ライフサイエンスコーパス: acyl-CoA dehydrogenase

1 een mapped onto the structure of short chain acyl-CoA dehydrogenase.

2 of mitochondrial medium- or very long-chain acyl-CoA dehydrogenase.

3 probe of the active site in the medium chain acyl-CoA dehydrogenase.

4 not require involvement of the medium-chain acyl-CoA dehydrogenase.

5 g thioester polarization in the medium chain acyl-CoA dehydrogenase.

6 such an intermediate in the biogenesis of an acyl-CoA dehydrogenase.

7 ogenase family except for IVD and long-chain acyl-CoA dehydrogenase.

8 The enzyme is a homologue of acyl-CoA dehydrogenase.

9 amate which acts as the base in medium chain acyl-CoA dehydrogenase.

10 not as favorable as that observed with other acyl-CoA dehydrogenases.

11 oxylation reaction which is unique among the acyl-CoA dehydrogenases.

12 and has high levels of homology with various acyl-CoA dehydrogenases.

13 The same mechanism may regulate other acyl-CoA dehydrogenases.

14 e dehydrogenase (PDH), citrate synthase, and acyl-CoA dehydrogenases.

15 ng induces a large enzyme potential shift in acyl-CoA dehydrogenases.

16 FkbI has a similar fold to acyl-CoA dehydrogenases.

17 ehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA dehydrogenase, 3-ketoacyl-CoA thiolase, and man

18 Acyl-CoA dehydrogenase 9 (ACAD9) is a recently identifie

19 Acyl-CoA dehydrogenase 9 (ACAD9) is an assembly factor f

20 Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two related enzymes with lysin

21 ased acetylation of mitochondrial long-chain acyl-CoA dehydrogenase, a known SIRT3 deacetylation targ

22 The flavoenzyme is a new member of the acyl-CoA dehydrogenase (ACAD) family, but it does not re

23 oned cDNA showed that NOA is a member of the acyl-CoA dehydrogenase (ACAD) superfamily.

24 rally distinct subfamily of acyl coenzyme A (acyl-CoA) dehydrogenase (ACAD) enzymes that are alpha2be

25 nalysis indicated that, like very-long-chain acyl-CoA dehydrogenase, ACAD-9 is a dimer, in contrast t

26 The acyl-CoA dehydrogenases (ACADs) are enzymes that catalyz

27 However, their oxidation in vivo by acyl-CoA dehydrogenases (ACADs) that catalyze the first

28 l side chain metabolism requires one or more acyl-CoA dehydrogenases (ACADs).

29 ogenase (VLCAD) is a member of the family of acyl-CoA dehydrogenases (ACADs).

30 (MCD) belongs to the family of FAD-dependent acyl-CoA dehydrogenase (ACD) and is a key enzyme of the

31 nserved Caenorhabditis elegans gene acdh-11 (acyl-CoA dehydrogenase [ACDH]) facilitates heat adaptati

32 Acyl-CoA dehydrogenases (ACDs) are a family of flavoenzy

33 of the enzymes discussed in this review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-gl

34 The measurement of acyl-CoA dehydrogenase activities is an essential part o

35 Acyl-CoA dehydrogenase activities were measured in rat s

36 nthesis of the substrates used for measuring acyl-CoA dehydrogenase activities; however, the yields a

37 cid oxidation enzyme integrity, medium-chain acyl-CoA dehydrogenase activity and fat oxidation are el

38 differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of t

39 confirmed that conversion is performed by an acyl-CoA dehydrogenase and a subsequent hydratase yieldi

40 Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two

41 he powerful epoxyketone residue involving an acyl-CoA dehydrogenase and an unconventional free-standi

42 and PPARalpha-regulated genes (medium chain acyl-CoA dehydrogenase and pyruvate dehydrogenase kinase

43 or medium-chain acyl CoAs, and medium-chain acyl-CoA dehydrogenase and short-chain acyl-CoA dehydrog

