ライフサイエンスコーパス: acyl carrier protein

1 yield an extended beta-ketoacyl chain (ACP = acyl carrier protein).

2 re identified as proteolytic products of the acyl carrier protein.

3 ranes via the synthesis of [(14)C]linolenoyl-acyl carrier protein.

4 very tight, albeit noncovalent, complex with acyl carrier protein.

5 fect of fatty acid length on the dynamics of acyl carrier protein.

6 other PKS domains, the ketoreductase and the acyl carrier protein.

7 on but did induce the deacylation of butyryl-acyl carrier protein.

8 ntermediate domain functions similarly to an acyl carrier protein.

9 cillatus for formation of the methoxymalonyl-acyl carrier protein.

10 ms through Claisen condensation with malonyl-acyl carrier protein.

11 tled between the enzymes as thioesters of an acyl carrier protein.

12 DP-N-acetylglucosamine acyltransferase), and acyl carrier protein.

13 inds exclusive of the native substrate, acyl-acyl carrier protein.

14 pantetheine group of either coenzyme A or an acyl-carrier protein.

15 -phosphopantetheine moiety of coenzyme A and acyl-carrier protein.

16 uginosa genome contains three genes encoding acyl carrier proteins.

17 exes along with a reduction in mitochondrial acyl carrier proteins.

18 ultimately being incorporated into essential acyl carrier proteins.

19 and 2e(-) dependent desaturation of stearoyl-acyl carrier protein (18:0-ACP) to yield oleoyl-ACP (18:

20 Gly, H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragment (H-Val-Gln-Ala-Ala

21 ave constructed a conditional null mutant of acyl carrier protein, a central component of the FAS II

22 e NADPH-dependent reduction of beta-ketoacyl-acyl carrier protein (AcAc-ACP) to generate (3S)-beta-hy

23 Every polyketide synthase module has an acyl carrier protein (ACP) and a ketosynthase (KS) domai

24 A interference (RNAi) or genomic deletion of acyl carrier protein (ACP) and beta-ketoacyl-ACP synthas

25 es coelicolor consists of three proteins: an acyl carrier protein (ACP) and two beta-ketoacyl ACP syn

26 mologues that utilize acetyl- or propionyl-S-acyl carrier protein (ACP) as a substrate.

27 at both PKSs are able to use dimethylmalonyl acyl carrier protein (ACP) as an extender unit.

28 ructures of acyl chain loaded species of the acyl carrier protein (ACP) as used in fatty acid biosynt

29 es are in the wall of the assembly facing an acyl carrier protein (ACP) bound to the ketoacyl synthas

30 hesis, malonyl groups are transferred to the acyl carrier protein (ACP) component of the polyketide s

31 ls with small interfering RNAs targeting the acyl carrier protein (ACP) component reduced ACP mRNA an

32 The diiron center in stearoyl-acyl carrier protein (ACP) desaturase (DS) from castor p

33 ation with 16:0-ACP; however, with 18:0-acyl acyl carrier protein (ACP) desaturation occurred at the

34 with TE1 for the acyl chain attached to the acyl carrier protein (ACP) domain of FASN is unknown.

35 d as an acyl-adenylate and ligation onto the acyl carrier protein (ACP) domain of MbtB to form covale

36 Mutation of the acyl carrier protein (ACP) domain of the upstream module

37 eates a reaction chamber for the intramodule acyl carrier protein (ACP) domain that carries building

38 id or macrolactone products from an adjacent acyl carrier protein (ACP) domain.

39 ntermediates, respectively, each bound to an acyl carrier protein (ACP) domain.

40 ntetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) domains in polyketide product

41 Acyl carrier protein (ACP) domains shuttle acyl intermed

42 esizes DSF by dehydration of a 3-hydroxyacyl-acyl carrier protein (ACP) fatty acid synthetic intermed

43 The acyl carrier protein (ACP) from fatty acid synthases seq

44 onsible for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the cor

45 Acyl carrier protein (ACP) is a cofactor in a variety of

46 Acyl carrier protein (ACP) is a key component of the fat

47 s atypical primer is transformed to pimeloyl-acyl carrier protein (ACP) methyl ester by two cycles of

48 in is cleavage of the ester bond of pimeloyl-acyl carrier protein (ACP) methyl ester.

