ライフサイエンスコーパス: acyltransferase

1 ul for mode of action studies on the PORCN O-acyltransferase.

2 e chloroplast acyl-ACP:lysophosphatidic acid acyltransferase.

3 tion site in Wnt, establishing Porcn as an O-acyltransferase.

4 te acyltransferase and lysophosphatidic acid acyltransferase.

5 recruitment not hitherto described for this acyltransferase.

6 oci is zDHHC9, a gene encoding a Ras protein acyltransferase.

7 el of acyl-CoA:1-acylglycerol-sn-3-phosphate acyltransferase.

8 -CoA carboxylase 1, and glycerol-3-phosphate acyltransferase.

9 enzyme can also serve as a lysophospholipid acyltransferase.

10 fatty acid synthase and glycerol-3-phosphate acyltransferase.

11 ransporters, cytochrome P450 enzymes, and an acyltransferase.

12 ng to a clade separate from most anthocyanin acyltransferases.

13 is-His-Cys (DHHC) motif-containing palmitoyl acyltransferases.

14 een in Gcn5-related N-acetyltransferase-like acyltransferases.

15 olic phospholipase A2alpha and CoA-dependent acyltransferases.

16 ty acid biosynthetic enzymes and specialized acyltransferases.

17 tain their side activity as lysophospholipid acyltransferases.

18 a series of reactions catalyzed by acylsugar acyltransferases.

19 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol

20 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endoplasmic reti

21 and co-expression of FUS3 and diacylglycerol acyltransferase 1 (DGAT1) further increased TAG levels t

22 iated with fat content, the Diacylglycerol O-Acyltransferase 1 (DGAT1) gene turned out to be a functi

23 Diacylglycerol O-acyltransferase 1 (DGAT1) has recently become a highly i

24 ation of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido

25 Diacylglycerol acyltransferase 1 (DGAT1) is an integral membrane enzyme

26 -synthesizing enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a critical role in hepat

27 The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy

28 ental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with

29 or overexpression of lysophosphatidycholine acyltransferase 1 (LPCAT1), two key enzymes of Lands' cy

30 aturated phosphatidylcholine (PC) by lyso-PC acyltransferase 1 (LPCAT1).

31 direct targeting of lysophosphatidylglycerol acyltransferase 1 (LPGAT1).

32 lyc12g006330--or S. lycopersicum acylsucrose acyltransferase 1 (Sl-ASAT1)--and Solyc04g012020 (Sl-ASA

33 duced cholesterol esterification by sterol-O-acyltransferase 1 (SOAT1).

34 The 1-acylglycerol-3-phosphate acyltransferase 1 haplotypes were associated with higher

35 argely via the enzyme DGAT (diacylglycerol O-acyltransferase 1) and degrade LD via ATGL (adipocyte tr

36 Niemann Pick C1 Like 1, Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceride transfer

37 e GC dinucleotide allele of diacylglycerol O-acyltransferase 1:g.10433-10434AA >GC was associated wit

38 presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, a

39 auveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are en

40 cell lines, mediated by acyl-CoA cholesterol acyltransferase-1 (ACAT-1) enzyme.

41 Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic tar

42 s well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of su

43 Overexpressing glycerol-3-phosphate acyltransferase-1 or -4 inhibited insulin signaling and

44 ession of castor phospholipid:diacylglycerol acyltransferase 1A in this line increased the proportion

45 mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2).

46 opyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.

47 This suggests that ATGL and diacylglycerol-O-acyltransferase 2 act coordinately in the hydrolysis/re-

48 itively inhibiting hepatocyte diacylglycerol acyltransferase 2.

49 synthetase long 1 (ACSL1) and diacylglycerol acyltransferase-2 (DGAT2), and (b) decreases in lipolysi

50 reased expression of acyl CoA:diacylglycerol acyltransferase-2 in the liver, and elevation of hepatic

51 Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in tri

52 id remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of

53 Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylch

54 Monoacylglycerol acyltransferase 3 (MGAT3) is an integral membrane enzyme

55 Glycerol-3-phosphate acyltransferase 4 (GPAT4), which catalyzes the first and

56 Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups grew poorly during t

57 d expression of 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) and promoted triacylglycerol

58 matic activity of a ripening-related alcohol acyltransferase (AAT1).

59 matic activity of a ripening-related alcohol acyltransferase (AAT1).

