute phase proteins.

23 s responsible for induction of CRP and other acute phase proteins.

24 the down-regulation of many coagulation and acute-phase proteins.

25 ion correlated with the genomic induction of acute-phase proteins.

26 inol concentrations in the whole group using acute-phase proteins.

27 with none and those with one or more raised acute-phase proteins.

28 f a set of liver-specific proteins named the acute-phase proteins.

29 d IL-6 mRNA, which induces the production of acute-phase proteins.

30 he spleen, or cytokine-mediated induction of acute-phase proteins.

31 ositive and decreased expression of negative acute-phase proteins.

32 tenidap decreased plasma levels of IL-6 and acute-phase proteins.

33 lutionarily conserved family of inflammatory acute-phase proteins.

34 d with a transient rise in interleukin-6 and acute-phase proteins.

35 ear relation of ferritin concentrations with acute-phase proteins.

36 onse genes, including those encoding several acute-phase proteins.

37 Thus, acute-phase protein A1AT is a physiological regulator of

38 The acute-phase protein A1AT is an inducer of hepcidin expre

39 Expression of the acute phase protein alpha(2)-macroglobulin is induced in

40 8 g/L), ferritin (3.7 micrograms/L), and the acute-phase protein alpha 1-antichymotrypsin (ACT; 0.06

41 and endotoxin core IgG antibody [EndoCAb]), acute-phase proteins (alpha-2 macroglobulin [alpha-2M],

42 The levels of five acute-phase proteins (alpha-2 macroglobulin, haptoglobin

43 We first examined whether the acute-phase protein, alpha-2 macroglobulin (A2M), a majo

44 relationships between concentrations of two acute-phase proteins, alpha 1-antichymotrypsin (ACT) and

45 entrations of plasma retinol and one or more acute-phase proteins (alpha1-acid-glycoprotein, alpha1-a

46 solution; the same ratio to Abeta of another acute phase protein, alpha1-antichymotrypsin, was not ac

47 to the serum concentration of one potential acute phase protein (alpha2 macroglobulin), and albumin

48 Decreases in acute phase protein and proinflammatory cytokine synthes

49 y responses, as evidenced by the presence of acute phase proteins and oxidative damage.

50 jective was to examine the relations between acute phase proteins and plasma retinol concentrations i

51 chemokines, oxidation markers, apoptosis and acute phase proteins and the levels of CD68 positive mac

52 lso support the idea that soluble CD14 is an acute-phase protein and that hepatocytes could be a sour

53 Decreases in circulating plasma markers and acute-phase proteins and an increased baseline effector

54 talyze fluctuations in the concentrations of acute-phase proteins and certain micronutrient biomarker

55 infiltrating Ly6C(pos) macrophages expressed acute-phase proteins and exhibited an inflammatory profi

56 tion and accompanying increases in levels of acute-phase proteins and markers of inflammation and pro

57 e spleen followed by increased production of acute-phase proteins and proinflammatory cytokines.

58 red proteome, including increased amounts of acute-phase proteins and proteins involved in the comple

59 ese data show that GSTs and GCS are negative acute-phase proteins and that decreased GCS activity res

60 aken for serum hepatic constitutive protein, acute phase protein, and proinflammatory cytokine analys

61 n, alpha 1 acid glycoprotein and albumin, an acute phase protein, and subsequent risk of myocardial i

62 The relations among hyporetinolemia, acute phase proteins, and vitamin A status in children a

63 d levels of microbial translocation markers, acute-phase proteins, and inflammatory markers were all

64 These proteins included the acute-phase proteins apolipoprotein J, fibrinogen, hapto

65 Nutritional surveys use acute phase protein (APP) biomarkers such as C-reactive

66 C/EBPalpha) is required for the induction of acute phase protein (APP) genes in newborn mice in respo

67 tory reactions, interleukin 6 (IL-6) induces acute phase protein (APP) genes through the Janus kinase

68 IL-1, and TNF-alpha) are potent inducers of acute phase proteins (APP).

69 Whether the positive acute-phase protein (APP) response to infection is affec

70 Fibrinogen-beta (FBG-beta), an important acute-phase protein (APP), is generated by the liver as

71 wing injury or infection, the liver releases acute-phase proteins (APP).

72 Acute phase proteins (APPs) are associated with malaria-

73 cids resembles the amino acid composition of acute phase proteins (APPs).

74 the increased or decreased pool sizes of the acute-phase proteins (APPs) during the metabolic respons

75 acterized by increased circulating levels of acute-phase proteins (APPs) generated by the liver.

