ライフサイエンスコーパス: adaptive immune system

1 r organisms and invertebrates, which lack an adaptive immune system.

2 e T-cell receptor (TCR) is a hallmark of the adaptive immune system.

3 the absence of Bach2 was dependent upon the adaptive immune system.

4 memory is a central feature of the mammalian adaptive immune system.

5 iota effects, or tumoricidal activity by the adaptive immune system.

6 D)J recombination to ensure diversity of the adaptive immune system.

7 ecific lymphocytes required for an efficient adaptive immune system.

8 een concurrently infecting pathogens and the adaptive immune system.

9 l link between proresolution signals and the adaptive immune system.

10 nnate immune responses are suppressed by the adaptive immune system.

11 ons and interactions of neutrophils with the adaptive immune system.

12 of the peripheral T-cell compartment of the adaptive immune system.

13 recognized as 'non-self' neo-antigens by the adaptive immune system.

14 that also function to bridge the innate and adaptive immune system.

15 ng evidence of complex interactions with the adaptive immune system.

16 sms that rely on antibodies as part of their adaptive immune system.

17 ather fully fledged, critical members of the adaptive immune system.

18 this powerful methodology for exploring the adaptive immune system.

19 ne of the most important interactions in the adaptive immune system.

20 ex roles in the regulation of the innate and adaptive immune system.

21 nvestigate relationships between arms of the adaptive immune system.

22 he first step of antigen presentation to the adaptive immune system.

23 ed by maladaptive response of the innate and adaptive immune system.

24 tain features that are characteristic of the adaptive immune system.

25 ith ganciclovir in mice lacking a functional adaptive immune system.

26 T cells are key players of the mammalian adaptive immune system.

27 cells in the emergence and evolution of the adaptive immune system.

28 to target murine ILCs in the presence of an adaptive immune system.

29 of a powerful new technology for probing the adaptive immune system.

30 ontrol of tumor growth is dependent upon the adaptive immune system.

31 eats)/Cas (CRISPR-associated), a prokaryotic adaptive immune system.

32 ial defense without collateral damage by the adaptive immune system.

33 recognized avidly by both the innate and the adaptive immune system.

34 play important roles both in the innate and adaptive immune system.

35 e human leukocyte antigen (HLA) genes of the adaptive immune system.

36 are orchestrated by both the innate and the adaptive immune system.

37 ed for up to 15 d yet was independent of the adaptive immune system.

38 well described stimulators of the innate and adaptive immune system.

39 ry pathways that involve both the innate and adaptive immune system.

40 ted to allow the virus to be masked from the adaptive immune system.

41 been given to their impact on the developing adaptive immune system.

42 egulation of innate immunity by cells of the adaptive immune system.

43 heterogeneity is an essential feature of the adaptive immune system.

44 mote tumor suppression via activation of the adaptive immune system.

45 , delta-opioid receptors, and T cells of the adaptive immune system.

46 tion of infectious and sterile agents to the adaptive immune system.

47 sequencing is a powerful tool to analyze the adaptive immune system.

48 he interface between the circulation and the adaptive immune system.

49 nally been regarded as a unique trait of the adaptive immune system.

50 fects on B cells, the other component of the adaptive immune system.

51 ant in lineage decision-making events in the adaptive immune system.

52 in protospacer integration by the CRISPR-Cas adaptive immune system.

53 igands, marking cells for recognition by the adaptive immune system.

54 correct defects in this important arm of the adaptive immune system.

55 by defects in the innate mucosal barrier and adaptive immune system.

56 ays an important role in both the innate and adaptive immune systems.

57 ial roles in both prokaryotic and vertebrate adaptive immune systems.

58 ning regulatory mechanisms of the innate and adaptive immune systems.

59 ly understood role in linking the innate and adaptive immune systems.

60 evolutionary relationship between innate and adaptive immune systems.

61 ays an important role in both the innate and adaptive immune systems.

62 ess vertebrates (cyclostomes) have different adaptive immune systems.

63 7 effector states in cells of the innate and adaptive immune systems.

64 ses through interactions with the innate and adaptive immune systems.

65 ted with deficiencies in both the innate and adaptive immune systems.

66 tory effects at all levels of the innate and adaptive immune systems.

67 and IL-13 from cells of both the innate and adaptive immune systems.

68 ing the functions of cells of the innate and adaptive immune systems.