60 previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition led to impaired APP pr

61 the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related enzyme (Are)2p, with 2 pl

62 terifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-cholesterol ac

63 by sequential phospholipase and transacylase/acyltransferase activities in conjunction with a decreas

64 ocyte acyl-CoA synthetase and diacylglycerol acyltransferase activities in postmenopausal women were

65 cholesterol efflux, and lecithin-cholesterol acyltransferase activities of the lipoprotein.

66 The N-terminal domain is not necessary for acyltransferase activity and is composed of an intrinsic

67 reticulum seems to lack lipolytic as well as acyltransferase activity as shown by enzymatic analysis

68 for high affinity cAMP binding and elevated acyltransferase activity in the absence of cAMP.

69 approximately 90% lower lecithin-cholesterol acyltransferase activity relative to circulating apoA1.

70 tion assay that is a direct readout of Porcn acyltransferase activity to perform structure-function a

71 fforts to produce in vitro reconstitution of acyltransferase activity using straight-chain analogues

72 1 +/- 8.5% reduction in lecithin-cholesterol acyltransferase activity, a finding corroborated using a

73 ols than controls but similar diacylglycerol acyltransferase activity, triacylglycerol secretion, and

74 production, in addition to lysophospholipid acyltransferase activity.

75 ine, are taken up by LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on

76 iency to generate triacylated cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, de

77 "Late" acyltransferases add secondary acyl chains to lipid A af

78 Protein S-acyltransferases, also known as palmitoyltransferases (P

79 ber of amino acid changes in two acylsucrose acyltransferases alter their acyl acceptor preferences,

80 tochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase and an increase in serine palmitoyl tran

81 ms from a cAMP-regulated to a cAMP-dependent acyltransferase and identified a unique asparagine resid

82 hosphate dehydrogenase, glycerol 3-phosphate acyltransferase and lysophosphatidic acid acyltransferas

83 ecreased expression of sn-1,2 diacylglycerol acyltransferase and mitochondrial acyl-CoA:glycerol-sn-3

84 rol to be esterified by acyl-CoA:cholesterol acyltransferase and stored in lipid droplets (LDs) in NP

85 iacylglycerol- and steryl ester-synthesizing acyltransferases and consequently the lipid droplets, th

86 ase motifs that are present in other studied acyltransferases and transacylases.

87 he chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1, which encodes the chl

88 poM, cholesteryl ester, lecithin:cholesterol acyltransferase, and S1P.

89 The activity of Dga1p, a diacylglycerol acyltransferase, and TG accumulation were both 30-35% lo

90 toyltransferase (NMT) and multiple palmitoyl acyltransferases, and these enzymes and their protein ta

91 pological organization of Hhat and ghrelin O-acyltransferase, another MBOAT family member.

92 phate dehydrogenase and glycerol 3-phosphate acyltransferase are expressed only during liver-stage de

93 zDHHC S-acyltransferases are enzymes catalyzing protein S-acylat

94 DHHC-S-acyltransferases are integral membrane proteins that cat

95 Acyltransferases are key contributors to triacylglycerol

96 The two mammalian AR-containing S-acyltransferases are the Golgi-localized zDHHC17 and zDH

97 Are2p, Aus1p, and Pdr11p, unlike the minor acyltransferase, Are1p, colocalize to sterol and sphingo

98 tion of a member of the BAHD family of plant acyltransferases as cocaine synthase.

99 , acylsugar assembly requires four acylsugar acyltransferases (ASATs) of the BAHD superfamily.

100 udies, we observe that inactivation of a cis-acyltransferase (AT) domain to circumvent its native ext

101 We identified recently a large trans-acyltransferase (AT) polyketide synthase gene cluster re

102 ybrid nonribosomal peptide synthetase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PK

103 RRL 18993 consists of 11 genes, featuring an acyltransferase (AT)-less type I polyketide synthase (PK

104 Acyltransferase (AT)-less type I polyketide synthases (P

105 he genes encoding bile acid-CoA:amino acid N-acyltransferase (BAAT) and bile acid-CoA ligase (SLC27A5

106 ow that the classification of CER2 as a BAHD acyltransferase based on sequence homology does not fit

107 receptor modulators and lecithin-cholesterol acyltransferase-based therapy, hold great promise for th

108 Acyltransferase binding studies with photo-labile RJPXD3

109 interestingly B. mori glycerol-3-phosphate O-acyltransferase (BmGPAT) was found to be expressed durin

110 ain with significant homology to carnitine O-acyltransferase (cAT).