44 y to receive electrons from the medium chain acyl-CoA dehydrogenase and the glutaryl-CoA dehydrogenas

45 atty acids by the mitochondrial medium-chain acyl-CoA dehydrogenase and the peroxisomal acyl-CoA oxid

46 Acyl-CoA dehydrogenases and acyl-CoA oxidases are two cl

47 a tetrameric enzyme that shares a fold with acyl-CoA dehydrogenases and class D flavin-containing mo

48 is similar to those of previously determined acyl-CoA dehydrogenases and consists of an NH2-terminal

49 7 and Phe-320, which are conserved among all acyl-CoA dehydrogenases and coordinate the enzyme-bound

50 base in medium-chain (MCAD) and short-chain acyl-CoA dehydrogenases and is conserved in all members

51 f these ORFs, two had sequence similarity to acyl-CoA dehydrogenases and polyketide synthases, respec

52 lism (eg, pyruvate dehydrogenase complex and Acyl-CoA dehydrogenase) and enzymes involved in electron

53 s, such as acetyl-CoA synthetase, long-chain acyl-CoA dehydrogenase, and 3-hydroxy-3-methylglutaryl-C

54 xidation, such as cytochrome c, medium-chain acyl-CoA dehydrogenase, and adipocyte protein 2.

55 ptide, beta myosin heavy chain, medium chain acyl-CoA dehydrogenase, and adrenomedullin correlate equ

56 nge the basal acyl-CoA oxidase, medium chain acyl-CoA dehydrogenase, and malic enzyme mRNA levels.

57 topropionic acid, an inhibitor of long chain acyl-CoA dehydrogenase, and partially inhibited by 2-tet

58 at liver is compared to that of medium chain acyl-CoA dehydrogenase, and the structural basis for the

59 nitine palmitoyl transferase-1, medium-chain acyl-CoA dehydrogenase, and uncoupling protein 3), calci

60 chain acyl-CoA dehydrogenase and short-chain acyl-CoA dehydrogenase are unable to catalyze oxidation

61 y, it appears that ACAD9 and very-long-chain acyl-CoA dehydrogenase are unable to compensate for each

62 lf-reaction of ETF with porcine medium chain acyl-CoA dehydrogenase are unaltered when alphaT244M ETF

63 The acyl-CoA dehydrogenases are a family of flavin adenine d

64 The acyl-CoA dehydrogenases are a family of flavoenzymes wit

65 The acyl-CoA dehydrogenases are a family of mitochondrial fl

66 The acyl-CoA dehydrogenases are a family of multimeric flavo

67 t is generally held that the active sites of acyl-CoA dehydrogenases are desolvated when substrate bi

68 the suppression of oxygen reactivity in the acyl-CoA dehydrogenases are discussed.

69 eview examines the structure of medium chain acyl-CoA dehydrogenase, as a representative of the dehyd

70 ious work demonstrated that the medium-chain acyl-CoA dehydrogenase both bioactivates and is inhibite

71 inactivation of short chain and medium chain acyl-CoA dehydrogenases by this inhibitor and related 2-

72 miting step in the inactivation of the other acyl-CoA dehydrogenases can involve the abstraction of a

73 nes encoding key mitochondrial (medium-chain acyl-CoA dehydrogenase, carnitine palmitoyltransferase I

74 The medium chain acyl-CoA dehydrogenase catalyzes the flavin-dependent ox

75 The crystal structure of rat short chain acyl-CoA dehydrogenase complexed with the inhibitor acet

76 Children with medium-chain acyl-coenzyme A (acyl-CoA) dehydrogenase defects can metabolize fatty aci

77 Multiple acyl-CoA dehydrogenase deficiencies (MADDs) are a hetero

78 tine are effective in some cases of multiple acyl-CoA dehydrogenase deficiency and primary carnitine

79 ciencies in ETF or ETF-QO result in multiple acyl-CoA dehydrogenase deficiency, a human metabolic dis