49 In this study, we expressed the acyl carrier protein (ACP) of FUM1 and in vitro loaded a

50 required the presence of an unsaturated acyl-acyl carrier protein (ACP) or acyl-CoA and was antagoniz

51 g fatty acids in thioester linkage to either acyl carrier protein (ACP) or CoA as acyl donors.

52 dicates that LuxI homologs prefer fatty acid-acyl carrier protein (ACP) over fatty acyl-CoA as the ac

53 thase (FASII) cycle for the beta-hydroxyacyl-acyl carrier protein (ACP) pathway intermediates.

54 Acyl carrier protein (ACP) plays an essential role in fa

55 Enoyl-acyl carrier protein (ACP) reductase catalyzes the last

56 Enoyl-acyl carrier protein (ACP) reductase catalyzes the last

57 on its similarity to FabG, the beta-ketoacyl-acyl carrier protein (ACP) reductase of type II fatty ac

58 Enoyl-acyl carrier protein (ACP) reductase, FabI, is a key enz

59 E. coli fabG encodes beta-ketoacyl-acyl carrier protein (ACP) reductase, the enzyme respons

60 ologues of Escherichia coli beta-hydroxyacyl-acyl carrier protein (ACP) reductase.

61 these assembly lines, the extender unit and acyl carrier protein (ACP) specificity of keto synthase

62 atalyze the reduction of 2-methyl-3-ketoacyl acyl carrier protein (ACP) substrates and in certain cas

63 Acyl carrier protein (ACP) synthase (AcpS) catalyzes the

64 ted via esterification by the bacterial acyl-acyl carrier protein (ACP) synthase AasC but inhibitors

65 st the KASIII domain of the beta-acetoacetyl-acyl carrier protein (ACP) synthase FabH.

66 beta-Ketoacyl-acyl carrier protein (ACP) synthase II (KASII) elongates

67 16:0 due to decreased activity of 3-ketoacyl-acyl carrier protein (ACP) synthase II.

68 ty acid synthases is catalyzed by 3-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII, FabH).

69 The beta-ketoacyl-acyl carrier protein (ACP) synthase III encoded by mtfab

70 0 microm cerulenin, an inhibitor of ketoacyl-acyl carrier protein (ACP) synthetase I/II.

71 he separate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/2-acylglycerolphos

72 Acyl-CoA and acyl-acyl carrier protein (ACP) synthetases activate exogenou

73 ytic efficiency with substrates linked to an acyl carrier protein (ACP) than with the corresponding C

74 rom a fatty acid synthetic intermediate, the acyl carrier protein (ACP) thioester of 3-hydroxydodecan

75 lasmid for the Umbellularia californica acyl-acyl carrier protein (ACP) thioesterase was shown to hav

76 ds are not efficiently converted to the acyl-acyl carrier protein (ACP) thioesters required by the pa

77 alyzes decarboxylation of 3-methylglutaconyl-acyl carrier protein (ACP) to 3-methylcrotonyl-ACP, the

78 by a specialized acyl-transferase that uses acyl carrier protein (ACP) to covalently link fatty acid

79 acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the FAS primer beta-a

80 We reveal that subunit B22 anchors an acyl carrier protein (ACP) to the complex, replicating t

81 e R-3-hydroxyacyl chain from R-3-hydroxyacyl acyl carrier protein (ACP) to the glucosamine 3-OH group

82 Acyl carrier protein (ACP) transports the growing fatty

83 the ATP-dependent acylation of the thiol of acyl carrier protein (ACP) with fatty acids with chain l

84 dule is comprised of a ketosynthase (KS), an acyl carrier protein (ACP), a malonyl-CoA:ACP transacyla

85 etosynthase (KS), acyl transferase (AT), and acyl carrier protein (ACP), a module may also include a

86 s a type I PKS module minimally contains AT, acyl carrier protein (ACP), and ketosynthase (KS) domain

87 transferases, a decarboxylase, an additional acyl carrier protein (ACP), and several oxygenases.