111 ions between DAT substrates catalyzed by the acyltransferase Chp2 (Rv1184c).

112 essential factor in fatty acid metabolism as acyltransferase cofactor and in energy production proces

113 ed by overexpressing SCT1, we identified the acyltransferase Cst26p/Psi1p as a regulator of Sct1p act

114 The broad substrate specificity of acyltransferase CT775 provides C.t. with the capacity to

115 Kinetically improved diacylglycerol acyltransferase (DGAT) variants were created to favorabl

116 Acyl CoA:1,2-diacylglycerol acyltransferase (DGAT)-2 is an integral membrane protein

117 these PUFAs available for the diacylglycerol acyltransferase (DGAT)-catalyzed reaction for TAG produc

118 genetic approaches to disrupt diacylglycerol acyltransferase (DGAT)-dependent LD biogenesis, we provi

119 2-diacylglycerol catalyzed by diacylglycerol acyltransferase (DGAT, EC 2.3.1.20).

120 d acyltransferases (LPAT) and diacylglycerol acyltransferases (DGAT) that are required for successive

121 When coexpressed with diacylglycerol O-acyltransferase (DGAT1) in Arabidopsis (Arabidopsis thal

122 ptimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors.

123 veral genes encoding acyl-CoA:diacylglycerol acyltransferases (DGATs) and phospholipid:diacylglycerol

124 Diacylglycerol acyltransferases (DGATs) catalyze a rate-limiting step o

125 acyltransferases (MGATs) and diacylglycerol acyltransferases (DGATs) catalyze the two consecutive st

126 ree out of five putative type II diglyceride acyltransferases (DGATs), the enzymes that catalyze TAG

127 Another gene (acyltransferase DH29), specific for spermidine conjugati

128 at the recycling endosome-resident palmitoyl acyltransferase DHHC2 interacts with and palmitoylates A

129 The cell surface palmitoyl acyltransferase DHHC5 regulates a growing number of cell

130 etion of the primary murine monoacylglycerol acyltransferase does not quantitatively affect lipid abs

131 that the L142 protein contains an N-terminal acyltransferase domain and a predicted C-terminal glycos

132 dentified a unique asparagine residue in the acyltransferase domain of KATms that assists in the enzy

133 ter analogs of rifamycin, we substituted the acyltransferase domain of module 6 of rifamycin polyketi

134 rization of a 52-kDa fragment containing the acyltransferase domain of Pks13.

135 Recently, the rs641738 membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) polymorphis

136 the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also c

137 and allosteric activation of the C-terminal acyltransferase domain.

138 accumulation of DAT, implicating Chp2 as an acyltransferase downstream of PapA3.

139 translational modification mediated by the O-acyltransferase encoded by the Drosophila porcupine homo

140 These are type I/IV trichome-expressed BAHD acyltransferases encoded by Solyc12g006330--or S. lycope

141 ree mass spectrometric assay to characterize acyltransferase enzymatic activity.

142 slational modification mediated by palmitoyl acyltransferase enzymes, a group of Zn(2+)-finger DHHC-d

143 pharmacological inhibition of Porcupine, an acyltransferase essential for Wnt secretion, alleviates

144 orcupine is a member of the membrane-bound O-acyltransferase family of proteins.

145 y, we examined whether members of the DHHC-S-acyltransferase family oligomerize in intact cells and i

146 tely, LpxJ is one member of a large class of acyltransferases found in a diverse range of organisms t

147 thesis locus shares similarity with LpxL, an acyltransferase from lipid A biosynthesis.

148 These lysine acyltransferases from Mycobacterium smegmatis (KATms) an

149 A (PLAs) and glycerophospholipid:cholesterol acyltransferases (GCATs), may target host cell lipids an

150 synthetase/2-acylglycerolphosphoethanolamine acyltransferase gene (aas) of Escherichia coli.

151 ed apicoplast-targeted lysophosphatidic acid acyltransferase gene was refractory to deletion and was

152 s UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase genes (la0512 and la4326 [lpxD1 and lpxD

153 otoxic part of LPS, through deletion of late acyltransferase genes, msbB or htrB, in GMMA-producing S

154 ified in this study was the murine glycine N-acyltransferase (GLYAT) enzymes, which are acetylated on

155 evere iron overload had glyceronephosphate O-acyltransferase (GNPAT) polymorphism p.D519G (rs11558492

156 Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane

157 that catalyzes this modification, ghrelin O-acyltransferase (GOAT), is receiving increased interest

158 t of knockout of the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acyla

159 study, we targeted the glycerol-3-phosphate acyltransferase GPAM along with choline kinase-alpha (CH

160 including mitochondrial glycerol-3-phosphate acyltransferase (GPAM), were exposed from metabolic path

161 Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separ

162 erols is catalyzed by a glycerol-3-phosphate acyltransferase (GPAT).