69 e of this study was to determine whether the adaptive immune system actively suppresses tumorigenesis

70 The innate and adaptive immune systems actively participate in this sur

71 (CRISPR-associated) operon form an RNA-based adaptive immune system against foreign genetic elements

72 cted endonuclease machineries that act as an adaptive immune system against foreign genetic elements.

73 Cas loci encode proteins that function as an adaptive immune system against infectious viruses and pl

74 An example of this is the acquired, or adaptive, immune system (AIS), which is composed of both

75 eration between the innate immune system and adaptive immune system, an event facilitated by activati

76 T cells represent a crucial component of the adaptive immune system and are thought to mediate anti-t

77 fects of the anti-CCR4 antibody required the adaptive immune system and CD4+ T cells.

78 odel glycoconjugate vaccine can activate the adaptive immune system and demonstrated that the mammali

79 microbiota and maturation of the innate and adaptive immune system and discuss examples of early-lif

80 disease in BPSM1 mice is independent of the adaptive immune system and does not appear to involve in

81 Our findings emphasize the role of the adaptive immune system and especially of activated drug-

82 consequences of alternative splicing in the adaptive immune system and give our view of important di

83 the central role that antibodies play in the adaptive immune system and in biotechnology, much remain

84 dependent on the presence of the functional adaptive immune system and independent of TLR4 signaling

85 the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their exploitation as

86 teins with essential roles in regulating the adaptive immune system and maintaining the extracellular

87 g-induced allergic hepatitis mediated by the adaptive immune system and suggest that impaired liver t

88 between the antigen recognition role of the adaptive immune system and the effector functions of mas

89 ent the results from being influenced by the adaptive immune system and used the armamentarium of met

90 T cell activation is a key event in the adaptive immune system and vital in the generation of pr

91 ations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells

92 ns between the microbiota and the innate and adaptive immune systems and discuss their potential to l

93 They bridge the innate and adaptive immune systems and mediate strong and rapid res

94 , notably at the interface of the innate and adaptive immune systems and within secondary lymphoid or

95 e ability to measure critical aspects of the adaptive immune system, and can be readily used for stud

96 of PLZF as a critical regulator in the human adaptive immune system, and identify a novel, essential

97 cell death, non-canonical NF-kappaB and the adaptive immune system, and might therefore represent a

98 nificantly reduced on cells from the newborn adaptive immune system, and neonatal antigen presenting

99 ct with and regulate cells of the innate and adaptive immune systems, and contribute to the resolutio

100 ll, gut microbiome, hypothalamus, innate and adaptive immune systems, and insulin-sensitive tissues.

101 cognate ligands triggers both the innate and adaptive immune systems, and thus can play a pivotal rol

102 C pathway since early diversification of the adaptive immune system approximately 500 Mya.

103 arch have established that components of the adaptive immune system are critical for transplant rejec

104 stnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored.

105 r the innate immune response and link to the adaptive immune system are increasingly recognized as a

106 The data identify the peripheral adaptive immune system as putatively involved in the mec

107 can elicit direct suppressive effects on the adaptive immune system, as serum from stroke patients in

108 ed cytokines and chemokines, and finally the adaptive immune system, as well as eosinophils as newly

109 Interactions between ILC2 cells and the adaptive immune system, as well as examination of potent

110 -talk between the coagulation system and the adaptive immune system at sites of vascular injury throu

111 s represent the earliest vertebrates with an adaptive immune system based on lymphocyte Ag receptors

112 ractions between molecules of the innate and adaptive immune systems bridge these two arms of immunit

113 ne therapies target single mechanisms in the adaptive immune system but not innate immunity.

114 ous and cyclic stimulation of the innate and adaptive immune system by endogenous nucleic acids relea

115 , suggesting that optimal stimulation of the adaptive immune system by the microbiota might be needed

116 mation phenomena and can link the innate and adaptive immune systems by enhancing graft immunogenicit

117 ay bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adju

118 Prokaryotes encode adaptive immune systems, called CRISPR-Cas (clustered re

119 terspaced short palindromic repeats (CRISPR) adaptive immune system can be used to facilitate efficie

120 otherapy, while activation of the innate and adaptive immune system can enhance the local efficacy of

121 by interacting with both the innate and the adaptive immune systems, can drive allergy and asthma pa

122 The adaptive immune system cannot generally employ this stra

123 CD8(+) T cells are specialized cells of the adaptive immune system capable of finding and eliminatin

124 CRISPR-Cas adaptive immune systems capture DNA fragments from invad

125 nes are known to result in impairment of the adaptive immune system, causing a group of disorders col

