ライフサイエンスコーパス: adaptive immune response

1 te immune properties to limit an exaggerated adaptive immune response.

2 minated by monocyte-macrophages, and then an adaptive immune response.

3 direct antiviral activities and shaping the adaptive immune response.

4 antiviral immunity that can also improve the adaptive immune response.

5 fic T cells is a fundamental property of the adaptive immune response.

6 he transcription factor NF-kappaB during the adaptive immune response.

7 activating innate immunity, which elicits an adaptive immune response.

8 p hypoxic microenvironments during the early adaptive immune response.

9 eta emerges as an important modulator of the adaptive immune response.

10 . pylori gGT on human DCs and the subsequent adaptive immune response.

11 ed for normal lymphocyte function during the adaptive immune response.

12 Mtb-specific T cells, enabling an effective adaptive immune response.

13 ively removing them from participation in an adaptive immune response.

14 d memory precursors at the initiation of the adaptive immune response.

15 st as they act to connect the innate and the adaptive immune response.

16 tion produces high-affinity Abs for a robust adaptive immune response.

17 n SHRs represent an abnormal proinflammatory adaptive immune response.

18 innate immunity in a mouse with a functional adaptive immune response.

19 the development of an effective and durable adaptive immune response.

20 ite of immunization is able to fine-tune the adaptive immune response.

21 important processes for the induction of an adaptive immune response.

22 olecular explanation for how Mtb impairs the adaptive immune response.

23 the initiation and shaping of the subsequent adaptive immune response.

24 ogression, and the development of an optimal adaptive immune response.

25 disease pathology, overriding the protective adaptive immune response.

26 vading pathogens but also for initiating the adaptive immune response.

27 uent T-cell activation are essential for the adaptive immune response.

28 8 mutation in cftr is coupled to an impaired adaptive immune response.

29 criptase, which may restore the HBV-specific adaptive immune response.

30 n of T cell-biased clones consistent with an adaptive immune response.

31 mation, but also suppress overall innate and adaptive immune response.

32 exposure to TH1 polarization of the neonatal adaptive immune response.

33 ect in cell to cell communication during the adaptive immune response.

34 Lipoproteins modulate innate and adaptive immune responses.

35 gans (SLOs) needs to be established to prime adaptive immune responses.

36 regulate the development of both innate and adaptive immune responses.

37 tribute to the activation and orientation of adaptive immune responses.

38 nistic link between acute TBI and long-term, adaptive immune responses.

39 ort antiviral immunity by linking innate and adaptive immune responses.

40 -specific lymphocytes to foster induction of adaptive immune responses.

41 species (ROS) can profoundly modulate T cell adaptive immune responses.

42 ctivating innate immune cells and initiating adaptive immune responses.

43 ion and suppressing activation of innate and adaptive immune responses.

44 on the induction of Gag and toxin B-specific adaptive immune responses.

45 dders, form reservoirs, and evoke innate and adaptive immune responses.

46 compounds directly but temporarily modulate adaptive immune responses.

47 apies include activation of either innate or adaptive immune responses.

48 hosphinic pseudotripeptides as regulators of adaptive immune responses.

49 and molecular events that connect innate and adaptive immune responses.

50 pro-inflammatory effects in both innate and adaptive immune responses.

51 ex, including humoral, cellular, innate, and adaptive immune responses.

52 of pathogen elimination, and also facilitate adaptive immune responses.

53 cluding, notably, those that link innate and adaptive immune responses.

54 the STING-cGAS pathway to trigger innate and adaptive immune responses.

55 ition receptors might also play key roles in adaptive immune responses.

56 the network integrity for the activation of adaptive immune responses.

57 nisms and modulate the subsequent innate and adaptive immune responses.

58 erging as decision-shapers during innate and adaptive immune responses.

59 ) play a critical role in shaping innate and adaptive immune responses.

60 e determinants of staphylococcal escape from adaptive immune responses.

61 r the FcgammaRIIIa-pSyk signal in modulating adaptive immune responses.

62 g hallmarks but also in developing antitumor adaptive immune responses.

63 om bacterial strategies that manipulate host adaptive immune responses.

64 ted because of the insufficient induction of adaptive immune responses.

65 IT cells function to promote both innate and adaptive immune responses.

66 information to generate tailored protective adaptive immune responses.

67 te ligands is a key step in the emergence of adaptive immune responses.

68 lls (DCs) form a key link between innate and adaptive immune responses.

69 ) and CD8(+) T cells are at the core of most adaptive immune responses.

