ライフサイエンスコーパス: acyl-CoA oxidase

1 cted based on the structure of a four-domain acyl-CoA oxidase.

2 enhanced expression of a known target gene, acyl-CoA oxidase.

3 n acyl-CoA dehydrogenase and the peroxisomal acyl-CoA oxidase.

4 ability to package catalase, luciferase and acyl-CoA oxidase.

5 rate-limiting enzyme of this cycle is fatty acyl-CoA oxidase.

6 e, we determine the crystal structure of the acyl-CoA oxidase 1 (ACOX-1) homodimer and the ACOX-2 hom

7 ered the expression of 28 transcripts [e.g., acyl-CoA oxidase 1 (ACOX1) and FAT atypical cadherin 1 (

8 Mice lacking acyl-CoA oxidase 1 (Acox1), the first enzyme of the pero

9 biogenesis and metabolism (e.g., PEX13p and acyl-CoA oxidase 1).

10 Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-C

11 CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme believed to be in

12 nitine palmitoyl transferase-1, (CPT-1), and acyl CoA oxidase (ACO) (p < 0.05).

13 Induction of HSD IV and acyl-CoA oxidase (ACO) proteins in rat liver at differen

14 ssion of the canonical PPARalpha-target gene acyl-CoA-oxidase (ACO) in a PPARalpha-dependent manner i

15 the 5'-flanking region of H202-producing rat acyl-CoA oxidase (ACOX) gene and in other genes inducibl

16 stem, which consists of three enzymes: fatty acyl-CoA oxidase (ACOX), enoyl-CoA hydratase/3-hydroxyac

17 yltransferase (CAT) fusion construct for rat acyl-CoA oxidase (ACOX), the rate-limiting enzyme in the

18 on of fatty acids is catalyzed by the enzyme acyl-CoA oxidase (ACOX), which oxidizes a fatty acyl-CoA

19 oyl-CoA hydratase (HD) and peroxisomal fatty acyl-CoA oxidase (ACOX).

20 ween ibr3 and acx3, which is defective in an acyl-CoA oxidase acting in fatty acid beta-oxidation, ha

21 ve in ACX1, ACX3, or ACX4 have reduced fatty acyl-CoA oxidase activity on specific substrates.

22 ated animals showed significant induction of acyl-CoA oxidase activity, probably caused by PPARalpha

23 Thus, ATP may serve as a regulator of acyl-CoA oxidase activity, thereby directly linking asca

24 sed in Escherichia coli and shown to possess acyl-CoA oxidase activity.

25 rate activation, fatty acids are oxidized by Acyl-CoA Oxidase (ACX) enzymes.

26 The Arabidopsis acyl-CoA oxidase (ACX) family comprises isozymes with di

27 ve in ACX3, two of the six Arabidopsis fatty acyl-CoA oxidase (ACX) genes.

28 henotype results from loss of function of an acyl-CoA oxidase (ACX1A) that catalyzes the first step i

29 0.0001) and increased peroxisomal activity (acyl CoA oxidase and catalase activity) compared to the

30 The final preparation contained an acyl-CoA oxidase and a second protein of the plant nucle

31 fied by peptide sequence analysis, including acyl-CoA oxidase and a trifunctional enzyme of the perox

32 PARalpha and the peroxisome-associated genes acyl-CoA oxidase and catalase.

33 he PPARalpha-responsive genes encoding fatty acyl-CoA oxidase and cytochrome P450 4A1.

34 rate that peroxisomal beta-oxidation enzymes acyl-CoA oxidase and D-bifunctional protein are essentia

35 Acyl-CoA oxidase and peroxisome proliferator-activated r

36 basis for the substrate specificities of the acyl-CoA oxidases and reveal why some of these enzymes h

37 e deficient in PPAR alpha, peroxisomal fatty acyl-CoA oxidase, and some of the other enzymes of the t

38 atabolism (carnitine palmitoyltransferase-I, acyl-CoA oxidase, and uncoupling protein-2) and their co

39 m to long-chain (ACX1) and long-chain (ACX2) acyl-CoA oxidases, and show that the corresponding endog

40 PARalpha (PPARalpha(-/-)), peroxisomal fatty acyl-CoA oxidase (AOX(-/-)), and in both PPARalpha and A

41 ng the PPARalpha-dependent regulation of the acyl-CoA oxidase (AOX) promoter, the rate-limiting step

42 ochrome P450 4A2 (CYP4A2)), and peroxisomal (acyl-CoA oxidase (AOX)) enzymes.

43 The first step of this system, catalyzed by acyl-CoA oxidase (AOX), converts fatty acyl-CoA to 2-tra

44 inding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix.