88 of the PKS and NRPS modules mediated by the acyl carrier protein (ACP), condensation (C) and ketored

89 p from the coenzyme A to a serine residue in acyl carrier protein (ACP), thereby activating ACP, an i

90 based on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty ac

91 study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role

92 S-adenosyl-l-methionine and either cellular acyl carrier protein (ACP)-coupled fatty acids or CoA-ar

93 ally, both acyltransferases catalyze an acyl-acyl carrier protein (ACP)-dependent transfer of a fatty

94 ituted extender units switches largely to an acyl carrier protein (ACP)-independent mode.

95 tic subunit (NFS1), LYR protein (ISD11), and acyl carrier protein (ACP).

96 thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP).

97 re thioesterified to either coenzyme A or an acyl carrier protein (ACP).

98 tive for UDP-GlcNAc and R-3-hydroxymyristoyl-acyl carrier protein (ACP).

99 g., malonyl-CoA or methylmalonyl-CoA) and an acyl carrier protein (ACP).

100 panthetheine and the serine-36 side chain of acyl carrier protein (ACP).

101 yl-CoA, ethylmalonyl-CoA, and methoxymalonyl-acyl carrier protein (ACP).

102 tion of FAS-I-derived acyl-CoAs with malonyl-acyl carrier protein (ACP).

103 unit derived from decarboxylation of malonyl-acyl carrier protein (ACP).

104 ADPH), a polyene was detected in the tryptic acyl carrier protein (ACP).

105 t are coupled via a phosphopantetheine to an acyl carrier protein (ACP).

106 PlsX is an acyl-acyl carrier protein (ACP):phosphate transacylase that i

107 rgets two essential proteins, beta-ketoacyl-[acyl carrier protein (ACP)] synthase II (FabF) and III (

108 se (KS)-acyl transferase (AT) didomains with acyl-carrier protein (ACP) and KR domains from different

109 n-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketid

110 yl-CoA:ACP transferase (MAT) didomain and an acyl-carrier protein (ACP) domain, whereas the second ap

111 inhibits the essential NADH-dependent enoyl-acyl-carrier protein (ACP) reductase, InhA.

112 hiolase superfamily, including beta-ketoacyl-acyl-carrier protein (ACP) synthases, polyketide synthas

113 in disclosed a region similar to malonyl-CoA:acyl-carrier protein (ACP) transacylases (MATs).

114 urbation likely required an interaction with acyl-carrier protein (ACP), as judged by the failure of

115 of 18:1 free fatty acid, 18:1-CoA, and 18:1-acyl-carrier protein (ACP).

116 gh the selective targeting of beta-ketoacyl-(acyl-carrier-protein (ACP)) synthase I/II (FabF/B) in th

117 nsferase, catalyses the acylation (from acyl-acyl carrier protein [ACP]) of Escherichia coli prohemol

118 plsX (acyl-acyl carrier protein [ACP]:phosphate acyltransferase), p

119 The third acyl carrier protein, Acp3, was a poor substrate for Rhl

120 global transcriptional regulator Fis and the acyl carrier protein AcpP, were identified in P. aerugin

121 for 4'-phosphopantetheine attachment to the acyl carrier protein (AcpP) of fatty acid synthesis.

122 e developed to target acpP, which encodes an acyl carrier protein (AcpP) that is thought to be essent

123 Acyl carrier proteins (ACPs) are essential to both fatty

124 Acyl carrier proteins (ACPs) are universal and highly co

125 Acyl carrier proteins (ACPs) are very small acidic prote

126 laboratory has developed methods to prepare acyl carrier proteins (ACPs) loaded with substrate mimet

127 Prior work showed that expression of acyl carrier proteins (ACPs) of a diverse set of bacteri

128 The acyl carrier proteins (ACPs) of fatty acid synthesis are

129 Acyl carrier proteins (ACPs) play a central role in acet

130 HMGS is highly selective for two specialized acyl carrier proteins (ACPs) that deliver the donor and

131 ion lies a gene that encodes the specialized acyl carrier protein AcpXL, on which the VLCFA is built.

