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1 a molecular clamp and as a microtubule-cargo adapter.
2 g" of gold nanorods decorated by the surface adapter.
3 oxic stress and autophagy involving the Doa1 adapter.
4 2), in which TRAF3 serves as the NIK-binding adapter.
5 r preferred orientations shift away from the adapter.
6 ays is adapter ligation using pre-adenylated adapters.
7 , possibly, cdc20 homolog 1 (Cdh1) E3 ligase adapters.
8 of nanoparticles using programmable surface adapters.
9 ALs adapters compared to presbyopic PALs non-adapters.
10 rs compared to incipient presbyopic PALs non-adapters.
11 via ligation of double-stranded DNA (dsDNA) adapters.
13 proteins provide docking sites for distinct adapter and effector proteins important for regulating d
15 via a canonical pathway involving the MyD88 adapter and the interleukin-1 receptor-associated kinase
16 Fremont, CA) using an anterior segment lens adapter and the split-spectrum amplitude decorrelation a
17 l intradermal devices, including intradermal adapters and disposable-syringe jet injectors, have also
18 n by membrane-localized Src homology 3 (SH3) adapters and N-WASP, resulting in the assembly of dynami
20 ul whole-body point-light displays (PLDs) as adapters and were then asked to perform an explicit cate
22 ts; explore the various reported designs for adapters; and consider future opportunities for this tec
24 ite mutant of Fgfr1, we established that FRS adapters are necessary for mediating most or all FGFR1 s
28 requires the effector caspases 1 and 11, the adapter ASC, and NLRP1, the sensor previously described
29 vation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release
31 d is capable of adenylating large amounts of adapter at ~100% efficiency and can efficiently adenylat
32 h a model in which Ltn1 uses 60S subunits as adapters, at least in part via its NTD, to target stalle
34 sidates the viral genome and functions as an adapter between the virus and the host cell machinery.
36 results in the sequestration of MyD88 (TLR2 adapter) by Act1/CIKS (IL17R adapter), thereby turning o
39 During normal signaling, the multidomain adapter CARD11 transitions from a closed, inactive state
41 ater (p < 0.03) in incipient presbyopic PALs adapters compared to incipient presbyopic PALs non-adapt
43 DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activate IkappaB kinase (IKK) and the
47 The structure suggests that the DUF is an adapter domain that stabilizes the aldehyde substrate bi
48 engagement of FRS and non-FRS intracellular adapters downstream of FGFRs could therefore in principl
50 lopment as an example, we show here that FRS adapters exhibit some selectivity in their requirement f
52 family protein TULP3 functions as a general adapter for ciliary trafficking of structurally diverse
54 ated protein 4 family-interacting protein 1) adapter for the ubiquitin ligase ITCH is genetically lin
58 n as an example to study the role of the FRS adapters FRS2 and FRS3 in mediating the functions of FGF
59 domain of VE-cadherin mediates an essential adapter function by binding directly to the transmembran
60 In summary, this study identifies a novel adapter function for VE-cadherin mediated by transmembra
61 a role for tRNA distinct from its canonical adapter function in translation, as cleavage of tRNAs by
63 BL1, via phosphorylated Tyr177, recruits the adapter GRB2-associated binding protein 2 (GAB2) as part
66 method relies on the ligation of sequencing adapters harboring random yet complementary double-stran
68 97 or siRNA-mediated depletion of p97 or its adapters impairs Ku80 removal after non-homologous end j
69 tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is ma
71 in (MyD88), and Toll-IL-1R domain-containing adapter inducing IFN-beta (TRIF)-dependent cytokine gene
72 daptor molecule Toll/IL-1R domain-containing adapter inducing IFN-beta and downstream production of t
75 to proapoptotic Toll-IL-1R domain-containing adapter inducing IFN-beta signaling, but was also trigge
77 ivated the TLR4/Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent signaling pathway co
78 D88-independent Toll/IL-1R domain-containing adapter inducing IFN-beta-IFN regulatory factor 3 pathwa
79 g the TLR4/MD-2/Toll/IL-1R domain-containing adapter inducing IFN-beta-mediated signaling, whereby PT
80 immunity are linked by TIR domain-containing adapter-inducing beta interferon (TRIF) during establish
81 volving Toll-IL-1-receptor domain-containing adapter-inducing IFN-alpha (TRIF) and nuclear factor kap
82 al for both MyD88- and TIR-domain-containing adapter-inducing IFN-beta (TRIF)-mediated signaling path
83 cules MyD88 and Toll/IL-IR domain-containing adapter-inducing IFN-beta (TRIF)-related adaptor molecul
84 ation with TLR4/Toll/IL-1R domain-containing adapter-inducing IFN-beta activation is an efficient str
85 adapter protein TRIF (TIR domain-containing adapter-inducing IFN-beta adapter protein) was also abla
86 protein Toll/IL-1 receptor domain-containing adapter-inducing IFN-beta and responded poorly to TLR ag
87 hrough the TLR4/Toll/IL-1R domain-containing adapter-inducing IFN-beta pathway, independent of the pr
89 Toll/IL-1 resistance (TIR) domain-containing adapter-inducing interferon beta) and activation of the
90 nduced endosomal TRIF (TIR domain-containing adapter-inducing interferon beta) signaling pathways.