70 lays a pivotal role in the modulation of the adaptive immune responses.

71 djuvants to augment induction of Ag-specific adaptive immune responses.

72 They also modulate innate and adaptive immune responses.

73 g through the T cell receptor (TCR) controls adaptive immune responses.

74 quently lead to the activation of innate and adaptive immune responses.

75 enic peptides and indirectly regulates human adaptive immune responses.

76 crobiota, leading to dysregulated innate and adaptive immune responses.

77 lower airways, combined with both innate and adaptive immune responses.

78 e blood was correlated with rapid innate and adaptive immune responses.

79 TGF-beta pathway, which negatively regulates adaptive immune responses.

80 ted tissue-specific regulation of innate and adaptive immune responses.

81 fenses by promoting nonprotective Th2-biased adaptive immune responses.

82 lso involved in the regulation of innate and adaptive immune responses.

83 f importance in generating T helper-1 biased adaptive immune responses.

84 ic injury contributes to impaired innate and adaptive immune responses.

85 nes associated with inflammatory, innate and adaptive immune responses.

86 rient supply to support clonal expansion and adaptive immune responses.

87 een demonstrated to induce strong innate and adaptive immune responses.

88 ses that modulate malaria-induced innate and adaptive immune responses.

89 ading to perturbation of the host innate and adaptive immune responses.

90 role in DENV-induced cytokine production and adaptive immune responses.

91 xes with their T-cell receptors and initiate adaptive immune responses.

92 ving the complementary actions of innate and adaptive immune responses.

93 ctive approach to enhance therapies boosting adaptive immune responses.

94 ll survival without involvement of innate or adaptive immune responses.

95 ound to play an important role in innate and adaptive immune responses.

96 vels, thereby presumably fostering efficient adaptive immune responses.

97 cute stages of sepsis often display impaired adaptive-immune responses.

98 tory cytokine induction by SVLP(+) DCs, with adaptive immune response activation ex vivo/in vivo.

99 s are important for pathogen elimination and adaptive immune response activation.

100 crophage infiltration initiates long-lasting adaptive immune responses after TBI.

101 that both capsid proteins contribute to the adaptive immune response against astrovirus.

102 d cytotoxic CD8+ T cells are key players for adaptive immune responses against acute infections with

103 I and MDA5 as critical players in innate and adaptive immune responses against DENV, and targeting th

104 ls to mesenteric lymph nodes (LNs) to induce adaptive immune responses against microbes and food Ags

105 Autoimmune diseases are characterized by adaptive immune responses against self-antigens, includi

106 mune cells, mechanisms of their synergy with adaptive immune responses against tumors, and discuss re

107 ibility complex class I molecules to trigger adaptive immune responses against virally or malignantly

108 racellular RNA transfer in the regulation of adaptive immune response, also contextualizing it in a b

109 se, which is followed by a strong and robust adaptive immune response and accompanied by viral cleara

110 DOWN genes) in MDD were associated with the adaptive immune response and included clusters of genes

111 , have been shown to suppress the innate and adaptive immune response and limit deleterious remodelin

112 HLAs are fundamental to the adaptive immune response and play critical roles in the

113 epletion in the clinic has revealed that the adaptive immune response and the downstream events initi

114 e function by cigarette smoke may thus alter adaptive immune responses and add to prolonged infection

115 that lymphadenectomy impairs acquisition of adaptive immune responses and antibody production in res

116 L-12) and IL-23 connect innate responses and adaptive immune responses and are also involved in autoi

117 "hyperactive." Hyperactive DCs induce potent adaptive immune responses and are elicited by caspase-11

118 re powerful APCs that can induce Ag-specific adaptive immune responses and are increasingly recognize

119 global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulatio

120 provide key molecules that drive innate and adaptive immune responses and control immune regulatory

121 deling that occurs within lymph nodes during adaptive immune responses and how it is regulated by den

122 we examined the effects of Spns2 deletion on adaptive immune responses and in autoimmune disease mode

123 sing viral infection onto cells that mediate adaptive immune responses and in protecting virions atta

124 ncomitant increases in tuberculosis-specific adaptive immune responses and interleukin 6 (IL-6) level

125 in murine DC can influence the generation of adaptive immune responses and may explain some aspects o

126 lesions exhibit an activation of innate and adaptive immune responses and pruritogenic pathways simi

127 the viral vectors to raise robust anti-tumor adaptive immune responses and sensitized established and

128 o leads to late PTB by initiating innate and adaptive immune responses and suggest that the PPARgamma

