ライフサイエンスコーパス: adamantane

1 esults are seen for the alternate substrate, adamantane.

2 caffolds of the general structure 1 based on adamantane.

3 ming by investigating a series of methylated adamantanes.

4 panded tetrahedranes, prismanes, cubanes and adamantanes.

5 susceptible to neuraminidase inhibitors and adamantanes.

6 The hydrocarbon in-adamantane (1), a high-energy adamantane isomer in which

7 thylbipyridine to a bulky hydrophobic group (adamantane, 1), a heme ligand (imidazole, 2), or F (3).

8 thylidene)cyclooctane (TMCO) from commercial adamantane-1,3-dicarboxylic acid has been developed.

9 antane.ethanolamine complex (8), and (S)-2-[(adamantane-1-carbonyl)amino]-3-phenylpropionic acid (15)

10 A series of eight 4-substituted 1-(adamantane-1-carbonyloxy)pyridine-2(1H)-thiones (1, X =

11 e collection led to the identification of 1, adamantane-1-carboxylic acid (3-methyl-3H-benzothiazol-2

12 12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhib

13 n could be reduced by a sEH inhibitor, 12-(3-adamantane-1-yl-ureido)-dodecanoic acid n-butyl ester wa

14 Starting from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (1

15 ,N (CH(3))(2)-Dmt-Tic-OH (1), H-Dmt-Tic-NH-1-adamantane (2), and N,N(CH(3))(2)-Dmt-Tic-NH-1-adamantan

16 opropylphenyl)-1H-pyrazole-3-carbonyl]amino] adamantane-2-carboxylic acid, hydrochloride] blocked inh

17 our novel nanoscale 1,3,5,7-tetrasubstituted adamantanes 22 and 25-27 designed for atomic force micro

18 Adamantanes 22 and 25-27 may also find application as ch

19 amantane (2), and N,N(CH(3))(2)-Dmt-Tic-NH-1-adamantane (3) were determined by X-ray single-crystal a

20 ll-defined tower-shaped 1,3,5-trisubstituted adamantanes 30 and 33 that incorporate a macrocyclic tri

21 series of guests based on 2,6-disubstituted adamantanes, 4,9-disubstituted diamantanes, 1,6-disubsti

22 PhMe = 4-methylbenzoic acid, and HO2C12H17 = adamantane acetic acid) in a stepwise fashion from S = 4

23 Using the proteasomal inhibitor adamantane-acetyl-(6-aminohexanoyl)3-(leucinyl)3-vinyl-(

24 Adamantanes (amantadine and rimantadine) are one of the

25 The adamantanes, amantadine and rimantadine, have been used

26 s a good structure-function relationship for adamantane amino derivatives inhibiting [(3)H]TCP or [(3

27 upon addition of a competitive binder (e.g., adamantane ammonium (ADA)) for CB[7], (2) by a dual pH-c

28 disubstituted diamantanes, and 1-substituted adamantane ammonium ions by direct and competitive (1)H

29 trated an alarming increase in resistance to adamantanes among influenza A(H3N2) viruses isolated in

30 x), and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperi

31 manifested only with the bulky C-terminal 1-adamantane analogues 2 and 3.

32 rochemical relevance, including naphthalene, adamantane and hexamethylenetetramine.

33 -Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-1-adamantane and N,N(Me)2-Dmt-Tic-NH-tBut were highly effe

34 We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 coun

35 ized by hydrophobic interactions between the adamantane and the TM peptide.

36 The angles of the linkers between adamantane and tpy head play a critical role in guiding

37 raise concerns about the appropriate use of adamantanes and draw attention to the importance of trac

38 , and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir.

39 ar acenes, cyclohexane, decalin, triptycene, adamantane, and [2.2]paracyclophane.

40 These anchors include cycloalkanes, adamantanes, and nitrogen heterocycles that compete favo

41 an alkylative dearomatization/acid-mediated adamantane annulation sequence that allows facile access

42 o oseltamivir and zanamivir and resistant to adamantane antiviral medications.

43 the neuraminidase inhibitors (NAIs) and the adamantanes, are well characterized, as are many mutatio

44 ongest bases are the decalin base 25 and the adamantane base 31.

45 ed first- and second-generation polycationic adamantane-based dendrons via a combined protection/depr

46 An adamantane-based NO donor 14 was synthesized and combine

47 ace as a supramolecular host/FRET donor, and adamantane-BHQ2 conjugates were employed as the guest/qu

48 The simulations suggested that the adamantane binds with an average metal-deuterium distanc

49 ifted signal associated with a perdeuterated adamantane bound to CP450cam, while signals presumably a

50 am, while signals presumably associated with adamantane bound to other cavities persisted.

51 angle spinning NMR spectra of perdeuterated adamantane bound to the active site of microcrystalline

52 ng ligand, camphor, was used to displace the adamantane-bound species.

