ライフサイエンスコーパス: acyl-coenzyme A

1 lglycerol using 2-monoacylglycerol and fatty acyl coenzyme A.

2 esters from cholesterol and long-chain fatty acyl coenzyme A.

3 The enzyme acyl coenzyme A:1-acyllysophosphatidylcholine acyltransf

4 FadR is a dimeric acyl coenzyme A (acyl CoA)-binding protein and transcrip

5 eins copurify with the Golgi adaptor protein acyl coenzyme A (acyl-CoA) binding domain protein 3 (ACB

6 iveness of various perdeuterated short-chain acyl coenzyme A (acyl-CoA) compounds as starter units fo

7 of an architecturally distinct subfamily of acyl coenzyme A (acyl-CoA) dehydrogenase (ACAD) enzymes

8 type I polyketide synthases (pltB, pltC), an acyl coenzyme A (acyl-CoA) dehydrogenase (pltE), an acyl

9 encodes a predicted protein with homology to acyl coenzyme A (acyl-CoA) ligases.

10 ion of carnitine fatty acid transferase with acyl coenzyme A (acyl-CoA) occurred.

11 A5174 confirmed a preference for short-chain acyl coenzyme A (acyl-CoA) substrates, supporting the id

12 Long-chain acyl coenzyme A (acyl-CoA) synthetase isoform 1 (ACSL1)

13 The AMP-forming acyl coenzyme A (acyl-CoA) synthetases are a large class

14 Short- and medium-chain acyl coenzyme A (acyl-CoA) synthetases catalyze the form

15 arbons or longer rescue growth by generating acyl coenzyme A (acyl-CoA) thioester beta-oxidation degr

16 n and activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to reg

17 t protein demonstrated both KAS activity and acyl coenzyme A (acyl-CoA):ACP transacylase (ACAT) activ

18 In vitro experiments point to fatty acyl coenzymes A (acyl-CoAs) rather than unesterified fa

19 Children with medium-chain acyl-coenzyme A (acyl-CoA) dehydrogenase defects can met

20 nnected by a single system intermediate, the acyl-coenzyme A (acyl-CoA) pool.

21 The 11 long-chain (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [(ACSVL)/fatty ac

22 protein" in sequence databases, exhibits an acyl-coenzyme A (acyl-CoA) thioesterase "hot dog" fold w

23 control of the activity of short-chain fatty acyl-coenzyme A (adenosine monophosphate-forming) synthe

24 Transmembrane domains of the acyl-coenzyme A and acyl phosphatidylcholine-utilizing d

25 I ceramide synthase that uses C16 fatty acid acyl-coenzyme A and dihydroxy LCB substrates but increas

26 Upon incubation of the enzyme with acyl-coenzyme A and reduced nicotinamide adenine dinucle

27 ide synthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB substrates.

28 ys using either acyl-acyl carrier protein or acyl coenzyme A as the substrate.

29 contrast, the purified acyltransferase uses acyl-coenzyme A as an acyl donor and shows no such prefe

30 while similar in vitro analyses using fatty acyl-coenzyme A as the substrate yielded medium-chain al

31 s interacting partner, Golgi adaptor protein acyl-coenzyme A binding domain containing protein 3 (ACB

32 , we uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serv

33 ombined experimental and simulation study of acyl-coenzyme A binding protein (ACBP), a two-state fold

34 ing temperature as the different variants of acyl-coenzyme A binding protein have similar m-values wh

35 Here, we identify the PO membrane protein acyl-coenzyme A-binding domain protein 5 (ACBD5) as a bi

36 Low-molecular mass (10 kD) cytosolic acyl-coenzyme A-binding protein (ACBP) has a substantial

37 Here we show that acyl-coenzyme A-binding protein (ACBP) potently facilita

38 SAR-related proteins THIOREDOXIN h3, ACYL-COENZYME A-BINDING PROTEIN6, and PATHOGENESIS-RELAT

39 ough the post-translational biotinylation of acyl coenzyme A carboxylases.

40 giotensin-converting enzyme inhibitor, or an acyl coenzyme A-cholesterol acyltransferase inhibitor.

41 dysfunction of the sterol esterifying enzyme acyl-coenzyme A-cholesterol acyltransferase (ACAT), whic

42 Previous studies have identified acyl-coenzyme A: cholesterol acyltransferase (ACAT), an

43 tion in 1993 of the first molecular probe of acyl-coenzyme A: cholesterol acyltransferase provided a

44 to an esterified storage form by the enzyme acyl-coenzyme A: cholesterol acyltransferase, is a criti

45 Acyl coenzyme A:cholesterol acyltransferase (ACAT) (EC 2

46 The inhibition of macrophage acyl coenzyme A:cholesterol acyltransferase (ACAT), whic

47 ubstrates for cholesteryl ester synthesis by acyl coenzyme A:cholesterol acyltransferase (ACAT).