163 The expression of glycerol-3-phosphate acyltransferase (GPAT3) was examined throughout the smal

164 ding the enzyme, named glycerophosphocholine acyltransferase (GPCAT).

165 Tissue transglutaminase (tTG) is an acyltransferase/GTP-binding protein that contributes to

166 Mice carrying compound mutations in hedgehog acyltransferase (Hhat) and patched1 (Ptch1) exhibited pe

167 Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzy

168 Hedgehog acyltransferase (HHAT) is the enzyme in the endoplasmic

169 recruits it to the promoter of Hedgehog (Hh) acyltransferase (HHAT) that catalyzes the rate-limiting

170 Here, we show that Hedgehog acyltransferase (Hhat), the enzyme responsible for the a

171 ide-by-side comparison of PORCN and Hedgehog acyltransferase (HHAT), two enzymes that attach 16-carbo

172 ntly, Chp1 was characterized as the terminal acyltransferase in sulfolipid 1 biosynthesis.

173 Furthermore, in vitro assays of acyltransferases in microsomal fractions prepared from d

174 in vivo activities of type-2 diacylglycerol acyltransferases in Nannochloropsis oceanica (NoDGAT2s o

175 tablished the role of C. trachomatis-encoded acyltransferases in producing the new disaturated molecu

176 hetic 4'-phosphopantetheine group among four acyltransferases, including LpxD.

177 wn of a multifunctional lipase/phospholipase/acyltransferase increased lipid yields without affecting

178 Overexpression of selected DHHC palmitoyl acyltransferases increased palmitoylation of APP and dou

179 or with palmitate with or without carnitine acyltransferase inhibition by mildronate.

180 racterization of the polyketide synthase and acyltransferase involved in biosynthesis of the dioic ac

181 PatA is an essential membrane associated acyltransferase involved in the biosynthesis of mycobact

182 The acyltransferase involved in the formation of these conju

183 Here, we identify the missing acyltransferase, Jhp0255, which transfers a secondary ac

184 es building blocks and intermediates between acyltransferase, ketosynthase and ketoreductase active s

185 LBC agar, named choA, was identified as an N-acyltransferase known to produce an acylated glycine mol

186 reviously reported that lecithin:cholesterol acyltransferase (LCAT) and LDL receptor double knock-out

187 holipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharac

188 transfer protein A1 and lecithin cholesterol acyltransferase (LCAT) gene loci.

189 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse chole

190 is closely regulated by lecithin-cholesterol acyltransferase (LCAT) which is produced in the liver.

191 The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I)

192 homologue of mammalian lecithin:cholesterol acyltransferase (LCAT), a key enzyme that produces chole

193 ferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from humans in ret

194 erification activity of lecithin:cholesterol acyltransferase (LCAT).

195 ng a circulating enzyme lecithin cholesterol acyltransferase (LCAT).

196 19 is a conserved residue in human glycine N-acyltransferase-like 2 (hGLYATL2) and in several other s

197 18:0 fatty alcohols, whereas the C-terminal acyltransferase-like domain was able to rescue the letha

198 haring similarities with FARs is fused to an acyltransferase-like domain, whereas, in most other orga

199 n avocado (Persea americana) mesocarp and no acyltransferase/lipase motifs in most oleosins.

200 Finally, apolipoprotein N-acyltransferase (Lnt) catalyzes the transfer of the sn-1

201 last enzyme in the pathway, apolipoprotein N-acyltransferase, Lnt, responsible for adding a third acy

202 erol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT).

203 Lysophosphatidic acid acyltransferase (LPAT) catalyzes acylation of the sn-2 p

204 The CT775 gene encodes an acyltransferase (LpaT) that selectively transfers fatty

205 These include lysophosphatidic acid acyltransferases (LPAT) and diacylglycerol acyltransfera

206 e action of acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) can transfer PUFAs on PC directl

207 Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) enzymes have central roles in ac

208 transferase (LPEAT), lysophosphatidylcholine acyltransferase (LPCAT), and lysophospholipase (LYPLA) c

209 y phospholipase A2 (sPLA2), lysophospholipid acyltransferase (LPEAT), lysophosphatidylcholine acyltra

210 in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1).