91 like receptor 3 (-/-), TIR-domain-containing adapter-inducing interferon-beta (-/-), and wild-type mi
92 like receptor 3 (-/-), TIR-domain-containing adapter-inducing interferon-beta (-/-), and wild-type mi
94 tein kinase 3 (RIPK3), TIR-domain-containing adapter-inducing interferon-beta (TRIF) and Z-DNA-bindin
95 a Toll/IL-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (TRIF) but less so for
96 tion factor 88 (MyD88)/TIR-domain-containing adapter-inducing interferon-beta (TRIF) double knockout
97 well as Toll-dependent TIR-domain-containing adapter-inducing interferon-beta (TRIF), which function
98 Toll/Interleukin-1R (TIR) domain-containing adapter-inducing interferon-beta (TRIF)-, TRIF-related a
99 8 adapter-like), TRAM (TIR domain-containing adapter-inducing interferon-beta (TRIF)-related adaptor
100 he pretreatment of WT, TIR domain-containing adapter-inducing interferon-beta knockout, and MyD88 ada
101 adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-beta) is essential for GN, b
102 terleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta-dependent response that
103 lated adaptor molecule/TIR domain-containing adapter-inducing interferon-beta-dependent signaling pat
104 nocytes by enhancing a TIR domain-containing adapter-inducing interferon-dependent response and favor
112 tured by oligo-dT primers and processed into adapter-ligated cDNA libraries that were sequenced using
114 ter phosphatase treatment; hence, subsequent adapter ligation and cDNA amplification steps are exclus
117 MAT-seq circumvents the issue of inefficient adapter ligation, a characteristic of conventional RNA s
118 ves fragmentation of genomic DNA followed by adapter ligation, bisulfite conversion and limited ampli
120 inducing interferon-beta knockout, and MyD88 adapter-like knockout macrophages with gedunin (10 micro
122 nd intracellular adaptors such as MAL (MyD88 adapter-like), TRAM (TIR domain-containing adapter-induc
123 The selective effect of gedunin on MyD88-adapter-like/myeloid differentiation primary response 88
125 immunological synapse via the transmembrane adapter linker for activation of T cells (LAT) and for T
126 CD45, and preassociation with the signaling adapters linker for activation of T cells and growth fac
127 between the monocyte populations is that the adapter Mal (encoded by TIRAP) has appeared crucial for
128 ng data files by trimming reads and removing adapters, mapping reads to a reference, counting gene fe
129 sphorylation does not occur by the canonical adapter mechanism demonstrated for other substrates, as
130 t also in cell survival, implying that other adapters mediate at least in part the signaling from FGF
131 itro in the absence or presence of the cargo adapter melanophilin (Mlph), which links myoVa to Rab27a
132 t both the myosin motor domain and the cargo adapter Mlph, which has an actin-binding domain that act
133 ith the adapter protein Rap1-GTP-interacting adapter molecule (RIAM) followed by the recruitment of t
135 rve injury increased ionized calcium binding adapter molecule 1 (Iba1) and phosphorylated p38 MAPK im
136 signaling, levels of ionized calcium-binding adapter molecule 1 and glial fibrillary acidic protein,
137 panmicroglial marker ionized calcium-binding adapter molecule 1 was decreased in all AD cases and the
138 not differ regarding ionized calcium-binding adapter molecule 1+ immunoreactivity for microglia, sugg
139 hocyte expression of ionized calcium-binding adapter molecule 1, toll-like receptor 2, and toll-like
140 NZB gene encoding the SLAM signaling pathway adapter molecule EWS-activated transcript 2 (EAT-2) is p
141 protein 2 (Grb2) is a ubiquitously expressed adapter molecule involved in signaling processes of nume
142 mice and mice lacking the Toll-like receptor adapter molecule MyD88 were infected with a pool of infe
143 m in cancer, with a focus on complement, the adapter molecule Stimulator of Interferon Genes, natural
144 ely TLR independent, but is dependent on the adapter molecule STING, suggesting that the type I IFN s
145 s an oxidative stress-responsive cytoplasmic adapter molecule that is an upstream regulator of both I
146 ase (IKK) subunit NEMO/IKKgamma (NEMO) is an adapter molecule that is critical for canonical activati
152 For all TLRs except TLR3, recruitment of the adapter, myeloid differentiation primary response gene 8
154 he subcellular distribution of the organizer/adapter NOX p47(phox) subunit is altered in PVN dendrite
155 e demonstrate that Grp170 binds to Sel1L, an adapter of the transmembrane Hrd1 E3 ubiquitin ligase po
156 ry response protein 88 (MyD88), a downstream adapter of TLRs including TLR7, abolished the RNA-induce
160 blocks cell-surface recruitment of the MyD88 adapter, one of the earliest events in TLR signaling.