132 mimetics are positioned on the actinorhodin acyl carrier protein (actACP) to probe the underpinnings

133 Long-chain acyl-acyl carrier proteins (acyl-ACP) are established biochem

134 AHLs are produced from acylated acyl-carrier protein (acyl-ACP) and S-adenosyl-L-methion

135 ay in the plastid, glycerol-3-phosphate acyl-acyl carrier protein acyltransferase, is thought to be e

136 und that RNAi depletion of the mitochondrial acyl carrier protein, an important component of the fatt

137 in blocking crosslinking of Escherichia coli acyl carrier protein and FabA, a direct mimic of the bio

138 thioester linkage to the human mitochondrial acyl carrier protein and is able to restore growth to th

139 tering (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains have been

140 Acyl carrier protein and substrate docking models shed l

141 The inactivation of acyl carrier protein and the cessation of fatty acid syn

142 dependent tailoring enzymes, a free-standing acyl carrier protein and two hypothetical proteins in oo

143 synthesis of fatty acyl-phosphate from acyl-acyl carrier protein, and then PlsY transfers the fatty

144 e have cloned all three genes, expressed the acyl carrier proteins, and characterized each as a subst

145 rate specificities and can employ acyl-CoAs, acyl carrier proteins, and galactolipids as acyl donors.

146 a thioesterase that hydrolyzes beta-ketoacyl acyl-carrier protein, and ShMKS1 is a decarboxylase that

147 thases cannot be functional unless their apo-acyl carrier proteins (apo-ACPs) are post-translationall

148 of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual rea

149 ing radiolabeled lipid A substrates and acyl-acyl carrier protein as the fatty acyl donor, we were ab

150 been observed in X-ray and NMR structures of acyl carrier proteins attached to different fatty acids.

151 ee carboxyl of either malonyl-CoA or malonyl-acyl carrier protein based on the ability of O-methylate

152 e (TtmT), five proteins for methoxymalonyl-S-acyl carrier protein biosynthesis (Ttm-ABCDE), eight pro

153 Acyl carrier proteins, both free-standing and as embedde

154 nse inhibition of synthesis of the family of acyl carrier proteins can be attributed to a single gene

155 sion, as an altered distribution of acylated acyl carrier proteins correlated with the SpoT-dependent

156 nthesis of either FabZ (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regu

157 l hadABC genes encoding the (3R)-hydroxyacyl-acyl carrier protein dehydratases resulted in more than

158 s such as methane monooxygenase and stearoyl acyl carrier protein Delta(9)-desaturase.

159 s of soluble methane monooxygenase, stearoyl acyl carrier protein Delta9 desaturase, and variants of

160 lian ribonucleotide reductases, and stearoyl acyl carrier protein Delta9-desaturase from plants, sugg

161 3 FATTY ACID DESATURASE3 (FAD3) and STEAROYL-ACYL CARRIER PROTEIN Delta9-DESATURASE6 (SAD6).

162 atty acids into its phospholipids by an acyl-acyl carrier protein-dependent pathway.

163 etailed biochemical studies with this unique acyl carrier protein-dependent, nonribosomal peptide syn

164 Stearoyl-acyl carrier protein desaturase (Delta9D) catalyzes the

165 Stearoyl-acyl carrier protein desaturase (SACPD) activity is esse

166 Stearoyl-acyl carrier protein desaturase (SACPD-C) has been repor

167 ganization of the soluble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypot

168 Stearoyl-acyl carrier protein desaturase-mediated conversion of s

169 ely determined by the action of the stearoyl-acyl-carrier-protein desaturase (SAD) homolog SAD5.

170 2 mutant, which encodes a defective stearoyl-acyl carrier protein-desaturase (S-ACP-DES) and conseque

171 via a mutation in the SSI2-encoded stearoyl-acyl carrier protein-desaturase, or by exogenous applica

172 ative trait loci to a region containing ACYL-ACYL CARRIER PROTEIN DESATURASE1 (AAD1) and AAD3 We foun

173 However, soluble plant acyl-ACP (acyl carrier protein) desaturases have been studied in f

174 genes, which encode an acyl transferase and acyl carrier protein directly involved in the biosynthes

175 of an invariant arginine at the hypothesized acyl carrier protein docking site in the context of the

176 transfer from acetyl-CoA to load an adjacent acyl carrier protein domain (ACP(L)).