48 The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) me

49 for cholesterol ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and

50 roteins, monocyte chemoattractant protein-1, acyl coenzyme A:cholesterol acyltransferase, and tissue

51 y lipoprotein cholesterol with or without an acyl-coenzyme A:cholesterol acyl-transferase inhibitor m

52 , fatty acyl Coenzyme A hydrolysis (FACoAH), acyl-Coenzyme A:cholesterol acyltransfer (ACAT), and fat

53 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) activ

54 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catal

55 The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) ester

56 nd in various pathophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has a

57 The rationale was that the acyl-coenzyme A:cholesterol acyltransferase (ACAT) in ho

58 We have found previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhib

59 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is a

60 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an

61 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an

62 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an

63 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) plays

64 Cholesterol trafficking to acyl-coenzyme A:cholesterol acyltransferase (ACAT) was a

65 substrate and/or as activator for the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT), by m

66 the physical interaction of the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-relat

67 nes with similarity to a human cDNA encoding acyl-coenzyme A:cholesterol acyltransferase (ACAT).

68 o express the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but

69 Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) an

70 Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is

71 Human acyl-coenzyme A:cholesterol acyltransferase 1 (hACAT1) e

72 y-3-methyl-glutaryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase 2 in infecte

73 liver is known to be catalyzed by the enzyme acyl-coenzyme A:cholesterol acyltransferase, ACAT, the n

74 In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), a

75 tracellular esterification of cholesterol by acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

76 Compound 1a increased esterification by acyl-coenzyme A:cholesteryl acyltransferase in NPC1 muta

77 ylates: the former as intermediates in fatty acyl coenzyme A (CoA) formation and the latter as precur

78 ing from the disruption of the gene encoding acyl coenzyme A (CoA) oxidase (AOX).

79 y sequential decarboxylative condensation of acyl coenzyme A (CoA) precursors, and the C-C bond-formi

80 es a decarboxylative condensation between an acyl coenzyme A (CoA) primer and malonyl-ACP.

81 tial carbon-carbon bond forming step between acyl coenzyme A (CoA) substrates offer a versatile route

82 a mitochondrion-associated long-chain fatty acyl coenzyme A (CoA) thioesterase that is highly expres

83 Acyl coenzyme A (CoA)-binding protein (ACBP; AcbA in Dic

84 diates in the unconventional secretion of an acyl coenzyme A (CoA)-binding protein that lacks an endo

85 ze an N-acyltransferase reaction using fatty acyl-coenzyme A (CoA) and long-chain base (LCB) substrat

86 at cleaves the thioester bonds of inhibitory acyl-coenzyme A (CoA) by-products generated during beta-

87 The Mycobacterium tuberculosis acyl-coenzyme A (CoA) carboxylases provide the building

88 Two genes, Psyr_2474, encoding an acyl-coenzyme A (CoA) dehydrogenase, and Psyr_4843, enco

89 The Arabidopsis (Arabidopsis thaliana) acyl-coenzyme A (CoA) desaturase-like (ADS) gene family

90 urases showed some similarity to presumptive acyl-coenzyme A (CoA) desaturases found in animals and p

91 DNAs was identified that encode a homolog of acyl-coenzyme A (CoA) desaturases found in animals, fung

92 Fatty acyl-coenzyme A (CoA) esters play a central role in the

93 They are similar in sequence to fatty acyl-coenzyme A (CoA) ligases (FACLs).

94 FAR) enzymes catalyze the reduction of fatty acyl-coenzyme A (CoA) or fatty acyl-acyl carrier protein

95 maturity were correlated with changes in the acyl-coenzyme A (CoA) pool in developing seeds of transg

96 e condensation of malonyl-ACP with different acyl-coenzyme A (CoA) primers.

97 oding either an acyl-acyl carrier protein or acyl-coenzyme A (CoA) reductase.

98 duced levels of intermediate and anaplerotic acyl-coenzyme A (CoA) species incorporated into the Kreb

99 yze the condensation of two long-chain fatty acyl-coenzyme A (CoA) substrates.

100 as 36 fadD genes annotated as putative fatty acyl-coenzyme A (CoA) synthetase genes, which encode enz

101 h the acyl-acyl carrier protein thioesterase:acyl-coenzyme A (CoA) synthetase mediated export mechani

102 Acyl-coenzyme A (CoA) synthetases (ACSs, EC 6.2.1.3) cat

103 Long-chain acyl-coenzyme A (CoA) synthetases (LACSs) activate free

104 g can be specifically reversed by long-chain acyl-coenzyme A (CoA) thioesters.