53 sistance to neuraminidase inhibitors and the adamantanes, but the ability of these viruses to replica

54 methylbutane, norbornane, nortricyclene, and adamantane by tritiodeprotonation or deuteriodeprotonati

55 Despite its intermediate size, adamantane (C(10)H(16), T(d)()) can enclose a wide varie

56 as employed because of the resistance of the adamantane cage toward cyclometalation reactions.

57 clodextrin (CD) with the hydrophobic part of adamantane carboxylate (AD) due to added salt or polar (

58 us involving the protonation state change of adamantane carboxylate at pH 5.8, and (3) by a dual pH-p

59 Me)2 = 3,5-dimethylbenzoic acid, HO2C11H15 = adamantane carboxylic acid, HO2C-th = 3-thiophene carbox

60 us substituted aminoquinolines coupled to an adamantane carrier are described.

61 The adamantane compounds, exemplified by JNJ303, are highly

62 (TCG)(4)TTPA with a tetrakis(triazolylphenyl)adamantane core and trimer DNA arms.

63 st synthesis of a tetraradical based upon an adamantane core bearing six equivalent nitroxide-nitroxi

64 the tetrakis[4-(resorcin-5-ylethynyl)phenyl]adamantane core.

65 The linker between the adamantane cores is constituted of short ethylene glycol

66 is(methylidene)bicyclo[3.3.1]nonane from the adamantane derivative were optimized, and diadducts of t

67 Memantine, an adamantane derivative, has been used for the treatment o

68 clo[4.3.1.1(3,8)]undecane (1), a benzo-1-aza-adamantane derivative, is described and features a previ

69 The mechanisms by which four adamantane derivatives (IEM-1857, -1592, -1460 and -1754

70 l(3), CD(2)Cl(2), and alcohol solutions with adamantane derivatives 15a,b, quinuclidine 15d, ammonium

71 lues of Ka for the interaction of CB[7] with adamantane derivatives 22-24 exceeds 10(12) M(-1)!

72 Both routes start from arylated adamantane derivatives and give the target compounds 12

73 we provide evidence for the binding site for adamantane derivatives and their putative access pathway

74 The adamantane derivatives have been used in HCV clinical tr

75 ions on the channel-blocking kinetics of the adamantane derivatives IEM-1754 and IEM-1857.

76 A plausible location of neutral and charged adamantane derivatives is shown in a model of the restin

77 We used a series of adamantane derivatives to probe the structure of the phe

78 In the case of the disubstituted adamantane derivatives, two and four conformers, respect

79 s has revolved around the synthesis of novel adamantane derivatives, we have recently found that othe

80 ted cation conductance and its inhibition by adamantane derivatives.

81 mization pathway of chiral 1,2-disubstituted adamantane derivatives.

82 y to accommodate larger guests like cationic adamantane derivatives.

83 The rigid adamantane-derived head unit with a single hydrogen atom

84 e identification of a novel benzylpiperazine adamantane diamide-derived compound that inhibits EboV i

85 ed to the affinity of CB[7].Diam(NMe3)2, the adamantane diammonium ion complexes (e.g., CB[7].2,6-Ad(

86 omplex [(((Ad)ArO)(3)N)U(III)(DME)] (1; Ad = adamantane, DME = 1,2-dimethoxyethane) reacts with the t

87 '-dimethylbipyridine to an enzyme substrate (adamantane, F(8)bp-Ad), a heme ligand (imidazole, F(8)bp

88 It is an important target of adamantane-family antiviral drugs, but drug resistance h

89 ex that contains a sterically more demanding adamantane functionalized ligand, [((AdArO)3tacn)UIII] (

90 vesicles as supramolecular templates and an adamantane-functionalized poly(acrylic acid) additive an

91 Adamantane functions as a hydride transfer agent and thu

92 ribe the functionalization of HA either with adamantanes (guest moieties) via controlled esterificati

93 Me)2-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-1-adamantane and N,N(Me)2-D

94 N,N(Me)2-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-

95 in the United States until susceptibility to adamantanes has been reestablished among circulating inf

96 Adamantanes have been used to treat influenza A virus in

97 side chain binds to either S1 or S2 and the adamantane headgroup binds to S1.

98 egy that harnesses an intramolecular beta-CD/adamantane host-guest interaction to generate a stabiliz

99 blies are instead composed of robust beta-CD/adamantane host/guest interactions.

100 orientation of the C-terminal substituent 1-adamantane in 2 and 3 was affected by differences in the

101 is of an exo-cis-exo stereoisomer containing adamantane in the tether exhibited an unusually close ap

102 in structure from bicyclo[2.2.1] through to adamantane, including some in the top-selling pharmaceut

103 ltaneous encapsulation of free ferrocene and adamantane inside the 1(2) capsular assembly.