177 revealed that (i) the PKSs contain a central acyl carrier protein domain and C-terminal phosphopantet

178 tion is governed by interactions between the acyl carrier protein domain and the ketosynthase domain

179 fully extended phosphopantetheine arm of the acyl carrier protein domain from module 5.

180 domain, transfer of the acetyl group to the acyl carrier protein domain is suppressed.

181 linkers could also be used to tether, to the acyl carrier protein domain of the fatty acid synthase,

182 disc-shaped structure capable of caging the acyl carrier protein domain proximal to each active site

183 ediates that are ready for transfer from its acyl carrier protein domain to its ketosynthase domain a

184 the malonyl group can be transferred to the acyl carrier protein domain, transfer of the acetyl grou

185 version of extracellular fatty acids to acyl-acyl carrier protein, elongation, and incorporation into

186 tructures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stal

187 the biosynthesis of the unusual aminomalonyl-acyl carrier protein extender unit and the signature car

188 ons at the interface that optimally position acyl carrier protein for acyl delivery and that directly

189 pantetheine modification of Escherichia coli acyl carrier protein for visualization and functional st

190 metabolism using inhibitors to prevent acyl-acyl carrier protein formation or glycerol-phosphate acy

191 FkbP using the appropriately loaded terminal acyl carrier protein from the PKS array, FkbA, as the ch

192 and the inherent conformational mobility of acyl carrier protein have stymied previous attempts to v

193 is then loaded onto phosphopantetheinylated acyl carrier protein (holo-MbtL) to form covalently acyl

194 ent activation of apo-ACPP to generate holo-(acyl carrier protein) (holo-ACPP) in an early step of fa

195 lytic chamber shows an unprecedented role of acyl carrier protein in product release.

196 hMKS2, are required to convert beta-ketoacyl acyl-carrier protein intermediates of the fatty acid bio

197 ons in which C12, C14, and C16 beta-ketoacyl-acyl-carrier-proteins (intermediates in fatty acid biosy

198 uce epimerized (2S)-2-methyl-3-ketoacyl-ACP (acyl carrier protein) intermediates.

199 -deformylating oxygenase (ADO) converts acyl-Acyl Carrier Proteins into corresponding n-1 alkanes via

200 Acyl carrier proteins involved in fatty acid biosynthesi

201 For example, acyl carrier protein is central to the biosynthesis of t

202 ia monocytogenes encode two functional enoyl-acyl carrier protein isoforms based on their ability to

203 aining both KasA and AcpM, the mycobacterial acyl carrier protein, KasA depletion did not induce the

204 Interestingly, acyl carrier protein knockout also leads to defects in a

205 dated Cryptosporidium ACS (and related acyl-[acyl-carrier-protein]-ligases) as pharmacological target

206 hase pathway have been identified in humans: acyl carrier protein, malonyl transferase, beta-ketoacyl

207 holoenzyme contains four subunits, having an acyl-carrier protein (MdcC subunit) with a distinct pros

208 pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein) metabolism in Yarrowia lipolytica

209 ylation and thus activation of mitochondrial acyl carrier protein (mtACP) of mitochondrial fatty acid

210 at transfers the octanoyl moiety of octanoyl-acyl carrier protein (octanoyl-ACP) to the lipoyl domain

211 Moreover, recent data indicate that the acyl carrier protein of Escherichia coli has a large pro

212 sence of an unsaturated thioester (of either acyl carrier protein or CoA) in order to bind the fabA a

213 get-specific deletions of ketosynthase (KS), acyl carrier protein, or ketoreductase.