76 ies of apparently healthy persons by using 2 acute-phase proteins (APPs), C-reactive protein (CRP) an

77 and increased brain and serum cytokines and acute-phase proteins (APPs).

78 t fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 ac

79 ction in edematous malnutrition implies that acute phase proteins are made with a corresponding deple

80 lammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a signific

81 ytokines, proteases, adhesion molecules, and acute phase proteins as participants in the generation o

82 by cytokines, which signal the synthesis of acute-phase proteins as well as changes in intermediary

83 anifestations of disease, including elevated acute-phase proteins, as well as the local consequences

84 y by measuring changes in plasma retinol and acute-phase proteins associated with subclinical infecti

85 Moreover, these studies have shown that acute phase protein biosynthesis in enterocytes is regul

86 esis of these cytokines by leukocytes and of acute-phase proteins by HepG2 cells.

87 Expression of the acute phase protein C-reactive protein (CRP) is tightly

88 Here we show that the acute phase protein C-reactive protein (CRP), a ligand f

89 Because the acute-phase protein C-reactive protein (CRP) is highly u

90 LytA prevented binding of C1q and the acute-phase protein C-reactive protein to S. pneumoniae,

91 ed with IGF-I/BP-3, whereas levels of type I acute phase proteins (C-reactive protein, alpha1-acid gl

92 leukin-6 and tumor necrosis factor alpha) or acute-phase proteins (C-reactive protein and serum amylo

93 The acute phase protein, C-reactive protein (CRP), can incre

94 ssed interleukin 1beta-induced expression of acute phase proteins, C-reactive protein, and haptoglobi

95 correlated with plasma concentrations of the acute-phase protein, C-reactive protein (CRP), and the a

96 oclonal antibody immunoassay for the classic acute-phase protein, C-reactive protein (CRP), in serum.

97 The acute-phase proteins, C-reactive protein and serum amylo

98 higher levels of proinflammatory cytokines, acute phase proteins, chemokines and cellular adhesion m

99 significant changes in several cytokines and acute-phase proteins: Compared with baseline, levels of

100 Elevated acute phase protein concentrations and infectious diseas

101 ations as a biomarker for sleep restriction, acute phase protein concentrations and malaria infection

102 The study was a nonconcurrent analysis of acute phase protein concentrations and other data from a

103 Many genes encoding acute phase proteins contain HNF-4alpha-binding sites in

104 t activation contributes to induction of the acute-phase proteins CRP and serum amyloid P-component (

105 Serum acute-phase proteins, cytokines, and insulin-like growth

106 indicates that soluble CD14 in plasma is an acute-phase protein derived, among other sources, from l

107 ells, elevated body temperatures and induced acute phase proteins, each indicative of infection, were

108 g and delivery of newly synthesized loads of acute-phase proteins, enhancing innate immunity and prev

109 y reduced levels of circulating and airspace acute-phase proteins, exhibited significantly elevated l

110 ck can significantly modulate the pattern of acute-phase protein expression and that fever may be an

111 a regulator of hepatocyte growth, and three acute phase protein family members.

112 atory process is facilitated by the negative acute-phase protein, fetuin.

113 tudies are needed to assess the potential of acute-phase proteins for inclusion in prediction models

114 rotein in hepatocytes resulting in a lack of acute phase protein gene induction in newborn C/EBPalpha

115 Northern blot analysis of acute-phase protein gene expression in neonatal mice tre

116 For acute phase protein genes, some were increased (TP53, JU

117 ntribute to the transcriptional induction of acute phase protein genes.

118 Unique for Dex was the upregulation of acute phase proteins (Gfap, Cp, Edn2) as well as Plexna2

119 major difference between Hpr and the soluble acute phase protein haptoglobin (Hp).

120 ipheral measurement of circulating levels of acute phase proteins have focused attention on Clusterin

121 Elevations of acute-phase proteins have been associated with an increa

122 mation, including inflammatory cytokines and acute-phase proteins, have been found in depressed patie

123 n A deficiency in individuals with no raised acute-phase proteins (healthy group) were much the same

124 ver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated

125 C-reactive protein (CRP), an acute phase protein in humans and rabbits, is part of th

126 P component or C-reactive protein, the major acute phase protein in humans, caused a decrease in the

127 C-reactive protein (CRP), the major acute phase protein in humans, was purified free of endo

128 Serum amyloid P component, the major acute phase protein in mice, increased from 27 microg/ml

129 rgy between dysregulated T-cell function and acute phase proteins in acute coronary syndromes.