126 unappreciated intertwining of the innate and adaptive immune systems: CD4(+) T cells priming NK cells

127 One major distinction between innate and adaptive immune system cells is the constitutive express

128 gy for the generation of mice with humanized adaptive immune systems, complete with tissue engraftmen

129 The adaptive immune system confers protection by generating

130 The CRISPR-Cas adaptive immune system confers sequence-specific immunit

131 Recently discovered bacteria and archaea adaptive immune system consisting of clustered regularly

132 t that chronic stress-induced changes in the adaptive immune system, contrary to conferring anxiety a

133 Thus, cells of both the innate and adaptive immune system contribute to end-organ damage an

134 The innate and adaptive immune systems control the spread of virus, for

135 C) lineages, it is clear that the innate and adaptive immune systems converge into 3 major kinds of c

136 enesis of CAV, cells from the innate and the adaptive immune system cooperate to reject the foreign h

137 The microbial adaptive immune system CRISPR mediates defense against f

138 The bacterial adaptive immune system CRISPR-Cas9 has been appropriated

139 epeats (CRISPR) and associated protein (Cas) adaptive immune system (CRISPR-Cas) (Barrangou & Marraff

140 epeats (CRISPR) and associated protein (Cas) adaptive immune system (CRISPR-Cas).

141 prokaryotic microbes enlist small RNA-based adaptive immune systems (CRISPR-Cas systems) that protec

142 Derived from the bacterial adaptive immune system, CRISPR-Cas9 has been coopted and

143 CRISPR-Cas adaptive immune systems defend microbes against foreign

144 epeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign

145 SCID mice, which lack an adaptive immune system due to the absence of T and B lym

146 n at steady state, while the presence of the adaptive immune system elevates their activation state.

147 Many prokaryotes possess an adaptive immune system encoded by clustered regularly in

148 icient to drive beiging independently of the adaptive immune system, eosinophils or IL-4 receptor sig

149 The innate and adaptive immune systems fail to control HCV infection in

150 olves lesion-formation, and clearance by the adaptive immune system, followed by persistence with low

151 arp1(-/-) mice, highlighting the role of the adaptive immune system for full protection.

152 Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infect

153 spaced short palindromic repeats) RNA-guided adaptive immune systems for targeted elimination of fore

154 vities, attempting to exploit the innate and adaptive immune systems for therapeutic gain, are well e

155 lso been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-b

156 ir role in specific activation of the CTL of adaptive immune system, function also as the main ligand

157 onsible for the activation of the innate and adaptive immune system, further accentuating inflammatio

158 Although most prokaryotic adaptive immune systems generally target DNA substrates,

159 of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and a

160 The adaptive immune system has been considered to play a min

161 y interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-

162 direct recognition of neo-mtpeptides by the adaptive immune system has not been demonstrated.

163 Historically, only cells of the adaptive immune system have been considered capable of r

164 er, the effects of leptin replacement on the adaptive immune system have not yet been reported in the

165 ly benign and is well controlled by the host adaptive immune system; however, it is considered carcin

166 The role of the adaptive immune system in adverse drug reactions that ta

167 -Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend

168 ts-CRISPR-associated genes (CRISPR-Cas), the adaptive immune system in bacteria, limits genetic diver

169 ciation study, point to abnormalities of the adaptive immune system in childhood IIMs.

170 wever, the discovery of a second, convergent adaptive immune system in jawless fish, focused on the s

171 CRISPR)-mediated virus defense represents an adaptive immune system in many bacteria and archaea.

172 and will discuss the roles of the innate and adaptive immune system in neurodevelopment and how T cel

173 ies examine the activation of the innate and adaptive immune system in obesity; inflammation within d

174 trates for the first time alterations in the adaptive immune system in patients with autoinflammatory

175 ed Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes.

176 The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14)

177 The adaptive immune system in Pseudomonas aeruginosa (type I

178 rug-induced liver injury are mediated by the adaptive immune system in response to hepatic drug-prote

179 gs further demonstrate the importance of the adaptive immune system in the efficacy of trastuzumab-co

180 trophils in crosstalk between the innate and adaptive immune system in the mouth.

181 , these data highlight the importance of the adaptive immune system in the regulation of NK cell acti

182 es and plasmids and function primarily as an adaptive immune system in these organisms.

183 ore MHC region predated the emergence of the adaptive immune system in vertebrates.