214 ters have been used as mimics of the natural acyl carrier protein pathway intermediates to assay FASI

215 train PAO1, which is annotated as a probable acyl carrier protein phosphodiesterase (acpD), has been

216 The Escherichia coli AcpH acyl carrier protein phosphodiesterase (also called ACP

217 cts as a thioesterase hydrolyzing 3-ketoacyl-acyl carrier proteins (plastid-localized intermediates o

218 Acyl carrier proteins play a central role in metabolism

219 Conformational differences among the stalled acyl carrier proteins provide the molecular basis for th

220 d A biosynthesis, the (R)-3-hydroxymyristoyl-acyl carrier protein ( R-3-OHC14-ACP)-dependent N-acylat

221 InhA, the enoyl acyl carrier protein reductase (ENR) from M. tuberculosi

222 mical tool to specifically inhibit the enoyl-acyl carrier protein reductase (FabI) of C. trachomatis

223 the bacterial target of 6-OH-BDE-47 as enoyl-acyl carrier protein reductase (FabI), an essential and

224 2-pyridone compound that inhibits the enoyl-acyl carrier protein reductase (FabI), has recently been

225 Staphylococcus aureus that targets the enoyl-acyl carrier protein reductase (FabI).

226 Mycobacterial enoyl acyl carrier protein reductase (InhA) is a clinically va

227 cobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA).

228 Beta-ketoacyl-acyl carrier protein reductase (KACPR) catalyzes the NAD

229 malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR).

230 The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbony

231 A cyanobacterial pathway consisting of acyl-Acyl Carrier Protein reductase and an aldehyde-deformyla

232 Enoyl-acyl carrier protein reductase catalyzes the last step i

233 results show that FabI is the primary enoyl-acyl carrier protein reductase of type II bacterial fatt

234 nzyme Mycobacterium tuberculosis InhA (enoyl-acyl carrier protein reductase) due to formation of an i

235 ts Arabidopsis (Arabidopsis thaliana) enoyl (acyl carrier protein) reductase (ENR).

236 Human enoyl-acyl carrier protein-reductase (hER) is one of the FAS c

237 Acyl carrier protein represents one of the most highly c

238 mRPE65 is a palmitoyl donor, revealing a new acyl carrier protein role for palmitoylated proteins.

239 fact a FAAL that transfers fatty acids to an acyl carrier protein (Rv0100).

240 Notably, type II acyl carrier proteins serve as a crucial interaction hub

241 During lipid A synthesis (Raetz pathway), acyl carrier protein shuttles acyl intermediates linked

242 that saFabI is NADPH-dependent, and prefers acyl carrier protein substrates carrying fatty acids wit

243 the ALT proteins used endogenous fatty acyl-acyl carrier protein substrates to generate fatty acids

244 of fatty acyl-coenzyme A (CoA) or fatty acyl-acyl carrier protein substrates to primary fatty alcohol

245 he peptide competes with both nucleotide and acyl carrier protein substrates.

246 caused concomitant loss of the mitochondrial acyl carrier protein subunit ACPM1 from the enzyme compl

247 transit peptide from the apicoplast-resident acyl carrier protein supports this idea.

248 of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase (ACP) II mtKasB, a mycobac

249 Acyl carrier protein synthase (AcpS) catalyzes the trans

250 ntetheinylated to 100% by S. coelicolor holo-acyl carrier protein synthase (ACPS), and the resultant

251 omyces, is an inhibitor of the beta-ketoacyl-acyl carrier protein synthase (KAS) enzymes in the bacte

252 The beta-ketoacyl-acyl carrier protein synthase (KS) domain of the modular

253 luding the elongation enzymes, beta-ketoacyl acyl carrier protein synthase I/II (FabF/B).

254 Beta-ketoacyl-acyl carrier protein synthase III (FabH) catalyzes a two

255 cid dehydrogenase complex and beta-keto acyl-acyl carrier protein synthase III from Bacillus subtilis

256 ation of the kasIII gene encoding 3-ketoacyl acyl carrier protein synthase III into tobacco plastids.

257 tochondrial fatty acid synthesis by ketoacyl-acyl carrier protein synthase is not vital for protein l

258 yl chains provided by mitochondrial ketoacyl-acyl carrier protein synthase to meet the high lipoate r

259 The Escherichia coli holo-(acyl carrier protein) synthase (ACPS) catalyzes the coen

260 one biosynthetic pathway, the beta-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme Pq

261 oduct that inhibits bacterial beta-ketoacyl-(acyl-carrier-protein) synthase (FabF), is described.