129 so highlight recent evidence suggesting that adaptive immune responses and treatment with immune modu

130 ic cells (DCs) are central regulators of the adaptive immune response, and as such are necessary for

131 inst invading microorganisms, priming of the adaptive immune response, and removal of immune complexe

132 nity, we studied parasite growth, innate and adaptive immune responses, and host survival in WT and C

133 umor regression by LATS1/2 deletion requires adaptive immune responses, and LATS1/2 deficiency enhanc

134 ial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the path

135 expanded roles of neutrophils in innate and adaptive immune responses, and summarize current knowled

136 high-affinity T-cell receptors to deepen the adaptive immune response; and reinvigorating older appro

137 Mechanistic insight into how adaptive immune responses are modified along the self-no

138 Maternal innate and adaptive immune responses are modulated during pregnancy

139 mmune cell trafficking to lymph nodes, where adaptive immune responses are mounted.

140 nt infection have suggested that ineffective adaptive immune responses are necessary for persistent v

141 Adaptive immune responses are tailored to different type

142 In patients with CHB, both innate and adaptive immune responses are weak and thus rarely lead

143 nate immune responses, leading to beneficial adaptive immune responses, are unknown.

144 t identification of a preexisting and stable adaptive immune response as defined by mRNA expression p

145 helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody producti

146 er, this therapy recruits both an innate and adaptive immune response, as deficiencies in either arm

147 tration during inflammation, induction of an adaptive immune response, as well as to dampening an ant

148 n of alarmins in the induction of innate and adaptive immune responses, as well as their contribution

149 ith this presentation, type 2 innate and TH2 adaptive immune responses associated with dampened infla

150 atory function that is capable of polarizing adaptive immune responses, at least in vitro.

151 FN response of mice was suppressed, then the adaptive immune responses became critical.

152 IL28B, which suggesting that the innate and adaptive immune responses both play an important role in

153 d Igs can provide valuable insights into the adaptive immune response, but bioinformatics pipelines f

154 NFAT1 has important roles in both innate and adaptive immune responses, but its involvement in cancer

155 combination (CSR) plays an important role in adaptive immune response by enabling mature B cells to s

156 helper (Th) cells play a central role in the adaptive immune response by providing help to B cells an

157 a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its den

158 Dendritic cells (DC) initiate and shape adaptive immune responses by presenting HLA-epitope comp

159 s, play crucial roles in defining innate and adaptive immune responses by regulating the trafficking

160 JAK/STAT pathway influences both innate and adaptive immune responses by suppressing alpha-SYN-induc

161 eptibility of CAST mice to VACV, whereas the adaptive immune response can be protective only if virus

162 hat the integration of TLR signaling into an adaptive immune response can further promote survival of

163 More broadly, they suggest that adaptive immune responses can contribute to innate IEL a

164 vaccination, or during secondary infection, adaptive immune responses can enhance both cytokine-driv

165 During adaptive immune responses, CD8(+) T cells with low TCR a

166 Effectors of the adaptive immune response-CD8(+) T cells that clear viral

167 multifactorial components of the innate and adaptive immune responses, controls parasitemia, and blo

168 re an important site at which the innate and adaptive immune responses converge but their architectur

169 The initiation of adaptive immune responses depends upon the careful maneu

170 ools to elucidate requirements for effective adaptive immune responses directed against Ftt.

171 sults highlight the impact of the endogenous adaptive immune response during primary SHIV infection.

172 Augmentation of adaptive immune responses during therapy was more impres

173 singly recognized as important regulators of adaptive immune responses, especially in setting the out

174 r, the existing models cannot support robust adaptive immune responses, especially the generation of

175 the generation of a strong yet self-tolerant adaptive immune response, essential in the face of the p

176 to assess whether the carbohydrate-specific adaptive immune response exemplified in our previous stu

177 r to HIV-1 transmission and that escape from adaptive immune responses exposes the virus to antiviral

178 nsplantation decreases the durability of the adaptive immune response following cART withdrawal and v

179 Sepsis is well known to alter innate and adaptive immune responses for sustained periods after cl

180 Sepsis clearly alters the innate and adaptive immune responses for sustained periods of time

181 nostimulatory effects that bridge innate and adaptive immune responses for the therapeutic treatment

182 mechanisms by which FcgammaRIIB controls the adaptive immune response have been described.

183 ow suggest a global disruption of the entire adaptive immune response in a segment of patients.

184 The greater adaptive immune response in aged versus young mice was l

185 FP may reduce the adaptive immune response in COPD and may be more effecti

186 ptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be

187 pe I IFN response, suggesting a role for the adaptive immune response in resolving infection.