104 hydrocarbon in-adamantane (1), a high-energy adamantane isomer in which one methine hydrogen atom is

105 An adamantane-labeled glutamine analog was selected through

106 ed with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see

107 s such as P4O6 and P4O10 that possess iconic adamantane-like cage structures, highly reactive phospho

108 e IR spectra and normal-mode analysis of the adamantane-like compound [Mn(4)O(6)(bpea)(4)](n+) (bpea

109 O pKa values for a series of rigid tricyclic adamantane-like triols containing 0-3 trifluoromethyl gr

110 These results indicate that adamantane metabolic stabilization sufficient to obtain

111 Rimantadine hydrochloride (alpha-methyl-1-adamantane-methalamine hydrochloride) is a chiral compou

112 thiophenol (74%), adamantamine (91%), and 1-adamantane methanol (75%), respectively.

113 le, 1-adamantane-p-toluenesulfonamide, and 1-adamantane methyl p-toluenesulfonate were reduced with 3

114 (1)H-(1)H NOE cross peaks indicate that the adamantane moiety of the drug is bound in the spacious p

115 be novel NitroMemantine drugs, comprising an adamantane moiety that binds in the NMDAR-associated ion

116 in-binding complex, with a freely accessible adamantane moiety.

117 The adamantane nucleus exposes three carboxylic acid groups

118 replacement by a single large molecule (here adamantane or ferrocene) entropically favourable.

119 Active drugs featured phenyl-, adamantane-, or alkyl residues at the methylene bridge.

120 Additionally, the starting racemic material, adamantane-oxazolidine-2-one, was resolved into single e

121 mines and heterocycles by decarboxylation of adamantane-oxazolidine-2-one.

122 Using the same conditions, thioanisole, 1-adamantane-p-toluenesulfonamide, and 1-adamantane methyl

123 The synthesis of the adamantane phenylalkylamines 2a-d, 3a-c, and 4a-e is des

124 AdabisGb(3) (two deacyl Gb(3)s linked to adamantane) protects against VT1/VT2 more effectively th

125 ansition from an inactive state (wherein the adamantane protein-binding headgroup is encapsulated) to

126 idged 1,2,4,5-tetraoxane characterized by an adamantane residue showed the highest activity (IC(5)(0)

127 ics of 2003, 1951, and 1947; and the rise in adamantane resistance among currently circulating human

128 We sought to assess adamantane resistance among influenza A viruses isolated

129 rculating in the United States demonstrating adamantane resistance highlights the clinical importance

130 eased due to the emergence of near-universal adamantane resistance in influenza A/H3N2 viruses during

131 Adamantane resistance in the A/H3N2 virus samples was 10

132 Adamantane resistance is imparted mainly by a S31N mutat

133 fied version of this method for detection of adamantane resistance mutations.

134 Adamantane resistance was found in only 1.2% of NY and W

135 ) in the M2 gene known to be correlated with adamantane resistance.

136 g, although at a level less significant than adamantane resistance.

137 iruses circulating in the United States were adamantane resistant.

138 ved compounds that inhibit the wild-type and adamantane-resistant forms of the influenza A M2 ion cha

139 clo[2.2.1]heptane, bicyclo[2.2.2]octane, and adamantane, respectively, were determined in the gas pha

140 eprotection strategy starting from different adamantane scaffolds.

141 biphenyl]-4-carboxylate ( 27: ) acts both on adamantane-sensitive and a resistant M2 variant encoding

142 Whereas the adamantane site binds CB solely via hydrophobic interact

143 the Fe(4)S(4) clusters are bridged with the adamantane [Sn(4)S(10)](4-) linking blocks, the electroc

144 seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses tha

145 dro-5-boraadamantane as well as some related adamantane systems, hitherto unknown as persistent long-

146 re TBA stands for tetrakis(p-hydroxybiphenyl)adamantane that assembles into a material from micromola

147 With the addition of catalytic amounts of adamantane the selectivity of this transformation can be

148 C 1s and S 2p binding energies are lower in adamantane thiol than alkane thiols on gold by 0.67 +/-

149 2''-terpyridine (tpy) ligands constructed on adamantane, three discrete 3D metallo-supramolecular arc

150 This intermediate was then conjugated to adamantane-trimerized GPI (2[(3-amino-3-carboxypropyl)(h

151 In this study, we present an adamantane-trimerized small molecule that has nanomolar

152 oxygen, nitric oxide, nitrous oxide, 1-azido adamantane, trimethylamine n-oxide, and 1,4-benzoquinone

153 chors (a flexible Letsinger type and a rigid adamantane type).

154 than 2 and was most consistent with a Cu4S6 adamantane-type species.

155 he opposite is true for the neutral molecule adamantane, which prefers the TID (or barbiturate) locus

156 sodesmic bond separation scheme to gas-phase adamantane yields a value for Delta(f)H degrees (298) wi