80 In three patients with very-long-chain acyl-CoA dehydrogenase deficiency, this treatment led ra

81 on transferring flavoprotein and short chain acyl-CoA dehydrogenase-electron transferring flavoprotei

82 sly expressed and purified FadE28-FadE29, an acyl-CoA dehydrogenase encoded by the igr operon, cataly

83 Rat and human short/branched chain acyl-CoA dehydrogenases exhibit key differences in subst

84 beta-oxidation gene (medium and short chain acyl-CoA dehydrogenase) expression levels remain unchang

85 nases and is conserved in all members of the acyl-CoA dehydrogenase family except for IVD and long-ch

86 atalytically essential glutamate base in the acyl-CoA dehydrogenase family is found either on the loo

87 When an acyl-CoA dehydrogenase family member, human short chain

88 elements: the nuclear pore complex (NPC) and acyl-CoA dehydrogenase family member-10 (ACAD10).

89 y been identified as being homologous to the acyl-CoA dehydrogenase family of enzymes.

90 -CoA dehydrogenase is the only member of the acyl-CoA dehydrogenase family with a cationic residue, A

91 ch is a tyrosine in all other members of the acyl-CoA dehydrogenase family, is important for conferri

92 n example of convergent evolution within the acyl-CoA dehydrogenase family, leading to the independen

93 activity, a property of other members of the acyl-CoA dehydrogenase family.

94 tional discrimination between members of the acyl-CoA dehydrogenase family.

95 ely high oxidase activity of the short chain acyl-CoA dehydrogenase from the obligate anaerobe Megasp

96 the targeted inactivation of the long chain acyl CoA dehydrogenase gene (Acadl) are also sensitive t

97 ement (NRRE-1) derived from the medium chain acyl-CoA dehydrogenase gene promoter and nuclear protein

98 susceptibility variations in the short-chain acyl-CoA dehydrogenase gene, and guidelines for the bioc

99 Short chain acyl-CoA dehydrogenase has maximal activity toward butyr

100 Comparison to other acyl-CoA dehydrogenases has provided additional insight

101 otein complex decreased, indicating that the acyl-CoA dehydrogenases have the ability to compete with

102 Short-chain acyl-CoA dehydrogenase (hSCAD) catalyzes the first matri

103 Human short-chain acyl-CoA dehydrogenase (hSCAD) catalyzes the first matri

104 on-transfer properties of human medium-chain acyl-CoA dehydrogenase (hwtMCADH) has been studied using

105 gene regulation of ACAD9 and very-long-chain acyl-CoA dehydrogenase identify the presence of two inde

106 defects have been identified in most of the acyl-CoA dehydrogenases in humans.

107 ydrogenase is also differentiated from other acyl-CoA dehydrogenases in that the catalytic base must

108 g chain acyl-CoA synthetase, very long chain acyl-CoA dehydrogenase) in livers of the ethanol-fed ani

109 of thioester substrates in the medium-chain acyl-CoA dehydrogenase involves alpha-proton abstraction

110 Short chain acyl-CoA dehydrogenase is a homotetramer with a subunit

111 The medium chain acyl-CoA dehydrogenase is rapidly inhibited by racemic 3

112 The overall structure of short chain acyl-CoA dehydrogenase is very similar to those of mediu

113 ed desolvation within the active site of the acyl-CoA dehydrogenases is discussed.

114 efines a side of the binding cavity in other acyl-CoA dehydrogenases is replaced by a leucine (Leu-37

115 ase is very similar to those of medium chain acyl-CoA dehydrogenase, isovaleryl-CoA dehydrogenase, an

116 A kinetic study of long-chain acyl-CoA dehydrogenase (LCAD) and very long-chain acyl-C

117 Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step

118 y, none have been documented with long-chain acyl-CoA dehydrogenase (LCAD) deficiency.