188 ressing an important cell linking innate and adaptive immune response in TB.

189 colitis, suggesting an important role of the adaptive immune response in the colonic environment in t

190 esults demonstrate an important role for the adaptive immune response in the control of ZIKV infectio

191 iliensis infection by downregulating the Th2 adaptive immune response in the lung, which protects the

192 sed in the BM appear less protected from the adaptive immune response in the presence of the anti-CD3

193 vide an update on the role of FcgammaRIIB in adaptive immune responses in autoimmunity, and then focu

194 study, we characterized the functional human adaptive immune responses in HCMV latently-infected huBL

195 is of key importance in the understanding of adaptive immune responses in health and disease.

196 complex does not cause any adverse innate or adaptive immune responses in immune-competent, hemophili

197 le of HIV-specific CD4(+) T cells in shaping adaptive immune responses in individuals infected with c

198 s growth ability and improves the innate and adaptive immune responses in infected animals.

199 tes, has profound consequences on innate and adaptive immune responses in inflamed tissues.

200 L-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.

201 However, the role of adaptive immune responses in NAFLD-promoted HCC is large

202 to the dorsal root ganglion, suggesting that adaptive immune responses in neuropathic pain could be s

203 ted whether inhibitory signals down-regulate adaptive immune responses in patients with ALF.

204 xpression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mi

205 s also capable of modulating host innate and adaptive immune responses in response to sepsis, transpl

206 frontiers of current knowledge of innate and adaptive immune responses in the brain and how these res

207 lesions in macaques suggests that persistent adaptive immune responses in the CNS also may develop in

208 ) has impeded our understanding of antiviral adaptive immune responses in the context of a human immu

209 press the generation of antiviral innate and adaptive immune responses in the first few days of infec

210 latory roles that would be lost in AATD, yet adaptive immune responses in the lung have not been inve

211 LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced

212 ngerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting th

213 ggesting that CRT triggers the activation of adaptive immune responses in the tumor microenvironment.

214 row-derived suppressor cells, inhibiting the adaptive immune responses in vivo and vitro.

215 timulated T and B cells and thereby curtails adaptive immune responses in vivo.

216 nodes [mLNs] causing reduced T cell-mediated adaptive immune responses (in particular Th17-like respo

217 MEDI551 potently inhibits pathogenic adaptive immune responses, including depleting autoantib

218 Adaptive immune responses, including TH2 responses, were

219 Resistance to infection was independent of adaptive immune responses, including the expansion of sp

220 NLRP10-deficient mice developed vigorous adaptive immune responses, indicating that there was not

221 st's immune system, the parasite renders the adaptive immune response ineffective.

222 espite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproduci

223 mplement activation also participates in the adaptive immune response, inflammation, hemostasis, embr

224 However, induction of the adaptive immune response is a critical step in host cont

225 This change in the adaptive immune response is associated with impaired vir

226 The adaptive immune response is regulated primarily by mecha

227 A critical hallmark of adaptive immune responses is the rapid and extensive exp

228 ) locus, which plays an integral role in the adaptive immune response, is an example of a complex gen

229 ave suppressed type I IFN responses and lack adaptive immune responses, leading to a prolonged infect

230 To achieve a durable adaptive immune response, lymphocytes must undergo clona

231 ttern recognition receptors in informing the adaptive immune response, markedly less attention has be

232 that attenuation of the chemokine-dependent adaptive immune response may be of therapeutic benefit f

233 , the memory component of the virus-specific adaptive immune response may improve viral control compa

234 lmonary changes in smoking mice and that the adaptive immune response may play a role at later stages

235 re successful, and how the correction of the adaptive immune response might impact on the innate side

236 (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of a

237 ar the main responsibility for initiation of adaptive immune responses necessary for antimicrobial im

238 ted virus growth and improved the innate and adaptive immune responses of infected animals.

239 To this end, we compared innate and adaptive immune responses of moDCs with those that were

240 Adaptive immune responses protect against infection with

241 rrelated with GC formation and expression of adaptive immune response-related genes.