45 dation pathway in mice at the level of fatty acyl-CoA oxidase (AOX), the first and rate-limiting enzy

46 We previously generated mice lacking fatty acyl-CoA oxidase (AOX), the first enzyme of the L-hydrox

47 e proliferators, whereas those lacking fatty acyl-CoA oxidase (AOX-/-), the first enzyme of the perox

48 Acyl-CoA dehydrogenases and acyl-CoA oxidases are two closely related FAD-containing

49 xpression of mRNAs for the peroxisomal fatty acyl-CoA oxidase, bifunctional enzyme, or thiolase, whic

50 sappeared; there was increased expression of acyl CoA oxidase, carnitine palmitoyl transferase 1, and

51 nditions for quantitative measurement of the acyl-CoA oxidase-catalyzed reaction are offered.

52 Yeast (Candida tropicalis) acyl-CoA oxidase catalyzes the oxidation of a variety of

53 ected with H2O2-generating peroxisomal fatty acyl-CoA oxidase cDNA, which encodes the first and rate-

54 mitoyltransferase I) and extramitochondrial (acyl-CoA oxidase, cytochrome P450 4A3) enzymes.

55 al beta-oxidation pathway--disorders such as acyl CoA oxidase deficiency and bifunctional protein def

56 Acyl-CoA oxidase-deficient cells accumulated 2-5 times m

57 02 (CrACX2), a gene encoding a member of the acyl-CoA oxidase/dehydrogenase superfamily.

58 utant, which disrupts a putative peroxisomal acyl-CoA oxidase/dehydrogenase, ibr1 and ibr10 display n

59 The peroxisomal acyl-CoA oxidase efficiently oxidizes 4-thiaacyl-CoA ana

60 amely acyl-CoA synthetase (acs-1 and acs-2), acyl-CoA oxidase (F08A8.1 and F08A8.2), and stearoyl-CoA

61 Fatty acyl-CoA oxidase (FACO) activity and mRNA were increased

62 anoyl-CoA alpha hydroxylase (PAHX) and fatty acyl-CoA oxidase (FACO) mRNA levels during differentiati

63 t derived from the endogenous PPAR-inducible acyl-CoA oxidase gene promoter.

64 onstitutively active human peroxisomal fatty acyl-CoA oxidase gene promoter.

65 nt (PPRE) found in the promoter of the fatty acyl-CoA oxidase gene.

66 Mutations in the acyl-CoA oxidase genes acox-1, -2, and -3 led to specifi

67 The genes for the two acyl-CoA oxidases have been termed AtACX1 and AtACX2.

68 lone or in pairs and purified, the resulting acyl-CoA oxidase homo- and heterodimers displayed differ

69 In addition, the structure of peroxisomal acyl-CoA oxidase II from rat liver is compared to that o

70 ion of acyl CoA synthetase-2 and peroxisomal acyl CoA oxidase in a time-dependent manner.

71 alpha and of the classical peroxisomal fatty acyl-CoA oxidase in energy metabolism, and in the develo

72 to be made for the roles of uncharacterized acyl-CoA oxidases in C. elegans and in other nematode sp

73 uences share significant homology with known acyl-CoA oxidases, including the conserved CGGHGY motif,

74 catalyzing straight-chain acyl-CoAs by fatty acyl-CoA oxidase, L-bifunctional protein, and thiolase,

75 CoA dehydrogenases) or failed to be induced (acyl-CoA oxidase, liver carnitine palmitoyl-CoA transfer

76 RXRalpha deficiency did not change the basal acyl-CoA oxidase, medium chain acyl-CoA dehydrogenase, a

77 substrate specificities suggest that the two acyl-CoA oxidases might play a general house-keeping rol

78 lpha-mediated responses such as induction of acyl-CoA oxidase mRNA by PPs are present in the MuSHalph

79 Cardiac fatty acyl-CoA oxidase mRNA levels increased at doses in which

80 ls from patients with deficiencies of either acyl-CoA oxidase or D-bifunctional protein, the first tw

81 f the genes encoding the peroxisomal enzymes acyl-CoA oxidase (POX1) and medium-chain acyl-CoA synthe

82 l-branched fatty acyl-CoAs by branched-chain acyl-CoA oxidase (pristanoyl-CoA oxidase/trihydroxycopro

83 AtACX2 are members of a family that includes acyl-CoA oxidases specific for shorter-chain acyl-CoAs.

84 arkably, we show that most of the C. elegans acyl-CoA oxidases that participate in ascaroside biosynt

85 ans-double bond by acyl-CoA dehydrogenase or acyl-CoA oxidase, the resultant 2,5, 7-decatrienoyl-CoA

86 A PPARalpha target gene, acyl CoA oxidase, was decreased by ethanol in wild-type

87 A second PPARalpha-responsive gene, acyl-CoA oxidase, was also induced in rat liver by diabe

88 When the acyl-CoA oxidases were expressed alone or in pairs and p

89 Full-length cDNAs coding for two distinct acyl-CoA oxidases were isolated by screening an Arabidop

90 result demonstrated that CrACX2 is a genuine acyl-CoA oxidase, which is responsible for the first ste

91 Here we show that three acyl-CoA oxidases, which catalyze the first step in thes

92 Acyl-CoA oxidases, which catalyze the first step in thes