119 Long-chain acyl-CoA dehydrogenase (LCAD) is a key mitochondrial fat

120 Long-chain acyl-CoA dehydrogenase (LCAD) is a mitochondrial fatty a

121 studied mice with a deficiency of long-chain acyl-CoA dehydrogenase (LCAD), a key enzyme in mitochond

122 genase (IVD), and Glu261 in human long chain acyl-CoA dehydrogenase (LCAD), has been suggested to aff

123 g the fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD).

124 ement has been altered to that of long chain acyl-CoA dehydrogenase (LCADH), Glu376Gly/Thr255Glu, hav

125 nheme FeII-dependent halogenase KtzD and the acyl-CoA dehydrogenase-like flavoprotein KtzA, proposed

126 been performed on the wild-type medium-chain acyl-CoA dehydrogenase (MCAD) and two of its mutant form

127 g of octenoyl-CoA to pig kidney medium chain acyl-CoA dehydrogenase (MCAD) by isothermal titration mi

128 Medium-chain acyl-CoA dehydrogenase (MCAD) catalyzes the flavin-depen

129 ox and ionization properties of medium-chain acyl-CoA dehydrogenase (MCAD) from pig kidney.

130 ctive site residue, Glu-376, of medium-chain acyl-CoA dehydrogenase (MCAD) has been known to abstract

131 fatty acid synthase (FASN) and medium chain acyl-CoA dehydrogenase (MCAD) protein within the same ce

132 376 --> Asp (E376D) mutation in medium chain acyl-CoA dehydrogenase (MCAD), creates a complementary c

133 identified as Glu376 in porcine medium chain acyl-CoA dehydrogenase (MCAD), Glu254 in human isovalery

134 octynoyl-CoA (inactivator) with medium chain acyl-CoA dehydrogenase (MCAD), were essentially identica

135 in regulating the gene encoding medium-chain acyl-CoA dehydrogenase (MCAD), which catalyzes the initi

136 The human liver medium chain acyl-CoA dehydrogenase (MCAD)-catalyzed reaction proceed

137 in the recombinant human liver medium-chain acyl-CoA dehydrogenase (MCAD)-catalyzed reaction, we bec

138 model between human ETF and pig medium-chain acyl-CoA dehydrogenase (MCAD).

139 oleacryloyl-CoA) to human liver medium-chain acyl-CoA dehydrogenase (MCAD).

140 oup) upon binding to pig kidney medium-chain acyl-CoA dehydrogenase (MCAD).

141 here it directly interacts with medium-chain acyl-CoA dehydrogenase (MCAD).

142 of the soluble ACADs including medium-chain acyl-CoA dehydrogenase (MCAD).

143 gion of the gene encoding human medium-chain acyl-CoA dehydrogenase (MCAD, which catalyzes a rate-lim

144 ructures of the wild type human medium-chain acyl-CoA dehydrogenase (MCADH) and a double mutant in wh

145 ATP content and medium Acyl-CoA dehydrogenase mRNA were lower in RXRalpha mutan

146 ter introduction of a 2-trans-double bond by acyl-CoA dehydrogenase or acyl-CoA oxidase, the resultan

147 es were reduced (long chain and medium chain acyl-CoA dehydrogenases) or failed to be induced (acyl-C

148 polipoprotein AI, AII, or CIII; medium chain acyl-CoA dehydrogenase; or stearoyl-CoA desaturase mRNAs

149 trate-binding cavity relative to short-chain acyl-CoA dehydrogenase, permitting the optimal binding o

150 synthases (pltB, pltC), an acyl coenzyme A (acyl-CoA) dehydrogenase (pltE), an acyl-CoA synthetase (

151 n the reaction catalyzed by pig medium-chain acyl-CoA dehydrogenase (pMCAD) has been investigated usi

152 With the exception of long-chain acyl-CoA dehydrogenase protein level, which was increase

153 Comparing the structures of four other acyl-CoA dehydrogenases provides further insights into t

154 se), 3-hydroxybutyryl-CoA dehydrogenase, and acyl-CoA dehydrogenase, respectively.