211 rmacologically relevant lysophosphospholipid acyltransferase (LPLAT) superfamily.

212 rfamily of enzymes known as lysophospholipid acyltransferases (LPLATs), which are present in all doma

213 UDP-N-acetylglucosamine acyltransferase (LpxA) and UDP-3-O-(acyl)-glucosamine ac

214 ferase (LpxA) and UDP-3-O-(acyl)-glucosamine acyltransferase (LpxD) constitute the essential, early a

215 report that B. cenocepacia has only one late acyltransferase, LpxL (BCAL0508), which adds a myristoyl

216 succinogenes can act before the 2' secondary acyltransferase, LpxL, as well as the 3-deoxy-d-manno-oc

217 Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis

218 Lecithin:retinol acyltransferase (LRAT) is the enzyme that traps vitamin

219 olocalization of RPE65 with lecithin:retinol acyltransferase (LRAT) that provides the hydrophobic sub

220 Lecithin-retinol acyltransferase (LRAT)-deficient mice and P23H mutant mi

221 Lysocardiolipin acyltransferase (LYCAT), a cardiolipin-remodeling enzyme

222 c reticulum, and that certain diacylglycerol acyltransferases may be the candidate enzymes catalyzing

223 DHHC-type protein acyltransferases may regulate the localization, stabilit

224 GOAT is a member of the membrane-bound O-acyltransferase (MBOAT) family, a group of polytopic int

225 ne (Porcn), a member of the membrane bound O-acyltransferase (MBOAT) family, and is required for Wnt

226 ved Asp residues within the membrane-bound O-acyltransferase (MBOAT) homology domain are segregated o

227 t-specific subfamily of the membrane bound O-acyltransferases (MBOAT) that acylate different lipid su

228 Here, we evaluated multifunctional O-acyltransferase (MFAT) as a candidate for this 11-cis-RE

229 ocess catalyzed by acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2.

230 Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol

231 that DGAT2 interacted with monoacylglycerol acyltransferase (MGAT)-2, an enzyme that catalyzes the s

232 Acyl-CoA:monoacylglycerol acyltransferases (MGATs) and diacylglycerol acyltransfer

233 The glycerol-3-phosphate acyltransferase, mitochondrial haplotypes were associate

234 Lpp activates Toll-like receptor 2, the MsbB acyltransferase modifies lipopolysaccharide.

235 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, wit

236 Mutations in predicted catalytic and acyltransferase motifs do not influence TAG levels, sugg

237 g genes encoding Braun lipoprotein (Lpp) and acyltransferase (MsbB), the latter of which modifies lip

238 An acyltransferase, named p-coumaroyl-CoA:monolignol transf

239 his class of antibiotics is powered by the N-acyltransferase (NAT) Orf11*/Dbv8 through N-acylation on

240 erase (LpxD) constitute the essential, early acyltransferases of lipid A biosynthesis.

241 involved in TAG accumulation (diacylglycerol acyltransferases or major lipid droplet protein) were in

242 In M. tuberculosis, the acyltransferase PapA3 catalyzes the formation of diacylt

243 Here we demonstrate that the protein acyltransferase Pat regulates genes on Salmonella Pathog

244 Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse.

245 C17), a single member of the broad palmitoyl acyltransferase (PAT) family, produces marked alteration

246 lation, we set out to identify the palmitoyl acyltransferase (PAT) involved.

247 esults also suggest that zDHHC3, a palmitoyl acyltransferase (PAT), catalyzes the palmitoylation of P

248 However, Gram-positive bacteria utilize an acyltransferase pathway for the biogenesis of phosphatid

249 novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflamm

250 -His-His-Cys) identifies a family of protein acyltransferases (PATs) that catalyze the S-palmitoylati

251 fied on over half of the family of palmitoyl-acyltransferases (PATs) that mediate protein palmitoylat

252 ce at membranes and is mediated by palmitoyl acyltransferases (PATs).

253 e evolutionarily conserved protein palmitoyl acyltransferases (PATs).

254 Phospholipid:diacylglycerol acyltransferase (PDAT) and diacylglycerol:acyl CoA acylt

255 ical analyses of phospholipid:diacylglycerol acyltransferase (PDAT) in the green microalga Chlamydomo

256 PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) is an enzyme that catalyzes the t

257 RASE1 (DGAT1) or PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) on seed lipid composition were as

258 ases (DGATs) and phospholipid:diacylglycerol acyltransferases (PDATs) from the flax genome database.