162 ed significantly increased expression of the adapter PI3Kgamma subunits Pik3r5 (p101) and Pik3r6 (p84
166 ole of adhesion- and degranulation-promoting adapter protein (ADAP) in promoting CD8 T cell responses
169 pansion by MSC EVs is mediated via the MyD88 adapter protein and is partially blocked by treatment wi
170 ngage caspase-1, in most cases requiring the adapter protein apoptosis-associated speck-like protein
171 dramatic relocalization of the inflammasome adapter protein apoptosis-associated speck-like protein
172 Many inflammasome receptors require the adapter protein ASC [apoptosis-associated speck-like pro
173 ion lies CrK-like (CRKL), a gene encoding an adapter protein belonging to the Crk family that is invo
180 been suggested that the kinase CheA and the adapter protein CheW are integral for receptor connectiv
181 lular localization of human UNC93B1 via both adapter protein complex (AP)1- and AP2-dependent traffic
182 have identified the beta subunit of the AP-3 adapter protein complex, AP3B1, as a binding partner for
183 nduced an increase in the association of the adapter protein cortactin with Pfn-1 in smooth muscle ce
184 tively, these results identify a microtubule adapter protein critical for trafficking of HIV-1 in the
185 nd genetic approaches revealed that the ShcA adapter protein critically influences proliferation and
187 olecular level, Siglec-15 interacts with the adapter protein DAP12 and can induce Akt activation when
189 cantly dependent on type I IFN and IPS-1 (an adapter protein downstream of the RIG-I pathway) signali
191 eceptor bound protein 10 (Grb10) is a signal adapter protein encoded by an imprinted gene that has ro
194 vitro Macrophages deficient in Mincle or its adapter protein Fc receptor gamma chain (FcRgamma) produ
196 ort that the c-Src kinase functions as a key adapter protein for the estrogen receptor (ER, ESR1) in
198 tested the hypothesis that Grb2 is a crucial adapter protein in (hem)immunoreceptor tyrosine-based ac
199 ological application we demonstrate that the adapter protein Inscuteable (mInsc) can actively promote
201 ates that Toll-like receptor (TLR) signaling adapter protein interactions with Toll/Interleukin-1 Rec
202 e myeloid differentiation protein 88 (MyD88) adapter protein is an important mediator of kidney allog
205 ing, the type 1 IL1 receptor or the receptor adapter protein MyD88, were not protected from tumor-ind
206 cle, we report that C57BL/6 mice lacking the adapter protein MyD88, which mediates signaling by TLRs
208 PP2A and increased its association with the adapter protein neuroblast differentiation-associated pr
211 roteins adhesion and degranulation promoting adapter protein or CT10 regulator of kinase/CT10 regulat
212 TRIP13 recognizes MAD2 with the help of the adapter protein p31(comet) We show that p31(comet) bindi
214 usly we reported that Jak3 interactions with adapter protein p52ShcA (Shc) facilitate mucosal homeost
215 association with the cellular focal adhesion adapter protein paxillin contributes to cell transformat
217 -bound Ras-related protein 1 (Rap1) with the adapter protein Rap1-GTP-interacting adapter molecule (R
219 hese data identify an important role for the adapter protein ShcA in later stages of thymic T cell de
220 f PD-1 was associated with expression of the adapter protein SHP-2, which signals to NF-kappaB; howev
222 of CaV1.1 in tsA201 cells is promoted by the adapter protein Stac3, because recent work has shown tha
223 ts intracellular DNA and signals through the adapter protein STING to initiate the antiviral response
224 mRNAs through the activity of the viral Rev adapter protein that forms a multimeric complex on these
225 at RANKL controls the expression of 3BP2, an adapter protein that is required for activation of SRC t
226 tor (TNFR)-associated factor 6 (TRAF6) is an adapter protein that mediates a wide array of protein-pr
228 otein A repetitions predominant [GARP]), the adapter protein that tethers TGF-beta to the membrane.