184 ertebrates (cyclostomes) have an alternative adaptive immune system in which lymphocytes somatically

185 e intricate interplay between the innate and adaptive immune systems in Ag-SP tolerance induction.

186 le of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature

187 of the biological function of CRISPR-Cas as adaptive immune systems in bacteria.

188 Adaptive immune systems in prokaryotes and animals give

189 CRISPR-Cas adaptive immune systems in prokaryotes boast a diversity

190 R-associated (cas) genes make up RNA-guided, adaptive immune systems in prokaryotes whose effector pr

191 integrating signals from the innate and the adaptive immune systems in the control of the B-cell imm

192 point to a dysregulation of both innate and adaptive immune systems in the disease, and it is likely

193 immunotherapies by activating the innate and adaptive immune systems in tumor microenvironment.

194 any cell types of the innate, as well as the adaptive immune system, including natural killer (NK) an

195 m, coupled with relative inactivation of the adaptive immune system, indicating the potential of tran

196 Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viru

197 Activation of cells in the adaptive immune system is a highly orchestrated process

198 y interspaced short palindromic repeats)-Cas adaptive immune system is an important defense system in

199 The efficiency of the adaptive immune system is dependent on the diversity of

200 tivity of NK cells to these signals from the adaptive immune system is heterogeneous and influenced b

201 systemic disease, it also suggests that the adaptive immune system is implicated in its pathogenesis

202 Previously, we showed that the adaptive immune system is involved in the control of the

203 A major feature of an adaptive immune system is its ability to generate B- and

204 e.g., during vaccination) independent of the adaptive immune system is mediated in part by macrophage

205 if and how the circadian clock regulates the adaptive immune system is mostly unclear.

206 in both immune cohorts, suggesting that the adaptive immune system is not efficiently suppressing tu

207 phage abound, the only documented bacterial adaptive immune system is the CRISPR/Cas (clustered regu

208 A fundamental aspect of the adaptive immune system is the generation and maintenance

209 ost remarkable innovations of the vertebrate adaptive immune system is the progressive organization o

210 Our knowledge about an involvement of the adaptive immune system is very limited.

211 Coordination of the innate and adaptive immune systems is paramount to the development

212 obial repeat sequence; its recognition as an adaptive immune system; its biological characterization;

213 Many archaea and bacteria have an adaptive immune system known as CRISPR which allows them

214 The B and T cells of the human adaptive immune system leverage a highly diverse reperto

215 r activate components of both the innate and adaptive immune system mark pDCs as inducers of potent a

216 rimental data support that the modulation of adaptive immune system may be used for treating and prev

217 provide new insights into how the innate and adaptive immune system may interact during allogeneic en

218 hat IGHV1-69 and IGHV4-39, while part of the adaptive immune system, may have evolved under selection

219 n DNA for destruction as part of a bacterial adaptive immune system mediated by clustered regularly i

220 lity Complex (MHC) is a key component of the adaptive immune system of all vertebrates and consists o

221 Furthermore, the adaptive immune system of cartilaginous fishes is unusua

222 volution has been invoked to explain how the adaptive immune system of jawed vertebrates arose from c

223 the effect of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide

224 st-stroke autoimmune complications driven by adaptive immune system overactivation, and that CD163 is

225 ory has traditionally been the domain of the adaptive immune system, present only in antigen-specific

226 CRISPR-Cas adaptive immune systems protect bacteria and archaea aga

227 The adaptive immune system protects its host from a myriad o

228 he repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse p

229 The adaptive immune system provides critical defense against

230 ibodies are critical components of the human adaptive immune system, providing versatile scaffolds to

231 o activate both components of the innate and adaptive immune system, put human pDCs forward as potent

232 The adaptive immune system relies on the diversity of recept

233 he efficient recognition of pathogens by the adaptive immune system relies on the diversity of recept

234 The enteric microbiota and the innate and adaptive immune system represent prime candidates that i

235 Cells of both the innate and adaptive immune system residing in adipose tissues, as w

236 the arterial wall, with both the innate and adaptive immune systems responding to many endogenous an

237 form in-depth systems analysis of innate and adaptive immune system responses to implanted biomateria

238 The T-cell actin cytoskeleton mediates adaptive immune system responses to peptide antigens by

239 d the cellular composition of the innate and adaptive immune systems, resulted in global changes in b

240 ectious agents, might disrupt control of the adaptive immune system resulting in serious pathologies.