262 losis genes encoding distinct beta-ketoacyl- acyl carrier protein synthases involved in mycolic acid

263 erized the essentiality of two beta-ketoacyl-acyl carrier protein synthases, KasA and KasB, in Mycoba

264 ellular fatty acids are activated by an acyl-acyl carrier protein synthetase (AasN) and validate type

265 The gene encoding the unique soluble acyl-acyl carrier protein synthetase (AasS) of the biolumines

266 t in the only cytoplasmic Synechocystis acyl-acyl carrier protein synthetase (SynAas) were highly res

267 oumarin inhibitors directly inhibit the acyl-acyl carrier protein synthetase activity of FadD32.

268 asS::kan strains retained low levels of acyl-acyl carrier protein synthetase consistent with prior in

269 lus, than to that of the membrane-bound acyl-acyl carrier protein synthetase of E. coli, an enzyme th

270 LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of

271 acylated cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, demonstrating the first

272 ional enzyme 2-acyl-GPE acyltransferase/acyl-acyl carrier protein synthetase.

273 r general elongase activity, one to ketoacyl acyl-carrier protein synthetase, and two each to fatty a

274 ne in the biosynthetic operon for NOS, as an acyl carrier protein that delivers 3-methylindolic acid

275 important role in the generation of octanoyl-acyl carrier protein, the lipoic acid precursor, as well

276 ty acid omega-6 desaturase 2 (FAD2) and acyl-acyl carrier protein thioesterase 2 (FATB) to improve ol

277 Starting with introducing an acyl-acyl carrier protein thioesterase gene, we made six succ

278 dramatic up-regulation of a specialized acyl-acyl carrier protein thioesterase paralog and the concer

279 s by heterologous over-expression of an acyl-acyl carrier protein thioesterase, or by suppression of

280 id desaturase and either desaturase or fatty acyl-carrier protein thioesterase.

281 he linker, by insertion of an unusually long acyl carrier protein-thioesterase linker from a modular

282 sion with cDNAs for various Cuphea FatB acyl-acyl carrier protein thioesterases (FatB) that produce a

283 previous attempts to visualize structurally acyl carrier protein tied to an overall catalytic cycle.

284 biosynthesis involves the conversion of acyl-acyl carrier protein to acylphosphate by PlsX and the tr

285 ting transfer of a dodecanoyl chain from one acyl carrier protein to another en route to the key bios

286 ain reorganization appears necessary for the acyl carrier protein to interact successively with both

287 condenses with either malonyl-CoA or malonyl-acyl carrier protein to produce 3-(2-aminophenyl)-3-oxop

288 e enzyme LpxL transfers laurate from lauroyl-acyl carrier protein to the 2'- R-3-hydroxymyristate moi

289 he transfer of R-3-hydroxymyristic acid from acyl carrier protein to the 3'-hydroxyl group of UDP-Glc

290 e R-3-hydroxyacyl chain from R-3-hydroxyacyl acyl carrier protein to the glucosamine 3-OH group of UD

291 ransfer of the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the E2 sub

292 The malonyl-coenzyme A:acyl carrier protein transacylase (FabD) of P. syringae

293 nyl-CoA in the absence of a malonyl-CoA:holo-acyl carrier protein transacylase (MCAT).

294 acterial proteasome substrates, malonyl Co-A acyl carrier protein transacylase and ketopantoate hydro

295 the expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the p

296 up, as well as decarboxylase (MdcD-MdcE) and acyl-carrier protein transferase (MdcA) catalytic activi

297 tic methodology in vitro to reversibly label acyl carrier protein variants and apply these tools to N

298 malonyl-CoA as the methyl acceptor, malonyl-acyl carrier protein was a far better acceptor of methyl

299 f an adaptor domain, the GNAT domain, and an acyl carrier protein, was assessed biochemically, reveal

300 er of approximately 20 residues connects the acyl carrier protein with the carboxy-terminal thioester