105 The nonenzymatic reaction of acyl-coenzyme A (CoA) with Cys-GlcN-Ins to produce acyl-

106 ting lysophosphatidylethanolamine (LPE) with acyl-coenzyme A (CoA), designated LYSOPHOSPHATIDYLETHANO

107 , we present the characterization of a novel acyl-coenzyme A (CoA)-dependent acyl-transferase that is

108 talyzing the final and committed step in the acyl-coenzyme A (CoA)-dependent biosynthesis of triacylg

109 s, sterol is esterified to a storage form by acyl-coenzyme A (CoA): cholesterol acyl transferase (ACA

110 Wax synthase (WS, fatty acyl-coenzyme A [coA]: fatty alcohol acyltransferase) ca

111 acuole fusion is stimulated by certain fatty acyl-coenzyme A compounds in a Sec18p-dependent fashion.

112 mitochondrial proteins shows that long-chain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated

113 tly decreased the expression of medium-chain acyl coenzyme A dehydrogenase (MCAD) and short-chain acy

114 Expression of the gene encoding medium-chain acyl coenzyme A dehydrogenase (MCAD), a nuclearly encode

115 nzyme A dehydrogenase (MCAD) and short-chain acyl coenzyme A dehydrogenase (SCAD), involved in the re

116 The identity of the gene encoding acyl coenzyme A dehydrogenase is a major remaining myste

117 into chains of spores, SCO6938 is a probable acyl coenzyme A dehydrogenase that contributes to the pr

118 urs in the hearts of mice lacking long-chain acyl coenzyme A dehydrogenase.

119 of a key beta-oxidation enzyme, medium chain acyl-coenzyme A dehydrogenase (MCAD), requires cis-actin

120 micromol x min(-1) x g(-1)) and medium chain acyl-coenzyme A dehydrogenase (MCAD; 1.8+/-0.1 versus 2.

121 Medium-chain acyl-coenzyme A dehydrogenase (MCAD; mouse gene Acadm; h

122 roduct have been investigated in short-chain acyl-coenzyme A dehydrogenase (SCAD) from Megasphaera el

123 We generated very-long-chain acyl-coenzyme A dehydrogenase (VLCAD)-deficient mice by

124 romosome 10q26.13 in the vicinity of ACADSB (acyl-Coenzyme A dehydrogenase), involved in cholesterol

125 erating factor (DAF, also known as CD55) and acyl-coenzyme A dehydrogenase, long chain, which are loc

126 iagnosed metabolic disorder was medium-chain acyl-coenzyme-A dehydrogenase deficiency.

127 amino acid sequence of IBAH and those of the acyl coenzyme A dehydrogenases.

128 jacent genes: single insertions in each of 2 acyl-coenzyme A dehydrogenases (fadE) plus 2 unique inse

129 ycle mediated by phospholipase A2 (PLA2) and acyl-coenzyme A-dependent monolysocardiolipin acyltransf

130 Binding of both aminoglycosides and acyl-coenzyme A derivatives is strongly enthalpically dr

131 parameters of binding of aminoglycosides and acyl-coenzyme A derivatives to AAC(6')-Iy and of two mut

132 ) while the association constants of several acyl-coenzyme A derivatives were similar (3.2 x 10(4)-4.

133 The recent cloning of a gene encoding acyl coenzyme A : diacylglycerol acyltransferase, an enz

134 gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT),

135 Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1)

136 Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1)

137 Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1)

138 Acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) is

139 In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2)

140 onfirmed that hepatic specific inhibition of acyl-coenzyme A:diacylglycerol acyltransferase with anti

141 liver disease demonstrate that inhibition of acyl-coenzyme A:diacylglycerol acyltransferase, the enzy

142 TAG accumulation in sdp1 roots requires both ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1)

143 ects of increased or decreased expression of ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1)

144 n and purification, with high recoveries, of acyl-coenzyme A esters differing widely in chain length

145 e quantitative isolation and purification of acyl-coenzyme A esters is presented.

146 Thus, acyl-coenzyme A esters were purified from both bovine re

147 at B. napus embryos have an endogenous fatty acyl-coenzyme A: fatty alcohol acyl-transferase activity

148 s: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme A hydrolysis (FACoAH), acyl-Coenzyme A:cho

149 d to decreased abundance of long-chain fatty acyl-coenzyme A in the mediobasal hypothalamus and blunt

150 ontrol appears to be the rate at which fatty acyl-coenzyme A is transported into the mitochondria by

151 tory effect of the FA metabolite, long-chain acyl-coenzyme A (LC-CoA).