242 tion, during which fluctuation of innate and adaptive immune response-related transcripts was observe

243 How tissue-resident macrophages (TRM) impact adaptive immune responses remains poorly understood.

244 Effective adaptive immune responses require a large repertoire of

245 Most adaptive immune responses require the activation of spec

246 negatively affected by a range of innate and adaptive immune responses, resulting in alterations in t

247 lifestyle that limits exposure to innate and adaptive immune responses, sequesters the organism from

248 elf immunogenic, inducing a uricase-specific adaptive immune response that occurred even when the enz

249 e siderophore-protein conjugates elicited an adaptive immune response that targeted bacterial stealth

250 nt changes to the microbiome, and innate and adaptive immune responses that are critical to the induc

251 ve important roles in stimulating innate and adaptive immune responses that are required for resistan

252 mals control persistent viral infections via adaptive immune responses that include production of neu

253 tch recombination (CSR) are key processes in adaptive immune responses that naturally generate DNA do

254 Engineering vaccines to induce adaptive immune responses that preferentially target con

255 role played by these molecules in innate and adaptive immune responses, their complex expression regu

256 tes play an essential regulatory role in the adaptive immune response through Ab production during in

257 eptible target cells and modulate innate and adaptive immune responses through their interaction with

258 stion of CD8(+) T cells severely impedes the adaptive immune response to chronic viral infections.

259 infected cells plays a role in the effective adaptive immune response to HIV.

260 B cells are a major part of the adaptive immune response to inhaled HDM allergen, partic

261 rst identified in bacteria and archaea as an adaptive immune response to invading genetic material, h

262 responses that are required for an effective adaptive immune response to M. tuberculosis infection ar

263 ough IFNgamma is the central mediator of the adaptive immune response to pathogens, it has been shown

264 of IL-2 secretion is critical to tailor the adaptive immune response to the antigen amount.

265 hysiological factors that mediate innate and adaptive immune response to vaccines.

266 T and B cells, murine NK cells also mediated adaptive immune responses to a secondary challenge with

267 tion by suppressing activation of innate and adaptive immune responses to alpha-SYN.

268 Cytotoxic therapies prime adaptive immune responses to cancer by stimulating the r

269 mmune responses that correlate with enhanced adaptive immune responses to concomitantly administered

270 macrophages displayed impaired Th1 and Th17 adaptive immune responses to H. pylori, which contribute

271 cART, including the possible contribution of adaptive immune responses to HIV-associated neurocogniti

272 N-alpha/beta signaling and efficacy of early adaptive immune responses to HSV-1 were dissected using

273 ole for MyD88 in coordinating the innate and adaptive immune responses to infection with this ubiquit

274 uggests that progestins significantly affect adaptive immune responses to influenza A virus infection

275 s expands the range of antigenic targets for adaptive immune responses to M. tuberculosis and may hel

276 is work extends previous knowledge regarding adaptive immune responses to MF59-adjuvanted vaccines, a

277 e the role of TOLLIP variation on innate and adaptive immune responses to mycobacteria and susceptibi

278 dent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal an

279 oting local OC cell fusion without affecting adaptive immune responses to oral bacteria.

280 s have identified important contributions of adaptive immune responses to parasite control, much less

281 Our results indicate that optimal innate and adaptive immune responses to Pneumocystis species are de

282 de that PAHSA treatment regulates innate and adaptive immune responses to prevent mucosal damage and

283 ividuals with somewhat reduced innate and/or adaptive immune responses to S. aureus, either because p

284 nally dependent developmental differences in adaptive immune responses to self-antigens independent o

285 rly, age cohorts that are deficient in their adaptive immune responses to such antigens.

286 ort tumor growth and to convert and suppress adaptive immune responses to the tumor.

287 e a powerful adjuvant activity for enhancing adaptive immune responses to tumor antigens released by

288 odulatory activity that can alter innate and adaptive immune responses to viral infection.

289 C57BL/6 mice mount cell-mediated and humoral adaptive immune responses to ZIKV, these responses were

290 they could contribute to the instruction of adaptive immune responses toward malaria parasites.

291 immune receptors that initiate an efficient adaptive immune response upon activation.

292 Despite its importance in shaping adaptive immune responses, viral clearance, and immune-b

293 Furthermore, adaptive immune responses were dispensable for house dus

294 , but LCs are required for specific types of adaptive immune responses when antigen is concentrated i

295 some degree of modulation of the innate and adaptive immune responses, which could help to control s

296 owever, whether modulations of the innate or adaptive immune responses will finally be more successfu

297 restingly, PHIP mounted efficient innate and adaptive immune responses with a deep HCMV imprint, reve

298 The patients mounted efficient innate and adaptive immune responses with a deep HCMV imprint.

299 ors play a central role in the initiation of adaptive immune responses with several TLR agonists acti

300 tinct IL-1-mediated, innate and Th1-mediated adaptive immune responses with Staphylococcus aureus and