155 CoA dehydrogenase (LCAD) and very long-chain acyl-CoA dehydrogenase revealed that 5-trans-tetradeceno

156 ns is dehydrogenated by short/branched-chain acyl-CoA dehydrogenase (SBCAD).

157 Rat short/branched chain acyl-CoA dehydrogenases (SBCAD) are more active toward s

158 Short chain acyl-CoA dehydrogenase (SCAD) is a homotetrameric flavoe

159 f liver-specific expression of a short-chain acyl-CoA dehydrogenase (SCAD) transgene in the SCAD-defi

160 late on substrate specificity in short chain acyl-CoA dehydrogenase (SCAD).

161 and E376Q mutants of the human medium chain acyl-CoA dehydrogenase showed that these two active site

162 te of FkbI reveal key differences from other acyl-CoA dehydrogenases, suggesting that FkbI may recogn

163 , which bears superficial resemblance to the acyl-CoA dehydrogenase superfamily of flavoproteins.

164 Structurally, the enzyme is a member of the acyl-CoA dehydrogenase superfamily.

165 places it into the well-characterized fatty acyl-CoA dehydrogenase superfamily.

166 nzyme nitroalkane oxidase is a member of the acyl-CoA dehydrogenase superfamily.

167 arget the FAD of the medium- and short-chain acyl-CoA dehydrogenases support this conclusion.

168 regulatory circuit involving a heat-induced acyl-CoA dehydrogenase that controls the lipid saturatio

169 drogenase 9 (ACAD9) is a recently identified acyl-CoA dehydrogenase that demonstrates maximum activit

170 longs to an important flavoprotein family of acyl-CoA dehydrogenases that catalyze the alpha,beta-deh

171 detectable semiquinone; however, like other acyl-CoA dehydrogenases, the human enzyme stabilizes an

172 mV), the greatest magnitude measured in any acyl-CoA dehydrogenase to date.

173 er flavoprotein that shuttles electrons from acyl-CoA dehydrogenases to coenzyme Q.

174 ydrogenase kinase, medium-chain length fatty acyl-CoA dehydrogenase, ubiquinone-cytochrome c reductas

175 the two human genes encoding very long chain acyl-CoA dehydrogenase (VLCAD) and postsynaptic density

176 Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the first step

177 Very long acyl-CoA dehydrogenase (VLCAD) deficiency is a genetic p

178 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is an inherite

179 ents have been found to have very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency, none have bee

180 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a major enzyme catalys

181 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a member of the family

182 s highly homologous to human very-long-chain acyl-CoA dehydrogenase was identified by large-scale ran

183 hydrogenase family member, human short chain acyl-CoA dehydrogenase, was incubated with dimethylglyci

184 With the known structure of medium chain acyl-CoA dehydrogenase, we hypothesize a possible struct

185 the fatty acid oxidation enzyme medium-chain acyl-CoA dehydrogenase, we tested whether acetylation-de

186 nitine palmitoyltransferase and medium-chain acyl-CoA dehydrogenase were unaltered with fasting.

187 -CoAs are poor substrates of very long-chain acyl-CoA dehydrogenase when compared with myristoyl-CoA.

188 ETF catalyzed by sarcosine and medium chain acyl-CoA dehydrogenases which reduce the flavin to the s

189 near Acads, a gene encoding the short chain acyl CoA dehydrogenase, which is mutated in BALB/cByJ mi

190 vity and steady-state levels of medium-chain acyl-CoA dehydrogenase, which catalyzes a rate-limiting

191 loning revealed that IBR3 encodes a putative acyl-CoA dehydrogenase with a consensus peroxisomal targ

192 CoA dehydrogenase, and bacterial short chain acyl-CoA dehydrogenase with a three-domain structure com

193 The turnover of medium chain acyl-CoA dehydrogenase with native ETF and ETF containin