152 mes, carnitine acyltransferases, involved in acyl-coenzyme A metabolism and as a carrier for long-cha

153 Acyl coenzyme A:monoacylglycerol acyltransferase (MGAT)

154 es the transfer of an acyl chain from either acyl-coenzyme A or acyl-acyl carrier protein onto LPA to

155 by (a) direct binding of fatty acids, fatty acyl-coenzyme A, or oxidized fatty acids; (b) oxidized f

156 and induction of fatty acid metabolism genes acyl coenzyme A oxidase and carnitine palmitoyltransfera

157 of the POX1 gene, which encodes peroxisomal acyl coenzyme A oxidase in the yeast Saccharomyces cerev

158 in plant peroxisomes requires the action of acyl-coenzyme A oxidase (ACX).

159 Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(-/-))

160 The idea that induction of acyl-coenzyme A oxidase leads to increased production of

161 e beta-oxidation double mutant acx1acx2 (for acyl-Coenzyme A oxidase), levels of TAG actually increas

162 in patients with deficiencies of peroxisomal acyl-coenzyme A oxidase, bifunctional enzyme, and 3-oxoa

163 , the sequence of the last 12 amino acids of acyl-coenzyme A oxidase.

164 In a database search for homologs of acyl-coenzyme A oxidases (ACX) in Arabidopsis, we identi

165 l groups (16:0, 18:1, 18:2, and 18:3) in the acyl-coenzyme A pool provide most of the acyl chains for

166 , DesT senses the overall composition of the acyl-coenzyme A pool to coordinate the expression of the

167 on of unsaturated fatty acids from saturated acyl-coenzyme A precursors.

168 Substantial differences in acyl-coenzyme A profiles between the retina and brain we

169 tep in which DMSP is modified by addition of acyl coenzyme A, rather than the immediate release of DM

170 a line expressing castor FA hydroxylase and acyl-Coenzyme A:RcDGAT2 in its seeds.

171 We purified an alcohol-forming fatty acyl-coenzyme A reductase (FAR) from developing embryos

172 The acyl-Coenzyme A substrate for this acyltransferase accum

173 -acyl carrier protein substrates rather than acyl coenzyme A substrates.

174 acid synthase (mas) and fadD28, an adjoining acyl coenzyme A synthase gene, involved in the productio

175 This gene encodes a putative 3-keto acyl coenzyme A synthase--an enzyme involved in the synt

176 s fadD33 (Rv1345), a gene that may encode an acyl-coenzyme A synthase and which previously was not kn

177 t with 2 mumol/L triacsin C (an inhibitor of acyl coenzyme A synthases) inhibited [3H]14,15-EET incor

178 To determine if FATP1 is a long chain acyl coenzyme A synthetase, FATP1-Myc/His fusion protein

179 l of this study is to explore parasite fatty acyl-coenzyme A synthetase (ACS) as a novel drug target.

180 ty of cells to activate (via very-long-chain acyl-coenzyme A synthetase [VLCS]) and subsequently degr

181 sis, which may be due to its very long chain acyl-coenzyme A synthetase activity.

182 bserved in thiolase (kat2-1) and peroxisomal acyl-Coenzyme A synthetase mutants (lacs6-1,lacs7-1), in

183 rospectroscopy, the cutin mutants long-chain acyl-coenzyme A synthetase2 (lacs2), permeable cuticle1

184 opollenin polyketide biosynthetic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA

185 This activation is mediated by long-chain acyl-coenzyme A synthetases (LACSs), which are encoded b

186 und in all living organisms and includes the acyl-coenzyme A synthetases, 4-coumarate:coenzyme A liga

187 elta knockout plants have a higher level, of acyl-coenzyme A than the wild type.

188 Saturated fatty acyl coenzyme A thioesters activate HNF-4 alpha, while c

189 It catalyzes acyl-coenzyme A thioesters to synthesize naringenin chal

190 Ts catalyze the sequential esterification of acyl-coenzyme A thioesters to the R4, R3, R3', and R2 po

191 Minimal activity was observed with aliphatic acyl-coenzyme A thioesters, which ruled out PaaI functio

192 , from the FAR2-catalyzed reduction of fatty acyl-coenzyme A to fatty alcohols, which are possible pr

193 elta hydrolyzes phosphatidylcholine and also acyl-coenzyme A to release fatty acids.

194 the reaction is an acyl group transfer from acyl-coenzyme A to the active-site cysteine of the enzym

195 a grass-expanded and -diverged clade of BAHD acyl-coenzyme A-utilizing transferases identified four m

196 other metabolic intermediates generated from acyl-coenzyme A, which is synthesized using lipoylated m