130 tudies have shown that there is synthesis of acute phase proteins in enterocytes.

131 ME7 animals allow independent measurement of acute phase proteins in the brain and circulation, we ex

132 f p19 resulted in constitutive expression of acute phase proteins in the liver.

133 Because CRP, the most commonly used acute-phase protein in clinical practice, is very stable

134 C-reactive protein (CRP) is not an acute-phase protein in mice, and therefore, mice are wid

135 IL-1 receptor antagonist anakinra suppressed acute-phase proteins in a patient with FMF and amyloidos

136 re accompanied by rises in concentrations of acute-phase proteins in plasma.

137 ables, peak values of 15 cytokines, and nine acute-phase proteins in serum were evaluated as potentia

138 Here, we posit that inflammatory and acute-phase proteins in the circulation increase after O

139 oteins that are homologous to C-reactive and acute-phase proteins in the immune system and have been

140 at shock response could affect expression of acute-phase proteins in the liver, the effects of a mode

141 The upregulation of acute-phase proteins in the retina of diabetic rats was

142 Acute-phase proteins increased with treatment at all dos

143 Elevated circulating acute phase proteins indicate disease risk.

144 Acute phase proteins indicated no evidence of an inflamm

145 Elevated serum levels of acute-phase proteins, indicating chronic subclinical inf

146 to the endogenous Foxp3 locus, that IL-6, an acute phase protein induced during inflammation, complet

147 Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory

148 ther increases in cytokine production and in acute phase protein-inducing ability in both patient gro

149 ared with FMF reflects greater production of acute phase protein-inducing cytokines in the former pat

150 could be due to differences in production of acute phase protein-inducing mediators, we studied PBMC

151 S and other microbial translocation markers, acute-phase proteins, inflammatory markers, and proinfla

152 Serum amyloid A (SAA) is a major acute phase protein involved in multiple physiological a

153 A major activity of acute phase proteins is to limit the inflammatory respon

154 rillation of Serum Amyloid A (SAA) - a major acute phase protein - is believed to play a role in the

155 active protein (CRP), the prototypical human acute phase protein, is an independent risk predictor of

156 Here, we show that haptoglobin, an acute phase protein, is an initiator of this MyD88-depen

157 YKL-40, a new acute-phase protein, is shown to be elevated in inflamma

158 ortality, incidence of infection and sepsis, acute phase protein levels, and muscle fractional synthe

159 Acute-phase protein levels on HDL may serve as novel bio

160 ost significantly upregulated factors is the acute phase protein lipocalin-2 (LCN2).

161 This acute phase protein may have a role in the progression o

162 sclerosis since C-reactive protein (CRP), an acute-phase protein monitored as a marker of inflammator

163 In response to LPS, acute phase protein mRNA induction are equivalent in typ

164 C-reactive protein (CRP) is a plasma acute-phase protein, normally not found in the brain.

165 More than half of these ligands were acute phase proteins or members of the complement or coa

166 e towards understanding how inflammation and acute phase proteins, particularly serum amyloid A and g

167 C-reactive protein (CRP) is an acute phase protein produced by hepatocytes.

168 ury, mortality, serum constitutive proteins, acute phase proteins, proinflammatory cytokines and insu

169 Fetuin, a negative acute-phase protein, recently was implicated as an anti-

170 C1-esterase inhibitor, an endogenous acute-phase protein, regulates various inflammatory and

171 ing a major modification of the mechanism of acute-phase protein regulation at 40 degreesC.

172 examined the association among elevations in acute phase proteins, reported illness, and hyporetinole

173 also reduced the lipopolysaccharide-induced acute phase protein response (C-reactive protein).

174 nergy, glucose, and lipid metabolism and the acute phase protein response; (3) the mechanisms by whic

175 ts is associated with induction of a hepatic acute-phase protein response and altered host energy and

176 higher in IL-6-/- mice (P < .05), while the acute-phase protein response was strongly attenuated (P

177 d by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and inflammation.

178 We conclude that the acute phase protein SAA plays an important role in HDL c

179 the chemokines CXCL1, CXCL2, and S100A8; the acute-phase protein SAA3; and the LPS binding protein CD

180 ember of the serpin family (SERPINA3), is an acute-phase protein secreted by hepatocytes in response

181 ntified as a carboxy-terminal peptide of the acute phase protein serum amyloid A (SAA) 1.