241 We examined whether cells of the adaptive immune system retain the memory of psychosocial

242 The adaptive immune system's capability to protect the body

243 s disease are limited, mainly because of the adaptive immune system's inability to generate protectiv

244 Thus, the interplay of the innate and adaptive immune system selectively targets virulent C. r

245 nce to a much more complex one involving the adaptive immune system, similarly to what occurs in usua

246 eflex, regulate responses to products of the adaptive immune system, specifically immune complex (IC)

247 It is unclear why the adaptive immune system, specifically the CD8(+) T cell r

248 r whether these links extend to cells of the adaptive immune system, such as T cells.

249 163 as a possible effector of stroke-induced adaptive immune system suppression.

250 CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against

251 s an ongoing dialogue between the innate and adaptive immune system that if left unchecked will lead

252 s proteins comprise a prokaryotic RNA-guided adaptive immune system that interferes with mobile genet

253 brates, have an alternative lymphocyte-based adaptive immune system that is based on somatically dive

254 he CRISPR-associated (cas) genes comprise an adaptive immune system that is one of the most widesprea

255 Short Palindromic Repeats (CRISPR) offer an adaptive immune system that protects bacteria and archae

256 CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archae

257 om the finding of the CRISPR system being an adaptive immune system that protects the prokaryotes aga

258 CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific d

259 However, a surprisingly sophisticated adaptive immune system that relies on small RNAs for seq

260 Vitamin D is a key regulator of innate and adaptive immune systems that may influence host suscepti

261 SPRs) are essential components of RNA-guided adaptive immune systems that protect bacteria and archae

262 Prokaryotic cells possess CRISPR-mediated adaptive immune systems that protect them from foreign g

263 CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against

264 teria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a

265 diverse biological processes, including the adaptive immune system, the development of neoplasms, an

266 mutations that eliminated a major arm of the adaptive immune system-the MHC II pathway of antigen pre

267 iety of molecular pathways of the innate and adaptive immune systems, their impact on the circulating

268 ulation expansion of cells of the innate and adaptive immune systems, their responses to inflammatory

269 ight an underappreciated contribution of the adaptive immune system to anti-CD47 adjuvant therapy and

270 rance is defined as nonresponsiveness of the adaptive immune system to antigens.

271 ors could be used to suppress the CRISPR-Cas adaptive immune system to enhance medical applications,

272 Hence, it may be possible to manipulate the adaptive immune system to enhance protective immunity in

273 g antibodies may therefore be easier for the adaptive immune system to generate than previously thoug

274 also functions intrinsically in cells of the adaptive immune system to inhibit proliferation.

275 events responsible for the inability of the adaptive immune system to mount an efficient antitumor r

276 The possible contribution of the maternal adaptive immune system to postsurgical pregnancy complic

277 The ability of the adaptive immune system to respond to arbitrary pathogens

278 the specific contributions of the innate and adaptive immune system to the generation of pain during

279 Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infect

280 The emergence of the adaptive immune system took a toll in the form of pathol

281 stimulates an antiviral state and drives the adaptive immune system toward an efficient and specific

282 sensing of foreign agents by the innate and adaptive immune system triggers complex signal transduct

283 Bacterial adaptive immune systems use CRISPRs (clustered regularly

284 Manipulating the adaptive immune system using biomaterials engineering ma

285 We hypothesized that an assessment of the adaptive immune system, using CD4+ T-lymphocyte transcri

286 Prokaryotic CRISPR-Cas adaptive immune systems utilize sequence-specific RNA-gu

287 Furthermore, pDC link the innate and adaptive immune systems via cytokine production and Ag p

288 ate immune cells and the cellular arm of the adaptive immune system, via effects on antigen presentat

289 However, the adaptive immune system was required for protection since

290 In addition, a crucial role for the adaptive immune system was shown on concomitant DEP+HDM

291 c might be supported more efficiently by the adaptive immune system when acidosis is triggered during

292 Antibody class switching is a feature of the adaptive immune system which enables diversification of

293 Memory is a hallmark of the adaptive immune system, which confers long-term protecti

294 The adaptive immune system, which is based on highly diverse

295 tight interaction between the innate and the adaptive immune system, which should be considered for t

296 molecules is an essential capability of the adaptive immune system, which until now was thought to b

297 metabolites interacting with the innate and adaptive immune system, which would set the basis for pr

298 hares functional features with the mammalian adaptive immune system, while also exhibiting characteri

299 g the most ancient vertebrates possessing an adaptive immune system with B and T lymphocytes that pro

300 ide a functional link between the innate and adaptive immune systems within visceral fat in mice.