259 As a result, RNase SrnA, acyltransferase PlaC, and metalloprotease ProA all prove

260 ansferase (PDAT) and diacylglycerol:acyl CoA acyltransferase play overlapping roles in triacylglycero

261 ion of Wnt3 by Porcupine, a membrane-bound O-acyltransferase, plays a significant role in the intrace

262 LPGAT1 (lysophosphatidylglycerol acyltransferase) polymorphisms were associated with lowe

263 Small molecules that disable the Wnt acyltransferase Porcupine (Porcn) are candidate anticanc

264 On the other hand, inhibitors of the Wnt acyltransferase Porcupine (Porcn) elicited neither effec

265 ion of the endoplasmic reticulum-localized O-acyltransferase porcupine (PORCN), which is necessary fo

266 ted fatty acid, to a conserved serine by the acyltransferase Porcupine (PORCN).

267 ''-O-ACYLTRANSFERASE (Vv3AT), encodes a BAHD acyltransferase protein (named after the first letter of

268 ber of a small subfamily of membrane-bound O-acyltransferase proteins that acylate secreted proteins,

269 pected that one of the genes might encode an acyltransferase, providing directions to our functional

270 ion and catalysis for an important family of acyltransferases, providing exciting possibilities for i

271 pid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1.

272 Ceramide synthases catalyze an N-acyltransferase reaction using fatty acyl-coenzyme A (Co

273 acyl-CoA synthetase and acyl-CoA:cholesterol acyltransferase, respectively.

274 of a Sterculia foetida lysophosphatidic acid acyltransferase (SfLPAT) increases CPA accumulation up t

275 tion of sterols with fatty acids by sterol O-acyltransferases (SOATs).

276 AALs that rely on an insertion motif for the acyltransferase specificity and thus makes FadD10 a new

277 enables the interrogation of other bacterial acyltransferases' structure-mechanism relationships, and

278 d, demonstrating that other lysophospholipid acyltransferases than the two LPEATs could acylate LPE T

279 T3 was shown to encode an acyl-CoA-dependent acyltransferase that catalyzes the transfer of short (fo

280 eages by targeting Porcn, a membrane-bound O-acyltransferase that is indispensable for the activity a

281 PORCN is a membrane-bound O-acyltransferase that is required for and dedicated to pa

282 Porcupine (PORCN) is a membrane bound O-acyltransferase that is required for Wnt palmitoylation,

283 me deletion mutant incapable of producing an acyltransferase that is responsible for the addition of

284 Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is

285 dentified DHHC-12 as the principal palmitoyl acyltransferase that palmitoylates gephyrin.

286 Porcupine is an O-acyltransferase that regulates Wnt secretion.

287 this domain is a dihydroxyacetone phosphate acyltransferase that uses preferentially 16:0-coenzyme A

288 is catalyzed by a family of transmembrane S-acyltransferases that contain a conserved zinc finger DH

289 in encoding BAHD (BEAT, AHCT, HCBT, and DAT) acyltransferases that specifically acylate monolignols w

290 conjunction with the enzyme lecithin:retinol acyltransferase to facilitate retinol uptake in some cel

291 concert with two previously identified BAHD acyltransferases--to reconstruct the entire cultivated t

292 Six KS domains from trans-acyltransferase (trans-AT) PKSs were subjected to a mass

293 ller of the two chromosomes, encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) mul

294 of Chlamydomonas reinhardtii diacylglycerol acyltransferase type two (DGTT) enzymes and use DGTT2 to

295 egative regulation of L-serine:palmitoyl-CoA acyltransferase, upregulating production of long-chain b

296 ulated gene, ANTHOCYANIN 3-O-GLUCOSIDE-6''-O-ACYLTRANSFERASE (Vv3AT), encodes a BAHD acyltransferase

297 g a subset of Populus trichocarpa BAHD/HXXXD acyltransferases, we identified a hydroxycinnamoyltransf

298 eta [RARbeta], CYP26A1, and lecithin retinol acyltransferase) were not altered in adipocytes from adi

299 in of zDHHC17 (HIP14) and zDHHC13 (HIP14L) S-acyltransferases, which is involved in both substrate re

300 mosome 11 locus containing a cluster of BAHD acyltransferases with one gene (named Sl-ASAT3) expresse