229 C57BL/6 mice, nor when signaling through the adapter protein TRIF (TIR domain-containing adapter-indu
231 lasmic capping complex assembles on Nck1, an adapter protein with functions in translation and tyrosi
234 ect binding to AtDCP1 rather than through an adapter protein, as known for membrane-coated organelles
235 ay have been facilitated by the bifunctional adapter protein, PSD-95, which associated with LRP1 sele
237 zinc finger-expressing, SLAM family receptor adapter protein-dependent thymocyte population that is e
242 ctive in the cytoplasm and that a variety of adapter proteins activate processive motility by linking
245 yotic cells require IQGAP family multidomain adapter proteins for cytokinesis, but many questions rem
246 This was attributed to the absence of both adapter proteins in platelets, as demonstrated by adopti
247 ink membrane subdomains, clathrin, and other adapter proteins involved in early steps of clathrin coa
248 TNF receptor-associated factor (TRAF)-family adapter proteins involved in TLR and TNFR pathways.
250 ractions between the tail and regions of the adapter proteins outside of the SH2/PTB domains are impo
252 ns (betaarrs) are versatile, multifunctional adapter proteins that are best known for their ability t
254 asmic reticulum (ER) is organized in part by adapter proteins that nucleate the formation of large pr
257 prime example is binding of the rigid 14-3-3 adapter proteins to their numerous partner proteins, who
258 ses occurred in macrophages deficient in the adapter proteins TRIF or MyD88 but not in macrophages de
259 ctivation, Toll-like receptor 4 (TLR4) binds adapter proteins, including MyD88 (myeloid differentiati
260 tegrin activation and is a carrier for other adapter proteins, Src kinase-associated phosphoprotein 1
261 tin and one of four different cargo-specific adapter proteins, the motor became ultraprocessive, movi
262 747) motif, to induce spreading and paxillin adapter recruitment to substrate- and talin-bound integr
264 al. (2014) report that degradation of cargo adapters releases yeast vacuoles and peroxisomes from my
265 w sequence evaluation, (2) read trimming and adapter removal, (3) read mapping and quality filtering,
266 ation sequencing reads, PALEOMIX carries out adapter removal, mapping against reference genomes, PCR
267 function, whereas double deficiency of both adapters resulted in markedly increased signal transduct
268 ssociated gene-9 (mda-9/syntenin) encodes an adapter scaffold protein whose expression correlates wit
271 tion-based strategy that leaves behind 38-bp adapter sequences, which must be computationally removed
272 n molecule family receptors and the specific adapter signaling lymphocytic activation molecule-associ
273 ull use of the sequence on both sides of the adapter site to build 'virtual libraries' of mate pairs,
274 o the centre of LAT-based complexes, and the adapter SLP-76 and actin molecules localize to the perip
275 e conversion and limited amplification using adapter-specific PCR primers in preparation for sequenci
277 M-PCR and unidirectionally ligated to bridge adapters; subsequent PCR steps amplify the single-strand
278 provide a detailed protocol for efficient DS adapter synthesis, library preparation and target enrich
280 Here, we present a versatile DNA surface adapter that can programmably self-assemble into various
281 adapter protein (ADAP) is a multifunctional adapter that regulates "inside-out" signaling from the T
282 gene, which encodes gigaxonin, an E3 ligase adapter that targets intermediate filament (IF) proteins
283 main containing proteins (BET) are chromatin adapters that bind acetylated histone marks via two tand
284 k and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to ful
285 binding proteins (PCBPs) are multifunctional adapters that mediate interactions between nucleic acids
286 ependent association with 14-3-3, a group of adapters that modulate dimerization and association betw
287 of MyD88 (TLR2 adapter) by Act1/CIKS (IL17R adapter), thereby turning off TLR2 signaling to restore
289 uses the toll receptor 3/4 induction factor adapter to initiate a different cytosolic adapter cascad
291 Rs, with the exception of TLR3, use an MyD88 adapter to Toll/IL-1 to initiate a proinflammatory casca
294 miseq does this by automating the process of adapter trimming, quality filtering, error correction, c
296 and the assembly vector is encoded by 'VEGAS adapter' (VA) sequences, which are orthogonal in sequenc
297 osin V motor Myo2 binds the vacuole-specific adapter Vac17 to attach to the vacuole/lysosome and init
298 ich SQSTM1/p62 plays a major role as a cargo adapter, we also were able to confirm that p62 binds to
299 photographers using the low-cost smartphone adapter were able to acquire optic nerve images at a sta
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