182 The acute phase protein serum amyloid A (SAA) has been well

183 We have previously reported that the acute phase protein serum amyloid A (SAA) is a potent ch

184 ing factor beta, inflammatory mediators, the acute phase protein serum amyloid P, vascular endothelia

185 The acute-phase protein serum amyloid A (A-SAA) was signific

186 The acute-phase protein serum amyloid A (SAA) is commonly co

187 The acute-phase protein serum amyloid A (SAA) is highly indu

188 e, all the six cytokines studied induced the acute-phase protein serum amyloid A when administered al

189 The endogenous acute-phase protein serum amyloid P (SAP) was expressed

190 HDL particles were enriched with acute-phase proteins (serum amyloid A, haptoglobin, and

191 showed comparable rises in the levels of two acute-phase proteins (serum amyloid P and C3) at 24, 48,

192 rkedly potentiated circulating levels of the acute phase proteins, serum amyloid A and IL-6, and the

193 ure supernatants and increased levels of the acute-phase protein, serum amyloid A (SAA).

194 Levels of several cytokines and acute-phase proteins significantly changed after treatme

195 oned medium increased mRNA levels of various acute-phase proteins such as albumin, fibrinogen, transf

196 In this context, acute-phase proteins such as Pentraxin-3 (PTX3) are rele

197 accompanied by a rapid rise in the blood of acute-phase proteins such as serum amyloid A (SAA).

198 Acute-phase proteins, such as C-reactive protein and alb

199 measuring cell proliferation or induction of acute phase protein synthesis.

200 terleukin-6 (IL-6) is the major regulator of acute-phase protein synthesis and one of the most studie

201 tuitary-adrenal axis and the potentiation of acute-phase protein synthesis.

202 Serum amyloid A (SAA) is a major acute-phase protein synthesized and secreted mainly by t

203 Hemopexin (Hx) is an acute-phase protein synthesized by hepatocytes in respon

204 and C-reactive protein, which are two of the acute-phase proteins synthesized in response to infectio

205 ch less serum amyloid A and haptoglobin (two acute-phase proteins) than WT mice, there were no other

206 C-reactive protein (CRP) is an acute phase protein that binds phosphocholine residues o

207 Human C-reactive protein (CRP) is an acute phase protein that binds to receptors on human and

208 t secretory phospholipase A(2) (sPLA(2)), an acute phase protein that has been found in association w

209 Serum amyloid A is an acute phase protein that is carried in the plasma largel

210 d TNF-alpha followed by a decrease in type I acute phase proteins that was associated with a concomit

211 C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphory

212 uman C-reactive protein (CRP), the classical acute-phase protein that binds to ligands exposed in dam

213 ata suggest that shrimp LGBP is an inducible acute-phase protein that may play a critical role in shr

214 C-reactive protein (CRP) is an acute-phase protein that plays an important defensive ro

215 Pentraxins are acute-phase proteins that belong to a family of evolutio

216 WAT also secretes many cytokines and acute-phase proteins that contribute to insulin resistan

217 P) is well characterized as one of the serum acute phase proteins, the levels of which increase drama

218 rHGH decreased acute phase proteins, tumor necrosis factor-alpha, and I

219 ultiple chemokines, cell adhesion molecules, acute-phase proteins, type I IL-1 receptor, and multiple

220 er is the primary site for the production of acute phase proteins, typically serum amyloid A1 (SAA1)

221 Analyses were performed on cytokines, acute-phase proteins, virus load, and CD4 cell counts.

222 globulins and autoantibodies, cytokines, and acute-phase proteins were additional abnormalities, all

223 Levels of 13 cytokines and nine acute-phase proteins were measured using a bead-based mu

224 Many acute-phase proteins were up-regulated early in murine c

225 ent, genes related to cellular effectors and acute-phase proteins were up-regulated, whereas genes la

226 Serum amyloid A (SAA) is a family of acute-phase proteins which are shown to correlate with c

227 ciated lipocalin (NGAL) is a 25-kDa secreted acute phase protein, which is also up-regulated in multi

228 Serum amyloid A (SAA) is an acute phase protein whose expression is markedly up-regu

229 Haptoglobin is an acute phase protein whose level increases severalfold du

230 C-reactive protein (CRP) is an acute phase protein whose levels are increased in many d

231 Fibrinogen is one of the acute-phase proteins whose levels are elevated during pe

232 Information about acute-phase proteins will enable plasma retinol concentr

233 C-reactive protein (CRP) is an acute-phase protein with a well-known association with i

234 Ceruloplasmin (Cp) is an acute-phase protein with ferroxidase, amine oxidase, and

235 C-reactive protein (CRP) is an acute-phase protein with therapeutic activity in mouse m